{"id":"https://openalex.org/W4391151863","doi":"https://doi.org/10.1098/rsob.230386","title":"Single-cell expression predicts neuron-specific protein homeostasis networks","display_name":"Single-cell expression predicts neuron-specific protein homeostasis networks","publication_year":2024,"publication_date":"2024-01-01","ids":{"openalex":"https://openalex.org/W4391151863","doi":"https://doi.org/10.1098/rsob.230386","pmid":"https://pubmed.ncbi.nlm.nih.gov/38262604","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10805596"},"language":"en","primary_location":{"id":"doi:10.1098/rsob.230386","doi":"https://doi.org/10.1098/rsob.230386","is_oa":true,"landing_page_url":"https://doi.org/10.1098/rsob.230386","pdf_url":null,"source":{"id":"https://openalex.org/S80033963","display_name":"Open Biology","issn_l":"2046-2441","issn":["2046-2441"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319787","host_organization_name":"Royal Society","host_organization_lineage":["https://openalex.org/P4310319787"],"host_organization_lineage_names":["Royal Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Open Biology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1098/rsob.230386","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5033615337","display_name":"Sebastian Pechmann","orcid":"https://orcid.org/0000-0002-4356-9470","observed_orcids":["https://orcid.org/0000-0002-4356-9470"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Sebastian Pechmann","raw_affiliation_strings":["Saarbr\u00fccken, Germany","Sebastian Pechmann Research Lab, Saarbr\u00fccken, Germany"],"raw_orcid":"https://orcid.org/0000-0002-4356-9470","affiliations":[{"raw_affiliation_string":"Saarbr\u00fccken, Germany","institution_ids":[]},{"raw_affiliation_string":"Sebastian Pechmann Research Lab, Saarbr\u00fccken, Germany","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5033615337"],"corresponding_institution_ids":[],"apc_list":{"value":1500,"currency":"GBP","value_usd":1839},"apc_paid":{"value":1500,"currency":"GBP","value_usd":1839},"fwci":0.6906,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.60973578,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"14","issue":"1","first_page":"230386","last_page":"230386"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10934","display_name":"Heat shock proteins research","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10934","display_name":"Heat shock proteins research","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11041","display_name":"Ubiquitin and proteasome pathways","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/proteostasis","display_name":"proteostasis","score":0.9879999756813049},{"id":"https://openalex.org/keywords/molecular-chaperones","display_name":"molecular chaperones","score":0.6740000247955322},{"id":"https://openalex.org/keywords/ubiquitin-ligase","display_name":"ubiquitin ligase","score":0.9890000224113464},{"id":"https://openalex.org/keywords/neurodegenerative-diseases","display_name":"neurodegenerative diseases","score":0.6600000262260437},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.8320000171661377},{"id":"https://openalex.org/keywords/parkinson-s-disease","display_name":"Parkinson's disease","score":1.0},{"id":"https://openalex.org/keywords/single-cell-gene-expression","display_name":"single-cell gene expression","score":0.6140000224113464},{"id":"https://openalex.org/keywords/human-brain","display_name":"human brain","score":0.5540000200271606},{"id":"https://openalex.org/keywords/excitatory-neurons","display_name":"excitatory neurons","score":0.8360000252723694},{"id":"https://openalex.org/keywords/inhibitory-neurons","display_name":"inhibitory neurons","score":1.0},{"id":"https://openalex.org/keywords/non-neuronal-cells","display_name":"non-neuronal cells","score":0.8169999718666077},{"id":"https://openalex.org/keywords/synaptogenesis","display_name":"synaptogenesis","score":0.7480000257492065},{"id":"https://openalex.org/keywords/transcriptional-regulation","display_name":"transcriptional regulation","score":0.6510000228881836},{"id":"https://openalex.org/keywords/protein-misfolding","display_name":"protein misfolding","score":0.6840000152587891},{"id":"https://openalex.org/keywords/network-evolution","display_name":"network evolution","score":0.43700000643730164},{"id":"https://openalex.org/keywords/protein-aggregation","display_name":"protein aggregation","score":0.3970000147819519}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8691596388816833},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5482193231582642},{"id":"https://openalex.org/C63645605","wikidata":"https://www.wikidata.org/wiki/Q103191","display_name":"Homeostasis","level":2,"score":0.5367885828018188},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.5112047791481018},{"id":"https://openalex.org/C2776925932","wikidata":"https://www.wikidata.org/wiki/Q1755122","display_name":"Neurodegeneration","level":3,"score":0.4698179066181183},{"id":"https://openalex.org/C2775962898","wikidata":"https://www.wikidata.org/wiki/Q5073152","display_name":"Chaperone (clinical)","level":2,"score":0.44986486434936523},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.42152321338653564},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2267128825187683},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.18133807182312012},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.13711130619049072},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000074702","descriptor_name":"Proteostasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005075","descriptor_name":"Biological Evolution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017510","descriptor_name":"Protein Folding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1098/rsob.230386","doi":"https://doi.org/10.1098/rsob.230386","is_oa":true,"landing_page_url":"https://doi.org/10.1098/rsob.230386","pdf_url":null,"source":{"id":"https://openalex.org/S80033963","display_name":"Open Biology","issn_l":"2046-2441","issn":["2046-2441"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319787","host_organization_name":"Royal Society","host_organization_lineage":["https://openalex.org/P4310319787"],"host_organization_lineage_names":["Royal Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Open Biology","raw_type":"journal-article"},{"id":"doi:10.1101/2023.03.14.532571","doi":"https://doi.org/10.1101/2023.03.14.532571","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2023.03.14.532571","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2023/03/15/2023.03.14.532571.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:10805596","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10805596","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Open Biol","raw_type":"Text"},{"id":"pmid:38262604","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38262604","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Open biology","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:84bf60ab97a048f1a57f2c955f6e4618","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/84bf60ab97a048f1a57f2c955f6e4618","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Open Biology, Vol 14, Iss 1 (2024)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1098/rsob.230386","doi":"https://doi.org/10.1098/rsob.230386","is_oa":true,"landing_page_url":"https://doi.org/10.1098/rsob.230386","pdf_url":null,"source":{"id":"https://openalex.org/S80033963","display_name":"Open Biology","issn_l":"2046-2441","issn":["2046-2441"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319787","host_organization_name":"Royal Society","host_organization_lineage":["https://openalex.org/P4310319787"],"host_organization_lineage_names":["Royal Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Open Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.46810001134872437,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4391151863.pdf","grobid_xml":"https://content.openalex.org/works/W4391151863.grobid-xml"},"referenced_works_count":66,"referenced_works":["https://openalex.org/W1966327575","https://openalex.org/W1971108880","https://openalex.org/W1978376889","https://openalex.org/W1978458868","https://openalex.org/W1984717026","https://openalex.org/W1993287310","https://openalex.org/W2010515885","https://openalex.org/W2064827935","https://openalex.org/W2076367743","https://openalex.org/W2085717111","https://openalex.org/W2089726971","https://openalex.org/W2101520669","https://openalex.org/W2104994386","https://openalex.org/W2114870653","https://openalex.org/W2122674036","https://openalex.org/W2128551987","https://openalex.org/W2135278768","https://openalex.org/W2140855217","https://openalex.org/W2156576736","https://openalex.org/W2162248797","https://openalex.org/W2165186407","https://openalex.org/W2270369744","https://openalex.org/W2481253841","https://openalex.org/W2520514017","https://openalex.org/W2553689505","https://openalex.org/W2755430790","https://openalex.org/W2794480084","https://openalex.org/W2894104882","https://openalex.org/W2898460257","https://openalex.org/W2902652978","https://openalex.org/W2913940235","https://openalex.org/W2916020270","https://openalex.org/W2945232783","https://openalex.org/W2952088773","https://openalex.org/W2952382191","https://openalex.org/W2960849263","https://openalex.org/W2969948459","https://openalex.org/W2973622744","https://openalex.org/W2998837808","https://openalex.org/W3010296929","https://openalex.org/W3026985819","https://openalex.org/W3061587943","https://openalex.org/W3088687225","https://openalex.org/W3093267706","https://openalex.org/W3095662667","https://openalex.org/W3109441892","https://openalex.org/W3112376646","https://openalex.org/W3128535705","https://openalex.org/W3133571965","https://openalex.org/W3153695932","https://openalex.org/W3163911339","https://openalex.org/W3165484394","https://openalex.org/W3165858085","https://openalex.org/W3188841664","https://openalex.org/W3197619341","https://openalex.org/W3198546360","https://openalex.org/W3202462310","https://openalex.org/W4200617527","https://openalex.org/W4224211484","https://openalex.org/W4225852862","https://openalex.org/W4281636822","https://openalex.org/W4282924643","https://openalex.org/W4284687727","https://openalex.org/W4294316687","https://openalex.org/W4312019583","https://openalex.org/W6929051165"],"related_works":["https://openalex.org/W1977496718","https://openalex.org/W2122674036","https://openalex.org/W4285157634","https://openalex.org/W2973622744","https://openalex.org/W1968892625","https://openalex.org/W2725405254","https://openalex.org/W953540999","https://openalex.org/W2069888159","https://openalex.org/W4200153105","https://openalex.org/W3016436937"],"abstract_inverted_index":{"The":[0],"protein":[1,46,85,98,132],"homeostasis":[2,47,86,99,133],"network":[3,87],"keeps":[4],"proteins":[5,21],"in":[6,50,61,104,151,170],"their":[7,171],"correct":[8],"shapes":[9],"and":[10,36,41,52,109,115,128,192],"avoids":[11],"unwanted":[12],"aggregation.":[13],"In":[14],"turn,":[15],"the":[16,27,71,79,83,89,135,144,152,159,175,183],"accumulation":[17],"of":[18,29,44,82,137,146,158,163,185],"aberrantly":[19],"misfolded":[20],"has":[22],"been":[23],"directly":[24],"associated":[25],"with":[26,101,122],"onset":[28],"ageing-associated":[30],"neurodegenerative":[31],"diseases":[32,62],"such":[33],"as":[34],"Alzheimer's":[35],"Parkinson's.":[37],"However,":[38],"a":[39],"detailed":[40],"rational":[42],"understanding":[43],"how":[45,53],"is":[48],"achieved":[49],"health,":[51],"it":[54],"can":[55],"be":[56,168],"targeted":[57],"for":[58,125,188],"therapeutic":[59],"intervention":[60],"remains":[63],"missing.":[64],"Here,":[65],"large-scale":[66],"single-cell":[67],"expression":[68,94],"data":[69],"from":[70],"Allen":[72],"Brain":[73],"Map":[74],"are":[75,118],"analysed":[76],"to":[77,134],"investigate":[78],"transcription":[80],"regulation":[81,136],"core":[84],"across":[88],"human":[90],"brain.":[91],"Remarkably,":[92],"distinct":[93],"profiles":[95],"suggest":[96],"specialized":[97],"networks":[100],"systematic":[102],"adaptations":[103],"excitatory":[105],"neurons,":[106],"inhibitory":[107],"neurons":[108],"non-neuronal":[110],"cells.":[111],"Moreover,":[112],"several":[113],"chaperones":[114],"Ubiquitin":[116],"ligases":[117],"found":[119],"transcriptionally":[120],"coregulated":[121],"genes":[123],"important":[124],"synapse":[126],"formation":[127],"maintenance,":[129],"thus":[130],"linking":[131],"neuronal":[138],"function.":[139],"Finally,":[140],"evolutionary":[141],"analyses":[142,187],"highlight":[143],"conservation":[145],"an":[147],"elevated":[148],"interaction":[149],"density":[150],"chaperone":[153,164],"network,":[154],"suggesting":[155],"that":[156],"one":[157],"most":[160],"exciting":[161],"aspects":[162],"action":[165,173],"may":[166],"yet":[167],"discovered":[169],"collective":[172],"at":[174],"systems":[176],"level.":[177],"More":[178],"generally,":[179],"our":[180],"work":[181],"highlights":[182],"power":[184],"computational":[186],"breaking":[189],"down":[190],"complexity":[191],"gaining":[193],"complementary":[194],"insights":[195],"into":[196],"fundamental":[197],"biological":[198],"problems.":[199]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2024-01-24T00:00:00"}
