{"id":"https://openalex.org/W4391104446","doi":"https://doi.org/10.18632/aging.205464","title":"The integration of multi-omics analysis and machine learning for the identification of prognostic assessment and immunotherapy efficacy through aging-associated genes in lung cancer","display_name":"The integration of multi-omics analysis and machine learning for the identification of prognostic assessment and immunotherapy efficacy through aging-associated genes in lung cancer","publication_year":2024,"publication_date":"2024-01-22","ids":{"openalex":"https://openalex.org/W4391104446","doi":"https://doi.org/10.18632/aging.205464","pmid":"https://pubmed.ncbi.nlm.nih.gov/38261733","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10866420"},"language":"en","primary_location":{"id":"doi:10.18632/aging.205464","doi":"https://doi.org/10.18632/aging.205464","is_oa":true,"landing_page_url":"https://doi.org/10.18632/aging.205464","pdf_url":"https://www.aging-us.com/article/205464/pdf","source":{"id":"https://openalex.org/S4210231119","display_name":"Aging","issn_l":"1945-4589","issn":["1945-4589"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316297","host_organization_name":"Impact Journals LLC","host_organization_lineage":["https://openalex.org/P4310316297"],"host_organization_lineage_names":["Impact Journals LLC"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Aging","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.aging-us.com/article/205464/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Wei Lu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210129955","display_name":"General Hospital of Shenyang Military Region","ror":"https://ror.org/0340t0585","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210129955"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wei Lu","raw_affiliation_strings":["Department of Respiratory, General Hospital of Northern Theater Command, Shenyang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Respiratory, General Hospital of Northern Theater Command, Shenyang, China","institution_ids":["https://openalex.org/I4210129955"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087167187","display_name":"Yun Zhou","orcid":"https://orcid.org/0000-0001-7353-620X","observed_orcids":["https://orcid.org/0000-0001-7353-620X"]},"institutions":[{"id":"https://openalex.org/I66867065","display_name":"East China Normal University","ror":"https://ror.org/02n96ep67","country_code":"CN","type":"education","lineage":["https://openalex.org/I66867065"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yun Zhou","raw_affiliation_strings":["Department of Respiratory, Wuhu Hospital, East China Normal University, The Second People\u2019s Hospital of Wuhu, Wuhu, Anhui, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Respiratory, Wuhu Hospital, East China Normal University, The Second People\u2019s Hospital of Wuhu, Wuhu, Anhui, China","institution_ids":["https://openalex.org/I66867065"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042869556","display_name":"Ruixuan Zhao","orcid":"https://orcid.org/0000-0003-2140-0794","observed_orcids":["https://orcid.org/0000-0003-2140-0794"]},"institutions":[{"id":"https://openalex.org/I4210129955","display_name":"General Hospital of Shenyang Military Region","ror":"https://ror.org/0340t0585","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210129955"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ruixuan Zhao","raw_affiliation_strings":["Department of Respiratory, General Hospital of Northern Theater Command, Shenyang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Respiratory, General Hospital of Northern Theater Command, Shenyang, China","institution_ids":["https://openalex.org/I4210129955"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101761456","display_name":"Qiushi Liu","orcid":"https://orcid.org/0000-0003-1194-6080","observed_orcids":["https://orcid.org/0000-0003-1194-6080"]},"institutions":[{"id":"https://openalex.org/I4210129955","display_name":"General Hospital of Shenyang Military Region","ror":"https://ror.org/0340t0585","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210129955"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qiushi Liu","raw_affiliation_strings":["Department of Respiratory, General Hospital of Northern Theater Command, Shenyang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Respiratory, General Hospital of Northern Theater Command, Shenyang, China","institution_ids":["https://openalex.org/I4210129955"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034003269","display_name":"Wei Yang","orcid":"https://orcid.org/0000-0002-7080-0500","observed_orcids":["https://orcid.org/0000-0002-7080-0500"]},"institutions":[{"id":"https://openalex.org/I4210129955","display_name":"General Hospital of Shenyang Military Region","ror":"https://ror.org/0340t0585","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210129955"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wei Yang","raw_affiliation_strings":["Department of Respiratory, General Hospital of Northern Theater Command, Shenyang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Respiratory, General Hospital of Northern Theater Command, Shenyang, China","institution_ids":["https://openalex.org/I4210129955"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5009150851","display_name":"Tianyi Zhu","orcid":"https://orcid.org/0000-0001-8192-6304","observed_orcids":["https://orcid.org/0000-0001-8192-6304","https://orcid.org/0009-0003-1223-0268"]},"institutions":[{"id":"https://openalex.org/I4210129955","display_name":"General Hospital of Shenyang Military Region","ror":"https://ror.org/0340t0585","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210129955"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Tianyi Zhu","raw_affiliation_strings":["Department of Respiratory, General Hospital of Northern Theater Command, Shenyang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Respiratory, General Hospital of Northern Theater Command, Shenyang, China","institution_ids":["https://openalex.org/I4210129955"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5009150851"],"corresponding_institution_ids":["https://openalex.org/I4210129955"],"apc_list":null,"apc_paid":null,"fwci":0.7086,"has_fulltext":true,"cited_by_count":5,"citation_normalized_percentile":{"value":0.69017782,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"16","issue":"2","first_page":"1860","last_page":"1878"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12334","display_name":"Lung Cancer Research Studies","score":0.38839998841285706,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12334","display_name":"Lung Cancer Research Studies","score":0.38839998841285706,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11297","display_name":"Ferroptosis and cancer prognosis","score":0.3621000051498413,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.1492999941110611,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lung-cancer","display_name":"lung cancer","score":0.9980000257492065},{"id":"https://openalex.org/keywords/prognostic-model","display_name":"prognostic model","score":0.8809999823570251},{"id":"https://openalex.org/keywords/immunotherapy-response","display_name":"immunotherapy response","score":0.7829999923706055},{"id":"https://openalex.org/keywords/immune-related-genes","display_name":"immune-related genes","score":0.671999990940094},{"id":"https://openalex.org/keywords/blk","display_name":"BLK","score":0.7020000219345093},{"id":"https://openalex.org/keywords/integrin-beta-4","display_name":"ITGB4","score":0.9929999709129333},{"id":"https://openalex.org/keywords/protein-kinase-c-eta","display_name":"protein kinase C eta","score":1.0},{"id":"https://openalex.org/keywords/snail1","display_name":"SNAI1","score":1.0},{"id":"https://openalex.org/keywords/immune-infiltration","display_name":"immune cell infiltration","score":0.5619999766349792},{"id":"https://openalex.org/keywords/immune-checkpoint-genes","display_name":"immune checkpoint genes","score":0.6790000200271606},{"id":"https://openalex.org/keywords/dna-repair-genes","display_name":"DNA repair genes","score":0.7329999804496765},{"id":"https://openalex.org/keywords/cellular-senescence","display_name":"cellular senescence","score":0.8629999756813049},{"id":"https://openalex.org/keywords/p53-signaling-pathway","display_name":"p53 pathway","score":0.8820000290870667},{"id":"https://openalex.org/keywords/focal-adhesions","display_name":"focal adhesions","score":0.7630000114440918},{"id":"https://openalex.org/keywords/single-cell-transcriptomics","display_name":"single-cell transcriptomics","score":0.5849999785423279},{"id":"https://openalex.org/keywords/risk-score","display_name":"risk score","score":0.38100001215934753}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6075660586357117},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.5840855836868286},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5633305907249451},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.5133713483810425},{"id":"https://openalex.org/C2780851360","wikidata":"https://www.wikidata.org/wiki/Q21686041","display_name":"Immune checkpoint","level":4,"score":0.47593310475349426},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.468789666891098},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.429824560880661},{"id":"https://openalex.org/C2780674031","wikidata":"https://www.wikidata.org/wiki/Q2012719","display_name":"Cancer immunotherapy","level":4,"score":0.4253823757171631},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3526408076286316},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.335262656211853},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.21370869874954224},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.18475830554962158}],"mesh":[{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000095028","descriptor_name":"Multiomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007167","descriptor_name":"Immunotherapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.18632/aging.205464","doi":"https://doi.org/10.18632/aging.205464","is_oa":true,"landing_page_url":"https://doi.org/10.18632/aging.205464","pdf_url":"https://www.aging-us.com/article/205464/pdf","source":{"id":"https://openalex.org/S4210231119","display_name":"Aging","issn_l":"1945-4589","issn":["1945-4589"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316297","host_organization_name":"Impact Journals LLC","host_organization_lineage":["https://openalex.org/P4310316297"],"host_organization_lineage_names":["Impact Journals LLC"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Aging","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10866420","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10866420","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10866420/pdf/aging-16-205464.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Aging (Albany NY)","raw_type":"Text"},{"id":"pmid:38261733","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38261733","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Aging","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.18632/aging.205464","doi":"https://doi.org/10.18632/aging.205464","is_oa":true,"landing_page_url":"https://doi.org/10.18632/aging.205464","pdf_url":"https://www.aging-us.com/article/205464/pdf","source":{"id":"https://openalex.org/S4210231119","display_name":"Aging","issn_l":"1945-4589","issn":["1945-4589"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316297","host_organization_name":"Impact Journals LLC","host_organization_lineage":["https://openalex.org/P4310316297"],"host_organization_lineage_names":["Impact Journals LLC"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Aging","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4391104446.pdf","grobid_xml":"https://content.openalex.org/works/W4391104446.grobid-xml"},"referenced_works_count":41,"referenced_works":["https://openalex.org/W1986815428","https://openalex.org/W2024492396","https://openalex.org/W2029080338","https://openalex.org/W2101861123","https://openalex.org/W2158805742","https://openalex.org/W2508069933","https://openalex.org/W2784371446","https://openalex.org/W2788548733","https://openalex.org/W2796573946","https://openalex.org/W2808491310","https://openalex.org/W2917343300","https://openalex.org/W2936435806","https://openalex.org/W2954805572","https://openalex.org/W2958520968","https://openalex.org/W3000339487","https://openalex.org/W3003526695","https://openalex.org/W3007935255","https://openalex.org/W3009247541","https://openalex.org/W3014402470","https://openalex.org/W3016280944","https://openalex.org/W3104684621","https://openalex.org/W3106005610","https://openalex.org/W3109862224","https://openalex.org/W3132661792","https://openalex.org/W3133005300","https://openalex.org/W3157423185","https://openalex.org/W3197593329","https://openalex.org/W3208677499","https://openalex.org/W3211451070","https://openalex.org/W4213091566","https://openalex.org/W4220837089","https://openalex.org/W4223655945","https://openalex.org/W4225919561","https://openalex.org/W4248178819","https://openalex.org/W4283755538","https://openalex.org/W4296354002","https://openalex.org/W4307913112","https://openalex.org/W4309409152","https://openalex.org/W4309476803","https://openalex.org/W4379056388","https://openalex.org/W4385335632"],"related_works":["https://openalex.org/W4405968566","https://openalex.org/W4206796630","https://openalex.org/W4416825725","https://openalex.org/W4400070439","https://openalex.org/W4312128771","https://openalex.org/W7201844347","https://openalex.org/W4402017374","https://openalex.org/W4304588360","https://openalex.org/W4405528858","https://openalex.org/W4226239462"],"abstract_inverted_index":{"BACKGROUND:":[0],"Recent":[1],"years":[2],"revealed":[3,124],"key":[4,94],"molecules":[5,31],"in":[6,14],"lung":[7,209],"cancer":[8,210],"research,":[9],"yet":[10],"their":[11],"exact":[12],"roles":[13],"disease":[15],"onset":[16],"and":[17,36,60,71,87,116,141,151,163,175,179,195,212],"progression":[18],"remain":[19],"uncertain.":[20],"Lung":[21],"cancer's":[22],"heterogeneity":[23],"complicates":[24],"prognosis":[25,35,211],"prediction.":[26,58],"This":[27],"study":[28],"integrates":[29],"pivotal":[30],"to":[32,47,109],"evaluate":[33],"patient":[34],"immunotherapy":[37,79],"efficacy.":[38],"METHODS:":[39],"The":[40,49,73],"WGCNA":[41],"algorithm":[42],"identified":[43,104],"module":[44,107],"genes":[45,206],"linked":[46],"immunity.":[48,110],"Lasso-Cox":[50,111],"method":[51],"built":[52],"a":[53],"prognostic":[54,120,202],"model":[55,203],"for":[56,118,191],"outcome":[57],"GO":[59],"KEGG":[61],"analyses":[62],"explored":[63],"gene":[64,95,186],"pathways.":[65],"ssGSEA":[66,166],"quantified":[67],"immune":[68,88,139,168,180,216],"cell":[69,98,169,189],"types":[70,190],"functions.":[72],"riskScore":[74],"predicts":[75,208],"the":[76,105,119,213],"effectiveness":[77],"of":[78,135,215],"based":[80],"on":[81],"its":[82],"correlation":[83],"with":[84,173],"DNA":[85],"repair":[86],"checkpoint":[89,181],"genes.":[90],"Single-cell":[91,183],"sequencing":[92],"examined":[93],"expression":[96,187],"across":[97,188],"types.":[99],"RESULTS:":[100],"Using":[101],"WGCNA,":[102],"we":[103],"MEbrown":[106],"related":[108],"selected":[112],"\"BLK,\"":[113],"\"ITGB4,\"":[114],"\"PRKCH,\"":[115],"\"SNAI1\"":[117],"model.":[121],"MF":[122],"analysis":[123,184],"enriched":[125],"functions":[126],"including":[127],"antigen":[128],"binding,":[129],"GTPase":[130],"regulator":[131],"activity.":[132],"In":[133,198],"terms":[134],"BP,":[136],"processes":[137],"like":[138],"signaling":[140],"mitotic":[142],"division":[143],"were":[144],"enriched.":[145],"CC":[146],"enrichment":[147],"included":[148],"immunoglobulin":[149],"complexes":[150],"chromosomal":[152],"regions.":[153],"Enriched":[154],"pathways":[155],"encompassed":[156],"Cell":[157],"cycle,":[158],"Focal":[159],"adhesion,":[160],"Cellular":[161],"senescence,":[162],"p53":[164],"signaling.":[165],"evaluated":[167],"abundance.":[170],"RiskScore":[171],"correlated":[172],"CTLA4":[174],"PD1":[176],"through":[177],"MMR":[178],"analysis.":[182],"indicated":[185],"BLK,":[192],"ITGB4,":[193],"PRKCH,":[194],"SNAI1.":[196],"CONCLUSION:":[197],"summary,":[199],"our":[200],"developed":[201],"utilizing":[204],"age-related":[205],"effectively":[207],"efficacy":[214],"therapy.":[217]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2024-01-23T00:00:00"}