{"id":"https://openalex.org/W4391290112","doi":"https://doi.org/10.1016/j.ekir.2024.01.032","title":"Focal Segmental Glomerulosclerosis Patient Baseline Characteristics in the Sparsentan Phase 3 DUPLEX Study","display_name":"Focal Segmental Glomerulosclerosis Patient Baseline Characteristics in the Sparsentan Phase 3 DUPLEX Study","publication_year":2024,"publication_date":"2024-01-28","ids":{"openalex":"https://openalex.org/W4391290112","doi":"https://doi.org/10.1016/j.ekir.2024.01.032","pmid":"https://pubmed.ncbi.nlm.nih.gov/38765567","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11101813"},"language":"en","primary_location":{"id":"doi:10.1016/j.ekir.2024.01.032","doi":"https://doi.org/10.1016/j.ekir.2024.01.032","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ekir.2024.01.032","pdf_url":"http://www.kireports.org/article/S2468024924000421/pdf","source":{"id":"https://openalex.org/S2764478277","display_name":"Kidney International Reports","issn_l":"2468-0249","issn":["2468-0249"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-2","norway-1","oarl","poland-40","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Kidney International Reports\u00ae","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"http://www.kireports.org/article/S2468024924000421/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5029482359","display_name":"Howard Trachtman","orcid":"https://orcid.org/0000-0001-7447-9489","observed_orcids":["https://orcid.org/0000-0001-7447-9489","https://orcid.org/0009-0006-7778-292X"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Howard Trachtman","raw_affiliation_strings":["Division of Nephrology, Department of Pediatrics, University of Michigan, Ann Arbor, Michigan, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Nephrology, Department of Pediatrics, University of Michigan, Ann Arbor, Michigan, USA","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088037254","display_name":"Jai Radhakrishnan","orcid":"https://orcid.org/0000-0003-3157-5141","observed_orcids":["https://orcid.org/0000-0003-3157-5141"]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jai Radhakrishnan","raw_affiliation_strings":["Division of Nephrology, Columbia University, New York, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Nephrology, Columbia University, New York, New York, USA","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014297070","display_name":"Michelle N. Rheault","orcid":"https://orcid.org/0000-0003-2494-3970","observed_orcids":["https://orcid.org/0000-0003-2494-3970"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Michelle N. Rheault","raw_affiliation_strings":["Division of Pediatric Nephrology, University of Minnesota Medical School, Minneapolis, Minnesota, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pediatric Nephrology, University of Minnesota Medical School, Minneapolis, Minnesota, USA","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022177889","display_name":"Charles E. Alpers","orcid":"https://orcid.org/0000-0002-1859-1772","observed_orcids":["https://orcid.org/0000-0002-1859-1772"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Charles E. Alpers","raw_affiliation_strings":["Department of Laboratory Medicine and Pathology, University of Washington, Seattle, Washington, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine and Pathology, University of Washington, Seattle, Washington, USA","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055078486","display_name":"Jonathan Barratt","orcid":"https://orcid.org/0000-0002-9063-7229","observed_orcids":["https://orcid.org/0000-0002-9063-7229"]},"institutions":[{"id":"https://openalex.org/I153648349","display_name":"University of Leicester","ror":"https://ror.org/04h699437","country_code":"GB","type":"education","lineage":["https://openalex.org/I153648349"]},{"id":"https://openalex.org/I2800440371","display_name":"Leicester General Hospital","ror":"https://ror.org/02zg49d29","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800440371","https://openalex.org/I2802445252"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Jonathan Barratt","raw_affiliation_strings":["Department of Cardiovascular Sciences, University of Leicester General Hospital, Leicester, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiovascular Sciences, University of Leicester General Hospital, Leicester, UK","institution_ids":["https://openalex.org/I153648349","https://openalex.org/I2800440371"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031624913","display_name":"Hiddo J.L. Heerspink","orcid":"https://orcid.org/0000-0002-3126-3730","observed_orcids":["https://orcid.org/0000-0002-3126-3730"]},"institutions":[{"id":"https://openalex.org/I1334415907","display_name":"University Medical Center Groningen","ror":"https://ror.org/03cv38k47","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I1334415907"]},{"id":"https://openalex.org/I169381384","display_name":"University of Groningen","ror":"https://ror.org/012p63287","country_code":"NL","type":"education","lineage":["https://openalex.org/I169381384"]},{"id":"https://openalex.org/I4210110309","display_name":"The George Institute for Global Health","ror":"https://ror.org/023331s46","country_code":"AU","type":"facility","lineage":["https://openalex.org/I4210110309"]}],"countries":["AU","NL"],"is_corresponding":false,"raw_author_name":"Hiddo J.L. Heerspink","raw_affiliation_strings":["Department of Clinical Pharmacy and Pharmacology, University of Medical Center Groningen, University of Groningen, Groningen, the Netherlands","The George Institute for Global Health, Sydney, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Pharmacy and Pharmacology, University of Medical Center Groningen, University of Groningen, Groningen, the Netherlands","institution_ids":["https://openalex.org/I1334415907","https://openalex.org/I169381384"]},{"raw_affiliation_string":"The George Institute for Global Health, Sydney, Australia","institution_ids":["https://openalex.org/I4210110309"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031510699","display_name":"Irene L. Noronha","orcid":"https://orcid.org/0000-0002-3208-4435","observed_orcids":["https://orcid.org/0000-0002-3208-4435"]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Irene L. Noronha","raw_affiliation_strings":["Division of Nephrology, University of S\u00e3o Paulo School of Medicine, S\u00e3o Paulo, Brazil","Nephrology, Division of Nephrology, University of S\u00e3o Paulo School of Medicine, S\u00e3o Paulo, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Nephrology, University of S\u00e3o Paulo School of Medicine, S\u00e3o Paulo, Brazil","institution_ids":["https://openalex.org/I17974374"]},{"raw_affiliation_string":"Nephrology, Division of Nephrology, University of S\u00e3o Paulo School of Medicine, S\u00e3o Paulo, Brazil","institution_ids":["https://openalex.org/I17974374"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027520502","display_name":"Vlado Perkovic","orcid":"https://orcid.org/0000-0002-4257-7620","observed_orcids":["https://orcid.org/0000-0002-4257-7620"]},"institutions":[{"id":"https://openalex.org/I31746571","display_name":"UNSW Sydney","ror":"https://ror.org/03r8z3t63","country_code":"AU","type":"education","lineage":["https://openalex.org/I31746571"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Vlado Perkovic","raw_affiliation_strings":["Faculty of Medicine, University of New South Wales Sydney, Sydney, New South Wales, Australia","Faculty of Medicine, University of New South Wales Sydney, Sydney, NSW, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Medicine, University of New South Wales Sydney, Sydney, New South Wales, Australia","institution_ids":["https://openalex.org/I31746571"]},{"raw_affiliation_string":"Faculty of Medicine, University of New South Wales Sydney, Sydney, NSW, Australia","institution_ids":["https://openalex.org/I31746571"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042356850","display_name":"Brad H. Rovin","orcid":"https://orcid.org/0000-0001-5639-0210","observed_orcids":["https://orcid.org/0000-0001-5639-0210"]},"institutions":[{"id":"https://openalex.org/I2802841970","display_name":"The Ohio State University Wexner Medical Center","ror":"https://ror.org/00c01js51","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2802841970"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brad Rovin","raw_affiliation_strings":["Division of Nephrology, Ohio State University Wexner Medical Center, Columbus, Ohio, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Nephrology, Ohio State University Wexner Medical Center, Columbus, Ohio, USA","institution_ids":["https://openalex.org/I2802841970"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075435520","display_name":"Hern\u00e1n Trimarchi","orcid":"https://orcid.org/0000-0002-6921-4811","observed_orcids":["https://orcid.org/0000-0002-6921-4811"]},"institutions":[{"id":"https://openalex.org/I4210148193","display_name":"Hospital Brit\u00e1nico de Buenos Aires","ror":"https://ror.org/04djj4v98","country_code":"AR","type":"healthcare","lineage":["https://openalex.org/I4210148193"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"Hern\u00e1n Trimarchi","raw_affiliation_strings":["Nephrology Service, Hospital Brit\u00e1nico de Buenos Aires, Buenos Aires, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nephrology Service, Hospital Brit\u00e1nico de Buenos Aires, Buenos Aires, Argentina","institution_ids":["https://openalex.org/I4210148193"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044094477","display_name":"Muh Geot Wong","orcid":"https://orcid.org/0000-0002-7575-9877","observed_orcids":["https://orcid.org/0000-0002-7575-9877"]},"institutions":[{"id":"https://openalex.org/I129604602","display_name":"The University of Sydney","ror":"https://ror.org/0384j8v12","country_code":"AU","type":"education","lineage":["https://openalex.org/I129604602"]},{"id":"https://openalex.org/I4210110309","display_name":"The George Institute for Global Health","ror":"https://ror.org/023331s46","country_code":"AU","type":"facility","lineage":["https://openalex.org/I4210110309"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Muh Geot Wong","raw_affiliation_strings":["Concord Clinical School, University of Sydney, Concord, New South Wales, Australia","The George Institute for Global Health, Sydney, Australia","Concord Clinical School, University of Sydney, Concord, NSW, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Concord Clinical School, University of Sydney, Concord, New South Wales, Australia","institution_ids":["https://openalex.org/I129604602"]},{"raw_affiliation_string":"The George Institute for Global Health, Sydney, Australia","institution_ids":["https://openalex.org/I4210110309"]},{"raw_affiliation_string":"Concord Clinical School, University of Sydney, Concord, NSW, Australia","institution_ids":["https://openalex.org/I129604602"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112411117","display_name":"Alex Mercer","orcid":"https://orcid.org/0009-0006-5279-1416","observed_orcids":["https://orcid.org/0009-0006-5279-1416"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alex Mercer","raw_affiliation_strings":["JAMCO Pharma Consulting, Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"JAMCO Pharma Consulting, Stockholm, Sweden","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047212794","display_name":"Jula K. Inrig","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405273497","display_name":"Travere Therapeutics (United States)","ror":"https://ror.org/05x5gq702","country_code":"US","type":"company","lineage":["https://openalex.org/I4405273497"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jula Inrig","raw_affiliation_strings":["Travere Therapeutics Inc., San Diego, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Travere Therapeutics Inc., San Diego, California, USA","institution_ids":["https://openalex.org/I4405273497"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014653223","display_name":"William E. Rote","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405273497","display_name":"Travere Therapeutics (United States)","ror":"https://ror.org/05x5gq702","country_code":"US","type":"company","lineage":["https://openalex.org/I4405273497"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William Rote","raw_affiliation_strings":["Travere Therapeutics Inc., San Diego, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Travere Therapeutics Inc., San Diego, California, USA","institution_ids":["https://openalex.org/I4405273497"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112487194","display_name":"Ed Murphy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405273497","display_name":"Travere Therapeutics (United States)","ror":"https://ror.org/05x5gq702","country_code":"US","type":"company","lineage":["https://openalex.org/I4405273497"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ed Murphy","raw_affiliation_strings":["Travere Therapeutics Inc., San Diego, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Travere Therapeutics Inc., San Diego, California, USA","institution_ids":["https://openalex.org/I4405273497"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072698697","display_name":"Patricia W. Bedard","orcid":"https://orcid.org/0009-0005-6121-3784","observed_orcids":["https://orcid.org/0009-0005-6121-3784"]},"institutions":[{"id":"https://openalex.org/I4405273497","display_name":"Travere Therapeutics (United States)","ror":"https://ror.org/05x5gq702","country_code":"US","type":"company","lineage":["https://openalex.org/I4405273497"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Patricia W. Bedard","raw_affiliation_strings":["Travere Therapeutics Inc., San Diego, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Travere Therapeutics Inc., San Diego, California, USA","institution_ids":["https://openalex.org/I4405273497"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Sandra Roth","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405273497","display_name":"Travere Therapeutics (United States)","ror":"https://ror.org/05x5gq702","country_code":"US","type":"company","lineage":["https://openalex.org/I4405273497"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sandra Roth","raw_affiliation_strings":["Travere Therapeutics Inc., San Diego, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Travere Therapeutics Inc., San Diego, California, USA","institution_ids":["https://openalex.org/I4405273497"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085776012","display_name":"Stewart Bieler","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405273497","display_name":"Travere Therapeutics (United States)","ror":"https://ror.org/05x5gq702","country_code":"US","type":"company","lineage":["https://openalex.org/I4405273497"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stewart Bieler","raw_affiliation_strings":["Travere Therapeutics Inc., San Diego, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Travere Therapeutics Inc., San Diego, California, USA","institution_ids":["https://openalex.org/I4405273497"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5071680096","display_name":"Radko Komers","orcid":"https://orcid.org/0009-0006-7814-5324","observed_orcids":["https://orcid.org/0009-0006-7814-5324"]},"institutions":[{"id":"https://openalex.org/I4405273497","display_name":"Travere Therapeutics (United States)","ror":"https://ror.org/05x5gq702","country_code":"US","type":"company","lineage":["https://openalex.org/I4405273497"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Radko Komers","raw_affiliation_strings":["Travere Therapeutics Inc., San Diego, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Travere Therapeutics Inc., San Diego, California, USA","institution_ids":["https://openalex.org/I4405273497"]}]}],"institutions":[],"countries_distinct_count":6,"institutions_distinct_count":16,"corresponding_author_ids":["https://openalex.org/A5014297070","https://openalex.org/A5029482359","https://openalex.org/A5088037254"],"corresponding_institution_ids":["https://openalex.org/I130238516","https://openalex.org/I27837315","https://openalex.org/I4210114445","https://openalex.org/I78577930"],"apc_list":{"value":2800,"currency":"USD","value_usd":2800},"apc_paid":{"value":2800,"currency":"USD","value_usd":2800},"fwci":1.9813,"has_fulltext":true,"cited_by_count":8,"citation_normalized_percentile":{"value":0.86545557,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":98},"biblio":{"volume":"9","issue":"4","first_page":"1020","last_page":"1030"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11029","display_name":"Renal Diseases and Glomerulopathies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11029","display_name":"Renal Diseases and Glomerulopathies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10373","display_name":"Renal Transplantation Outcomes and Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2747","display_name":"Transplantation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/focal-segmental-glomerulosclerosis","display_name":"focal segmental glomerulosclerosis","score":0.9769999980926514},{"id":"https://openalex.org/keywords/sparsentan","display_name":"sparsentan","score":1.0},{"id":"https://openalex.org/keywords/irbesartan","display_name":"irbesartan","score":0.7960000038146973},{"id":"https://openalex.org/keywords/endothelin-receptor-antagonists","display_name":"endothelin receptor antagonists","score":0.7110000252723694},{"id":"https://openalex.org/keywords/angiotensin-receptor-blockers","display_name":"angiotensin receptor blockers","score":0.8709999918937683},{"id":"https://openalex.org/keywords/apol1-genotype","display_name":"APOL1 genotype","score":0.7450000047683716},{"id":"https://openalex.org/keywords/urine-protein-creatinine-ratio","display_name":"urine protein-to-creatinine ratio","score":0.8130000233650208},{"id":"https://openalex.org/keywords/chronic-kidney-disease","display_name":"chronic kidney disease","score":0.7409999966621399},{"id":"https://openalex.org/keywords/pediatric-patients","display_name":"pediatric patients","score":0.753000020980835},{"id":"https://openalex.org/keywords/baseline-characteristics","display_name":"baseline characteristics","score":0.6809999942779541}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.900081217288971},{"id":"https://openalex.org/C2778415529","wikidata":"https://www.wikidata.org/wiki/Q1435223","display_name":"Focal segmental glomerulosclerosis","level":4,"score":0.7555251121520996},{"id":"https://openalex.org/C99611785","wikidata":"https://www.wikidata.org/wiki/Q6453233","display_name":"Duplex (building)","level":3,"score":0.716245174407959},{"id":"https://openalex.org/C2777390665","wikidata":"https://www.wikidata.org/wiki/Q5571239","display_name":"Glomerulosclerosis","level":4,"score":0.43410399556159973},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.42854446172714233},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4105681777000427},{"id":"https://openalex.org/C2780368995","wikidata":"https://www.wikidata.org/wiki/Q605006","display_name":"Glomerulonephritis","level":3,"score":0.10382753610610962},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.0598331093788147},{"id":"https://openalex.org/C2779561371","wikidata":"https://www.wikidata.org/wiki/Q570197","display_name":"Proteinuria","level":3,"score":0.05868387222290039},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.1016/j.ekir.2024.01.032","doi":"https://doi.org/10.1016/j.ekir.2024.01.032","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ekir.2024.01.032","pdf_url":"http://www.kireports.org/article/S2468024924000421/pdf","source":{"id":"https://openalex.org/S2764478277","display_name":"Kidney International Reports","issn_l":"2468-0249","issn":["2468-0249"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-2","norway-1","oarl","poland-40","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Kidney International Reports\u00ae","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11101813","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11101813","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11101813/pdf/main.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Kidney Int Rep","raw_type":"Text"},{"id":"pmid:38765567","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38765567","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Kidney international reports","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:88d1185da86c4b8f8decb8bb524f012e","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/88d1185da86c4b8f8decb8bb524f012e","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Kidney International Reports, Vol 9, Iss 4, Pp 1020-1030 (2024)","raw_type":"article"},{"id":"pmh:oai:pure.rug.nl:openaire/d0ac7345-2e1d-41cc-bbd1-95f761367a68","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/11370/d0ac7345-2e1d-41cc-bbd1-95f761367a68","pdf_url":null,"source":{"id":"https://openalex.org/S4306400420","display_name":"University of Groningen research database (University of Groningen / Centre for Information Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I169381384","host_organization_name":"University of Groningen","host_organization_lineage":["https://openalex.org/I169381384"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Trachtman, H, Radhakrishnan, J, Rheault, M N, Alpers, C E, Barratt, J, Heerspink, H J L, Noronha, I L, Perkovic, V, Rovin, B, Trimarchi, H, Wong, M G, Mercer, A, Inrig, J, Rote, W, Murphy, E, Bedard, P W, Roth, S, Bieler, S & Komers, R 2024, 'Focal Segmental Glomerulosclerosis Patient Baseline Characteristics in the Sparsentan Phase 3 DUPLEX Study', Kidney International Reports, vol. 9, no. 4, pp. 1020-1030. https://doi.org/10.1016/j.ekir.2024.01.032","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1016/j.ekir.2024.01.032","doi":"https://doi.org/10.1016/j.ekir.2024.01.032","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ekir.2024.01.032","pdf_url":"http://www.kireports.org/article/S2468024924000421/pdf","source":{"id":"https://openalex.org/S2764478277","display_name":"Kidney International Reports","issn_l":"2468-0249","issn":["2468-0249"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-2","norway-1","oarl","poland-40","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Kidney International Reports\u00ae","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320307773","display_name":"GlaxoSmithKline","ror":"https://ror.org/01xsqw823"},{"id":"https://openalex.org/F4320318412","display_name":"Argenx","ror":"https://ror.org/04spfxf63"},{"id":"https://openalex.org/F4320319293","display_name":"Gal\u00e1pagos","ror":"https://ror.org/04e4j5d46"},{"id":"https://openalex.org/F4526693783","display_name":"MedVal Scientific Information Services","ror":null},{"id":"https://openalex.org/F8936655697","display_name":"Travere Therapeutics","ror":"https://ror.org/05x5gq702"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4391290112.pdf","grobid_xml":"https://content.openalex.org/works/W4391290112.grobid-xml"},"referenced_works_count":43,"referenced_works":["https://openalex.org/W1972855150","https://openalex.org/W1988824489","https://openalex.org/W1991210746","https://openalex.org/W2015170224","https://openalex.org/W2051978340","https://openalex.org/W2065013649","https://openalex.org/W2096179755","https://openalex.org/W2098823303","https://openalex.org/W2100732774","https://openalex.org/W2101052694","https://openalex.org/W2119111969","https://openalex.org/W2122770875","https://openalex.org/W2133476890","https://openalex.org/W2136089239","https://openalex.org/W2136212618","https://openalex.org/W2142522073","https://openalex.org/W2152298559","https://openalex.org/W2156753852","https://openalex.org/W2163543028","https://openalex.org/W2327710376","https://openalex.org/W2593771998","https://openalex.org/W2727604819","https://openalex.org/W2765092896","https://openalex.org/W2767557721","https://openalex.org/W2783430372","https://openalex.org/W2788969813","https://openalex.org/W2898491544","https://openalex.org/W2906428833","https://openalex.org/W2909726367","https://openalex.org/W2995605526","https://openalex.org/W2999129752","https://openalex.org/W3005350465","https://openalex.org/W3007591785","https://openalex.org/W3040054418","https://openalex.org/W3049359784","https://openalex.org/W3162886856","https://openalex.org/W3172220972","https://openalex.org/W3200479416","https://openalex.org/W3217492688","https://openalex.org/W4293102518","https://openalex.org/W4317608095","https://openalex.org/W4319662527","https://openalex.org/W4324311608"],"related_works":["https://openalex.org/W4229027438","https://openalex.org/W2999129752","https://openalex.org/W4403831592","https://openalex.org/W4247884243","https://openalex.org/W7116952444","https://openalex.org/W4392977407","https://openalex.org/W2594073619","https://openalex.org/W4407863268","https://openalex.org/W2617438993","https://openalex.org/W7203834484"],"abstract_inverted_index":{"Introduction":[0],"The":[1,98],"phase":[2],"3":[3],"DUPLEX":[4,26],"trial":[5],"is":[6,28],"evaluating":[7,37],"sparsentan,":[8],"a":[9,29,75,243],"novel,":[10],"non-immunosuppressive,":[11],"single-molecule":[12],"dual":[13],"endothelin":[14],"angiotensin":[15],"receptor":[16],"antagonist,":[17],"in":[18,54,74,156,222,228,242],"patients":[19,55,104,180],"with":[20,67,79],"focal":[21],"segmental":[22],"glomerulosclerosis":[23],"(FSGS).":[24],"Methods":[25],"(NCT03493685)":[27],"global,":[30],"multicenter,":[31],"randomized,":[32],"double-blind,":[33],"parallel-group,":[34],"active-controlled":[35],"study":[36,116,227],"the":[38,224,237],"efficacy":[39],"and":[40,60,81,114,135,200,212,246],"safety":[41],"of":[42,182,193,236,240],"sparsentan":[43,241],"800":[44],"mg":[45,51],"once":[46,52],"daily":[47,53],"versus":[48],"irbesartan":[49],"300":[50],"aged":[56],"8-75":[57],"years":[58,62],"(USA/UK)":[59],"18-75":[61],"(ex-USA/UK)":[63],"weighing":[64],"\u226520":[65],"kg":[66],"biopsy-proven":[68],"FSGS":[69,229,249],"or":[70,131,145,188],"documented":[71],"genetic":[72],"mutation":[73],"podocyte":[76,197],"protein":[77],"associated":[78],"FSGS,":[80],"urine":[82],"protein/creatinine":[83],"ratio":[84],"(UP/C)":[85],"\u22651.5":[86],"g/g.":[87],"Baseline":[88,149],"characteristics":[89],"blinded":[90],"to":[91,173,196,230],"treatment":[92,238],"allocation":[93],"are":[94],"reported":[95],"descriptively.":[96],"Results":[97],"primary":[99],"analysis":[100],"population":[101],"includes":[102],"371":[103],"(336":[105],"adult,":[106],"35":[107],"pediatric":[108],"[<18":[109],"years])":[110],"who":[111],"were":[112,123,166],"randomized":[113],"received":[115],"drug":[117],"(median":[118],"age,":[119],"42":[120],"years).":[121],"Patients":[122,165],"White":[124],"(73.0%),":[125],"Asian":[126],"(13.2%),":[127],"Black/African":[128],"American":[129],"(6.7%)":[130],"other":[132],"race":[133],"(7.0%)":[134],"from":[136],"North":[137],"America":[138,143],"(38.8%),":[139],"Europe":[140],"(36.1%),":[141],"South":[142],"(12.7%),":[144],"Asia":[146],"Pacific":[147],"(12.4%).":[148],"median":[150],"UP/C":[151],"was":[152],"3.0":[153],"g/g;":[154],"42.6%":[155],"nephrotic-range":[157],"(UP/C":[158],">3.5":[159],"g/g":[160,163],"[adults];":[161],">2.0":[162],"[pediatrics]).":[164],"evenly":[167],"distributed":[168],"across":[169],"eGFR":[170],"categories":[171],"corresponding":[172],"chronic":[174],"kidney":[175],"disease":[176],"stages":[177],"1-3b.":[178],"Thirty-three":[179],"(9.4%":[181],"352":[183],"evaluable":[184],"samples)":[185],"had":[186,204,215],"pathogenic":[187,190],"likely":[189],"(P/LP)":[191],"variants":[192],"genes":[194],"essential":[195],"structural":[198],"integrity":[199],"function,":[201],"27":[202],"(7.7%)":[203],"P/LP":[205],"collagen":[206],"gene":[207],"(":[208],"COL4A3/4/5":[209],")":[210],"variants,":[211],"14":[213],"(4.0%)":[214],"high-risk":[216],"APOL1":[217],"genotypes.":[218],"Conclusions":[219],"Patient":[220],"enrollment":[221],"DUPLEX,":[223],"largest":[225],"interventional":[226],"date,":[231],"will":[232],"enable":[233],"important":[234],"characterization":[235],"effect":[239],"geographically":[244],"broad":[245],"clinically":[247],"diverse":[248],"population.":[250]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2024-01-28T00:00:00"}