{"id":"https://openalex.org/W4391096790","doi":"https://doi.org/10.1200/jco.2024.42.3_suppl.560","title":"Impact of next-generation sequencing in biliary tract cancer treatment.","display_name":"Impact of next-generation sequencing in biliary tract cancer treatment.","publication_year":2024,"publication_date":"2024-01-20","ids":{"openalex":"https://openalex.org/W4391096790","doi":"https://doi.org/10.1200/jco.2024.42.3_suppl.560"},"language":"en","primary_location":{"id":"doi:10.1200/jco.2024.42.3_suppl.560","doi":"https://doi.org/10.1200/jco.2024.42.3_suppl.560","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1200/jco.2024.42.3_suppl.560","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100902007","display_name":"Priya Goyal","orcid":"https://orcid.org/0009-0006-4693-7570","observed_orcids":["https://orcid.org/0009-0006-4693-7570"]},"institutions":[{"id":"https://openalex.org/I184565670","display_name":"Georgetown University","ror":"https://ror.org/05vzafd60","country_code":"US","type":"education","lineage":["https://openalex.org/I184565670"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Priya Goyal","raw_affiliation_strings":["Georgetown University, Washington, DC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Georgetown University, Washington, DC","institution_ids":["https://openalex.org/I184565670"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091243104","display_name":"Mahmoud Ouf","orcid":"https://orcid.org/0009-0004-9799-3498","observed_orcids":["https://orcid.org/0009-0004-9799-3498"]},"institutions":[{"id":"https://openalex.org/I4390039356","display_name":"Georgetown Lombardi Comprehensive Cancer Center","ror":"https://ror.org/035zrb927","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I184565670","https://openalex.org/I4390039356"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mahmoud Ouf","raw_affiliation_strings":["Georgetown University/Lombardi Comprehensive Cancer Center, Washington, DC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Georgetown University/Lombardi Comprehensive Cancer Center, Washington, DC","institution_ids":["https://openalex.org/I4390039356"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076186971","display_name":"Seema Agarwal","orcid":"https://orcid.org/0000-0002-8854-252X","observed_orcids":["https://orcid.org/0000-0002-8854-252X"]},"institutions":[{"id":"https://openalex.org/I184565670","display_name":"Georgetown University","ror":"https://ror.org/05vzafd60","country_code":"US","type":"education","lineage":["https://openalex.org/I184565670"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Seema Agarwal","raw_affiliation_strings":["Georgetown University, Washington, DC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Georgetown University, Washington, DC","institution_ids":["https://openalex.org/I184565670"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079834643","display_name":"Gary M. Kupfer","orcid":"https://orcid.org/0000-0002-3988-2894","observed_orcids":["https://orcid.org/0000-0002-3988-2894"]},"institutions":[{"id":"https://openalex.org/I2799903593","display_name":"Georgetown University Medical Center","ror":"https://ror.org/00hjz7x27","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799903593"]},{"id":"https://openalex.org/I4390039356","display_name":"Georgetown Lombardi Comprehensive Cancer Center","ror":"https://ror.org/035zrb927","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I184565670","https://openalex.org/I4390039356"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gary Kupfer","raw_affiliation_strings":["Georgetown Lombardi Comprehensive Cancer Center, Washington, DC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Georgetown Lombardi Comprehensive Cancer Center, Washington, DC","institution_ids":["https://openalex.org/I2799903593","https://openalex.org/I4390039356"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031352538","display_name":"Reetu Mukherji","orcid":"https://orcid.org/0000-0001-7384-0498","observed_orcids":["https://orcid.org/0000-0001-7384-0498"]},"institutions":[{"id":"https://openalex.org/I2802534011","display_name":"MedStar Georgetown University Hospital","ror":"https://ror.org/03ja1ak26","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2802534011","https://openalex.org/I86755215"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Reetu Mukherji","raw_affiliation_strings":["MedStar Georgetown University Hospital, Washington, DC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MedStar Georgetown University Hospital, Washington, DC","institution_ids":["https://openalex.org/I2802534011"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055915497","display_name":"Benjamin Adam Weinberg","orcid":"https://orcid.org/0000-0002-0408-4817","observed_orcids":["https://orcid.org/0000-0002-0408-4817"]},"institutions":[{"id":"https://openalex.org/I4390039356","display_name":"Georgetown Lombardi Comprehensive Cancer Center","ror":"https://ror.org/035zrb927","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I184565670","https://openalex.org/I4390039356"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Benjamin Adam Weinberg","raw_affiliation_strings":["Lombardi Comprehensive Cancer Center, Washington, DC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lombardi Comprehensive Cancer Center, Washington, DC","institution_ids":["https://openalex.org/I4390039356"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060044072","display_name":"Marcus Smith Noel","orcid":"https://orcid.org/0000-0002-3658-6950","observed_orcids":["https://orcid.org/0000-0002-3658-6950"]},"institutions":[{"id":"https://openalex.org/I2802534011","display_name":"MedStar Georgetown University Hospital","ror":"https://ror.org/03ja1ak26","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2802534011","https://openalex.org/I86755215"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marcus Smith Noel","raw_affiliation_strings":["MedStar Georgetown University Hospital, Washington, DC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MedStar Georgetown University Hospital, Washington, DC","institution_ids":["https://openalex.org/I2802534011"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061373605","display_name":"John Lindsay Marshall","orcid":"https://orcid.org/0000-0002-3449-2344","observed_orcids":["https://orcid.org/0000-0002-3449-2344"]},"institutions":[{"id":"https://openalex.org/I2802534011","display_name":"MedStar Georgetown University Hospital","ror":"https://ror.org/03ja1ak26","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2802534011","https://openalex.org/I86755215"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John Marshall","raw_affiliation_strings":["MedStar Georgetown University Hospital, Washington, DC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MedStar Georgetown University Hospital, Washington, DC","institution_ids":["https://openalex.org/I2802534011"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5045096676","display_name":"Aiwu Ruth He","orcid":"https://orcid.org/0000-0002-2104-0816","observed_orcids":["https://orcid.org/0000-0002-2104-0816"]},"institutions":[{"id":"https://openalex.org/I2802534011","display_name":"MedStar Georgetown University Hospital","ror":"https://ror.org/03ja1ak26","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2802534011","https://openalex.org/I86755215"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aiwu Ruth He","raw_affiliation_strings":["MedStar Georgetown University Hospital, Washington, DC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MedStar Georgetown University Hospital, Washington, DC","institution_ids":["https://openalex.org/I2802534011"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"42","issue":"3_suppl","first_page":"560","last_page":"560"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11364","display_name":"Cholangiocarcinoma and Gallbladder Cancer Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11364","display_name":"Cholangiocarcinoma and Gallbladder Cancer Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12460","display_name":"Pediatric Hepatobiliary Diseases and Treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10518","display_name":"Gallbladder and Bile Duct Disorders","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/biliary-tract-cancer","display_name":"biliary tract cancer","score":1.0},{"id":"https://openalex.org/keywords/molecular-profiling","display_name":"molecular profiling","score":0.8650000095367432},{"id":"https://openalex.org/keywords/actionable-mutations","display_name":"actionable mutations","score":0.843999981880188},{"id":"https://openalex.org/keywords/next-generation-sequencing","display_name":"next-generation sequencing","score":0.7799999713897705},{"id":"https://openalex.org/keywords/survival","display_name":"survival","score":0.5529999732971191},{"id":"https://openalex.org/keywords/intrahepatic-cholangiocarcinoma","display_name":"intrahepatic cholangiocarcinoma","score":0.9570000171661377},{"id":"https://openalex.org/keywords/extrahepatic-cholangiocarcinoma","display_name":"extrahepatic cholangiocarcinoma","score":0.9789999723434448},{"id":"https://openalex.org/keywords/gallbladder-cancer","display_name":"gallbladder cancer","score":0.9860000014305115},{"id":"https://openalex.org/keywords/kras","display_name":"KRAS","score":0.9509999752044678},{"id":"https://openalex.org/keywords/fgfr2","display_name":"FGFR2","score":0.9990000128746033},{"id":"https://openalex.org/keywords/idh1","display_name":"IDH1","score":0.8989999890327454},{"id":"https://openalex.org/keywords/her2","display_name":"HER2","score":0.7329999804496765},{"id":"https://openalex.org/keywords/brca1-2","display_name":"BRCA1/2","score":0.9779999852180481},{"id":"https://openalex.org/keywords/pd-l1","display_name":"PD-L1","score":0.9739999771118164},{"id":"https://openalex.org/keywords/targeted-therapy","display_name":"targeted therapy","score":0.7829999923706055}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9236477613449097},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7231534719467163},{"id":"https://openalex.org/C2781187634","wikidata":"https://www.wikidata.org/wiki/Q20969980","display_name":"KRAS","level":4,"score":0.7088756561279297},{"id":"https://openalex.org/C3017919176","wikidata":"https://www.wikidata.org/wiki/Q124292","display_name":"Biliary tract cancer","level":4,"score":0.6580630540847778},{"id":"https://openalex.org/C2776534502","wikidata":"https://www.wikidata.org/wiki/Q977787","display_name":"Gallbladder cancer","level":3,"score":0.6342781186103821},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.5533056259155273},{"id":"https://openalex.org/C2909135397","wikidata":"https://www.wikidata.org/wiki/Q124292","display_name":"Intrahepatic Cholangiocarcinoma","level":2,"score":0.5430862307548523},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.5300872921943665},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.4183316230773926},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.41108042001724243},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4039241075515747},{"id":"https://openalex.org/C2780258809","wikidata":"https://www.wikidata.org/wiki/Q414143","display_name":"Gemcitabine","level":3,"score":0.19661131501197815},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.15373310446739197}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1200/jco.2024.42.3_suppl.560","doi":"https://doi.org/10.1200/jco.2024.42.3_suppl.560","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1200/jco.2024.42.3_suppl.560","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4378893177","https://openalex.org/W7203976797","https://openalex.org/W3029917977","https://openalex.org/W4382806882","https://openalex.org/W4286265345","https://openalex.org/W4412591769","https://openalex.org/W4286299657","https://openalex.org/W2520639290","https://openalex.org/W7213551838","https://openalex.org/W3087891437"],"abstract_inverted_index":{"560":[0],"Background:":[1],"Incorporating":[2],"molecular":[3,20,176,221],"profiling":[4,122,177,222],"in":[5,64,76,125,143,155],"BTC":[6,213],"treatment":[7,228],"has":[8],"increased.":[9],"With":[10],"this":[11],"study,":[12],"we":[13],"aimed":[14],"to":[15,199],"analyze":[16],"the":[17,23,32,65,77,84,90,96,104,118,128,148,200,203,227],"impact":[18],"of":[19,25,35,83,98,108,117,127,147,152,158,202,226],"profiles":[21],"on":[22],"survival":[24,181,196],"patients":[26,36,53,70,73,129,145,189],"with":[27,37,54,190,238],"BTC.":[28],"Methods:":[29],"This":[30],"is":[31],"retrospective":[33],"analysis":[34],"biopsy-proven":[38],"biliary":[39],"tract":[40],"cancer":[41,45,109],"at":[42,57],"our":[43],"comprehensive":[44],"center":[46],"GI":[47],"oncology":[48],"clinic":[49],"from":[50],"2018-2022.":[51],"Only":[52],"continued":[55],"care":[56],"Lombardi":[58],"Comprehensive":[59],"Cancer":[60],"Center":[61],"were":[62,74,92,141],"included":[63,75],"study.":[66],"Results:":[67],"Of":[68],"217":[69],"screened;":[71],"160":[72],"final":[78],"analysis.":[79],"The":[80,150],"mean":[81],"age":[82],"cohort":[85,204],"was":[86,103,123,160,236],"63":[87],"years,":[88],"and":[89,115,130],"majority":[91],"females":[93],"(55%).":[94],"In":[95],"order":[97,157],"frequency,":[99],"intrahepatic":[100],"cholangiocarcinoma":[101,113],"(77.5%)":[102],"most":[105],"common":[106],"type":[107],"followed":[110],"by":[111],"extrahepatic":[112],"(15.6%),":[114],"carcinoma":[116],"Gallbladder":[119],"(6.9%).":[120],"Molecular":[121],"performed":[124],"49.4%":[126],"actionable":[131,153,191,234],"mutations":[132,154,192,235],"for":[133],"FDA":[134],"approved":[135],"treatments":[136],"or":[137],"clinical":[138],"trial":[139],"enrollment":[140],"found":[142],"42":[144],"(26.3%)":[146],"patients.":[149],"spectrum":[151],"decreasing":[156],"frequency":[159],"KRAS":[161],"(n=11),":[162],"FGFR2":[163],"(n=9),":[164],"IDH-1":[165],"(n=8),":[166],"Her-2neu":[167],"(n=5),":[168,170],"BRCA1/2":[169],"&":[171],"PD-L1(n=4).":[172],"Patients":[173,218],"who":[174,219],"underwent":[175,220],"had":[178,193,230],"significantly":[179],"better":[180,195,231,240],"(43\u00b15":[182],"months":[183,206],"vs.":[184,207],"25\u00b14,":[185],"p":[186,210],"0.013).":[187],"Notably,":[188],"even":[194,239],"as":[197,223],"compared":[198],"rest":[201],"(52\u00b18":[205],"26\u00b17":[208],"months,":[209],"0.019).":[211],"Conclusions:":[212],"exhibits":[214],"diverse":[215],"genetic":[216],"alterations.":[217],"a":[224],"part":[225],"plan":[229],"survival.":[232,241],"Identifying":[233],"associated":[237]},"counts_by_year":[],"updated_date":"2026-10-27T15:51:10.671819","created_date":"2024-01-23T00:00:00"}
