{"id":"https://openalex.org/W4391091247","doi":"https://doi.org/10.1200/jco.2024.42.3_suppl.165","title":"Liver steatosis and fibrosis as independent prognostic factors affecting survival in colorectal cancer with liver metastases.","display_name":"Liver steatosis and fibrosis as independent prognostic factors affecting survival in colorectal cancer with liver metastases.","publication_year":2024,"publication_date":"2024-01-20","ids":{"openalex":"https://openalex.org/W4391091247","doi":"https://doi.org/10.1200/jco.2024.42.3_suppl.165"},"language":"en","primary_location":{"id":"doi:10.1200/jco.2024.42.3_suppl.165","doi":"https://doi.org/10.1200/jco.2024.42.3_suppl.165","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1200/jco.2024.42.3_suppl.165","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Nikhil Gupta","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nikhil Gupta","raw_affiliation_strings":["Case Western Reserve University, Cleveland, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Case Western Reserve University, Cleveland, OH","institution_ids":["https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057948201","display_name":"Eashwar V. Somasundaram","orcid":"https://orcid.org/0000-0001-8806-6992","observed_orcids":["https://orcid.org/0000-0001-8806-6992"]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eashwar Somasundaram","raw_affiliation_strings":["Massachusetts General Hospital, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Massachusetts General Hospital, Boston, MA","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044648533","display_name":"Andrew Dhawan","orcid":"https://orcid.org/0000-0002-5027-1277","observed_orcids":["https://orcid.org/0000-0002-5027-1277"]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew Dhawan","raw_affiliation_strings":["Cleveland Clinic, Cleveland, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cleveland Clinic, Cleveland, OH","institution_ids":["https://openalex.org/I1316902750"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5024863178","display_name":"Jacob G. Scott","orcid":"https://orcid.org/0000-0003-2971-7673","observed_orcids":["https://orcid.org/0000-0003-2971-7673"]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jacob Scott","raw_affiliation_strings":["Cleveland Clinic, Cleveland, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cleveland Clinic, Cleveland, OH","institution_ids":["https://openalex.org/I1316902750"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"42","issue":"3_suppl","first_page":"165","last_page":"165"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.9648000001907349,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.9648000001907349,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10335","display_name":"Colorectal Cancer Surgical Treatments","score":0.01269999984651804,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.007600000128149986,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/colorectal-liver-metastases","display_name":"colorectal liver metastases","score":0.9350000023841858},{"id":"https://openalex.org/keywords/hepatic-steatosis","display_name":"hepatic steatosis","score":0.9860000014305115},{"id":"https://openalex.org/keywords/liver-fibrosis","display_name":"liver fibrosis","score":0.9769999980926514},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.9800000190734863},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.9959999918937683},{"id":"https://openalex.org/keywords/disease-free-survival","display_name":"disease-free survival","score":0.9900000095367432},{"id":"https://openalex.org/keywords/clinical-risk-score","display_name":"clinical risk score","score":0.8059999942779541},{"id":"https://openalex.org/keywords/extrahepatic-disease","display_name":"extrahepatic disease","score":0.9639999866485596},{"id":"https://openalex.org/keywords/neoadjuvant-chemotherapy","display_name":"neoadjuvant chemotherapy","score":0.6930000185966492},{"id":"https://openalex.org/keywords/liver-resection","display_name":"hepatectomy","score":0.8539999723434448},{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":0.5619999766349792},{"id":"https://openalex.org/keywords/comorbidity","display_name":"comorbidities","score":0.6710000038146973},{"id":"https://openalex.org/keywords/disease-progression","display_name":"disease progression","score":0.3799999952316284}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9401959776878357},{"id":"https://openalex.org/C2776175330","wikidata":"https://www.wikidata.org/wiki/Q1365091","display_name":"Steatosis","level":2,"score":0.6971554756164551},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.652314305305481},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.6278217434883118},{"id":"https://openalex.org/C50382708","wikidata":"https://www.wikidata.org/wiki/Q223218","display_name":"Proportional hazards model","level":2,"score":0.576349139213562},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5197463035583496},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5073124766349792},{"id":"https://openalex.org/C2778772119","wikidata":"https://www.wikidata.org/wiki/Q6058862","display_name":"Fatty liver","level":3,"score":0.5038277506828308},{"id":"https://openalex.org/C146357865","wikidata":"https://www.wikidata.org/wiki/Q1123245","display_name":"Stage (stratigraphy)","level":2,"score":0.4750095307826996},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.47484591603279114},{"id":"https://openalex.org/C2780559512","wikidata":"https://www.wikidata.org/wiki/Q605709","display_name":"Fibrosis","level":2,"score":0.43809276819229126},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.33234596252441406},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1200/jco.2024.42.3_suppl.165","doi":"https://doi.org/10.1200/jco.2024.42.3_suppl.165","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1200/jco.2024.42.3_suppl.165","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9922999739646912}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4294938624","https://openalex.org/W2273197607","https://openalex.org/W4393985219","https://openalex.org/W3133575142","https://openalex.org/W2024981084","https://openalex.org/W2467894147","https://openalex.org/W2350904989","https://openalex.org/W7168589165","https://openalex.org/W7166810773","https://openalex.org/W3029178962"],"abstract_inverted_index":{"165":[0],"Background:":[1],"Colorectal":[2],"cancer":[3],"is":[4,105,125,413],"one":[5],"of":[6,10,21,25,43,49,96,122,195,201,208,213,216,222,229,254,267,277,288,309,318,328,338,349,398],"the":[7,14,17,50,94,100,313,396,399,403],"leading":[8],"causes":[9],"cancer-related":[11],"death,":[12],"and":[13,28,35,56,83,98,111,118,131,151,176,227,285,346,368,384,393,427],"liver":[15,44,51,72,81,129,202,289,319,350,391],"represents":[16],"most":[18],"common":[19],"site":[20],"metastases.":[22],"Greater":[23],"depth":[24],"tissue":[26,290,351],"invasion":[27],"lymph":[29],"node":[30],"metastases":[31,73,320],"(more":[32],"advanced":[33],"T":[34],"N":[36],"stage)":[37],"are":[38,58,375],"associated":[39,64],"with":[40,53,65,70,137],"increased":[41,366],"risk":[42,205,258],"metastases,":[45,203],"but":[46],"how":[47,417],"co-pathologies":[48,419],"associate":[52],"disease":[54,210,269,330],"progression":[55,407],"survival":[57,67,175,311,383,386],"not":[59],"known.":[60],"Further,":[61],"prognostic":[62],"factors":[63,79,252,307],"overall":[66,174,255,385,428],"in":[68,135,160,188,237,312,378,402,408,421],"patients":[69,136],"colorectal":[71],"(CRLM)":[74],"remain":[75],"poorly":[76],"understood.":[77],"Clinical":[78],"affecting":[80],"morphology":[82],"biomechanical":[84],"properties,":[85],"such":[86],"as":[87,370],"preexisting":[88],"fibrosis":[89,112,132,230,392],"or":[90],"steatosis,":[91],"may":[92],"impact":[93,133,395],"pathogenesis":[95,117],"CRLM":[97,116],"thus":[99],"clinical":[101,166,204,251,257,306],"prognosis.":[102,119],"Current":[103],"literature":[104],"mixed":[106],"about":[107],"whether":[108,128],"prior":[109],"steatosis":[110,130,217,278,339,367,394],"contribute":[113],"significantly":[114],"to":[115,126,415],"The":[120,154],"purpose":[121],"this":[123,409],"study":[124,162],"evaluate":[127],"outcomes":[134],"CRLM.":[138],"Methods:":[139],"All":[140,233],"CLRM":[141],"cases":[142],"(n":[143],"=":[144,261,264,271,274,280,283,295,298,322,325,332,335,341,344,356,359],"197)":[145],"that":[146,365,390],"underwent":[147],"resection":[148,200,317],"between":[149],"2003":[150],"2007":[152],"from":[153],"Cancer":[155],"Imaging":[156],"Archive":[157],"were":[158,186,235,301],"included":[159,187],"our":[161],"cohort.":[163],"For":[164],"each":[165],"covariate,":[167],"we":[168],"generated":[169],"a":[170,179,189],"univariate":[171],"model":[172,246],"for":[173],"those":[177],"meeting":[178],"modest":[180],"predictive":[181,253,308],"threshold":[182],"(p":[183],"<":[184],"0.15)":[185],"multivariable":[190,242],"model.":[191],"These":[192],"included:":[193],"presence":[194,207,215,228,266,276,327,337],"major":[196],"comorbidity,":[197],"chemotherapy":[198,315],"preceding":[199,316],"score,":[206],"extrahepatic":[209,268,329],"at":[211],"time":[212],"diagnosis,":[214],"on":[218,231],"CT":[219,373],"imaging,":[220],"percentage":[221],"residual":[223],"tumor":[224,406,425],"after":[225],"treatment,":[226],"CT.":[232],"statistics":[234],"performed":[236],"R":[238],"(v.2022.12.0).":[239],"Results:":[240],"A":[241],"Cox":[243],"proportional":[244],"hazards":[245],"identified":[247],"four":[248,303],"statistically":[249,304],"significant":[250,305],"survival:":[256],"score":[259],"(HR":[260,270,279,294,321,331,340,355],"1.60,":[262],"p":[263,273,282,297,324,334,343,358],"0.026),":[265],"2.33,":[272],"0.027),":[275],"0.51,":[281],"0.0057),":[284],"fibrotic":[286,347],"proportion":[287,348],"less":[291,352],"than":[292,353],"40%":[293,354],"2.63,":[296],"0.033).":[299],"There":[300],"also":[302],"disease-free":[310,382],"liver:":[314],"2.28,":[323],"0.0011),":[326],"2.18,":[333],"0.024),":[336],"0.49,":[342],"0.0030),":[345],"2.74,":[357],"0.016).":[360],"Conclusions:":[361],"Our":[362],"findings":[363],"suggest":[364],"fibrosis,":[369],"assessed":[371],"by":[372],"scans,":[374],"paradoxically":[376],"protective":[377],"CRLM,":[379],"showing":[380],"longer":[381],"rates.":[387],"We":[388],"hypothesize":[389],"microenvironment":[397],"neoplastic":[400],"cells":[401],"liver,":[404],"impairing":[405],"milieu.":[410],"Further":[411],"research":[412],"needed":[414],"assess":[416],"non-neoplastic":[418],"resulting":[420],"biophysical":[422],"changes":[423],"affect":[424],"growth":[426],"survival.":[429]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-10-17T09:40:24.721904","created_date":"2024-01-23T00:00:00"}