{"id":"https://openalex.org/W4391069244","doi":"https://doi.org/10.1016/j.prmcm.2024.100370","title":"Design and development of high-dose bioactive oil-loaded transdermal patch with the aid of natural waste as an adsorbent- optimization with SeDeM-SLA tool","display_name":"Design and development of high-dose bioactive oil-loaded transdermal patch with the aid of natural waste as an adsorbent- optimization with SeDeM-SLA tool","publication_year":2024,"publication_date":"2024-01-21","ids":{"openalex":"https://openalex.org/W4391069244","doi":"https://doi.org/10.1016/j.prmcm.2024.100370"},"language":"en","primary_location":{"id":"doi:10.1016/j.prmcm.2024.100370","doi":"https://doi.org/10.1016/j.prmcm.2024.100370","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.prmcm.2024.100370","pdf_url":null,"source":{"id":"https://openalex.org/S4210232177","display_name":"Pharmacological Research - Modern Chinese Medicine","issn_l":"2667-1425","issn":["2667-1425"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","poland-20"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacological Research - Modern Chinese Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1016/j.prmcm.2024.100370","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086312817","display_name":"Nikhil Girase","orcid":"https://orcid.org/0000-0002-9160-7574","observed_orcids":["https://orcid.org/0000-0002-9160-7574"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nikhil Girase","raw_affiliation_strings":["Department of Industrial Pharmacy and Quality Assurance, R. C. Patel Institute of Pharmaceutical Education and Research, Shirpur, India 425405"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Industrial Pharmacy and Quality Assurance, R. C. Patel Institute of Pharmaceutical Education and Research, Shirpur, India 425405","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046654088","display_name":"Umesh Dilip Laddha","orcid":"https://orcid.org/0000-0002-4038-3953","observed_orcids":["https://orcid.org/0000-0002-4038-3953"]},"institutions":[{"id":"https://openalex.org/I878213199","display_name":"Savitribai Phule Pune University","ror":"https://ror.org/044g6d731","country_code":"IN","type":"education","lineage":["https://openalex.org/I878213199"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Umesh D. Laddha","raw_affiliation_strings":["MET's Institute of Pharmacy, Bhujbal Knowledge City, Affiliated to Savitribai Phule Pune University, Nashik, MS, India 422003"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MET's Institute of Pharmacy, Bhujbal Knowledge City, Affiliated to Savitribai Phule Pune University, Nashik, MS, India 422003","institution_ids":["https://openalex.org/I878213199"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053281599","display_name":"Devanshi S. Shah","orcid":"https://orcid.org/0000-0003-4281-0151","observed_orcids":["https://orcid.org/0000-0003-4281-0151"]},"institutions":[{"id":"https://openalex.org/I167751958","display_name":"Institute of Chemical Technology","ror":"https://ror.org/00ykac431","country_code":"IN","type":"education","lineage":["https://openalex.org/I167751958"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Devanshi S. Shah","raw_affiliation_strings":["Department of Pharmaceutical Science and technology, Institute of Chemical Technology, Mumbai, India 400016"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Science and technology, Institute of Chemical Technology, Mumbai, India 400016","institution_ids":["https://openalex.org/I167751958"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041270813","display_name":"Shailesh S. Chalikwar","orcid":"https://orcid.org/0000-0003-1550-1310","observed_orcids":["https://orcid.org/0000-0003-1550-1310"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Shailesh S. Chalikwar","raw_affiliation_strings":["Department of Industrial Pharmacy and Quality Assurance, R. C. Patel Institute of Pharmaceutical Education and Research, Shirpur, India 425405"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Industrial Pharmacy and Quality Assurance, R. C. Patel Institute of Pharmaceutical Education and Research, Shirpur, India 425405","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5065243431","display_name":"Kailas Kalicharan Moravkar","orcid":"https://orcid.org/0000-0002-0269-1576","observed_orcids":["https://orcid.org/0000-0002-0269-1576"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Kailas K. Moravkar","raw_affiliation_strings":["Department of Industrial Pharmacy and Quality Assurance, R. C. Patel Institute of Pharmaceutical Education and Research, Shirpur, India 425405","Principal Research Engineer, Regeron Inc., Chuncheon-si, Gangwon-do 24232, South Korea"],"raw_orcid":"https://orcid.org/0000-0002-0269-1576","affiliations":[{"raw_affiliation_string":"Department of Industrial Pharmacy and Quality Assurance, R. C. Patel Institute of Pharmaceutical Education and Research, Shirpur, India 425405","institution_ids":[]},{"raw_affiliation_string":"Principal Research Engineer, Regeron Inc., Chuncheon-si, Gangwon-do 24232, South Korea","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5041270813","https://openalex.org/A5065243431"],"corresponding_institution_ids":[],"apc_list":{"value":1300,"currency":"USD","value_usd":1300},"apc_paid":{"value":1300,"currency":"USD","value_usd":1300},"fwci":0.4825,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.5144339,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"10","issue":null,"first_page":"100370","last_page":"100370"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10704","display_name":"Advancements in Transdermal Drug Delivery","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10704","display_name":"Advancements in Transdermal Drug Delivery","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10771","display_name":"Wound Healing and Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/transdermal-patch","display_name":"transdermal patch","score":0.859000027179718},{"id":"https://openalex.org/keywords/rheumatoid-arthritis","display_name":"rheumatoid arthritis","score":0.984000027179718},{"id":"https://openalex.org/keywords/hydroxypropyl-methylcellulose","display_name":"hydroxypropyl methylcellulose","score":0.7950000166893005},{"id":"https://openalex.org/keywords/peg","display_name":"PEG","score":0.9760000109672546},{"id":"https://openalex.org/keywords/solvent-casting","display_name":"solvent casting","score":0.8510000109672546},{"id":"https://openalex.org/keywords/in-vitro-drug-release","display_name":"in vitro drug release","score":0.7390000224113464},{"id":"https://openalex.org/keywords/anti-inflammatory-activity","display_name":"anti-inflammatory activity","score":0.9120000004768372},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.847000002861023},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.9890000224113464},{"id":"https://openalex.org/keywords/cytokines","display_name":"cytokines","score":0.527999997138977},{"id":"https://openalex.org/keywords/paw-edema","display_name":"paw edema","score":0.6959999799728394},{"id":"https://openalex.org/keywords/nsaid-adverse-effects","display_name":"NSAID adverse effects","score":0.6050000190734863}],"concepts":[{"id":"https://openalex.org/C205679159","wikidata":"https://www.wikidata.org/wiki/Q3375179","display_name":"Transdermal","level":2,"score":0.7807849645614624},{"id":"https://openalex.org/C2779232237","wikidata":"https://www.wikidata.org/wiki/Q20817212","display_name":"Ginseng","level":3,"score":0.6065776348114014},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5222988128662109},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.5057559013366699},{"id":"https://openalex.org/C150394285","wikidata":"https://www.wikidata.org/wiki/Q180254","display_name":"Adsorption","level":2,"score":0.458615779876709},{"id":"https://openalex.org/C2775842315","wikidata":"https://www.wikidata.org/wiki/Q1145270","display_name":"Transdermal patch","level":3,"score":0.44278308749198914},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.4383620619773865},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.37433651089668274},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.3686731457710266},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.26963746547698975},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1016/j.prmcm.2024.100370","doi":"https://doi.org/10.1016/j.prmcm.2024.100370","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.prmcm.2024.100370","pdf_url":null,"source":{"id":"https://openalex.org/S4210232177","display_name":"Pharmacological Research - Modern Chinese Medicine","issn_l":"2667-1425","issn":["2667-1425"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","poland-20"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacological Research - Modern Chinese Medicine","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:928d8ab894a7433ebfe01adf0be8e728","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/928d8ab894a7433ebfe01adf0be8e728","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Pharmacological Research - Modern Chinese Medicine, Vol 10, Iss , Pp 100370- (2024)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.prmcm.2024.100370","doi":"https://doi.org/10.1016/j.prmcm.2024.100370","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.prmcm.2024.100370","pdf_url":null,"source":{"id":"https://openalex.org/S4210232177","display_name":"Pharmacological Research - Modern Chinese Medicine","issn_l":"2667-1425","issn":["2667-1425"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","poland-20"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacological Research - Modern Chinese Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":21,"referenced_works":["https://openalex.org/W126724734","https://openalex.org/W184827354","https://openalex.org/W1964551301","https://openalex.org/W1973073798","https://openalex.org/W2047808197","https://openalex.org/W2076781731","https://openalex.org/W2101102966","https://openalex.org/W2106465273","https://openalex.org/W2791245592","https://openalex.org/W2801638461","https://openalex.org/W3102563980","https://openalex.org/W3123125120","https://openalex.org/W3165724391","https://openalex.org/W3190882738","https://openalex.org/W3206785112","https://openalex.org/W4200209658","https://openalex.org/W4200431111","https://openalex.org/W4221005748","https://openalex.org/W4294755189","https://openalex.org/W4319601658","https://openalex.org/W4378070111"],"related_works":["https://openalex.org/W3021469968","https://openalex.org/W3081086657","https://openalex.org/W7162773997","https://openalex.org/W4412446872","https://openalex.org/W7216553857","https://openalex.org/W4414292390","https://openalex.org/W4405727682","https://openalex.org/W4417201272","https://openalex.org/W3049078389","https://openalex.org/W7214745161"],"abstract_inverted_index":{"Rheumatoid":[0],"arthritis":[1],"(RA)":[2],"is":[3,24,52],"an":[4],"autoimmune":[5],"disease":[6],"that":[7],"affects":[8],"joints":[9],"significantly.":[10],"Its":[11],"prevalence":[12],"varies":[13],"globally,":[14],"with":[15,200],"more":[16],"impact":[17,89],"on":[18,34,241,255],"females":[19],"than":[20],"males.":[21],"Presently":[22],"it":[23],"treated":[25],"using":[26,119,149],"NSAIDs":[27],"which":[28],"unfortunately":[29],"show":[30],"significant":[31,247],"adverse":[32],"effects":[33],"the":[35,55,72,81,84,88,91,109,131,134,150,215,256],"liver":[36],"and":[37,80,127,147,172,193,227,233,239,252],"renal":[38],"system":[39],"after":[40],"long-term":[41],"use.":[42],"Conventional":[43],"topical":[44],"use":[45],"of":[46,54,74,90,107,112,137,145,222,235],"bioactive":[47],"oils":[48],"like":[49],"ginseng":[50,75,96,113,211],"oil":[51,76,97,212],"one":[53],"best":[56],"natural":[57],"options":[58],"to":[59,224,260],"treat":[60],"RA,":[61],"but":[62],"poor":[63],"retention":[64],"time":[65],"has":[66],"limited":[67],"its":[68],"usefulness.":[69],"By":[70],"considering":[71],"involvement":[73],"in":[77,101,249],"managing":[78],"RA":[79],"associated":[82],"limitations,":[83],"proposed":[85],"study":[86,208],"investigated":[87],"transdermal":[92,135],"patch":[93,162,217],"prepared":[94,141,216],"by":[95,118,142],"loaded-natural":[98],"biocompatible":[99],"adsorbent":[100,115,139],"treating":[102],"RA.":[103],"At":[104],"early":[105],"stage":[106],"research,":[108],"flow":[110,125],"property":[111],"oil-loaded":[114,138],"was":[116],"optimized":[117],"advanced":[120],"technology,":[121],"viz.":[122],"Brookfield":[123],"powder":[124],"tester":[126],"SeDeM":[128],"model.":[129],"In":[130,205],"lateral":[132],"stage,":[133],"patches":[136,155],"were":[140,156],"variable":[143],"concentrations":[144],"HPMC":[146],"PEG":[148],"solvent":[151],"casting":[152],"method.":[153],"Prepared":[154],"evaluated":[157],"for":[158],"various":[159],"parameters.":[160],"Optimized":[161],"showed":[163,209,245],"average":[164,166],"thickness,":[165],"weight,":[167],"folding":[168],"endurance,":[169],"tensile":[170],"strength,":[171],"moisture":[173],"content":[174],"as":[175],"0.38":[176],"\u00b1":[177,181,188,195],"0.10":[178],"mm,":[179],"0.215":[180],"0.41":[182],"gm/":[183],"2":[184],"sq.":[185],"inch,":[186],"145":[187],"0.20,":[189],"3.370\u00b1":[190],"0.16":[191],"MPA/mm":[192],"3.770":[194],"0.81":[196],"%,":[197],"respectively,":[198],"along":[199],"satisfactory":[201],"skin":[202],"adherence":[203],"property.":[204],"vitro":[206],"diffusion":[207],"increased":[210],"release":[213,229],"from":[214],"at":[218],"a":[219,246,261],"specific":[220],"interval":[221],"up":[223],"10":[225],"h,":[226],"then":[228],"diminished.":[230],"Anti-inflammatory":[231],"test":[232],"measurement":[234],"cytokines":[236,257],"levels":[237],"(IL-6":[238],"TNF-\u03b1)":[240],"male":[242],"Wistar":[243],"rats":[244],"reduction":[248],"paw":[250],"edema":[251],"notable":[253],"control":[254],"level":[258],"compared":[259],"conventional":[262],"approach.":[263]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2024-01-22T00:00:00"}