{"id":"https://openalex.org/W4391246498","doi":"https://doi.org/10.1101/2024.01.26.24301821","title":"Aberrant fast spiking interneuronal activity precedes seizure transitions in humans","display_name":"Aberrant fast spiking interneuronal activity precedes seizure transitions in humans","publication_year":2024,"publication_date":"2024-01-26","ids":{"openalex":"https://openalex.org/W4391246498","doi":"https://doi.org/10.1101/2024.01.26.24301821","pmid":"https://pubmed.ncbi.nlm.nih.gov/38343792","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10854323"},"language":"en","primary_location":{"id":"doi:10.1101/2024.01.26.24301821","doi":"https://doi.org/10.1101/2024.01.26.24301821","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2024.01.26.24301821","pdf_url":"https://www.medrxiv.org/content/medrxiv/early/2024/01/26/2024.01.26.24301821.full.pdf","source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.medrxiv.org/content/medrxiv/early/2024/01/26/2024.01.26.24301821.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5065135434","display_name":"Edward M. Merricks","orcid":"https://orcid.org/0000-0001-8172-3152","observed_orcids":["https://orcid.org/0000-0001-8172-3152"]},"institutions":[{"id":"https://openalex.org/I2799503643","display_name":"Columbia University Irving Medical Center","ror":"https://ror.org/01esghr10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799503643"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Edward M. Merricks","raw_affiliation_strings":["Department of Neurology, Columbia University Medical Center, New York, NY 10032","Department of Neurology, Columbia University Medical Center"],"raw_orcid":"https://orcid.org/0000-0001-8172-3152","affiliations":[{"raw_affiliation_string":"Department of Neurology, Columbia University Medical Center, New York, NY 10032","institution_ids":["https://openalex.org/I2799503643"]},{"raw_affiliation_string":"Department of Neurology, Columbia University Medical Center","institution_ids":["https://openalex.org/I2799503643"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034511305","display_name":"Sarita S. Deshpande","orcid":"https://orcid.org/0000-0002-9014-2170","observed_orcids":["https://orcid.org/0000-0002-9014-2170"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sarita S. Deshpande","raw_affiliation_strings":["Committee on Neurobiology, University of Chicago, Chicago, IL 60637","Medical Scientist Training Program, University of Chicago, Chicago, IL 60637","Section of Pediatric Neurology, University of Chicago, Chicago, IL 60637","Committee on Neurobiology, University of Chicago","Medical Scientist Training Program, University of Chicago","Section of Pediatric Neurology, University of Chicago"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Committee on Neurobiology, University of Chicago, Chicago, IL 60637","institution_ids":["https://openalex.org/I40347166"]},{"raw_affiliation_string":"Medical Scientist Training Program, University of Chicago, Chicago, IL 60637","institution_ids":["https://openalex.org/I40347166"]},{"raw_affiliation_string":"Section of Pediatric Neurology, University of Chicago, Chicago, IL 60637","institution_ids":["https://openalex.org/I40347166"]},{"raw_affiliation_string":"Committee on Neurobiology, University of Chicago","institution_ids":["https://openalex.org/I40347166"]},{"raw_affiliation_string":"Medical Scientist Training Program, University of Chicago","institution_ids":["https://openalex.org/I40347166"]},{"raw_affiliation_string":"Section of Pediatric Neurology, University of Chicago","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074740287","display_name":"Alexander HCW Agopyan-Miu","orcid":"https://orcid.org/0000-0003-1914-7857","observed_orcids":["https://orcid.org/0000-0003-1914-7857"]},"institutions":[{"id":"https://openalex.org/I2799503643","display_name":"Columbia University Irving Medical Center","ror":"https://ror.org/01esghr10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799503643"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexander H. Agopyan-Miu","raw_affiliation_strings":["Department of Neurological Surgery, Columbia University Medical Center, New York, NY 10032","Department of Neurological Surgery, Columbia University Medical Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurological Surgery, Columbia University Medical Center, New York, NY 10032","institution_ids":["https://openalex.org/I2799503643"]},{"raw_affiliation_string":"Department of Neurological Surgery, Columbia University Medical Center","institution_ids":["https://openalex.org/I2799503643"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020782922","display_name":"Elliot H. Smith","orcid":"https://orcid.org/0000-0003-4323-4643","observed_orcids":["https://orcid.org/0000-0003-4323-4643"]},"institutions":[{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]},{"id":"https://openalex.org/I2799503643","display_name":"Columbia University Irving Medical Center","ror":"https://ror.org/01esghr10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799503643"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elliot H. Smith","raw_affiliation_strings":["Department of Neurology, Columbia University Medical Center, New York, NY 10032","Department of Neurosurgery, University of Utah, Salt Lake City, UT 84132","Department of Neurology, Columbia University Medical Center","Department of Neurosurgery, University of Utah"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Columbia University Medical Center, New York, NY 10032","institution_ids":["https://openalex.org/I2799503643"]},{"raw_affiliation_string":"Department of Neurosurgery, University of Utah, Salt Lake City, UT 84132","institution_ids":["https://openalex.org/I223532165"]},{"raw_affiliation_string":"Department of Neurology, Columbia University Medical Center","institution_ids":["https://openalex.org/I2799503643"]},{"raw_affiliation_string":"Department of Neurosurgery, University of Utah","institution_ids":["https://openalex.org/I223532165"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010560758","display_name":"Emily D. Schlafly","orcid":"https://orcid.org/0009-0003-9601-2654","observed_orcids":["https://orcid.org/0009-0003-9601-2654"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Emily D. Schlafly","raw_affiliation_strings":["Graduate Program in Neuroscience, Boston University, Boston, MA 02215","Graduate Program in Neuroscience, Boston University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate Program in Neuroscience, Boston University, Boston, MA 02215","institution_ids":["https://openalex.org/I111088046"]},{"raw_affiliation_string":"Graduate Program in Neuroscience, Boston University","institution_ids":["https://openalex.org/I111088046"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074628106","display_name":"Guy M. McKhann","orcid":"https://orcid.org/0000-0002-9695-3564","observed_orcids":["https://orcid.org/0000-0002-9695-3564"]},"institutions":[{"id":"https://openalex.org/I2799503643","display_name":"Columbia University Irving Medical Center","ror":"https://ror.org/01esghr10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799503643"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Guy M. McKhann","raw_affiliation_strings":["Department of Neurological Surgery, Columbia University Medical Center, New York, NY 10032","Department of Neurological Surgery, Columbia University Medical Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurological Surgery, Columbia University Medical Center, New York, NY 10032","institution_ids":["https://openalex.org/I2799503643"]},{"raw_affiliation_string":"Department of Neurological Surgery, Columbia University Medical Center","institution_ids":["https://openalex.org/I2799503643"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Robert R. Goodman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405258748","display_name":"Hackensack Meridian School of Medicine","ror":"https://ror.org/014xxfg68","country_code":"US","type":"education","lineage":["https://openalex.org/I4405258748"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert R. Goodman","raw_affiliation_strings":["Department of Neurosurgery, Hackensack Meridian School of Medicine, Nutley, NJ 07110","Department of Neurosurgery, Hackensack Meridian School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, Hackensack Meridian School of Medicine, Nutley, NJ 07110","institution_ids":["https://openalex.org/I4405258748"]},{"raw_affiliation_string":"Department of Neurosurgery, Hackensack Meridian School of Medicine","institution_ids":["https://openalex.org/I4405258748"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082661128","display_name":"Sameer Anil Sheth","orcid":"https://orcid.org/0000-0001-8770-8965","observed_orcids":["https://orcid.org/0000-0001-8770-8965"]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sameer A. Sheth","raw_affiliation_strings":["Department of Neurosurgery, Baylor College of Medicine, Houston, TX 77030","Department of Neurosurgery, Baylor College of Medicine"],"raw_orcid":"https://orcid.org/0000-0001-8770-8965","affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, Baylor College of Medicine, Houston, TX 77030","institution_ids":["https://openalex.org/I181547552"]},{"raw_affiliation_string":"Department of Neurosurgery, Baylor College of Medicine","institution_ids":["https://openalex.org/I181547552"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005714907","display_name":"Bradley E. Greger","orcid":"https://orcid.org/0000-0002-6702-7596","observed_orcids":["https://orcid.org/0000-0002-6702-7596"]},"institutions":[{"id":"https://openalex.org/I55732556","display_name":"Arizona State University","ror":"https://ror.org/03efmqc40","country_code":"US","type":"education","lineage":["https://openalex.org/I55732556"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bradley Greger","raw_affiliation_strings":["School of Biology and Health Systems Engineering, Arizona State University, Tempe, AZ 85287","School of Biology and Health Systems Engineering, Arizona State University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Biology and Health Systems Engineering, Arizona State University, Tempe, AZ 85287","institution_ids":["https://openalex.org/I55732556"]},{"raw_affiliation_string":"School of Biology and Health Systems Engineering, Arizona State University","institution_ids":["https://openalex.org/I55732556"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077015482","display_name":"Paul A. House","orcid":"https://orcid.org/0000-0002-0631-9472","observed_orcids":["https://orcid.org/0000-0002-0631-9472"]},"institutions":[{"id":"https://openalex.org/I108785884","display_name":"Intermountain Healthcare","ror":"https://ror.org/04mvr1r74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I108785884"]},{"id":"https://openalex.org/I2803061204","display_name":"Intermountain Medical Center","ror":"https://ror.org/009c06z12","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I108785884","https://openalex.org/I2803061204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paul A. House","raw_affiliation_strings":["Intermountain Healthcare, Murray, UT 84107","Intermountain Healthcare"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Intermountain Healthcare, Murray, UT 84107","institution_ids":["https://openalex.org/I108785884","https://openalex.org/I2803061204"]},{"raw_affiliation_string":"Intermountain Healthcare","institution_ids":["https://openalex.org/I108785884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047068032","display_name":"Emad N. Eskandar","orcid":"https://orcid.org/0000-0002-0682-2625","observed_orcids":["https://orcid.org/0000-0002-0682-2625","https://orcid.org/0000-0003-4743-2938"]},"institutions":[{"id":"https://openalex.org/I1335289525","display_name":"Montefiore Medical Center","ror":"https://ror.org/044ntvm43","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1335289525","https://openalex.org/I19772626"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Emad N. Eskandar","raw_affiliation_strings":["Department of Neurological Surgery, Montefiore Medical Center, Bronx, NY 10461","Department of Neurological Surgery, Montefiore Medical Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurological Surgery, Montefiore Medical Center, Bronx, NY 10461","institution_ids":["https://openalex.org/I1335289525"]},{"raw_affiliation_string":"Department of Neurological Surgery, Montefiore Medical Center","institution_ids":["https://openalex.org/I1335289525"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109221140","display_name":"Joseph R. Madsen","orcid":"https://orcid.org/0009-0001-5377-8997","observed_orcids":["https://orcid.org/0009-0001-5377-8997"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joseph R. Madsen","raw_affiliation_strings":["Department of Neurosurgery, Brigham and Women\u2019s Hospital & Harvard Medical School, Boston, MA 02115","Department of Neurosurgery, Massachusetts General Hospital & Harvard Medical School, Boston, MA 02114","Department of Neurosurgery, Brigham and Women's Hospital & Harvard Medical School","Department of Neurosurgery, Massachusetts General Hospital & Harvard Medical School"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, Brigham and Women\u2019s Hospital & Harvard Medical School, Boston, MA 02115","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]},{"raw_affiliation_string":"Department of Neurosurgery, Massachusetts General Hospital & Harvard Medical School, Boston, MA 02114","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Department of Neurosurgery, Brigham and Women's Hospital & Harvard Medical School","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]},{"raw_affiliation_string":"Department of Neurosurgery, Massachusetts General Hospital & Harvard Medical School","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031778533","display_name":"Sydney S. Cash","orcid":"https://orcid.org/0000-0002-4557-6391","observed_orcids":["https://orcid.org/0000-0002-4557-6391"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sydney S. Cash","raw_affiliation_strings":["Department of Neurology, Massachusetts General Hospital & Harvard Medical School, Boston, MA 02114","Department of Neurology, Massachusetts General Hospital & Harvard Medical School"],"raw_orcid":"https://orcid.org/0000-0002-4557-6391","affiliations":[{"raw_affiliation_string":"Department of Neurology, Massachusetts General Hospital & Harvard Medical School, Boston, MA 02114","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Department of Neurology, Massachusetts General Hospital & Harvard Medical School","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056097437","display_name":"Andrew J. Trevelyan","orcid":"https://orcid.org/0000-0001-9307-4241","observed_orcids":["https://orcid.org/0000-0001-9307-4241"]},"institutions":[{"id":"https://openalex.org/I84884186","display_name":"Newcastle University","ror":"https://ror.org/01kj2bm70","country_code":"GB","type":"education","lineage":["https://openalex.org/I84884186"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Andrew J. Trevelyan","raw_affiliation_strings":["Newcastle University Biosciences Institute, Newcastle upon Tyne, United Kingdom, NE2 4HH","Newcastle University Biosciences Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Newcastle University Biosciences Institute, Newcastle upon Tyne, United Kingdom, NE2 4HH","institution_ids":["https://openalex.org/I84884186"]},{"raw_affiliation_string":"Newcastle University Biosciences Institute","institution_ids":["https://openalex.org/I84884186"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019358239","display_name":"Wim van Drongelen","orcid":"https://orcid.org/0000-0001-8950-5424","observed_orcids":["https://orcid.org/0000-0001-8950-5424"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wim van Drongelen","raw_affiliation_strings":["Committee on Computational Neuroscience, University of Chicago, Chicago, IL 60637","Committee on Neurobiology, University of Chicago, Chicago, IL 60637","Section of Pediatric Neurology, University of Chicago, Chicago, IL 60637","Committee on Computational Neuroscience, University of Chicago","Committee on Neurobiology, University of Chicago","Section of Pediatric Neurology, University of Chicago"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Committee on Computational Neuroscience, University of Chicago, Chicago, IL 60637","institution_ids":["https://openalex.org/I40347166"]},{"raw_affiliation_string":"Committee on Neurobiology, University of Chicago, Chicago, IL 60637","institution_ids":["https://openalex.org/I40347166"]},{"raw_affiliation_string":"Section of Pediatric Neurology, University of Chicago, Chicago, IL 60637","institution_ids":["https://openalex.org/I40347166"]},{"raw_affiliation_string":"Committee on Computational Neuroscience, University of Chicago","institution_ids":["https://openalex.org/I40347166"]},{"raw_affiliation_string":"Committee on Neurobiology, University of Chicago","institution_ids":["https://openalex.org/I40347166"]},{"raw_affiliation_string":"Section of Pediatric Neurology, University of Chicago","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5041807795","display_name":"Catherine A. Schevon","orcid":"https://orcid.org/0000-0002-4485-7933","observed_orcids":["https://orcid.org/0000-0002-4485-7933"]},"institutions":[{"id":"https://openalex.org/I2799503643","display_name":"Columbia University Irving Medical Center","ror":"https://ror.org/01esghr10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799503643"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Catherine A. Schevon","raw_affiliation_strings":["Department of Neurology, Columbia University Medical Center, New York, NY 10032","Department of Neurology, Columbia University Medical Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Columbia University Medical Center, New York, NY 10032","institution_ids":["https://openalex.org/I2799503643"]},{"raw_affiliation_string":"Department of Neurology, Columbia University Medical Center","institution_ids":["https://openalex.org/I2799503643"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":14,"corresponding_author_ids":["https://openalex.org/A5041807795","https://openalex.org/A5065135434"],"corresponding_institution_ids":["https://openalex.org/I2799503643"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10094","display_name":"Epilepsy research and treatment","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10094","display_name":"Epilepsy research and treatment","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10581","display_name":"Neural dynamics and brain function","score":0.007199999876320362,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fast-spiking-interneurons","display_name":"fast-spiking interneurons","score":0.9319999814033508},{"id":"https://openalex.org/keywords/seizure-onset","display_name":"seizure onset","score":0.7279999852180481},{"id":"https://openalex.org/keywords/seizure-propagation","display_name":"seizure propagation","score":0.796999990940094},{"id":"https://openalex.org/keywords/gabaergic-inhibition","display_name":"GABAergic inhibition","score":0.7639999985694885},{"id":"https://openalex.org/keywords/neocortex","display_name":"neocortex","score":0.718999981880188},{"id":"https://openalex.org/keywords/computational-modeling","display_name":"computational modeling","score":0.6110000014305115}],"concepts":[{"id":"https://openalex.org/C112592302","wikidata":"https://www.wikidata.org/wiki/Q1207387","display_name":"Excitatory postsynaptic potential","level":3,"score":0.856612503528595},{"id":"https://openalex.org/C17077164","wikidata":"https://www.wikidata.org/wiki/Q1185869","display_name":"Inhibitory postsynaptic potential","level":2,"score":0.8055064082145691},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.7837479114532471},{"id":"https://openalex.org/C2779177108","wikidata":"https://www.wikidata.org/wiki/Q18356742","display_name":"GABAergic","level":3,"score":0.6792202591896057},{"id":"https://openalex.org/C2779296341","wikidata":"https://www.wikidata.org/wiki/Q1500732","display_name":"Interneuron","level":3,"score":0.6060734391212463},{"id":"https://openalex.org/C2778186239","wikidata":"https://www.wikidata.org/wiki/Q41571","display_name":"Epilepsy","level":2,"score":0.4292532205581665},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.42774707078933716}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1101/2024.01.26.24301821","doi":"https://doi.org/10.1101/2024.01.26.24301821","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2024.01.26.24301821","pdf_url":"https://www.medrxiv.org/content/medrxiv/early/2024/01/26/2024.01.26.24301821.full.pdf","source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"},{"id":"pmid:38343792","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38343792","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"medRxiv : the preprint server for health sciences","raw_type":"Preprint"},{"id":"pmh:oai:pubmedcentral.nih.gov:10854323","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10854323","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"medRxiv","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1101/2024.01.26.24301821","doi":"https://doi.org/10.1101/2024.01.26.24301821","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2024.01.26.24301821","pdf_url":"https://www.medrxiv.org/content/medrxiv/early/2024/01/26/2024.01.26.24301821.full.pdf","source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.8371999859809875,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4391246498.pdf","grobid_xml":"https://content.openalex.org/works/W4391246498.grobid-xml"},"referenced_works_count":93,"referenced_works":["https://openalex.org/W846247396","https://openalex.org/W1148789100","https://openalex.org/W1497716686","https://openalex.org/W1604724533","https://openalex.org/W1608961846","https://openalex.org/W1897507705","https://openalex.org/W1901195584","https://openalex.org/W1912234705","https://openalex.org/W1946443775","https://openalex.org/W1963710870","https://openalex.org/W1965625137","https://openalex.org/W1966474984","https://openalex.org/W1970604942","https://openalex.org/W1973119090","https://openalex.org/W1973275441","https://openalex.org/W1975867578","https://openalex.org/W1976715146","https://openalex.org/W1985940938","https://openalex.org/W1992147695","https://openalex.org/W1999270514","https://openalex.org/W2002650190","https://openalex.org/W2003743055","https://openalex.org/W2017602373","https://openalex.org/W2024690244","https://openalex.org/W2028756092","https://openalex.org/W2031003452","https://openalex.org/W2032773159","https://openalex.org/W2038573700","https://openalex.org/W2052540595","https://openalex.org/W2056571308","https://openalex.org/W2059754952","https://openalex.org/W2063091823","https://openalex.org/W2065811708","https://openalex.org/W2066765190","https://openalex.org/W2089931972","https://openalex.org/W2095796165","https://openalex.org/W2096519870","https://openalex.org/W2101604610","https://openalex.org/W2105003565","https://openalex.org/W2109930285","https://openalex.org/W2113077979","https://openalex.org/W2119795785","https://openalex.org/W2131797361","https://openalex.org/W2136104104","https://openalex.org/W2142181855","https://openalex.org/W2150310369","https://openalex.org/W2157239334","https://openalex.org/W2157338202","https://openalex.org/W2157874245","https://openalex.org/W2207892023","https://openalex.org/W2221931548","https://openalex.org/W2302128506","https://openalex.org/W2318137864","https://openalex.org/W2319172225","https://openalex.org/W2413930114","https://openalex.org/W2498750458","https://openalex.org/W2503929286","https://openalex.org/W2581980900","https://openalex.org/W2594617181","https://openalex.org/W2761700512","https://openalex.org/W2772626215","https://openalex.org/W2794206544","https://openalex.org/W2802019646","https://openalex.org/W2891111388","https://openalex.org/W2918117004","https://openalex.org/W2921970464","https://openalex.org/W2949520295","https://openalex.org/W2950313546","https://openalex.org/W2969325811","https://openalex.org/W2971351488","https://openalex.org/W3012706327","https://openalex.org/W3034889226","https://openalex.org/W3097843261","https://openalex.org/W3107309971","https://openalex.org/W3134362490","https://openalex.org/W3168885856","https://openalex.org/W3180181381","https://openalex.org/W3188907836","https://openalex.org/W3201662917","https://openalex.org/W3201939842","https://openalex.org/W4226246548","https://openalex.org/W4231727956","https://openalex.org/W4232821155","https://openalex.org/W4288713673","https://openalex.org/W4297380755","https://openalex.org/W4312210377","https://openalex.org/W4313558094","https://openalex.org/W4316171002","https://openalex.org/W4360977237","https://openalex.org/W4376615180","https://openalex.org/W4385520118","https://openalex.org/W4387293278","https://openalex.org/W6968617474"],"related_works":["https://openalex.org/W2131797361","https://openalex.org/W2949520295","https://openalex.org/W4289523669","https://openalex.org/W4390746614","https://openalex.org/W1963710870","https://openalex.org/W2495482469","https://openalex.org/W4387293278","https://openalex.org/W2169707336","https://openalex.org/W4412472380","https://openalex.org/W2937134625"],"abstract_inverted_index":{"Abstract":[0],"There":[1],"is":[2],"active":[3],"debate":[4],"regarding":[5],"how":[6],"GABAergic":[7],"function":[8],"changes":[9],"during":[10,30],"seizure":[11,84,125],"initiation":[12],"and":[13,15,53],"propagation,":[14],"whether":[16],"interneuronal":[17],"activity":[18,43],"drives":[19],"or":[20],"impedes":[21],"the":[22,66,94],"pathophysiology.":[23],"Here,":[24],"we":[25,72],"track":[26],"cell-type":[27],"specific":[28],"firing":[29,58,104],"spontaneous":[31],"human":[32],"seizures":[33],"to":[34,56,60,76,83,106,121],"identify":[35],"neocortical":[36],"mechanisms":[37],"of":[38,91,102],"inhibitory":[39,103,122],"failure.":[40],"Fast-spiking":[41],"interneuron":[42,109],"was":[44],"maximal":[45],"over":[46],"1":[47],"second":[48],"before":[49],"equivalent":[50],"excitatory":[51,113],"increases,":[52],"showed":[54],"transitions":[55],"out-of-phase":[57],"prior":[59],"local":[61],"tissue":[62],"becoming":[63],"incorporated":[64],"into":[65],"seizure-driving":[67],"territory.":[68],"Using":[69],"computational":[70],"modeling,":[71],"linked":[73],"this":[74],"observation":[75],"transient":[77,100],"saturation":[78],"block":[79],"as":[80,86],"a":[81,116],"precursor":[82],"invasion,":[85],"supported":[87],"by":[88],"multiple":[89],"lines":[90],"evidence":[92],"in":[93],"patient":[95],"data.":[96],"We":[97],"propose":[98],"that":[99,119],"blocking":[101],"due":[105],"selective":[107],"fast-spiking":[108],"saturation\u2014resulting":[110],"from":[111],"intense":[112],"synaptic":[114],"drive\u2014is":[115],"novel":[117],"mechanism":[118],"contributes":[120],"failure,":[123],"allowing":[124],"propagation.":[126]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2024-01-27T00:00:00"}