{"id":"https://openalex.org/W4391101283","doi":"https://doi.org/10.1158/1541-7786.c.6541686.v1","title":"Data from Basal-like Breast Cancer Cells Induce Phenotypic and Genomic Changes in Macrophages","display_name":"Data from Basal-like Breast Cancer Cells Induce Phenotypic and Genomic Changes in Macrophages","publication_year":2023,"publication_date":"2023-04-03","ids":{"openalex":"https://openalex.org/W4391101283","doi":"https://doi.org/10.1158/1541-7786.c.6541686.v1"},"language":"en","primary_location":{"id":"doi:10.1158/1541-7786.c.6541686.v1","doi":"https://doi.org/10.1158/1541-7786.c.6541686.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1541-7786.c.6541686.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/1541-7786.c.6541686.v1","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5089143039","display_name":"Delisha A. Stewart","orcid":"https://orcid.org/0000-0001-7516-2790","observed_orcids":["https://orcid.org/0000-0001-7516-2790"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Delisha A. Stewart","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069506234","display_name":"Yinmeng Yang","orcid":"https://orcid.org/0000-0002-5985-4241","observed_orcids":["https://orcid.org/0000-0002-5985-4241"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yinmeng Yang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059125261","display_name":"Liza Makowski","orcid":"https://orcid.org/0000-0002-5337-8037","observed_orcids":["https://orcid.org/0000-0002-5337-8037"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Liza Makowski","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5064051970","display_name":"Melissa A. Troester","orcid":"https://orcid.org/0000-0001-9506-6624","observed_orcids":["https://orcid.org/0000-0001-9506-6624"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Melissa A. Troester","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11313","display_name":"Immune cells in cancer","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11313","display_name":"Immune cells in cancer","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12626","display_name":"Cancer, Stress, Anesthesia, and Immune Response","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/basal-like-breast-cancer","display_name":"basal-like breast cancer","score":1.0},{"id":"https://openalex.org/keywords/macrophage-polarization","display_name":"macrophage polarization","score":0.8579999804496765},{"id":"https://openalex.org/keywords/monocyte-macrophage-differentiation","display_name":"monocyte-to-macrophage differentiation","score":0.8730000257492065},{"id":"https://openalex.org/keywords/macrophage-migration","display_name":"macrophage migration","score":0.7080000042915344},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.734000027179718},{"id":"https://openalex.org/keywords/cancer-associated-macrophages","display_name":"cancer-associated macrophages","score":0.6869999766349792},{"id":"https://openalex.org/keywords/cytokine-production","display_name":"cytokine production","score":0.7110000252723694},{"id":"https://openalex.org/keywords/interleukin-1beta","display_name":"IL-1\u03b2","score":0.8999999761581421},{"id":"https://openalex.org/keywords/interleukin-1-receptor-antagonist","display_name":"interleukin-1 receptor antagonist","score":0.9430000185966492},{"id":"https://openalex.org/keywords/thp-1-cells","display_name":"THP-1 cells","score":0.859000027179718},{"id":"https://openalex.org/keywords/luminal-breast-cancer","display_name":"luminal breast cancer","score":0.7730000019073486},{"id":"https://openalex.org/keywords/tumor-stroma-interactions","display_name":"tumor-stroma interactions","score":0.5759999752044678},{"id":"https://openalex.org/keywords/osteoprotegerin","display_name":"osteoprotegerin","score":0.7829999923706055},{"id":"https://openalex.org/keywords/mcp-1","display_name":"MCP-1","score":0.8389999866485596}],"concepts":[{"id":"https://openalex.org/C16930146","wikidata":"https://www.wikidata.org/wiki/Q4381253","display_name":"Stromal cell","level":2,"score":0.6540892124176025},{"id":"https://openalex.org/C2910375186","wikidata":"https://www.wikidata.org/wiki/Q184204","display_name":"M2 Macrophage","level":4,"score":0.5512760281562805},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5323007106781006},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.5283882021903992},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5272349715232849},{"id":"https://openalex.org/C2779244956","wikidata":"https://www.wikidata.org/wiki/Q184204","display_name":"Macrophage","level":3,"score":0.5193427801132202},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5171627402305603},{"id":"https://openalex.org/C2776682551","wikidata":"https://www.wikidata.org/wiki/Q21072584","display_name":"Macrophage polarization","level":4,"score":0.5031980872154236},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.4540761709213257},{"id":"https://openalex.org/C2781184567","wikidata":"https://www.wikidata.org/wiki/Q107244","display_name":"Monocyte","level":2,"score":0.4524945914745331},{"id":"https://openalex.org/C7244527","wikidata":"https://www.wikidata.org/wiki/Q6725501","display_name":"Macrophage-activating factor","level":4,"score":0.43596720695495605},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3592172861099243},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3569020628929138},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.1330222189426422},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.08212071657180786},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.07309138774871826},{"id":"https://openalex.org/C49382859","wikidata":"https://www.wikidata.org/wiki/Q286498","display_name":"Lymphokine","level":3,"score":0.06834793090820312}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1541-7786.c.6541686.v1","doi":"https://doi.org/10.1158/1541-7786.c.6541686.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1541-7786.c.6541686.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/1541-7786.c.6541686.v1","doi":"https://doi.org/10.1158/1541-7786.c.6541686.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1541-7786.c.6541686.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9476000070571899}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2098791467","https://openalex.org/W2030521677","https://openalex.org/W4300515238","https://openalex.org/W4392700648","https://openalex.org/W2120781746","https://openalex.org/W2885999130","https://openalex.org/W2159267081","https://openalex.org/W2801493685","https://openalex.org/W2809963962","https://openalex.org/W1919137762"],"abstract_inverted_index":{"Abstract":[0],"Basal-like":[1],"breast":[2,10,76,153,163],"cancer":[3,11,38,77],"(BBC)":[4],"is":[5,46],"an":[6,222],"aggressive":[7],"subtype":[8],"of":[9,20,28,109,118,135,169,187,197,207,224,228],"that":[12,43,236],"has":[13],"no":[14],"biologically":[15],"targeted":[16],"therapy.":[17],"The":[18],"interactions":[19],"BBCs":[21,53,150,165],"with":[22,31,72,85,107,149,178],"stromal":[23,230],"cells":[24,33,100],"are":[25,237],"important":[26,48],"determinants":[27],"tumor":[29],"biology,":[30],"inflammatory":[32],"playing":[34],"well-recognized":[35],"roles":[36],"in":[37,68,101,181,192,240],"progression.":[39],"Despite":[40],"the":[41,126,156,225,229],"fact":[42],"macrophage\u2013BBC":[44,193],"communication":[45],"bidirectional,":[47],"questions":[49],"remain":[50],"about":[51],"how":[52],"affect":[54],"adjacent":[55],"immune":[56,231,249],"cells.":[57,78],"This":[58],"study":[59],"investigated":[60],"monocyte-to-macrophage":[61],"differentiation":[62,90,168],"and":[63,65,91,112,120,129,141,173,203,243],"polarization":[64,92],"gene":[66,105],"expression":[67,106,158],"response":[69],"to":[70,98,161,171,212,221,251],"coculture":[71,82,102],"basal-like":[73,241],"versus":[74,137],"luminal":[75,138,152,162],"Changes":[79],"induced":[80],"by":[81],"were":[83,123],"compared":[84],"changes":[86,180],"observed":[87],"under":[88],"classical":[89],"conditions.":[93],"Monocytes":[94],"(THP-1":[95],"cells)":[96],"exposed":[97],"BBC":[99,136],"had":[103],"altered":[104],"upregulation":[108,196],"both":[110],"M1":[111,119],"M2":[113,121],"macrophage":[114,175,216],"markers.":[115],"Two":[116],"sets":[117],"markers":[122],"selected":[124],"from":[125,146],"PCR":[127],"profiles":[128],"used":[130],"for":[131,247],"dual":[132],"immunofluorescent":[133],"staining":[134],"cocultured":[139],"THP-1s,":[140],"cancer-adjacent,":[142],"benign":[143],"tissue":[144],"sections":[145],"patients":[147],"diagnosed":[148],"or":[151],"cancer,":[154],"confirming":[155],"differential":[157],"patterns.":[159],"Relative":[160],"cancers,":[164],"also":[166],"increased":[167],"monocytes":[170],"macrophages":[172],"stimulated":[174],"migration.":[176,217],"Consistent":[177],"these":[179],"cellular":[182],"phenotype,":[183],"a":[184],"distinct":[185],"pattern":[186],"cytokine":[188],"secretion":[189],"was":[190],"evident":[191],"cocultures,":[194],"including":[195],"NAP-2,":[198],"osteoprotegerin,":[199],"MIG,":[200],"MCP-1,":[201],"MCP-3,":[202],"interleukin":[204],"(IL)-1\u03b2.":[205],"Application":[206],"IL-1":[208],"receptor":[209],"antagonist":[210],"(IL-1RA)":[211],"cocultures":[213],"attenuated":[214],"BBC-induced":[215],"These":[218],"data":[219],"contribute":[220],"understanding":[223],"BBC-mediated":[226],"activation":[227],"response,":[232],"implicating":[233],"specific":[234],"cytokines":[235],"differentially":[238],"expressed":[239],"microenvironments":[242],"suggesting":[244],"plausible":[245],"targets":[246],"modulating":[248],"responses":[250],"BBCs.":[252],"Mol":[253],"Cancer":[254],"Res;":[255],"10(6);":[256],"727\u201338.":[257],"\u00a92012":[258],"AACR.":[259]},"counts_by_year":[],"updated_date":"2026-08-21T09:56:20.448147","created_date":"2024-01-23T00:00:00"}