{"id":"https://openalex.org/W4391303389","doi":"https://doi.org/10.1200/jco.2024.42.4_suppl.298","title":"Microboost dose escalation for localized prostate cancer within a statewide radiation oncology quality consortium.","display_name":"Microboost dose escalation for localized prostate cancer within a statewide radiation oncology quality consortium.","publication_year":2024,"publication_date":"2024-01-29","ids":{"openalex":"https://openalex.org/W4391303389","doi":"https://doi.org/10.1200/jco.2024.42.4_suppl.298"},"language":"en","primary_location":{"id":"doi:10.1200/jco.2024.42.4_suppl.298","doi":"https://doi.org/10.1200/jco.2024.42.4_suppl.298","is_oa":true,"landing_page_url":"https://doi.org/10.1200/jco.2024.42.4_suppl.298","pdf_url":"https://ascopubs.org/doi/pdfdirect/10.1200/JCO.2024.42.4_suppl.298","source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://ascopubs.org/doi/pdfdirect/10.1200/JCO.2024.42.4_suppl.298","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5084266886","display_name":"S.N. Regan","orcid":"https://orcid.org/0000-0002-5449-8348","observed_orcids":["https://orcid.org/0000-0002-5449-8348"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Samuel Regan","raw_affiliation_strings":["University of Michigan, Ann Arbor, MI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Michigan, Ann Arbor, MI","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076313479","display_name":"Michael P. Dykstra","orcid":"https://orcid.org/0000-0003-0834-7669","observed_orcids":["https://orcid.org/0000-0003-0834-7669"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael Dykstra","raw_affiliation_strings":["University of Michigan, Ann Arbor, MI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Michigan, Ann Arbor, MI","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003483276","display_name":"Huiying Yin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Huiying Yin","raw_affiliation_strings":["University of Michigan, Ann Arbor, MI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Michigan, Ann Arbor, MI","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018226548","display_name":"Patrick William McLaughlin","orcid":"https://orcid.org/0000-0002-3703-5296","observed_orcids":["https://orcid.org/0000-0002-3703-5296"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Patrick McLaughlin","raw_affiliation_strings":["Providence Assarian Cancer Center, Novi, MI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Providence Assarian Cancer Center, Novi, MI","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035702352","display_name":"Amit K. Bhatt","orcid":"https://orcid.org/0009-0002-5590-8705","observed_orcids":["https://orcid.org/0009-0002-5590-8705"]},"institutions":[{"id":"https://openalex.org/I4210090317","display_name":"The Barbara Ann Karmanos Cancer Institute","ror":"https://ror.org/00ee40h97","country_code":"US","type":"facility","lineage":["https://openalex.org/I2800590384","https://openalex.org/I4210090317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amit Bhatt","raw_affiliation_strings":["Karmanos Cancer Institute at McLaren, Lansing, MI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Karmanos Cancer Institute at McLaren, Lansing, MI","institution_ids":["https://openalex.org/I4210090317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053960294","display_name":"Thomas Pence Boike","orcid":"https://orcid.org/0000-0003-0870-6764","observed_orcids":["https://orcid.org/0000-0003-0870-6764"]},"institutions":[{"id":"https://openalex.org/I4210135627","display_name":"Michigan Healthcare Professionals","ror":"https://ror.org/03rzd8715","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210135627"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas Pence Boike","raw_affiliation_strings":["Michigan Healthcare Professionals, Farmington Hills, MI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Michigan Healthcare Professionals, Farmington Hills, MI","institution_ids":["https://openalex.org/I4210135627"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078807086","display_name":"Eleanor Walker","orcid":"https://orcid.org/0009-0005-5141-9658","observed_orcids":["https://orcid.org/0009-0005-5141-9658"]},"institutions":[{"id":"https://openalex.org/I2803043754","display_name":"Henry Ford Hospital","ror":"https://ror.org/0193sb042","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I154057602","https://openalex.org/I2803043754"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eleanor M. Walker","raw_affiliation_strings":["Henry Ford Hospital, Troy, MI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Henry Ford Hospital, Troy, MI","institution_ids":["https://openalex.org/I2803043754"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111343476","display_name":"Mark Zaki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210129224","display_name":"Covenant HealthCare","ror":"https://ror.org/0373pbp25","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210129224"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark A. Zaki","raw_affiliation_strings":["Covenant Radiation Center, Saginaw, MI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Covenant Radiation Center, Saginaw, MI","institution_ids":["https://openalex.org/I4210129224"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038217917","display_name":"Randi Kendrick","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Randi Kendrick","raw_affiliation_strings":["University of Michigan, Ann Arbor, MI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Michigan, Ann Arbor, MI","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040652349","display_name":"Mazen Mislmani","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210166668","display_name":"West Michigan Cancer Center","ror":"https://ror.org/05rzk0426","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210166668"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mazen Mislmani","raw_affiliation_strings":["West Michigan Cancer Center, Grand Rapids, MI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"West Michigan Cancer Center, Grand Rapids, MI","institution_ids":["https://openalex.org/I4210166668"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114172889","display_name":"Sarah Paluch","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210129224","display_name":"Covenant HealthCare","ror":"https://ror.org/0373pbp25","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210129224"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sarah Paluch","raw_affiliation_strings":["Covenant Healthcare, Saginaw, MI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Covenant Healthcare, Saginaw, MI","institution_ids":["https://openalex.org/I4210129224"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108419946","display_name":"Dale William Litzenberg","orcid":"https://orcid.org/0000-0001-8883-2175","observed_orcids":["https://orcid.org/0000-0001-8883-2175"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dale Litzenberg","raw_affiliation_strings":["University of Michigan, Ann Arbor, MI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Michigan, Ann Arbor, MI","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078412790","display_name":"Melissa A. Mietzel","orcid":"https://orcid.org/0000-0003-3222-9849","observed_orcids":["https://orcid.org/0000-0003-3222-9849"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Melissa A. Mietzel","raw_affiliation_strings":["University of Michigan, Ann Arbor, MI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Michigan, Ann Arbor, MI","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109353965","display_name":"Vrinda Narayana","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vrinda Narayana","raw_affiliation_strings":["University of Michigan, Ann Arbor, MI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Michigan, Ann Arbor, MI","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001301120","display_name":"Andrea Lynn Smith","orcid":"https://orcid.org/0000-0002-9194-4888","observed_orcids":["https://orcid.org/0000-0002-9194-4888"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrea Smith","raw_affiliation_strings":["University of Michigan, Ann Arbor, MI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Michigan, Ann Arbor, MI","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028976669","display_name":"David K. Heimburger","orcid":"https://orcid.org/0000-0002-7080-3488","observed_orcids":["https://orcid.org/0000-0002-7080-3488"]},"institutions":[{"id":"https://openalex.org/I1316844076","display_name":"Munson Medical Center","ror":"https://ror.org/005qzv038","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316844076"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David K. Heimburger","raw_affiliation_strings":["Munson Healthcare, Traverse City, MI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Munson Healthcare, Traverse City, MI","institution_ids":["https://openalex.org/I1316844076"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060316016","display_name":"Matthew J. Schipper","orcid":"https://orcid.org/0000-0001-6728-4720","observed_orcids":["https://orcid.org/0000-0001-6728-4720"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew J. Schipper","raw_affiliation_strings":["University of Michigan, Ann Arbor, MI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Michigan, Ann Arbor, MI","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073099461","display_name":"Will Jackson","orcid":"https://orcid.org/0000-0001-8709-5978","observed_orcids":["https://orcid.org/0000-0001-8709-5978"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William C. Jackson","raw_affiliation_strings":["University of Michigan, Ann Arbor, MI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Michigan, Ann Arbor, MI","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5034708452","display_name":"Robert Timothy Dess","orcid":"https://orcid.org/0000-0003-2331-3758","observed_orcids":["https://orcid.org/0000-0003-2331-3758"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert Timothy Dess","raw_affiliation_strings":["University of Michigan, Ann Arbor, MI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Michigan, Ann Arbor, MI","institution_ids":["https://openalex.org/I27837315"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"42","issue":"4_suppl","first_page":"298","last_page":"298"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10124","display_name":"Prostate Cancer Diagnosis and Treatment","score":0.711899995803833,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10124","display_name":"Prostate Cancer Diagnosis and Treatment","score":0.711899995803833,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10358","display_name":"Advanced Radiotherapy Techniques","score":0.2831999957561493,"subfield":{"id":"https://openalex.org/subfields/3108","display_name":"Radiation"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T13123","display_name":"Advances in Oncology and Radiotherapy","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/localized-prostate-cancer","display_name":"localized prostate cancer","score":0.8840000033378601},{"id":"https://openalex.org/keywords/external-beam-radiotherapy","display_name":"external beam radiotherapy","score":0.7929999828338623},{"id":"https://openalex.org/keywords/simultaneous-integrated-boost","display_name":"simultaneous integrated boost","score":0.546999990940094},{"id":"https://openalex.org/keywords/dosimetric-parameters","display_name":"dosimetric parameters","score":0.675000011920929},{"id":"https://openalex.org/keywords/fiducial-markers","display_name":"fiducial markers","score":0.8579999804496765},{"id":"https://openalex.org/keywords/rectal-spacer","display_name":"rectal spacer","score":0.9470000267028809},{"id":"https://openalex.org/keywords/image-guided-radiotherapy","display_name":"image-guided radiotherapy","score":0.8199999928474426},{"id":"https://openalex.org/keywords/hypofractionated-radiotherapy","display_name":"hypofractionated radiotherapy","score":0.8230000138282776},{"id":"https://openalex.org/keywords/brachytherapy-boost","display_name":"brachytherapy boost","score":0.8169999718666077},{"id":"https://openalex.org/keywords/prostate-adenocarcinoma","display_name":"prostate adenocarcinoma","score":0.6899999976158142},{"id":"https://openalex.org/keywords/treatment-utilization-patterns","display_name":"treatment utilization patterns","score":0.42100000381469727},{"id":"https://openalex.org/keywords/flame-trial","display_name":"FLAME trial","score":0.5289999842643738},{"id":"https://openalex.org/keywords/androgen-deprivation-therapy","display_name":"androgen deprivation therapy","score":0.6769999861717224}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9298865795135498},{"id":"https://openalex.org/C2992520072","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation oncology","level":3,"score":0.7565021514892578},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.7428571581840515},{"id":"https://openalex.org/C2776056953","wikidata":"https://www.wikidata.org/wiki/Q1182511","display_name":"De-escalation","level":2,"score":0.6731171607971191},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5484049916267395},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5142252445220947},{"id":"https://openalex.org/C2776598537","wikidata":"https://www.wikidata.org/wiki/Q1812651","display_name":"Clinical Oncology","level":3,"score":0.44694069027900696},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.41531747579574585},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.3974491059780121},{"id":"https://openalex.org/C19527891","wikidata":"https://www.wikidata.org/wiki/Q1120908","display_name":"Medical physics","level":1,"score":0.39672327041625977}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1200/jco.2024.42.4_suppl.298","doi":"https://doi.org/10.1200/jco.2024.42.4_suppl.298","is_oa":true,"landing_page_url":"https://doi.org/10.1200/jco.2024.42.4_suppl.298","pdf_url":"https://ascopubs.org/doi/pdfdirect/10.1200/JCO.2024.42.4_suppl.298","source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1200/jco.2024.42.4_suppl.298","doi":"https://doi.org/10.1200/jco.2024.42.4_suppl.298","is_oa":true,"landing_page_url":"https://doi.org/10.1200/jco.2024.42.4_suppl.298","pdf_url":"https://ascopubs.org/doi/pdfdirect/10.1200/JCO.2024.42.4_suppl.298","source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4391303389.pdf","grobid_xml":"https://content.openalex.org/works/W4391303389.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4403021278","https://openalex.org/W4386986223","https://openalex.org/W2129656462","https://openalex.org/W4402907360","https://openalex.org/W3125222626","https://openalex.org/W7034245304","https://openalex.org/W4200459022","https://openalex.org/W4401067917","https://openalex.org/W4414557391","https://openalex.org/W4391051254"],"abstract_inverted_index":{"298":[0],"Background:":[1],"The":[2],"phase":[3],"III":[4],"FLAME":[5],"trial":[6],"demonstrated":[7],"that":[8,48],"in":[9,53,171,180,205,223,271,364,374,413],"localized":[10],"prostate":[11,81,264,361],"cancer,":[12],"an":[13,22,395],"external":[14],"beam":[15],"radiotherapy":[16,87],"(EBRT)":[17],"simultaneous":[18],"integrated":[19],"microboost":[20,44,60,195,202,226,272,331,371,393],"to":[21,41,58,121,147],"MRI-defined":[23],"dominant":[24],"intraprostatic":[25],"lesion":[26],"improves":[27],"biochemical":[28],"control":[29],"without":[30,225],"affecting":[31],"toxicity":[32],"and":[33,62,103,131,134,160,201,207,221,227,229,254,316,345,347,367,389,400,405],"quality":[34],"of":[35,126,183,240,298,330,358,376],"life.":[36],"Given":[37],"the":[38,67,299],"complexity":[39],"required":[40],"deliver":[42],"high":[43],"doses,":[45],"we":[46],"hypothesized":[47],"practice":[49],"patterns":[50],"are":[51],"variable":[52],"clinical":[54],"practice.":[55,415],"We":[56],"aimed":[57],"characterize":[59],"utilization":[61],"evaluate":[63,122],"dosimetric":[64,114],"parameters":[65],"within":[66],"statewide":[68],"Michigan":[69],"Radiation":[70],"Oncology":[71],"Quality":[72],"Consortium":[73],"(MROQC).":[74],"Methods:":[75],"Men":[76],"with":[77,84,158,163,188,231,238,335,360,383],"intermediate":[78],"or":[79,217,339],"high-risk":[80,164],"adenocarcinoma":[82],"treated":[83,187,363],"curative":[85],"intent":[86],"for":[88,113],"intact":[89],"disease":[90],"were":[91,111,119,154,203],"included.":[92],"Data":[93],"was":[94,169,178,236,269,285,292,332,372,381],"prospectively":[95],"collected,":[96],"including":[97],"T/N-category,":[98],"Gleason":[99],"score,":[100],"prostate-specific":[101],"antigen,":[102],"percent":[104],"positive":[105],"biopsy":[106],"cores.":[107],"Full":[108],"DICOM":[109],"files":[110],"available":[112],"data.":[115],"Multivariable":[116],"analyses":[117],"(MVA)":[118],"used":[120,204],"associations":[123],"between":[124],"receipt":[125,329],"microboost,":[127,232],"known":[128],"prognostic":[129],"factors,":[130],"fiducial":[132,252,346],"marker":[133,253],"rectal":[135,255,319,348],"spacer":[136,256,349],"placement":[137,257],"(advanced":[138],"image":[139],"guided":[140],"radiation":[141],"therapy":[142,168],"(IGRT)).":[143],"Results:":[144],"From":[145],"10/26/20":[146],"06/26/23,":[148],"741":[149],"patients":[150,212,273,303],"across":[151],"26":[152],"centers":[153],"enrolled,":[155],"71%":[156],"(n=528)":[157],"intermediate-risk":[159],"29%":[161,181],"(n=213)":[162],"disease.":[165],"Androgen":[166],"deprivation":[167],"planned":[170],"61%.":[172],"EBRT":[173,189,224,377,392],"+":[174],"whole-gland":[175],"brachytherapy":[176],"boost":[177,200,283,289],"utilized":[179,373],"(n=217/741)":[182],"patients.":[184],"Of":[185],"those":[186],"(71%,":[190],"n=524/741),":[191],"10%":[192,375],"received":[193,213],"a":[194,241,353,370],"(n":[196],"=":[197,280,314,325],"53/524).":[198],"Brachytherapy":[199],"9":[206],"7":[208],"centers,":[209],"respectively.":[210,233],"Most":[211],"either":[214],"conventional":[215],"fractionation":[216],"moderate":[218],"hypofractionation-":[219],"11%":[220],"66%":[222],"21%":[228],"60%":[230],"Microboost":[234,302,379],"treatment":[235],"associated":[237,334,382],"use":[239,380],"planning":[242,265,342],"MRI":[243,343,387],"(91%":[244],"vs.":[245,259,276,311,322],"62%,":[246],"p":[247,261,279,313,324],"<0.0001)":[248],"as":[249,251],"well":[250],"(76%":[258],"45%,":[260],"<0.0001).":[262],"Median":[263,288],"target":[266],"volume":[267,284],"(PTV)":[268],"smaller":[270],"(127":[274],"cc":[275],"91":[277],"cc,":[278],"0.002);":[281],"median":[282],"21":[286],"cc.":[287],"dose":[290,397],"(D0.1cc)":[291],"117%":[293],"(IQR":[294],"115%":[295],"\u2013":[296],"119%)":[297],"PTV":[300],"prescription.":[301],"had":[304],"significantly":[305,333],"higher":[306,384],"mean":[307],"bladder":[308],"D1cc[%]":[309,320],"(105.7%":[310],"103.4%,":[312],"0.002)":[315],"numerically":[317],"lower":[318],"(90.7%":[321],"94.1%,":[323],"0.065).":[326],"On":[327],"MVA,":[328],"grade":[336,385],"group":[337],"4":[338],"5":[340],"disease,":[341],"use,":[344],"use.":[350],"Conclusions:":[351],"Within":[352],"large,":[354],"diverse":[355],"prospective":[356],"cohort":[357],"men":[359],"cancer":[362],"both":[365],"academic":[366],"community":[368],"settings,":[369],"cases.":[378],"group,":[386],"planning,":[388],"advanced":[390],"IGRT.":[391],"is":[394],"emerging":[396],"escalation":[398],"strategy":[399],"further":[401],"studies":[402],"confirming":[403],"safety":[404],"improved":[406],"clinically":[407],"meaningful":[408],"outcomes":[409],"may":[410],"increase":[411],"uptake":[412],"routine":[414]},"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2024-01-30T00:00:00"}