{"id":"https://openalex.org/W4391232002","doi":"https://doi.org/10.1093/ibd/izae020.145","title":"IHIBITION OF TRNA QUEUOSINE MODIFICATION CAUSE MITOCHONDRIAL DYSFUNCTION AND APOPTOSIS IN THE INTESTINAL EPITHELIAL CELLS","display_name":"IHIBITION OF TRNA QUEUOSINE MODIFICATION CAUSE MITOCHONDRIAL DYSFUNCTION AND APOPTOSIS IN THE INTESTINAL EPITHELIAL CELLS","publication_year":2024,"publication_date":"2024-01-25","ids":{"openalex":"https://openalex.org/W4391232002","doi":"https://doi.org/10.1093/ibd/izae020.145"},"language":"en","primary_location":{"id":"doi:10.1093/ibd/izae020.145","doi":"https://doi.org/10.1093/ibd/izae020.145","is_oa":true,"landing_page_url":"https://doi.org/10.1093/ibd/izae020.145","pdf_url":"https://academic.oup.com/ibdjournal/article-pdf/30/Supplement_1/S67/56417731/izae020.145.pdf","source":{"id":"https://openalex.org/S45123234","display_name":"Inflammatory Bowel Diseases","issn_l":"1078-0998","issn":["1078-0998","1536-4844"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Inflammatory Bowel Diseases","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/ibdjournal/article-pdf/30/Supplement_1/S67/56417731/izae020.145.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112437973","display_name":"Di Ran","orcid":"https://orcid.org/0009-0003-3433-3495","observed_orcids":["https://orcid.org/0009-0003-3433-3495"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Di Ran","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060252047","display_name":"Yongguo Zhang","orcid":"https://orcid.org/0000-0002-8299-0233","observed_orcids":["https://orcid.org/0000-0002-8299-0233"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yong-guo Zhang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5007677073","display_name":"Jun Sun","orcid":"https://orcid.org/0000-0001-7465-3133","observed_orcids":["https://orcid.org/0000-0001-7465-3133"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jun Sun","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4055,"currency":"USD","value_usd":4055},"apc_paid":null,"fwci":0.1174,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.32369806,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":94},"biblio":{"volume":"30","issue":"Supplement_1","first_page":"S67","last_page":"S68"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11482","display_name":"RNA modifications and cancer","score":0.9848999977111816,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11482","display_name":"RNA modifications and cancer","score":0.9848999977111816,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.004000000189989805,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.0032999999821186066,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[],"concepts":[{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.7174986600875854},{"id":"https://openalex.org/C153957851","wikidata":"https://www.wikidata.org/wiki/Q201448","display_name":"Transfer RNA","level":4,"score":0.7173066735267639},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.47293758392333984},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3819660544395447},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.360590398311615},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3529539108276367},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3452029228210449},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3354324996471405},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.26585257053375244},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1583499312400818},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.1574096381664276}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1093/ibd/izae020.145","doi":"https://doi.org/10.1093/ibd/izae020.145","is_oa":true,"landing_page_url":"https://doi.org/10.1093/ibd/izae020.145","pdf_url":"https://academic.oup.com/ibdjournal/article-pdf/30/Supplement_1/S67/56417731/izae020.145.pdf","source":{"id":"https://openalex.org/S45123234","display_name":"Inflammatory Bowel Diseases","issn_l":"1078-0998","issn":["1078-0998","1536-4844"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Inflammatory Bowel Diseases","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1093/ibd/izae020.145","doi":"https://doi.org/10.1093/ibd/izae020.145","is_oa":true,"landing_page_url":"https://doi.org/10.1093/ibd/izae020.145","pdf_url":"https://academic.oup.com/ibdjournal/article-pdf/30/Supplement_1/S67/56417731/izae020.145.pdf","source":{"id":"https://openalex.org/S45123234","display_name":"Inflammatory Bowel Diseases","issn_l":"1078-0998","issn":["1078-0998","1536-4844"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Inflammatory Bowel Diseases","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4391232002.pdf","grobid_xml":"https://content.openalex.org/works/W4391232002.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2040216736","https://openalex.org/W1998434095","https://openalex.org/W2012158738","https://openalex.org/W3148810057","https://openalex.org/W1979806605","https://openalex.org/W2075273261","https://openalex.org/W2755853517","https://openalex.org/W2905191830","https://openalex.org/W2939643004","https://openalex.org/W2145294892"],"abstract_inverted_index":{"Abstract":[0],"BACKGROUND":[1],"Transfer":[2],"RNA":[3],"(tRNA)":[4],"modifications":[5,70,112],"occur":[6],"through":[7,126,173],"the":[8,17,20,66,72,79,106,167,203,209,218,233,237,257,263,283,292,301],"action":[9],"of":[10,61,68,74,81,110,169,177,211,259,285],"specific":[11,279],"enzymes":[12],"that":[13,50],"recognize":[14],"and":[15,29,35,78,96,108,117,145,165,183,189,217,246,275],"modify":[16],"nucleotides":[18],"within":[19],"tRNA":[21,42,286],"molecule.":[22],"Queuine":[23],"tRNA-ribosyltransferase":[24],"catalytic":[25],"subunit":[26],"1":[27],"(QTRT1)":[28],"QTRT":[30],"2":[31],"co-localize":[32],"in":[33,41,57,71,113,132,149,153,163,166,200,202,221,232,256,262,288,291,311],"mitochondria":[34,180,245],"form":[36],"a":[37,54,271,276],"heterodimeric":[38],"TGT":[39],"participating":[40],"Queuosine":[43],"(tRNA-Q)":[44],"modification.":[45],"Our":[46,265],"previous":[47],"study":[48],"demonstrated":[49],"Q-tRNA":[51],"modification":[52,251,287,298],"plays":[53,252],"novel":[55],"role":[56,255,284],"regulating":[58],"barrier":[59],"functions":[60],"intestinal":[62,75,114,293],"epithelial":[63],"cells.":[64,136,156],"However,":[65],"roles":[67],"tRNA-Q":[69,111,250,297],"maintenance":[73],"mitochondrial":[76,115,124,150,185,223,260,272,289,309],"homeostasis":[77,116],"progression":[80],"inflammatory":[82],"bowel":[83],"disease":[84],"(IBD)":[85],"are":[86],"still":[87],"unclear.":[88],"METHODS":[89],"We":[90],"used":[91,139],"QTRT1":[92,101,133,154,204,238,242],"knockout":[93],"(KO)":[94],"mice":[95,206],"cultured":[97],"cell":[98],"lines":[99],"with":[100,129,181],"knockdown":[102],"(KD)":[103],"to":[104,236,281,307],"investigate":[105],"impact":[107],"mechanism":[109],"inflammation.":[118,294],"RESULTS":[119],"Initially,":[120],"we":[121,138,158,196],"confirmed":[122],"QTRT1's":[123],"localization":[125],"immunofluorescence":[127],"co-localization":[128],"Mitotracker":[130],"staining":[131,144,226],"KD":[134,155],"CaCO2-BBE":[135],"Then":[137],"flow":[140],"cytometry":[141],"MitoSox":[142],"Red":[143],"revealed":[146],"an":[147,198,253],"increase":[148,199,230],"ROS":[151,273],"production":[152],"Furthermore,":[157],"observed":[159],"heightened":[160],"mitophagy":[161],"both":[162],"vitro":[164],"colon":[168,234],"QTRT1KO":[170],"mice,":[171],"evident":[172],"significantly":[174],"enhanced":[175],"fusion":[176],"Mtphagy":[178],"Dye-labeled":[179],"lysosomes,":[182],"altered":[184],"proteins":[186],"(Tomm20,":[187],"LC3,":[188],"Cytochrome":[190],"C)":[191],"via":[192],"Western":[193],"Blotting.":[194],"Notably,":[195],"identified":[197],"apoptosis":[201,229],"KO":[205],"evidenced":[207],"by":[208],"upregulation":[210],"phosphorylated":[212],"PARP,":[213],"cleaved":[214],"Caspase":[215,277],"3,":[216],"Bax/BCL-2":[219],"ratio":[220],"colonic":[222],"proteins.":[224],"TUNEL":[225],"corroborated":[227],"this":[228],"specifically":[231],"due":[235],"deficiency.":[239],"CONCLUSIONS":[240],"Reduced":[241],"induced":[243],"dysfunctional":[244],"Caspase-3":[247],"dependent":[248],"apoptosis.":[249],"unexplored":[254],"pathogenesis":[258],"function":[261,290,310],"intestine.":[264],"upcoming":[266],"research":[267],"will":[268,299],"employ":[269],"N-acetyl-l-cysteine,":[270],"inhibitor,":[274],"3":[278],"inhibitor":[280],"ascertain":[282],"Insights":[295],"into":[296],"pave":[300],"road":[302],"for":[303],"new":[304],"therapeutic":[305],"strategies":[306],"restore":[308],"IBD.":[312]},"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2026-10-09T09:14:12.587421","created_date":"2025-10-10T00:00:00"}
