{"id":"https://openalex.org/W4391122154","doi":"https://doi.org/10.18240/ijo.2024.02.11","title":"Effect of aflibercept combined with triamcinolone acetonide on aqueous humor growth factor and inflammatory mediators in diabetic macular edema","display_name":"Effect of aflibercept combined with triamcinolone acetonide on aqueous humor growth factor and inflammatory mediators in diabetic macular edema","publication_year":2024,"publication_date":"2024-01-22","ids":{"openalex":"https://openalex.org/W4391122154","doi":"https://doi.org/10.18240/ijo.2024.02.11","pmid":"https://pubmed.ncbi.nlm.nih.gov/38371257","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10827616"},"language":"en","primary_location":{"id":"doi:10.18240/ijo.2024.02.11","doi":"https://doi.org/10.18240/ijo.2024.02.11","is_oa":true,"landing_page_url":"https://doi.org/10.18240/ijo.2024.02.11","pdf_url":"http://www.ijo.cn/gjyken/article/pdf/20240211","source":{"id":"https://openalex.org/S2481947471","display_name":"International Journal of Ophthalmology","issn_l":"2222-3959","issn":["2222-3959","2227-4898"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-40","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311965","host_organization_name":"Press of International Journal of Ophthalmology (IJO PRESS)","host_organization_lineage":["https://openalex.org/P4310311965"],"host_organization_lineage_names":["Press of International Journal of Ophthalmology (IJO PRESS)"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Ophthalmology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"http://www.ijo.cn/gjyken/article/pdf/20240211","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043423141","display_name":"De-Shuang Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I159948400","display_name":"Jinan University","ror":"https://ror.org/02xe5ns62","country_code":"CN","type":"education","lineage":["https://openalex.org/I159948400"]},{"id":"https://openalex.org/I4405259636","display_name":"Aier Eye Hospital Group (China)","ror":"https://ror.org/02fz07e24","country_code":"CN","type":"company","lineage":["https://openalex.org/I4405259636"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"De-Shuang Li","raw_affiliation_strings":["Shenzhen Aier Eye Hospital, Aier Eye Hospital, Jinan University, Shenzhen 518031, Guangdong Province, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shenzhen Aier Eye Hospital, Aier Eye Hospital, Jinan University, Shenzhen 518031, Guangdong Province, China","institution_ids":["https://openalex.org/I159948400","https://openalex.org/I4405259636"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100687479","display_name":"Jinglin Zhang","orcid":"https://orcid.org/0000-0002-9801-9847","observed_orcids":["https://orcid.org/0000-0002-9801-9847"]},"institutions":[{"id":"https://openalex.org/I159948400","display_name":"Jinan University","ror":"https://ror.org/02xe5ns62","country_code":"CN","type":"education","lineage":["https://openalex.org/I159948400"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jing-Lin Zhang","raw_affiliation_strings":["Guangzhou Aier Eye Hospital, Jinan University, Guangzhou 510040, Guangdong Province, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Guangzhou Aier Eye Hospital, Jinan University, Guangzhou 510040, Guangdong Province, China","institution_ids":["https://openalex.org/I159948400"]}]},{"author_position":"last","author":{"id":null,"display_name":"Bo Qin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I159948400","display_name":"Jinan University","ror":"https://ror.org/02xe5ns62","country_code":"CN","type":"education","lineage":["https://openalex.org/I159948400"]},{"id":"https://openalex.org/I4405259636","display_name":"Aier Eye Hospital Group (China)","ror":"https://ror.org/02fz07e24","country_code":"CN","type":"company","lineage":["https://openalex.org/I4405259636"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Bo Qin","raw_affiliation_strings":["Shenzhen Aier Eye Hospital, Aier Eye Hospital, Jinan University, Shenzhen 518031, Guangdong Province, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shenzhen Aier Eye Hospital, Aier Eye Hospital, Jinan University, Shenzhen 518031, Guangdong Province, China","institution_ids":["https://openalex.org/I159948400","https://openalex.org/I4405259636"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":1800,"currency":"USD","value_usd":1800},"apc_paid":{"value":1800,"currency":"USD","value_usd":1800},"fwci":2.0881,"has_fulltext":true,"cited_by_count":6,"citation_normalized_percentile":{"value":0.83959922,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"17","issue":"2","first_page":"297","last_page":"303"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11377","display_name":"Retinal and Macular Surgery","score":0.002099999925121665,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11194","display_name":"Ocular Diseases and Beh\u00e7et\u2019s Syndrome","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/diabetic-macular-edema","display_name":"diabetic macular edema","score":0.8899999856948853},{"id":"https://openalex.org/keywords/aflibercept","display_name":"aflibercept","score":1.0},{"id":"https://openalex.org/keywords/triamcinolone-acetonide","display_name":"triamcinolone acetonide","score":1.0},{"id":"https://openalex.org/keywords/subtenon-injection","display_name":"subtenon injection","score":0.9259999990463257},{"id":"https://openalex.org/keywords/aqueous-humor-cytokines","display_name":"aqueous humor cytokines","score":0.9240000247955322},{"id":"https://openalex.org/keywords/vascular-endothelial-growth-factor","display_name":"vascular endothelial growth factor","score":0.8690000176429749},{"id":"https://openalex.org/keywords/mcp-1","display_name":"MCP-1","score":0.9419999718666077},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.9929999709129333},{"id":"https://openalex.org/keywords/interleukin-8","display_name":"interleukin-8","score":0.9990000128746033},{"id":"https://openalex.org/keywords/interleukin-1beta","display_name":"IL-1\u03b2","score":0.949999988079071},{"id":"https://openalex.org/keywords/anti-vegf-therapy","display_name":"anti-VEGF therapy","score":0.843999981880188},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.7149999737739563},{"id":"https://openalex.org/keywords/central-macular-thickness","display_name":"central macular thickness","score":0.8370000123977661},{"id":"https://openalex.org/keywords/visual-acuity","display_name":"visual acuity","score":0.8109999895095825}],"concepts":[{"id":"https://openalex.org/C2778749236","wikidata":"https://www.wikidata.org/wiki/Q4689286","display_name":"Aflibercept","level":4,"score":0.9311283230781555},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8800133466720581},{"id":"https://openalex.org/C2778903070","wikidata":"https://www.wikidata.org/wiki/Q2211240","display_name":"Triamcinolone acetonide","level":2,"score":0.7749874591827393},{"id":"https://openalex.org/C2777025900","wikidata":"https://www.wikidata.org/wiki/Q29725","display_name":"Vascular endothelial growth factor","level":3,"score":0.6793802380561829},{"id":"https://openalex.org/C118487528","wikidata":"https://www.wikidata.org/wiki/Q161437","display_name":"Ophthalmology","level":1,"score":0.6589757800102234},{"id":"https://openalex.org/C2993390227","wikidata":"https://www.wikidata.org/wiki/Q827681","display_name":"Aqueous humor","level":2,"score":0.6285960078239441},{"id":"https://openalex.org/C2780347916","wikidata":"https://www.wikidata.org/wiki/Q1813737","display_name":"Macular edema","level":3,"score":0.566680908203125},{"id":"https://openalex.org/C2780886150","wikidata":"https://www.wikidata.org/wiki/Q152234","display_name":"Edema","level":2,"score":0.4754366874694824},{"id":"https://openalex.org/C2779829184","wikidata":"https://www.wikidata.org/wiki/Q631361","display_name":"Diabetic retinopathy","level":3,"score":0.44970250129699707},{"id":"https://openalex.org/C2778257484","wikidata":"https://www.wikidata.org/wiki/Q555066","display_name":"Visual acuity","level":2,"score":0.31720811128616333},{"id":"https://openalex.org/C167734588","wikidata":"https://www.wikidata.org/wiki/Q4356503","display_name":"VEGF receptors","level":2,"score":0.27288395166397095},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.2615821063518524},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.24537700414657593},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.22271814942359924},{"id":"https://openalex.org/C2777802072","wikidata":"https://www.wikidata.org/wiki/Q413299","display_name":"Bevacizumab","level":3,"score":0.20791524648666382},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.1579887568950653},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.05679428577423096}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.18240/ijo.2024.02.11","doi":"https://doi.org/10.18240/ijo.2024.02.11","is_oa":true,"landing_page_url":"https://doi.org/10.18240/ijo.2024.02.11","pdf_url":"http://www.ijo.cn/gjyken/article/pdf/20240211","source":{"id":"https://openalex.org/S2481947471","display_name":"International Journal of Ophthalmology","issn_l":"2222-3959","issn":["2222-3959","2227-4898"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-40","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311965","host_organization_name":"Press of International Journal of Ophthalmology (IJO PRESS)","host_organization_lineage":["https://openalex.org/P4310311965"],"host_organization_lineage_names":["Press of International Journal of Ophthalmology (IJO PRESS)"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Ophthalmology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10827616","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10827616","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10827616/pdf/ijo-17-02-297.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Ophthalmol","raw_type":"Text"},{"id":"pmid:38371257","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38371257","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of ophthalmology","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:69aa3224d86e441781a8f02c6b30167d","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/69aa3224d86e441781a8f02c6b30167d","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"International Journal of Ophthalmology, Vol 17, Iss 2, Pp 297-303 (2024)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.18240/ijo.2024.02.11","doi":"https://doi.org/10.18240/ijo.2024.02.11","is_oa":true,"landing_page_url":"https://doi.org/10.18240/ijo.2024.02.11","pdf_url":"http://www.ijo.cn/gjyken/article/pdf/20240211","source":{"id":"https://openalex.org/S2481947471","display_name":"International Journal of Ophthalmology","issn_l":"2222-3959","issn":["2222-3959","2227-4898"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-40","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311965","host_organization_name":"Press of International Journal of Ophthalmology (IJO PRESS)","host_organization_lineage":["https://openalex.org/P4310311965"],"host_organization_lineage_names":["Press of International Journal of Ophthalmology (IJO PRESS)"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Ophthalmology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9940000176429749,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320329174","display_name":"Shenzhen Municipal Science and Technology Innovation Council","ror":"https://ror.org/017n8df75"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4391122154.pdf","grobid_xml":"https://content.openalex.org/works/W4391122154.grobid-xml"},"referenced_works_count":33,"referenced_works":["https://openalex.org/W1613696384","https://openalex.org/W1967511768","https://openalex.org/W1968099474","https://openalex.org/W1985442806","https://openalex.org/W1986843662","https://openalex.org/W1999847819","https://openalex.org/W2004918005","https://openalex.org/W2019616115","https://openalex.org/W2086706252","https://openalex.org/W2091774189","https://openalex.org/W2106307355","https://openalex.org/W2483493520","https://openalex.org/W2622237379","https://openalex.org/W2767463793","https://openalex.org/W2790671645","https://openalex.org/W2888829038","https://openalex.org/W2891381665","https://openalex.org/W2907272721","https://openalex.org/W2935593865","https://openalex.org/W2985331317","https://openalex.org/W3014221515","https://openalex.org/W3083259832","https://openalex.org/W3137484626","https://openalex.org/W3143300155","https://openalex.org/W3164714599","https://openalex.org/W3173991675","https://openalex.org/W4200026682","https://openalex.org/W4205617600","https://openalex.org/W4210318070","https://openalex.org/W4210803628","https://openalex.org/W4214688168","https://openalex.org/W4220671284","https://openalex.org/W4243551365"],"related_works":["https://openalex.org/W2899292500","https://openalex.org/W4390976053","https://openalex.org/W3037331797","https://openalex.org/W4393210188","https://openalex.org/W7125125242","https://openalex.org/W4383375958","https://openalex.org/W2761020912","https://openalex.org/W2282280347","https://openalex.org/W2007155254","https://openalex.org/W2912316553"],"abstract_inverted_index":{"AIM:":[0],"To":[1],"investigate":[2],"the":[3,53,57,67,73,92,144,161,187,201,213],"efficacy":[4,178,215],"of":[5,11,86,98,164,220],"aflibercept":[6,68,74,145,172,221],"combined":[7,75,148,173,195],"with":[8,76,174,196],"sub-tenon":[9],"injection":[10],"triamcinolone":[12],"acetonide":[13],"(TA)":[14],"in":[15,25,32,160,179],"treating":[16],"diabetic":[17],"macular":[18,132,209],"edema":[19,210],"(DME)":[20],"and":[21,28,44,56,72,112,135,138,147,158,171,190,205],"to":[22,207,218],"examine":[23],"changes":[24],"growth":[26,101],"factors":[27],"inflammatory":[29],"mediator":[30],"levels":[31,97],"aqueous":[33,84,96,162,202],"humor":[34,85,163,203],"after":[35,139],"injection.":[36],"METHODS:":[37],"Totally":[38],"67":[39],"DME":[40,54,62,165,180],"patients":[41,47,166],"(67":[42],"eyes)":[43,49],"30":[45],"cataract":[46],"(32":[48],"were":[50,115,141],"enrolled":[51],"as":[52],"group":[55,63,69,78,146],"control":[58],"group,":[59,80],"respectively.":[60],"The":[61,83,95,153],"was":[64,89],"divided":[65],"into":[66],"(34":[70],"cases)":[71],"TA":[77,175,197],"(combined":[79],"33":[81],"cases).":[82],"both":[87],"groups":[88],"collected":[90],"during":[91],"study":[93],"period.":[94],"vascular":[99],"endothelial":[100],"factor":[102],"(VEGF),":[103],"monocyte":[104],"chemoattractant":[105],"protein-1":[106],"(MCP-1),":[107],"interleukin-6":[108],"(IL-6),":[109],"interleukin-8":[110],"(IL-8),":[111],"interleukin-1\u03b2":[113],"(IL-1\u03b2)":[114],"detected":[116],"using":[117],"a":[118],"microsphere":[119],"suspension":[120],"array":[121],"technology":[122],"(Luminex":[123],"200TM).":[124],"Aqueous":[125],"cytokines,":[126],"best-corrected":[127],"visual":[128],"acuity":[129],"(BCVA),":[130],"central":[131],"thickness":[133],"(CMT),":[134],"complications":[136],"before":[137],"treatment":[140],"compared":[142],"between":[143],"group.":[149],"RESULTS:":[150],">0.05).":[151],"CONCLUSION:":[152],"cytokines":[154,204],"VEGF,":[155],"MCP-1,":[156],"IL-6,":[157],"IL-8":[159],"are":[167],"significantly":[168],"increased.":[169],"Aflibercept":[170,194],"have":[176,191],"good":[177],"patients,":[181],"can":[182,198],"effectively":[183],"reduce":[184],"CMT,":[185],"improve":[186],"patient's":[188],"vision,":[189],"high":[192],"safety.":[193],"quickly":[199],"down-regulate":[200],"help":[206],"relieve":[208],"rapidly.":[211],"However,":[212],"long-term":[214],"is":[216],"comparable":[217],"that":[219],"alone.":[222]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":1}],"updated_date":"2026-10-29T09:56:32.521200","created_date":"2024-01-23T00:00:00"}