{"id":"https://openalex.org/W4391200767","doi":"https://doi.org/10.2460/ajvr.1996.57.07.1044","title":"Induction and maintenance of anesthesia in dogs by intravenous administration of methohexital","display_name":"Induction and maintenance of anesthesia in dogs by intravenous administration of methohexital","publication_year":1996,"publication_date":"1996-07-01","ids":{"openalex":"https://openalex.org/W4391200767","doi":"https://doi.org/10.2460/ajvr.1996.57.07.1044","mag":"10488159","pmid":"https://pubmed.ncbi.nlm.nih.gov/8807019"},"language":"en","primary_location":{"id":"doi:10.2460/ajvr.1996.57.07.1044","doi":"https://doi.org/10.2460/ajvr.1996.57.07.1044","is_oa":true,"landing_page_url":"https://doi.org/10.2460/ajvr.1996.57.07.1044","pdf_url":"https://avmajournals.avma.org/downloadpdf/view/journals/ajvr/57/7/ajvr.1996.57.07.1044.pdf","source":{"id":"https://openalex.org/S196975874","display_name":"American Journal of Veterinary Research","issn_l":"0002-9645","issn":["0002-9645","1943-5681"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-2","medline","norway-1","oarl","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4322545313","host_organization_name":"American Veterinary Medical Association","host_organization_lineage":["https://openalex.org/P4322545313"],"host_organization_lineage_names":["American Veterinary Medical Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Veterinary Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://avmajournals.avma.org/downloadpdf/view/journals/ajvr/57/7/ajvr.1996.57.07.1044.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5066447332","display_name":"William Brooks Gentry","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"W. Brooks Gentry","raw_affiliation_strings":["From the Department of Anesthesia, Northwestern University Medical School, Chicago, IL 60611-3008"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Anesthesia, Northwestern University Medical School, Chicago, IL 60611-3008","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111758978","display_name":"Tom C. Krejcie","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tom C. Krejcie","raw_affiliation_strings":["From the Department of Anesthesia, Northwestern University Medical School, Chicago, IL 60611-3008"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Anesthesia, Northwestern University Medical School, Chicago, IL 60611-3008","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028506802","display_name":"Thomas K. Henthorn","orcid":"https://orcid.org/0000-0002-8993-3936","observed_orcids":["https://orcid.org/0000-0002-8993-3936"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas K. Henthorn","raw_affiliation_strings":["From the Department of Anesthesia, Northwestern University Medical School, Chicago, IL 60611-3008"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Anesthesia, Northwestern University Medical School, Chicago, IL 60611-3008","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5054511999","display_name":"Michael J. Avram","orcid":"https://orcid.org/0000-0001-6637-1355","observed_orcids":["https://orcid.org/0000-0001-6637-1355"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael J. Avram","raw_affiliation_strings":["From the Department of Anesthesia, Northwestern University Medical School, Chicago, IL 60611-3008"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Anesthesia, Northwestern University Medical School, Chicago, IL 60611-3008","institution_ids":["https://openalex.org/I111979921"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I111979921"],"apc_list":null,"apc_paid":null,"fwci":1.5346,"has_fulltext":true,"cited_by_count":5,"citation_normalized_percentile":{"value":0.83113069,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"57","issue":"7","first_page":"1044","last_page":"1049"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11905","display_name":"Veterinary Pharmacology and Anesthesia","score":0.9789999723434448,"subfield":{"id":"https://openalex.org/subfields/3404","display_name":"Small Animals"},"field":{"id":"https://openalex.org/fields/34","display_name":"Veterinary"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11905","display_name":"Veterinary Pharmacology and Anesthesia","score":0.9789999723434448,"subfield":{"id":"https://openalex.org/subfields/3404","display_name":"Small Animals"},"field":{"id":"https://openalex.org/fields/34","display_name":"Veterinary"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10436","display_name":"Anesthesia and Sedative Agents","score":0.020800000056624413,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12930","display_name":"Biomedical and Chemical Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/methohexital","display_name":"methohexital","score":1.0},{"id":"https://openalex.org/keywords/anesthesia-induction","display_name":"anesthesia induction","score":0.6899999976158142},{"id":"https://openalex.org/keywords/anesthesia-maintenance","display_name":"anesthesia maintenance","score":0.8989999890327454},{"id":"https://openalex.org/keywords/dogs","display_name":"dogs","score":0.8259999752044678},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.921999990940094},{"id":"https://openalex.org/keywords/pharmacodynamics","display_name":"pharmacodynamics","score":0.7940000295639038},{"id":"https://openalex.org/keywords/dose-response-relationship","display_name":"dose-response relationship","score":0.6190000176429749},{"id":"https://openalex.org/keywords/emergence-from-anesthesia","display_name":"emergence from anesthesia","score":0.6309999823570251},{"id":"https://openalex.org/keywords/extubation","display_name":"extubation","score":0.7670000195503235},{"id":"https://openalex.org/keywords/volume-of-distribution","display_name":"volume of distribution","score":0.7250000238418579},{"id":"https://openalex.org/keywords/elimination-clearance","display_name":"elimination clearance","score":0.9599999785423279},{"id":"https://openalex.org/keywords/hemodynamic-stability","display_name":"hemodynamic stability","score":0.5849999785423279}],"concepts":[{"id":"https://openalex.org/C2777260365","wikidata":"https://www.wikidata.org/wiki/Q851813","display_name":"Methohexital","level":3,"score":0.9176150560379028},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.6904842853546143},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6588762998580933},{"id":"https://openalex.org/C2780765947","wikidata":"https://www.wikidata.org/wiki/Q12033531","display_name":"Administration (probate law)","level":2,"score":0.606845498085022},{"id":"https://openalex.org/C2776277131","wikidata":"https://www.wikidata.org/wiki/Q422740","display_name":"Propofol","level":2,"score":0.1305244266986847},{"id":"https://openalex.org/C17744445","wikidata":"https://www.wikidata.org/wiki/Q36442","display_name":"Political science","level":0,"score":0.0},{"id":"https://openalex.org/C199539241","wikidata":"https://www.wikidata.org/wiki/Q7748","display_name":"Law","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000768","descriptor_name":"Anesthesia, General","qualifier_ui":"Q000662","qualifier_name":"veterinary","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001835","descriptor_name":"Body Weight","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004285","descriptor_name":"Dogs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007262","descriptor_name":"Infusions, Intravenous","qualifier_ui":"Q000662","qualifier_name":"veterinary","is_major_topic":false},{"descriptor_ui":"D008657","descriptor_name":"Metabolic Clearance Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008723","descriptor_name":"Methohexital","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D008723","descriptor_name":"Methohexital","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D008723","descriptor_name":"Methohexital","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010424","descriptor_name":"Pentobarbital","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D010424","descriptor_name":"Pentobarbital","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018686","descriptor_name":"Anesthetics, Intravenous","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D018686","descriptor_name":"Anesthetics, Intravenous","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D018686","descriptor_name":"Anesthetics, Intravenous","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.2460/ajvr.1996.57.07.1044","doi":"https://doi.org/10.2460/ajvr.1996.57.07.1044","is_oa":true,"landing_page_url":"https://doi.org/10.2460/ajvr.1996.57.07.1044","pdf_url":"https://avmajournals.avma.org/downloadpdf/view/journals/ajvr/57/7/ajvr.1996.57.07.1044.pdf","source":{"id":"https://openalex.org/S196975874","display_name":"American Journal of Veterinary Research","issn_l":"0002-9645","issn":["0002-9645","1943-5681"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-2","medline","norway-1","oarl","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4322545313","host_organization_name":"American Veterinary Medical Association","host_organization_lineage":["https://openalex.org/P4322545313"],"host_organization_lineage_names":["American Veterinary Medical Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Veterinary Research","raw_type":"journal-article"},{"id":"pmid:8807019","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8807019","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of veterinary research","raw_type":"Journal Article"},{"id":"mag:10488159","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8807019","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"doi:10.2460/ajvr.1996.57.07.1044","doi":"https://doi.org/10.2460/ajvr.1996.57.07.1044","is_oa":true,"landing_page_url":"https://doi.org/10.2460/ajvr.1996.57.07.1044","pdf_url":"https://avmajournals.avma.org/downloadpdf/view/journals/ajvr/57/7/ajvr.1996.57.07.1044.pdf","source":{"id":"https://openalex.org/S196975874","display_name":"American Journal of Veterinary Research","issn_l":"0002-9645","issn":["0002-9645","1943-5681"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-2","medline","norway-1","oarl","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4322545313","host_organization_name":"American Veterinary Medical Association","host_organization_lineage":["https://openalex.org/P4322545313"],"host_organization_lineage_names":["American Veterinary Medical Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Veterinary Research","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8560000061988831,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4391200767.pdf","grobid_xml":"https://content.openalex.org/works/W4391200767.grobid-xml"},"referenced_works_count":1,"referenced_works":["https://openalex.org/W2395380129"],"related_works":["https://openalex.org/W2131658123","https://openalex.org/W1575651264","https://openalex.org/W4230921833","https://openalex.org/W2108703004","https://openalex.org/W2144660613","https://openalex.org/W3048604093","https://openalex.org/W1969224258","https://openalex.org/W2802948421","https://openalex.org/W1985761075","https://openalex.org/W2781159277"],"abstract_inverted_index":{"OBJECTIVE:":[0],"To":[1],"devise":[2],"and":[3,12,27,45,86,129,148,158,187,221,224],"test":[4],"an":[5],"i.v.":[6,181],"methohexital":[7,38,49,66,96,118,182],"infusion":[8,67,88,183],"regimen":[9,89,102,184,206],"for":[10,185,228],"induction":[11,186],"maintenance":[13,188],"of":[14,109,115,117,126,167,204,210],"surgical":[15],"anesthesia":[16,189,209],"in":[17,43,56,68,93,105,119,190,208,216,222,230,234],"dogs":[18,71,122,152,191],"from":[19],"which":[20,150],"they":[21],"would":[22,91],"rapidly":[23],"recover.":[24],"DESIGN:":[25],"Dose-response":[26],"plasma":[28,95,137],"concentration-effect":[29],"study.":[30],"ANIMALS:":[31],"11":[32],"clinically":[33],"normal":[34],"dogs.":[35,47,110],"PROCEDURE:":[36],"Bolus":[37],"pharmacokinetic":[39],"variables":[40,199],"were":[41,61,79,156],"determined":[42,62],"ketamine-":[44],"pentobarbital-anesthetized":[46],"Plasma":[48],"concentrations":[50,97,138],"required":[51,139,174],"to":[52,58,82,140,144,171,213,218],"inhibit":[53],"purposeful":[54],"movement":[55,142],"response":[57,143,217],"painful":[59],"stimuli":[60,220],"during":[63],"a":[64,73,84,106,145,163,195,235],"stepped":[65],"the":[69,120,151],"same":[70],"on":[72],"second":[74,107],"occasion.":[75],"These":[76],"pharmacokinetic/pharmacodynamic":[77],"data":[78],"next":[80],"used":[81],"design":[83],"bolus":[85],"two-stage":[87],"that":[90],"result":[92],"stable":[94],"with":[98],"prolonged":[99],"infusion.":[100],"This":[101],"was":[103,123,133,192],"tested":[104],"group":[108],"RESULTS:":[111],"Mean":[112,136],"steady-state":[113],"volume":[114],"distribution":[116],"anesthetized":[121],"1.50":[124],"L/kg":[125],"body":[127],"weight":[128],"mean":[130],"elimination":[131],"clearance":[132],"10.2":[134],"ml/kg/min.":[135],"prevent":[141,214],"noxious":[146,219],"stimulus":[147],"at":[149],"could":[153],"be":[154],"extubated":[155],"11.8":[157],"6.9":[159],"micrograms/ml,":[160],"respectively.":[161],"After":[162],"6-hour":[164,196],"infusion,":[165,197],"recovery":[166],"airway":[168],"reflexes":[169],"sufficient":[170,211],"allow":[172],"extubation":[173],"67":[175],"minutes.":[176],"CONCLUSIONS:":[177],"An":[178],"easily":[179],"implemented":[180],"developed.":[193],"During":[194],"hemodynamic":[198],"did":[200],"not":[201],"change.":[202],"Use":[203],"this":[205],"resulted":[207],"depth":[212],"withdrawal":[215],"reliable":[223],"acceptable":[225],"emergence":[226],"times":[227],"use":[229],"canine":[231],"survival":[232],"studies":[233],"cost-effective":[236],"manner.":[237]},"counts_by_year":[{"year":2018,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2024-01-25T00:00:00"}