{"id":"https://openalex.org/W4391242633","doi":"https://doi.org/10.47760/ijpsm.2024.v09i01.003","title":"Characterization and Improvement Dissolution Profile of the Hydrochlorothiazide-\u03b2-Cyclodextrin Inclusion Complex using Kneading Method","display_name":"Characterization and Improvement Dissolution Profile of the Hydrochlorothiazide-\u03b2-Cyclodextrin Inclusion Complex using Kneading Method","publication_year":2024,"publication_date":"2024-01-25","ids":{"openalex":"https://openalex.org/W4391242633","doi":"https://doi.org/10.47760/ijpsm.2024.v09i01.003"},"language":"en","primary_location":{"id":"doi:10.47760/ijpsm.2024.v09i01.003","doi":"https://doi.org/10.47760/ijpsm.2024.v09i01.003","is_oa":true,"landing_page_url":"http://doi.org/10.47760/ijpsm.2024.v09i01.003","pdf_url":"http://dx.doi.org/10.47760/ijpsm.2024.v09i01.003","source":{"id":"https://openalex.org/S4210220426","display_name":"International Journal of Pharmaceutical Sciences and Medicine","issn_l":"2519-9889","issn":["2519-9889"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Pharmaceutical Sciences and Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"http://dx.doi.org/10.47760/ijpsm.2024.v09i01.003","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5004042320","display_name":"Maria Dona Octavia","orcid":"https://orcid.org/0000-0003-4310-6035","observed_orcids":["https://orcid.org/0000-0003-4310-6035"]},"institutions":[{"id":"https://openalex.org/I4405274312","display_name":"Sekolah Tinggi Ilmu Farmasi Padang","ror":"https://ror.org/01gcq7r68","country_code":"ID","type":"education","lineage":["https://openalex.org/I4405274312"]}],"countries":["ID"],"is_corresponding":true,"raw_author_name":"Maria Dona Octavia","raw_affiliation_strings":["Department of Pharmaceutics, School of Pharmaceutical Science (STIFARM) Padang, West Sumatra, Indonesia, 25147"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutics, School of Pharmaceutical Science (STIFARM) Padang, West Sumatra, Indonesia, 25147","institution_ids":["https://openalex.org/I4405274312"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5093792762","display_name":"Nia Dwi Agraini","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405274312","display_name":"Sekolah Tinggi Ilmu Farmasi Padang","ror":"https://ror.org/01gcq7r68","country_code":"ID","type":"education","lineage":["https://openalex.org/I4405274312"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Nia Dwi Agraini","raw_affiliation_strings":["Department of Pharmaceutics, School of Pharmaceutical Science (STIFARM) Padang, West Sumatra, Indonesia, 25147"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutics, School of Pharmaceutical Science (STIFARM) Padang, West Sumatra, Indonesia, 25147","institution_ids":["https://openalex.org/I4405274312"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059710762","display_name":"Rina Wahyuni","orcid":"https://orcid.org/0000-0001-6471-9733","observed_orcids":["https://orcid.org/0000-0001-6471-9733"]},"institutions":[{"id":"https://openalex.org/I4405274312","display_name":"Sekolah Tinggi Ilmu Farmasi Padang","ror":"https://ror.org/01gcq7r68","country_code":"ID","type":"education","lineage":["https://openalex.org/I4405274312"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Rina Wahyuni","raw_affiliation_strings":["Department of Pharmaceutics, School of Pharmaceutical Science (STIFARM) Padang, West Sumatra, Indonesia, 25147"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutics, School of Pharmaceutical Science (STIFARM) Padang, West Sumatra, Indonesia, 25147","institution_ids":["https://openalex.org/I4405274312"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080716074","display_name":"Yeni Novita Sari","orcid":"https://orcid.org/0000-0002-2429-5291","observed_orcids":["https://orcid.org/0000-0002-2429-5291"]},"institutions":[{"id":"https://openalex.org/I4405274312","display_name":"Sekolah Tinggi Ilmu Farmasi Padang","ror":"https://ror.org/01gcq7r68","country_code":"ID","type":"education","lineage":["https://openalex.org/I4405274312"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Yeni Novita Sari","raw_affiliation_strings":["Department of Pharmaceutics, School of Pharmaceutical Science (STIFARM) Padang, West Sumatra, Indonesia, 25147"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutics, School of Pharmaceutical Science (STIFARM) Padang, West Sumatra, Indonesia, 25147","institution_ids":["https://openalex.org/I4405274312"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5066261417","display_name":"Addina Zafrul","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405274312","display_name":"Sekolah Tinggi Ilmu Farmasi Padang","ror":"https://ror.org/01gcq7r68","country_code":"ID","type":"education","lineage":["https://openalex.org/I4405274312"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Addina Zafrul","raw_affiliation_strings":["Department of Pharmaceutics, School of Pharmaceutical Science (STIFARM) Padang, West Sumatra, Indonesia, 25147"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutics, School of Pharmaceutical Science (STIFARM) Padang, West Sumatra, Indonesia, 25147","institution_ids":["https://openalex.org/I4405274312"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5004042320"],"corresponding_institution_ids":["https://openalex.org/I4405274312"],"apc_list":null,"apc_paid":null,"fwci":0.1608,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.33525785,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"9","issue":"1","first_page":"38","last_page":"45"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10256","display_name":"Drug Solubulity and Delivery Systems","score":1.0,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10256","display_name":"Drug Solubulity and Delivery Systems","score":1.0,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11881","display_name":"Crystallization and Solubility Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hydrochlorothiazide","display_name":"hydrochlorothiazide","score":1.0},{"id":"https://openalex.org/keywords/beta-cyclodextrin","display_name":"\u03b2-cyclodextrin","score":0.9890000224113464},{"id":"https://openalex.org/keywords/inclusion-complexes","display_name":"inclusion complexes","score":0.968999981880188},{"id":"https://openalex.org/keywords/kneading-method","display_name":"kneading method","score":0.9959999918937683},{"id":"https://openalex.org/keywords/solubility-enhancement","display_name":"solubility enhancement","score":0.8180000185966492},{"id":"https://openalex.org/keywords/dissolution-rate","display_name":"dissolution rate","score":0.8529999852180481},{"id":"https://openalex.org/keywords/bcs-class-iv-drugs","display_name":"BCS class IV drugs","score":0.7720000147819519},{"id":"https://openalex.org/keywords/antihypertensive-drugs","display_name":"antihypertensive drugs","score":0.8199999928474426},{"id":"https://openalex.org/keywords/physical-mixtures","display_name":"physical mixtures","score":0.47600001096725464},{"id":"https://openalex.org/keywords/eutectic-mixtures","display_name":"eutectic mixtures","score":0.753000020980835},{"id":"https://openalex.org/keywords/amorphous-phase","display_name":"amorphous phase","score":0.5820000171661377},{"id":"https://openalex.org/keywords/physicochemical-characterization","display_name":"physicochemical characterization","score":0.765999972820282}],"concepts":[{"id":"https://openalex.org/C2780361556","wikidata":"https://www.wikidata.org/wiki/Q423930","display_name":"Hydrochlorothiazide","level":3,"score":0.8667083978652954},{"id":"https://openalex.org/C2779433975","wikidata":"https://www.wikidata.org/wiki/Q40417805","display_name":"Cyclodextrin","level":2,"score":0.7633991837501526},{"id":"https://openalex.org/C88380143","wikidata":"https://www.wikidata.org/wiki/Q416674","display_name":"Dissolution","level":2,"score":0.7600613832473755},{"id":"https://openalex.org/C109359841","wikidata":"https://www.wikidata.org/wiki/Q728944","display_name":"Inclusion (mineral)","level":2,"score":0.6781362891197205},{"id":"https://openalex.org/C2780841128","wikidata":"https://www.wikidata.org/wiki/Q5073781","display_name":"Characterization (materials science)","level":2,"score":0.6696940064430237},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4871382415294647},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.32793164253234863},{"id":"https://openalex.org/C42360764","wikidata":"https://www.wikidata.org/wiki/Q83588","display_name":"Chemical engineering","level":1,"score":0.32181042432785034},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.2768530249595642},{"id":"https://openalex.org/C199289684","wikidata":"https://www.wikidata.org/wiki/Q83353","display_name":"Mineralogy","level":1,"score":0.1721264123916626},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.12554284930229187},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.12061873078346252},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.09341657161712646},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.08916351199150085},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.04966747760772705},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.47760/ijpsm.2024.v09i01.003","doi":"https://doi.org/10.47760/ijpsm.2024.v09i01.003","is_oa":true,"landing_page_url":"http://doi.org/10.47760/ijpsm.2024.v09i01.003","pdf_url":"http://dx.doi.org/10.47760/ijpsm.2024.v09i01.003","source":{"id":"https://openalex.org/S4210220426","display_name":"International Journal of Pharmaceutical Sciences and Medicine","issn_l":"2519-9889","issn":["2519-9889"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Pharmaceutical Sciences and Medicine","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.47760/ijpsm.2024.v09i01.003","doi":"https://doi.org/10.47760/ijpsm.2024.v09i01.003","is_oa":true,"landing_page_url":"http://doi.org/10.47760/ijpsm.2024.v09i01.003","pdf_url":"http://dx.doi.org/10.47760/ijpsm.2024.v09i01.003","source":{"id":"https://openalex.org/S4210220426","display_name":"International Journal of Pharmaceutical Sciences and Medicine","issn_l":"2519-9889","issn":["2519-9889"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Pharmaceutical Sciences and Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.6240000128746033,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4391242633.pdf","grobid_xml":"https://content.openalex.org/works/W4391242633.grobid-xml"},"referenced_works_count":5,"referenced_works":["https://openalex.org/W2035034315","https://openalex.org/W2073394985","https://openalex.org/W2948420913","https://openalex.org/W4244636297","https://openalex.org/W4246488185"],"related_works":["https://openalex.org/W4312614070","https://openalex.org/W2191849897","https://openalex.org/W2378613264","https://openalex.org/W1997838676","https://openalex.org/W2085138446","https://openalex.org/W3169926060","https://openalex.org/W2515253499","https://openalex.org/W2285819802","https://openalex.org/W2340655152","https://openalex.org/W2078886686"],"abstract_inverted_index":{"Hydrochlorothiazide":[0],"is":[1],"a":[2,33,37,52,57,126,156,169,193],"drug":[3],"antihypertensives":[4],"are":[5,86],"classified":[6],"into":[7],"Biopharmaceutics":[8],"Classification":[9],"System":[10],"(BCS)":[11],"class":[12],"IV,":[13],"so":[14],"required":[15],"technique":[16],"formulation":[17],"to":[18,65],"improve":[19],"solubility,":[20],"one":[21],"of":[22,40,59,69,78,81,107,160],"them":[23],"with":[24,32,36,119,150,198,203],"complex":[25,29,70,116,162,177,214],"inclusion.":[26],"The":[27,200],"inclusion":[28,72,117,178,213],"was":[30,208],"prepared":[31,55],"kneading":[34],"method":[35],"comparison":[38],"amount":[39],"hydrochlorothiazide":[41,118,140,179,189],"-":[42,180],"\u03b2-":[43,151],"cyclodextrin":[44],"1:1":[45,60],"(F1)":[46],"mol,":[47,50],"2:1":[48],"(F2)":[49],"and":[51,76,93,103,186],"physical":[53,166,201],"mixture":[54,202],"in":[56,158,192],"ratio":[58],"mol.":[61],"This":[62],"research":[63],"aims":[64],"see":[66],"the":[67,161,204,211],"effect":[68],"formation":[71],"on":[73],"dissolution":[74,104,190,206],"rate":[75],"characteristics":[77],"physicochemical":[79,108,185],"properties":[80],"hydrochlorothiazide.":[82],"Complex":[83],"inclusions":[84,163],"formed":[85],"characterized":[87],"by":[88,210],"scanning":[89,100],"electron":[90],"microscopy":[91],"(SEM),":[92],"infrared":[94],"spectrophotometer":[95],"(FT-IR).":[96],"X-ray":[97],"diffraction,":[98],"differential":[99],"calorimetry":[101],"(DSC),":[102],"profiles.":[105],"Characterization":[106,130],"results":[109,131,174,207],"analysis":[110,133,143,154],"diffraction":[111],"X-rays":[112],"show":[113,175],"that":[114,164,176],"powder":[115,199],"\u03b2-cyclodextrin":[120,181],"experiences":[121],"decline":[122,157],"peak":[123],"intensity":[124],"approaches":[125],"more":[127],"amorphous":[128],"nature.":[129],"FT-IR":[132],"shows":[134,144,155],"No":[135],"interaction":[136],"chemistry":[137],"exists":[138],"between":[139],"\u03b2-cyclodextrin.":[141],"SEM":[142],"morphology":[145],"substance":[146],"active":[147],"Already":[148],"coated":[149],"cyclodextrin.":[152],"DSC":[153],"enthalpy":[159],"indicate":[165],"interactions":[167],"form":[168],"simple":[170],"eutectic":[171],"mixture.":[172],"Research":[173],"can":[182,187],"repair":[183],"characteristic":[184],"increase":[188],"profile":[191],"way":[194],"significant":[195],"(p<0.05)":[196],"compared":[197],"highest":[205],"shown":[209],"F1":[212],"(82.843":[215],"%).":[216]},"counts_by_year":[{"year":2024,"cited_by_count":1}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2024-01-26T00:00:00"}