{"id":"https://openalex.org/W4391152269","doi":"https://doi.org/10.1016/j.bbalip.2024.159461","title":"Silencing ANGPTL8 reduces mouse preadipocyte differentiation and insulin signaling","display_name":"Silencing ANGPTL8 reduces mouse preadipocyte differentiation and insulin signaling","publication_year":2024,"publication_date":"2024-01-23","ids":{"openalex":"https://openalex.org/W4391152269","doi":"https://doi.org/10.1016/j.bbalip.2024.159461","pmid":"https://pubmed.ncbi.nlm.nih.gov/38272177"},"language":"en","primary_location":{"id":"doi:10.1016/j.bbalip.2024.159461","doi":"https://doi.org/10.1016/j.bbalip.2024.159461","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.bbalip.2024.159461","pdf_url":null,"source":{"id":"https://openalex.org/S4210172276","display_name":"Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids","issn_l":"1388-1981","issn":["1388-1981","1879-2618"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/j.bbalip.2024.159461","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5035343244","display_name":"Anindya Ghosh","orcid":"https://orcid.org/0000-0002-8432-5288","observed_orcids":["https://orcid.org/0000-0002-8432-5288"]},"institutions":[{"id":"https://openalex.org/I4210142730","display_name":"Centre Hospitalier de l\u2019Universit\u00e9 de Montr\u00e9al","ror":"https://ror.org/0410a8y51","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4210142730","https://openalex.org/I4405279980"]},{"id":"https://openalex.org/I70931966","display_name":"Universit\u00e9 de Montr\u00e9al","ror":"https://ror.org/0161xgx34","country_code":"CA","type":"education","lineage":["https://openalex.org/I70931966"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Anindya Ghosh","raw_affiliation_strings":["Departments of Nutrition, Biochemistry and Molecular Medicine, University of Montreal, and Montreal Diabetes Research Center, Centre de Recherche du Centre Hospitalier de l'Universit\u00e9 de Montr\u00e9al (CRCHUM), Montr\u00e9al, QC, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Nutrition, Biochemistry and Molecular Medicine, University of Montreal, and Montreal Diabetes Research Center, Centre de Recherche du Centre Hospitalier de l'Universit\u00e9 de Montr\u00e9al (CRCHUM), Montr\u00e9al, QC, Canada","institution_ids":["https://openalex.org/I4210142730","https://openalex.org/I70931966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087967743","display_name":"Yat Hei Leung","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210142730","display_name":"Centre Hospitalier de l\u2019Universit\u00e9 de Montr\u00e9al","ror":"https://ror.org/0410a8y51","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4210142730","https://openalex.org/I4405279980"]},{"id":"https://openalex.org/I70931966","display_name":"Universit\u00e9 de Montr\u00e9al","ror":"https://ror.org/0161xgx34","country_code":"CA","type":"education","lineage":["https://openalex.org/I70931966"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Yat Hei Leung","raw_affiliation_strings":["Departments of Nutrition, Biochemistry and Molecular Medicine, University of Montreal, and Montreal Diabetes Research Center, Centre de Recherche du Centre Hospitalier de l'Universit\u00e9 de Montr\u00e9al (CRCHUM), Montr\u00e9al, QC, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Nutrition, Biochemistry and Molecular Medicine, University of Montreal, and Montreal Diabetes Research Center, Centre de Recherche du Centre Hospitalier de l'Universit\u00e9 de Montr\u00e9al (CRCHUM), Montr\u00e9al, QC, Canada","institution_ids":["https://openalex.org/I4210142730","https://openalex.org/I70931966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111117252","display_name":"Jeffrey C. Yu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Jeffrey Yu","raw_affiliation_strings":["Department of Medicine, McGill University, Montr\u00e9al, QC, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, McGill University, Montr\u00e9al, QC, Canada","institution_ids":["https://openalex.org/I5023651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005999411","display_name":"ROBERT M. SLADEK","orcid":"https://orcid.org/0000-0002-2730-1204","observed_orcids":["https://orcid.org/0000-0002-2730-1204"]},"institutions":[{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Robert Sladek","raw_affiliation_strings":["Department of Medicine, McGill University, Montr\u00e9al, QC, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, McGill University, Montr\u00e9al, QC, Canada","institution_ids":["https://openalex.org/I5023651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000028694","display_name":"Isabelle Ch\u00e9nier","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210142730","display_name":"Centre Hospitalier de l\u2019Universit\u00e9 de Montr\u00e9al","ror":"https://ror.org/0410a8y51","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4210142730","https://openalex.org/I4405279980"]},{"id":"https://openalex.org/I70931966","display_name":"Universit\u00e9 de Montr\u00e9al","ror":"https://ror.org/0161xgx34","country_code":"CA","type":"education","lineage":["https://openalex.org/I70931966"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Isabelle Ch\u00e9nier","raw_affiliation_strings":["Departments of Nutrition, Biochemistry and Molecular Medicine, University of Montreal, and Montreal Diabetes Research Center, Centre de Recherche du Centre Hospitalier de l'Universit\u00e9 de Montr\u00e9al (CRCHUM), Montr\u00e9al, QC, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Nutrition, Biochemistry and Molecular Medicine, University of Montreal, and Montreal Diabetes Research Center, Centre de Recherche du Centre Hospitalier de l'Universit\u00e9 de Montr\u00e9al (CRCHUM), Montr\u00e9al, QC, Canada","institution_ids":["https://openalex.org/I4210142730","https://openalex.org/I70931966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039115595","display_name":"Abel K. Oppong","orcid":"https://orcid.org/0000-0002-8006-1537","observed_orcids":["https://orcid.org/0000-0002-8006-1537"]},"institutions":[{"id":"https://openalex.org/I4210142730","display_name":"Centre Hospitalier de l\u2019Universit\u00e9 de Montr\u00e9al","ror":"https://ror.org/0410a8y51","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4210142730","https://openalex.org/I4405279980"]},{"id":"https://openalex.org/I70931966","display_name":"Universit\u00e9 de Montr\u00e9al","ror":"https://ror.org/0161xgx34","country_code":"CA","type":"education","lineage":["https://openalex.org/I70931966"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Abel K. Oppong","raw_affiliation_strings":["Departments of Nutrition, Biochemistry and Molecular Medicine, University of Montreal, and Montreal Diabetes Research Center, Centre de Recherche du Centre Hospitalier de l'Universit\u00e9 de Montr\u00e9al (CRCHUM), Montr\u00e9al, QC, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Nutrition, Biochemistry and Molecular Medicine, University of Montreal, and Montreal Diabetes Research Center, Centre de Recherche du Centre Hospitalier de l'Universit\u00e9 de Montr\u00e9al (CRCHUM), Montr\u00e9al, QC, Canada","institution_ids":["https://openalex.org/I4210142730","https://openalex.org/I70931966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111876175","display_name":"Marie\u2010Line Peyot","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210142730","display_name":"Centre Hospitalier de l\u2019Universit\u00e9 de Montr\u00e9al","ror":"https://ror.org/0410a8y51","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4210142730","https://openalex.org/I4405279980"]},{"id":"https://openalex.org/I70931966","display_name":"Universit\u00e9 de Montr\u00e9al","ror":"https://ror.org/0161xgx34","country_code":"CA","type":"education","lineage":["https://openalex.org/I70931966"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Marie-Line Peyot","raw_affiliation_strings":["Departments of Nutrition, Biochemistry and Molecular Medicine, University of Montreal, and Montreal Diabetes Research Center, Centre de Recherche du Centre Hospitalier de l'Universit\u00e9 de Montr\u00e9al (CRCHUM), Montr\u00e9al, QC, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Nutrition, Biochemistry and Molecular Medicine, University of Montreal, and Montreal Diabetes Research Center, Centre de Recherche du Centre Hospitalier de l'Universit\u00e9 de Montr\u00e9al (CRCHUM), Montr\u00e9al, QC, Canada","institution_ids":["https://openalex.org/I4210142730","https://openalex.org/I70931966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102977871","display_name":"S.R. Murthy Madiraju","orcid":"https://orcid.org/0000-0002-2613-2074","observed_orcids":["https://orcid.org/0000-0002-2613-2074"]},"institutions":[{"id":"https://openalex.org/I4210142730","display_name":"Centre Hospitalier de l\u2019Universit\u00e9 de Montr\u00e9al","ror":"https://ror.org/0410a8y51","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4210142730","https://openalex.org/I4405279980"]},{"id":"https://openalex.org/I70931966","display_name":"Universit\u00e9 de Montr\u00e9al","ror":"https://ror.org/0161xgx34","country_code":"CA","type":"education","lineage":["https://openalex.org/I70931966"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"S.R. Murthy Madiraju","raw_affiliation_strings":["Departments of Nutrition, Biochemistry and Molecular Medicine, University of Montreal, and Montreal Diabetes Research Center, Centre de Recherche du Centre Hospitalier de l'Universit\u00e9 de Montr\u00e9al (CRCHUM), Montr\u00e9al, QC, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Nutrition, Biochemistry and Molecular Medicine, University of Montreal, and Montreal Diabetes Research Center, Centre de Recherche du Centre Hospitalier de l'Universit\u00e9 de Montr\u00e9al (CRCHUM), Montr\u00e9al, QC, Canada","institution_ids":["https://openalex.org/I4210142730","https://openalex.org/I70931966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007130952","display_name":"Irina Al\u2010Khairi","orcid":"https://orcid.org/0000-0002-3547-9926","observed_orcids":["https://orcid.org/0000-0002-3547-9926"]},"institutions":[{"id":"https://openalex.org/I4210165735","display_name":"Dasman Diabetes Institute","ror":"https://ror.org/05tppc012","country_code":"KW","type":"education","lineage":["https://openalex.org/I4210165735"]}],"countries":["KW"],"is_corresponding":false,"raw_author_name":"Irina Al-Khairi","raw_affiliation_strings":["Dasman Diabetes Institute, Dasman 15462, Kuwait"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dasman Diabetes Institute, Dasman 15462, Kuwait","institution_ids":["https://openalex.org/I4210165735"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043950009","display_name":"Thangavel Alphonse Thanaraj","orcid":"https://orcid.org/0000-0002-4574-5343","observed_orcids":["https://orcid.org/0000-0002-4574-5343"]},"institutions":[{"id":"https://openalex.org/I4210165735","display_name":"Dasman Diabetes Institute","ror":"https://ror.org/05tppc012","country_code":"KW","type":"education","lineage":["https://openalex.org/I4210165735"]}],"countries":["KW"],"is_corresponding":false,"raw_author_name":"Thangavel Alphonse Thanaraj","raw_affiliation_strings":["Dasman Diabetes Institute, Dasman 15462, Kuwait"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dasman Diabetes Institute, Dasman 15462, Kuwait","institution_ids":["https://openalex.org/I4210165735"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036936439","display_name":"Jehad Ahmed Abubaker","orcid":"https://orcid.org/0000-0003-0681-7305","observed_orcids":["https://orcid.org/0000-0003-0681-7305"]},"institutions":[{"id":"https://openalex.org/I4210165735","display_name":"Dasman Diabetes Institute","ror":"https://ror.org/05tppc012","country_code":"KW","type":"education","lineage":["https://openalex.org/I4210165735"]}],"countries":["KW"],"is_corresponding":false,"raw_author_name":"Jehad Abubaker","raw_affiliation_strings":["Dasman Diabetes Institute, Dasman 15462, Kuwait"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dasman Diabetes Institute, Dasman 15462, Kuwait","institution_ids":["https://openalex.org/I4210165735"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045720408","display_name":"Fahd Al\u2010Mulla","orcid":"https://orcid.org/0000-0001-5409-3829","observed_orcids":["https://orcid.org/0000-0001-5409-3829"]},"institutions":[{"id":"https://openalex.org/I4210165735","display_name":"Dasman Diabetes Institute","ror":"https://ror.org/05tppc012","country_code":"KW","type":"education","lineage":["https://openalex.org/I4210165735"]}],"countries":["KW"],"is_corresponding":false,"raw_author_name":"Fahd Al-Mulla","raw_affiliation_strings":["Dasman Diabetes Institute, Dasman 15462, Kuwait"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dasman Diabetes Institute, Dasman 15462, Kuwait","institution_ids":["https://openalex.org/I4210165735"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043172423","display_name":"Marc Prentki","orcid":"https://orcid.org/0000-0002-0499-3324","observed_orcids":["https://orcid.org/0000-0002-0499-3324"]},"institutions":[{"id":"https://openalex.org/I4210142730","display_name":"Centre Hospitalier de l\u2019Universit\u00e9 de Montr\u00e9al","ror":"https://ror.org/0410a8y51","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4210142730","https://openalex.org/I4405279980"]},{"id":"https://openalex.org/I70931966","display_name":"Universit\u00e9 de Montr\u00e9al","ror":"https://ror.org/0161xgx34","country_code":"CA","type":"education","lineage":["https://openalex.org/I70931966"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Marc Prentki","raw_affiliation_strings":["Departments of Nutrition, Biochemistry and Molecular Medicine, University of Montreal, and Montreal Diabetes Research Center, Centre de Recherche du Centre Hospitalier de l'Universit\u00e9 de Montr\u00e9al (CRCHUM), Montr\u00e9al, QC, Canada. Electronic address: marc.prentki@umontreal.ca","Departments of Nutrition, Biochemistry and Molecular Medicine, University of Montreal, and Montreal Diabetes Research Center, Centre de Recherche du Centre Hospitalier de l'Universit\u00e9 de Montr\u00e9al (CRCHUM), Montr\u00e9al, QC, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Nutrition, Biochemistry and Molecular Medicine, University of Montreal, and Montreal Diabetes Research Center, Centre de Recherche du Centre Hospitalier de l'Universit\u00e9 de Montr\u00e9al (CRCHUM), Montr\u00e9al, QC, Canada. Electronic address: marc.prentki@umontreal.ca","institution_ids":["https://openalex.org/I4210142730","https://openalex.org/I70931966"]},{"raw_affiliation_string":"Departments of Nutrition, Biochemistry and Molecular Medicine, University of Montreal, and Montreal Diabetes Research Center, Centre de Recherche du Centre Hospitalier de l'Universit\u00e9 de Montr\u00e9al (CRCHUM), Montr\u00e9al, QC, Canada","institution_ids":["https://openalex.org/I4210142730","https://openalex.org/I70931966"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5076487680","display_name":"Mohamed Abu\u2010Farha","orcid":"https://orcid.org/0000-0001-8357-1252","observed_orcids":["https://orcid.org/0000-0001-8357-1252"]},"institutions":[{"id":"https://openalex.org/I4210165735","display_name":"Dasman Diabetes Institute","ror":"https://ror.org/05tppc012","country_code":"KW","type":"education","lineage":["https://openalex.org/I4210165735"]}],"countries":["KW"],"is_corresponding":true,"raw_author_name":"Mohamed Abu-Farha","raw_affiliation_strings":["Dasman Diabetes Institute, Dasman 15462, Kuwait. Electronic address: mohamed.abufarha@dasmaninstitute.org","Dasman Diabetes Institute, Dasman 15462, Kuwait"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dasman Diabetes Institute, Dasman 15462, Kuwait. Electronic address: mohamed.abufarha@dasmaninstitute.org","institution_ids":["https://openalex.org/I4210165735"]},{"raw_affiliation_string":"Dasman Diabetes Institute, Dasman 15462, Kuwait","institution_ids":["https://openalex.org/I4210165735"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5043172423","https://openalex.org/A5076487680"],"corresponding_institution_ids":["https://openalex.org/I4210142730","https://openalex.org/I4210165735","https://openalex.org/I70931966"],"apc_list":{"value":3450,"currency":"USD","value_usd":3450},"apc_paid":{"value":3450,"currency":"USD","value_usd":3450},"fwci":0.6672,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.59916993,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":96},"biblio":{"volume":"1869","issue":"3","first_page":"159461","last_page":"159461"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11072","display_name":"Peroxisome Proliferator-Activated Receptors","score":0.39309999346733093,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11072","display_name":"Peroxisome Proliferator-Activated Receptors","score":0.39309999346733093,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11457","display_name":"Adipose Tissue and Metabolism","score":0.2054000049829483,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11844","display_name":"Lipid metabolism and biosynthesis","score":0.20419999957084656,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/angptl8","display_name":"ANGPTL8","score":1.0},{"id":"https://openalex.org/keywords/adipogenic-differentiation","display_name":"adipogenesis","score":0.8600000143051147},{"id":"https://openalex.org/keywords/preadipocytes","display_name":"preadipocytes","score":0.9670000076293945},{"id":"https://openalex.org/keywords/insulin-signaling","display_name":"insulin signaling","score":0.9769999980926514},{"id":"https://openalex.org/keywords/lipoprotein-lipase","display_name":"lipoprotein lipase","score":0.8029999732971191},{"id":"https://openalex.org/keywords/triglyceride-accumulation","display_name":"triglyceride accumulation","score":0.8939999938011169},{"id":"https://openalex.org/keywords/lipolysis","display_name":"lipolysis","score":0.9950000047683716},{"id":"https://openalex.org/keywords/ppargamma","display_name":"PPAR\u03b3","score":0.9520000219345093},{"id":"https://openalex.org/keywords/akt-phosphorylation","display_name":"Akt phosphorylation","score":0.9309999942779541},{"id":"https://openalex.org/keywords/nf-kappab-signaling","display_name":"NF-\u03baB signaling","score":0.9020000100135803},{"id":"https://openalex.org/keywords/extracellular-matrix","display_name":"extracellular matrix","score":0.8949999809265137},{"id":"https://openalex.org/keywords/angptl3","display_name":"ANGPTL3","score":0.8519999980926514},{"id":"https://openalex.org/keywords/angptl4","display_name":"ANGPTL4","score":0.9779999852180481},{"id":"https://openalex.org/keywords/adipogenic-gene-expression","display_name":"adipogenic gene expression","score":0.6119999885559082}],"concepts":[{"id":"https://openalex.org/C122927707","wikidata":"https://www.wikidata.org/wiki/Q2824461","display_name":"Adipogenesis","level":3,"score":0.7145920395851135},{"id":"https://openalex.org/C2776175234","wikidata":"https://www.wikidata.org/wiki/Q357519","display_name":"Adipocyte","level":3,"score":0.7072157263755798},{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.6520148515701294},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6198819279670715},{"id":"https://openalex.org/C171089720","wikidata":"https://www.wikidata.org/wiki/Q193583","display_name":"Adipose tissue","level":2,"score":0.5904877185821533},{"id":"https://openalex.org/C94879076","wikidata":"https://www.wikidata.org/wiki/Q420014","display_name":"Lipoprotein lipase","level":3,"score":0.5845041871070862},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5815950632095337},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5076264142990112},{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.4936474561691284},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.48730266094207764},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.4809345602989197},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.4640207886695862},{"id":"https://openalex.org/C119056186","wikidata":"https://www.wikidata.org/wiki/Q1431332","display_name":"Gene silencing","level":3,"score":0.4472464621067047},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.43492555618286133},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.4325523376464844},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.12852802872657776},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.08724385499954224},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.07959094643592834}],"mesh":[{"descriptor_ui":"D000091306","descriptor_name":"Angiopoietin-Like Protein 8","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D034741","descriptor_name":"RNA, Small Interfering","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050156","descriptor_name":"Adipogenesis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.bbalip.2024.159461","doi":"https://doi.org/10.1016/j.bbalip.2024.159461","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.bbalip.2024.159461","pdf_url":null,"source":{"id":"https://openalex.org/S4210172276","display_name":"Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids","issn_l":"1388-1981","issn":["1388-1981","1879-2618"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids","raw_type":"journal-article"},{"id":"pmid:38272177","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38272177","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochimica et biophysica acta. Molecular and cell biology of lipids","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/j.bbalip.2024.159461","doi":"https://doi.org/10.1016/j.bbalip.2024.159461","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.bbalip.2024.159461","pdf_url":null,"source":{"id":"https://openalex.org/S4210172276","display_name":"Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids","issn_l":"1388-1981","issn":["1388-1981","1879-2618"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8048999905586243,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":79,"referenced_works":["https://openalex.org/W1651622892","https://openalex.org/W1749976475","https://openalex.org/W1973094248","https://openalex.org/W1995806275","https://openalex.org/W2016991304","https://openalex.org/W2017292651","https://openalex.org/W2030424006","https://openalex.org/W2038706336","https://openalex.org/W2058804806","https://openalex.org/W2059992589","https://openalex.org/W2069711307","https://openalex.org/W2077907566","https://openalex.org/W2097899015","https://openalex.org/W2097948046","https://openalex.org/W2102819300","https://openalex.org/W2103504539","https://openalex.org/W2104005232","https://openalex.org/W2110687686","https://openalex.org/W2114104545","https://openalex.org/W2115509231","https://openalex.org/W2117219849","https://openalex.org/W2117415893","https://openalex.org/W2120480222","https://openalex.org/W2131271579","https://openalex.org/W2138553782","https://openalex.org/W2139819899","https://openalex.org/W2145025818","https://openalex.org/W2159675211","https://openalex.org/W2161392469","https://openalex.org/W2164167307","https://openalex.org/W2169456326","https://openalex.org/W2179438025","https://openalex.org/W2183506233","https://openalex.org/W2197346931","https://openalex.org/W2210580213","https://openalex.org/W2253889546","https://openalex.org/W2344942178","https://openalex.org/W2413888173","https://openalex.org/W2437968965","https://openalex.org/W2525160505","https://openalex.org/W2531285001","https://openalex.org/W2552488592","https://openalex.org/W2582743722","https://openalex.org/W2606804985","https://openalex.org/W2614451399","https://openalex.org/W2730976293","https://openalex.org/W2789373612","https://openalex.org/W2795228071","https://openalex.org/W2799553143","https://openalex.org/W2809888393","https://openalex.org/W2883025088","https://openalex.org/W2890781037","https://openalex.org/W2908320623","https://openalex.org/W2910111050","https://openalex.org/W2914362161","https://openalex.org/W2927130493","https://openalex.org/W2949355358","https://openalex.org/W2965444317","https://openalex.org/W3032087370","https://openalex.org/W3045901676","https://openalex.org/W3091295894","https://openalex.org/W3102105545","https://openalex.org/W3130247074","https://openalex.org/W3157950658","https://openalex.org/W3160890790","https://openalex.org/W3189264236","https://openalex.org/W3199497409","https://openalex.org/W3211803164","https://openalex.org/W3214222238","https://openalex.org/W4229043993","https://openalex.org/W4238669558","https://openalex.org/W4293562693","https://openalex.org/W4317545566","https://openalex.org/W4319823716","https://openalex.org/W4361304957","https://openalex.org/W4378515720","https://openalex.org/W6688736702","https://openalex.org/W6717951777","https://openalex.org/W7098669547"],"related_works":["https://openalex.org/W4381337524","https://openalex.org/W2614451399","https://openalex.org/W3162040510","https://openalex.org/W3164326830","https://openalex.org/W2943589174","https://openalex.org/W3011071184","https://openalex.org/W3045901676","https://openalex.org/W4394938752","https://openalex.org/W4291018642","https://openalex.org/W2809288593"],"abstract_inverted_index":{"ANGPTL8,":[0],"expressed":[1,44],"mainly":[2],"in":[3,17,39,51,66,76,84,180,184,201],"the":[4,10,18,61,131,185],"liver":[5],"and":[6,21,30,53,68,97,122,138,151],"adipose":[7],"tissue,":[8],"regulates":[9],"activity":[11],"of":[12,63,104,108,124,136],"lipoprotein":[13],"lipase":[14],"(LPL)":[15],"present":[16],"extracellular":[19,149,186],"space":[20],"triglyceride":[22],"(TG)":[23],"metabolism":[24],"through":[25],"its":[26,82],"interaction":[27],"with":[28],"ANGPTL3":[29],"ANGPTL4.":[31],"Whether":[32],"intracellular":[33,64,178],"ANGPTL8":[34,47,65,89,109,128,176,193],"can":[35],"also":[36,98],"exert":[37],"effects":[38,183],"tissues":[40],"where":[41],"it":[42,71],"is":[43,45],"uncertain.":[46],"expression":[48,83,135,194],"was":[49,158],"low":[50],"preadipocytes":[52,116],"much":[54],"increased":[55],"during":[56,164],"differentiation.":[57,105,166],"To":[58],"better":[59],"understand":[60],"role":[62,75],"adipocytes":[67],"assess":[69],"whether":[70],"may":[72],"play":[73],"a":[74],"adipocyte":[77,92,165],"differentiation,":[78,93],"we":[79],"knocked":[80],"down":[81],"normal":[85,171],"mouse":[86],"subcutaneous":[87],"preadipocytes.":[88],"knockdown":[90,129],"reduced":[91,159],"cellular":[94],"TG":[95],"accumulation":[96],"isoproterenol-stimulated":[99],"lipolysis":[100],"at":[101,160],"day":[102],"7":[103,123],"RNA-Seq":[106],"analysis":[107],"siRNA":[110,113],"or":[111],"control":[112],"transfected":[114],"SC":[115],"on":[117,170],"days":[118],"0,":[119],"2,":[120],"4":[121],"differentiation":[125,197],"showed":[126],"that":[127,175],"impeded":[130],"early":[132,162],"(day":[133],"2)":[134],"adipogenic":[137],"insulin":[139,202],"signaling":[140,203],"genes,":[141],"PPAR\u03b3,":[142],"as":[143,145],"well":[144],"genes":[146],"related":[147],"to":[148,182],"matrix":[150],"NF-\u03baB":[152],"signaling.":[153],"Insulin":[154],"mediated":[155],"Akt":[156],"phosphorylation":[157],"an":[161],"stage":[163],"This":[167],"study":[168],"based":[169],"primary":[172],"cells":[173],"shows":[174],"has":[177],"actions":[179],"addition":[181],"space,":[187],"like":[188],"modulating":[189],"LPL":[190],"activity.":[191],"Preadipocyte":[192],"modulates":[195],"their":[196],"possibly":[198],"via":[199],"changes":[200],"gene":[204],"expression.":[205]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2024-01-24T00:00:00"}