{"id":"https://openalex.org/W4391132005","doi":"https://doi.org/10.15275/ssmj1903256","title":"Sequence gene variants in PPARGC1A rs8192678, PPARG2 rs1801282, FTO rs9939609, LEP rs7799039, LEPR rs1137101 and nonalcoholic fatty liver disease","display_name":"Sequence gene variants in PPARGC1A rs8192678, PPARG2 rs1801282, FTO rs9939609, LEP rs7799039, LEPR rs1137101 and nonalcoholic fatty liver disease","publication_year":2023,"publication_date":"2023-09-30","ids":{"openalex":"https://openalex.org/W4391132005","doi":"https://doi.org/10.15275/ssmj1903256"},"language":"en","primary_location":{"id":"doi:10.15275/ssmj1903256","doi":"https://doi.org/10.15275/ssmj1903256","is_oa":true,"landing_page_url":"http://doi.org/10.15275/ssmj1903256","pdf_url":"http://dx.doi.org/10.15275/ssmj1903256","source":{"id":"https://openalex.org/S4306529129","display_name":"Saratov Journal of Medical Scientific Research","issn_l":"1995-0039","issn":["1995-0039","2076-2518"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","russia-white-list-2"],"host_organization":"https://openalex.org/P4310312603","host_organization_name":"Saratov State Medical University","host_organization_lineage":["https://openalex.org/P4310312603"],"host_organization_lineage_names":["Saratov State Medical University"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Saratov Journal of Medical Scientific Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"http://dx.doi.org/10.15275/ssmj1903256","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5016501665","display_name":"Ekaterina D. Pankova","orcid":"https://orcid.org/0000-0002-6301-7630","observed_orcids":["https://orcid.org/0000-0002-6301-7630"]},"institutions":[{"id":"https://openalex.org/I2802878566","display_name":"Chelyabinsk State Medical Academy","ror":"https://ror.org/05srfkv34","country_code":"RU","type":"education","lineage":["https://openalex.org/I2802878566"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Ekaterina D. Pankova","raw_affiliation_strings":["South-Urals State Medical University","South-Urals State Medical University, Chelyabinsk, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"South-Urals State Medical University","institution_ids":["https://openalex.org/I2802878566"]},{"raw_affiliation_string":"South-Urals State Medical University, Chelyabinsk, Russia","institution_ids":["https://openalex.org/I2802878566"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028255857","display_name":"\u0412. \u0421. \u0427\u0443\u043b\u043a\u043e\u0432","orcid":"https://orcid.org/0000-0002-0952-6856","observed_orcids":["https://orcid.org/0000-0002-0952-6856"]},"institutions":[{"id":"https://openalex.org/I99205534","display_name":"Yaroslav-the-Wise Novgorod State University","ror":"https://ror.org/04qzrw529","country_code":"RU","type":"education","lineage":["https://openalex.org/I99205534"]}],"countries":["RU"],"is_corresponding":true,"raw_author_name":"Vasiliy S. Chulkov","raw_affiliation_strings":["Institute of Medical Education of theYaroslav the Wise Novgorod State Medical University","Institute of Medical Education of the Yaroslav the Wise Novgorod State Medical University, Veliky Novgorod, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Medical Education of theYaroslav the Wise Novgorod State Medical University","institution_ids":["https://openalex.org/I99205534"]},{"raw_affiliation_string":"Institute of Medical Education of the Yaroslav the Wise Novgorod State Medical University, Veliky Novgorod, Russia","institution_ids":["https://openalex.org/I99205534"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112032603","display_name":"E. Gavrilova","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802878566","display_name":"Chelyabinsk State Medical Academy","ror":"https://ror.org/05srfkv34","country_code":"RU","type":"education","lineage":["https://openalex.org/I2802878566"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Elena  S. Gavrilova","raw_affiliation_strings":["South-Urals State Medical University","South-Urals State Medical University, Chelyabinsk, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"South-Urals State Medical University","institution_ids":["https://openalex.org/I2802878566"]},{"raw_affiliation_string":"South-Urals State Medical University, Chelyabinsk, Russia","institution_ids":["https://openalex.org/I2802878566"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Maria  A. Zotova","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802878566","display_name":"Chelyabinsk State Medical Academy","ror":"https://ror.org/05srfkv34","country_code":"RU","type":"education","lineage":["https://openalex.org/I2802878566"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Maria  A. Zotova","raw_affiliation_strings":["South-Urals State Medical University","South-Urals State Medical University, Chelyabinsk, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"South-Urals State Medical University","institution_ids":["https://openalex.org/I2802878566"]},{"raw_affiliation_string":"South-Urals State Medical University, Chelyabinsk, Russia","institution_ids":["https://openalex.org/I2802878566"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104150047","display_name":"Veronika Andreevna Sumerkina","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802878566","display_name":"Chelyabinsk State Medical Academy","ror":"https://ror.org/05srfkv34","country_code":"RU","type":"education","lineage":["https://openalex.org/I2802878566"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Veronika A. Sumerkina","raw_affiliation_strings":["South-Urals State Medical University","South-Urals State Medical University, Chelyabinsk, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"South-Urals State Medical University","institution_ids":["https://openalex.org/I2802878566"]},{"raw_affiliation_string":"South-Urals State Medical University, Chelyabinsk, Russia","institution_ids":["https://openalex.org/I2802878566"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032134740","display_name":"S.V. Zhmaylova","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I99205534","display_name":"Yaroslav-the-Wise Novgorod State University","ror":"https://ror.org/04qzrw529","country_code":"RU","type":"education","lineage":["https://openalex.org/I99205534"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Svetlana  V. Zhmaylova","raw_affiliation_strings":["Institute of Medical Education of theYaroslav the Wise Novgorod State Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Medical Education of theYaroslav the Wise Novgorod State Medical University","institution_ids":["https://openalex.org/I99205534"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5083860687","display_name":"Tatiana I. Okonenko","orcid":"https://orcid.org/0000-0002-7431-3777","observed_orcids":["https://orcid.org/0000-0002-7431-3777"]},"institutions":[{"id":"https://openalex.org/I99205534","display_name":"Yaroslav-the-Wise Novgorod State University","ror":"https://ror.org/04qzrw529","country_code":"RU","type":"education","lineage":["https://openalex.org/I99205534"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Tatiana I. Okonenko","raw_affiliation_strings":["Institute of Medical Education of theYaroslav the Wise Novgorod State Medical University","Institute of Medical Education of the Yaroslav the Wise Novgorod State Medical University, Veliky Novgorod, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Medical Education of theYaroslav the Wise Novgorod State Medical University","institution_ids":["https://openalex.org/I99205534"]},{"raw_affiliation_string":"Institute of Medical Education of the Yaroslav the Wise Novgorod State Medical University, Veliky Novgorod, Russia","institution_ids":["https://openalex.org/I99205534"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5028255857"],"corresponding_institution_ids":["https://openalex.org/I99205534"],"apc_list":{"value":3800,"currency":"RUB","value_usd":36},"apc_paid":{"value":3800,"currency":"RUB","value_usd":36},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"19","issue":"3","first_page":"256","last_page":"260"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10351","display_name":"Liver Disease Diagnosis and Treatment","score":0.9613999724388123,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10351","display_name":"Liver Disease Diagnosis and Treatment","score":0.9613999724388123,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.01850000023841858,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13984","display_name":"Nutrition, Genetics, and Disease","score":0.00430000014603138,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/non-alcoholic-fatty-liver-disease","display_name":"non-alcoholic fatty liver disease","score":0.9800000190734863},{"id":"https://openalex.org/keywords/genetic-susceptibility","display_name":"genetic susceptibility","score":0.5569999814033508},{"id":"https://openalex.org/keywords/fto-rs9939609","display_name":"FTO rs9939609","score":0.9990000128746033},{"id":"https://openalex.org/keywords/single-nucleotide-polymorphisms","display_name":"single nucleotide polymorphisms","score":0.859000027179718},{"id":"https://openalex.org/keywords/hepatic-steatosis","display_name":"hepatic steatosis","score":0.8190000057220459},{"id":"https://openalex.org/keywords/liver-fibrosis","display_name":"liver fibrosis","score":0.9900000095367432},{"id":"https://openalex.org/keywords/shear-wave-elastography","display_name":"shear wave elastography","score":0.8500000238418579},{"id":"https://openalex.org/keywords/young-women","display_name":"young women","score":0.8930000066757202},{"id":"https://openalex.org/keywords/russian-population","display_name":"Russian population","score":0.9900000095367432}],"concepts":[{"id":"https://openalex.org/C2776954865","wikidata":"https://www.wikidata.org/wiki/Q1546498","display_name":"Nonalcoholic fatty liver disease","level":4,"score":0.8153688907623291},{"id":"https://openalex.org/C12304452","wikidata":"https://www.wikidata.org/wiki/Q21118081","display_name":"PPARGC1A","level":5,"score":0.6327213048934937},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5447309017181396},{"id":"https://openalex.org/C130241916","wikidata":"https://www.wikidata.org/wiki/Q20970208","display_name":"Peroxisome proliferator-activated receptor gamma","level":4,"score":0.45545899868011475},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4351575970649719},{"id":"https://openalex.org/C2780428817","wikidata":"https://www.wikidata.org/wiki/Q14912501","display_name":"FTO gene","level":5,"score":0.4259694516658783},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.42318496108055115},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.3739633560180664},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3608083724975586},{"id":"https://openalex.org/C2778772119","wikidata":"https://www.wikidata.org/wiki/Q6058862","display_name":"Fatty liver","level":3,"score":0.3520495295524597},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.34615159034729004},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.33076879382133484},{"id":"https://openalex.org/C187345961","wikidata":"https://www.wikidata.org/wiki/Q419629","display_name":"Peroxisome proliferator-activated receptor","level":3,"score":0.2518257200717926},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.16436341404914856},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.16141459345817566},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.10195645689964294},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.09010681509971619},{"id":"https://openalex.org/C77445288","wikidata":"https://www.wikidata.org/wiki/Q637488","display_name":"Coactivator","level":4,"score":0.0},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.15275/ssmj1903256","doi":"https://doi.org/10.15275/ssmj1903256","is_oa":true,"landing_page_url":"http://doi.org/10.15275/ssmj1903256","pdf_url":"http://dx.doi.org/10.15275/ssmj1903256","source":{"id":"https://openalex.org/S4306529129","display_name":"Saratov Journal of Medical Scientific Research","issn_l":"1995-0039","issn":["1995-0039","2076-2518"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","russia-white-list-2"],"host_organization":"https://openalex.org/P4310312603","host_organization_name":"Saratov State Medical University","host_organization_lineage":["https://openalex.org/P4310312603"],"host_organization_lineage_names":["Saratov State Medical University"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Saratov Journal of Medical Scientific Research","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.15275/ssmj1903256","doi":"https://doi.org/10.15275/ssmj1903256","is_oa":true,"landing_page_url":"http://doi.org/10.15275/ssmj1903256","pdf_url":"http://dx.doi.org/10.15275/ssmj1903256","source":{"id":"https://openalex.org/S4306529129","display_name":"Saratov Journal of Medical Scientific Research","issn_l":"1995-0039","issn":["1995-0039","2076-2518"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","russia-white-list-2"],"host_organization":"https://openalex.org/P4310312603","host_organization_name":"Saratov State Medical University","host_organization_lineage":["https://openalex.org/P4310312603"],"host_organization_lineage_names":["Saratov State Medical University"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Saratov Journal of Medical Scientific Research","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4391132005.pdf","grobid_xml":"https://content.openalex.org/works/W4391132005.grobid-xml"},"referenced_works_count":7,"referenced_works":["https://openalex.org/W1493931204","https://openalex.org/W1542828922","https://openalex.org/W1983211345","https://openalex.org/W2160859576","https://openalex.org/W2162141349","https://openalex.org/W3032966415","https://openalex.org/W3047737482"],"related_works":["https://openalex.org/W4413451857","https://openalex.org/W3185274265","https://openalex.org/W1983211345","https://openalex.org/W2145363460","https://openalex.org/W2514064755","https://openalex.org/W2785687799","https://openalex.org/W2569525704","https://openalex.org/W3197198988","https://openalex.org/W2729367348","https://openalex.org/W2973719914"],"abstract_inverted_index":{"Objective:":[0],"to":[1],"evaluate":[2],"the":[3,64,77,132,136,144,151],"association":[4],"of":[5,63,76,79,95,138,153],"sequence":[6,88],"variants":[7,89],"PPARGC1A":[8],"rs8192678,":[9],"PPARG2":[10],"rs1801282,":[11],"FTO":[12],"rs9939609,":[13],"LEP":[14],"rs7799039,":[15],"LEPR":[16],"rs1137101":[17],"with":[18,47,73,91],"non-alcoholic":[19],"fatty":[20],"liver":[21,65,80],"disease":[22],"(nAFLD)":[23],"at":[24],"young":[25,129],"adults":[26],"in":[27,97,128,131],"Russian":[28,133],"population.":[29],"Material":[30],"and":[31,66,82,100,111],"methods.":[32],"The":[33,122],"case-control":[34],"study":[35],"included":[36],"100":[37],"patients":[38],"divided":[39],"into":[40],"two":[41,87],"groups:":[42],"group":[43,50],"1":[44],"(cases)":[45],"\u2014":[46],"nAFLD":[48,54,96,140,155],"(n=50);":[49],"2":[51],"(controls)":[52],"without":[53],"(n=50).":[55],"All":[56],"subjects":[57],"underwent":[58],"a":[59],"standard":[60],"ultrasound":[61,67],"examination":[62],"shear":[68],"wave":[69],"elastography":[70],"(Aixplorer,":[71],"France)":[72],"an":[74,92],"assessment":[75],"severity":[78],"steatosis":[81],"fibrosis.":[83],"Results.":[84],"We":[85],"found":[86],"associated":[90],"increased":[93,135,150],"risk":[94],"women:":[98],"rs9939609":[99,103,126],"rs7799039:":[101],"A/A":[102,123],"genotype":[104,113,124,146],"(OR":[105,115],"5,33;":[106],"95%":[107,117],"Cl":[108,118],"1,14-24,90;":[109],"p=0,041)":[110],"G/G":[112,145],"rs7799039":[114,148],"7,5;":[116],"1,04-54,12;":[119],"p=0,026).":[120],"Conclusion.":[121],"ofthe":[125,147],"gene":[127,149],"women":[130],"population":[134],"chance":[137,152],"having":[139,154],"by":[141,156],"5":[142],"times,":[143],"7.5":[157],"times.":[158]},"counts_by_year":[],"updated_date":"2026-11-13T13:42:25.865203","created_date":"2024-01-24T00:00:00"}