{"id":"https://openalex.org/W4391038077","doi":"https://doi.org/10.1016/j.hybadv.2024.100144","title":"Development and assessment of rutin loaded transfersomes to improve ex vivo membrane permeability and in vitro efficacy","display_name":"Development and assessment of rutin loaded transfersomes to improve ex vivo membrane permeability and in vitro efficacy","publication_year":2024,"publication_date":"2024-01-19","ids":{"openalex":"https://openalex.org/W4391038077","doi":"https://doi.org/10.1016/j.hybadv.2024.100144"},"language":"en","primary_location":{"id":"doi:10.1016/j.hybadv.2024.100144","doi":"https://doi.org/10.1016/j.hybadv.2024.100144","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.hybadv.2024.100144","pdf_url":null,"source":{"id":"https://openalex.org/S4387284451","display_name":"Hybrid Advances","issn_l":"2773-207X","issn":["2773-207X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hybrid Advances","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1016/j.hybadv.2024.100144","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5069181379","display_name":"Kamlesh Wadher","orcid":"https://orcid.org/0000-0002-3782-3380","observed_orcids":["https://orcid.org/0000-0002-3782-3380"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Kamlesh Wadher","raw_affiliation_strings":["Department of Pharmaceutics, Smt. Kishoritai Bhoyar College of Pharmacy, Kamptee, Nagpur, Maharashtra, 441002, India"],"raw_orcid":"https://orcid.org/0000-0002-3782-3380","affiliations":[{"raw_affiliation_string":"Department of Pharmaceutics, Smt. Kishoritai Bhoyar College of Pharmacy, Kamptee, Nagpur, Maharashtra, 441002, India","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058612955","display_name":"Sagar Trivedi","orcid":"https://orcid.org/0000-0001-6764-0019","observed_orcids":["https://orcid.org/0000-0001-6764-0019"]},"institutions":[{"id":"https://openalex.org/I133978751","display_name":"Rashtrasant Tukadoji Maharaj Nagpur University","ror":"https://ror.org/04esgv207","country_code":"IN","type":"education","lineage":["https://openalex.org/I133978751"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Sagar Trivedi","raw_affiliation_strings":["Department of Pharmaceutical Sciences, Rashtrasant Tukadoji Maharaj Nagpur University, Nagpur, Maharashtra, 440033, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences, Rashtrasant Tukadoji Maharaj Nagpur University, Nagpur, Maharashtra, 440033, India","institution_ids":["https://openalex.org/I133978751"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076737288","display_name":"Nilesh Ramesh Rarokar","orcid":"https://orcid.org/0000-0003-3401-7997","observed_orcids":["https://orcid.org/0000-0003-3401-7997"]},"institutions":[{"id":"https://openalex.org/I4210146358","display_name":"Raisoni Group of Institutions","ror":"https://ror.org/03dp11s58","country_code":"IN","type":"education","lineage":["https://openalex.org/I4210146358"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Nilesh Rarokar","raw_affiliation_strings":["G H Raisoni Institute of Life Sciences, Shradha Park, Hingna-Wadi Link Road, MIDC, Nagpur, 440016, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"G H Raisoni Institute of Life Sciences, Shradha Park, Hingna-Wadi Link Road, MIDC, Nagpur, 440016, India","institution_ids":["https://openalex.org/I4210146358"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5024317491","display_name":"Milind Janrao Umekar","orcid":"https://orcid.org/0000-0002-2170-0896","observed_orcids":["https://orcid.org/0000-0002-2170-0896"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Milind Umekar","raw_affiliation_strings":["Department of Pharmaceutics, Smt. Kishoritai Bhoyar College of Pharmacy, Kamptee, Nagpur, Maharashtra, 441002, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutics, Smt. Kishoritai Bhoyar College of Pharmacy, Kamptee, Nagpur, Maharashtra, 441002, India","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5069181379","https://openalex.org/A5076737288"],"corresponding_institution_ids":["https://openalex.org/I4210146358"],"apc_list":{"value":1500,"currency":"USD","value_usd":1500},"apc_paid":{"value":1500,"currency":"USD","value_usd":1500},"fwci":6.5947,"has_fulltext":false,"cited_by_count":41,"citation_normalized_percentile":{"value":0.98463646,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"5","issue":null,"first_page":"100144","last_page":"100144"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10704","display_name":"Advancements in Transdermal Drug Delivery","score":1.0,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10704","display_name":"Advancements in Transdermal Drug Delivery","score":1.0,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10256","display_name":"Drug Solubulity and Delivery Systems","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rutin","display_name":"rutin","score":0.9679999947547913},{"id":"https://openalex.org/keywords/transfersomes","display_name":"transfersomes","score":0.9819999933242798},{"id":"https://openalex.org/keywords/melanoma","display_name":"melanoma","score":0.8820000290870667},{"id":"https://openalex.org/keywords/topical-drug-delivery","display_name":"topical drug delivery","score":0.7929999828338623},{"id":"https://openalex.org/keywords/transdermal-patch","display_name":"transdermal patch","score":0.7749999761581421},{"id":"https://openalex.org/keywords/skin-permeability","display_name":"skin permeability","score":0.5590000152587891},{"id":"https://openalex.org/keywords/b16f10-melanoma","display_name":"B16F10 melanoma","score":0.8429999947547913},{"id":"https://openalex.org/keywords/sodium-deoxycholate","display_name":"sodium deoxycholate","score":0.9980000257492065},{"id":"https://openalex.org/keywords/drug-encapsulation","display_name":"drug encapsulation","score":0.597000002861023},{"id":"https://openalex.org/keywords/skin-deposition","display_name":"skin deposition","score":0.5709999799728394},{"id":"https://openalex.org/keywords/skin-irritation","display_name":"skin irritation","score":0.7580000162124634},{"id":"https://openalex.org/keywords/anticancer-agents","display_name":"anticancer agents","score":0.6779999732971191}],"concepts":[{"id":"https://openalex.org/C205679159","wikidata":"https://www.wikidata.org/wiki/Q3375179","display_name":"Transdermal","level":2,"score":0.7483189105987549},{"id":"https://openalex.org/C26291073","wikidata":"https://www.wikidata.org/wiki/Q310484","display_name":"Ex vivo","level":3,"score":0.5970940589904785},{"id":"https://openalex.org/C2775963812","wikidata":"https://www.wikidata.org/wiki/Q407857","display_name":"Rutin","level":3,"score":0.5816755890846252},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.558417558670044},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5142444968223572},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.4945366084575653},{"id":"https://openalex.org/C2779820397","wikidata":"https://www.wikidata.org/wiki/Q1392806","display_name":"Drug delivery","level":2,"score":0.45147034525871277},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.4458667039871216},{"id":"https://openalex.org/C2777789703","wikidata":"https://www.wikidata.org/wiki/Q192102","display_name":"Skin cancer","level":3,"score":0.41516047716140747},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.3422464430332184},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.3384222984313965},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2449909746646881},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.08417952060699463},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.07715445756912231},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.07651159167289734},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.0},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1016/j.hybadv.2024.100144","doi":"https://doi.org/10.1016/j.hybadv.2024.100144","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.hybadv.2024.100144","pdf_url":null,"source":{"id":"https://openalex.org/S4387284451","display_name":"Hybrid Advances","issn_l":"2773-207X","issn":["2773-207X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hybrid Advances","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:6eb5271038f24b3fb219de766be25f7b","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/6eb5271038f24b3fb219de766be25f7b","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Hybrid Advances, Vol 5, Iss , Pp 100144- (2024)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.hybadv.2024.100144","doi":"https://doi.org/10.1016/j.hybadv.2024.100144","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.hybadv.2024.100144","pdf_url":null,"source":{"id":"https://openalex.org/S4387284451","display_name":"Hybrid Advances","issn_l":"2773-207X","issn":["2773-207X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hybrid Advances","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G6779215939","display_name":null,"funder_award_id":"IF 190486","funder_id":"https://openalex.org/F4320320719","funder_display_name":"Department of Science and Technology, Ministry of Science and Technology, India"},{"id":"https://openalex.org/G7586375755","display_name":null,"funder_award_id":"RPS-8-15/FDC/RPS/SC","funder_id":"https://openalex.org/F4320320736","funder_display_name":"All India Council for Technical Education"}],"funders":[{"id":"https://openalex.org/F4320320719","display_name":"Department of Science and Technology, Ministry of Science and Technology, India","ror":"https://ror.org/0101xrq71"},{"id":"https://openalex.org/F4320320736","display_name":"All India Council for Technical Education","ror":"https://ror.org/00xcd7y72"},{"id":"https://openalex.org/F4320321540","display_name":"Ministry of Science and Technology of the People's Republic of China","ror":"https://ror.org/027s68j25"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":42,"referenced_works":["https://openalex.org/W1529934495","https://openalex.org/W1972723441","https://openalex.org/W1976748394","https://openalex.org/W1982058172","https://openalex.org/W1985293526","https://openalex.org/W1992527461","https://openalex.org/W1992628540","https://openalex.org/W1994381824","https://openalex.org/W1998167669","https://openalex.org/W2035262025","https://openalex.org/W2041912496","https://openalex.org/W2059681271","https://openalex.org/W2066884258","https://openalex.org/W2075706054","https://openalex.org/W2168089247","https://openalex.org/W2181631481","https://openalex.org/W2273594182","https://openalex.org/W2734694266","https://openalex.org/W2763904605","https://openalex.org/W2883463089","https://openalex.org/W2901715957","https://openalex.org/W2903753184","https://openalex.org/W2909224734","https://openalex.org/W2964774721","https://openalex.org/W2972633450","https://openalex.org/W3024872581","https://openalex.org/W3045668696","https://openalex.org/W3047240386","https://openalex.org/W3049536786","https://openalex.org/W3083987393","https://openalex.org/W3130912116","https://openalex.org/W3146830234","https://openalex.org/W3162471863","https://openalex.org/W3174324209","https://openalex.org/W3187073801","https://openalex.org/W3217654606","https://openalex.org/W4200535037","https://openalex.org/W4283746915","https://openalex.org/W4308922462","https://openalex.org/W4309860437","https://openalex.org/W4310066851","https://openalex.org/W4387035502"],"related_works":["https://openalex.org/W4285273001","https://openalex.org/W3194444790","https://openalex.org/W4394824484","https://openalex.org/W3003749765","https://openalex.org/W2616126002","https://openalex.org/W4323311992","https://openalex.org/W3141960370","https://openalex.org/W2891987281","https://openalex.org/W2146662057","https://openalex.org/W4399492699"],"abstract_inverted_index":{"The":[0,89,111],"melanoma":[1],"is":[2],"the":[3,12,19,29,41,55,138,166,177,189,201,211,215],"most":[4],"dangerous":[5],"kind":[6],"of":[7,31,36,58,73,77,80,91,97,102,141,147,169,179,191,207,221],"skin":[8,24,56,119,135,162],"cancer":[9],"begins":[10],"in":[11,129,156],"melanocytes,":[13],"or":[14],"cells":[15],"that":[16,21],"make":[17],"melanin,":[18],"pigment":[20],"gives":[22],"your":[23],"its":[25],"color.":[26],"Due":[27],"to":[28,50,53,133],"need":[30],"local":[32],"effect":[33],"topical":[34,202],"administration":[35],"anticancer":[37,222],"drugs":[38],"could":[39,213],"be":[40,214],"best":[42],"option":[43],"for":[44,193,218],"clinical":[45],"therapy.":[46],"Present":[47],"study":[48,187],"aimed":[49],"formulate":[51],"transfersomes":[52,63],"enhance":[54,134],"penetration":[57],"rutin":[59],"(Rtn).":[60],"Rutin":[61],"loaded":[62],"(RtnTFs)":[64],"were":[65,127],"formulated":[66,125],"by":[67,209],"employing":[68],"central":[69],"composite":[70],"design":[71],"(CCD)":[72],"experiment":[74],"and":[75,83,99,196],"comprising":[76],"various":[78],"ratios":[79],"phospholipid":[81],"90H":[82],"sodium":[84],"deoxycholate":[85],"as":[86],"independent":[87],"variables.":[88],"assessment":[90],"critical":[92],"parameters":[93],"suggested":[94],"higher":[95,114,139,198],"encapsulation":[96],"Rtn":[98,148],"improved":[100],"stability":[101],"formulation":[103],"with":[104,197,204],"significant":[105],"drug":[106,175,208],"release":[107,168,206],"(P":[108,182],"<":[109,183],"0.05).":[110,184],"RtnTFs":[112,126],"shows":[113],"cell":[115,121],"inhibition":[116],"on":[117],"Murine":[118],"Melanoma":[120],"line":[122],"(B16\u2013F10).":[123],"Further,":[124],"incorporated":[128],"transdermal":[130],"patches":[131],"(TPs)":[132],"deposition.":[136],"However":[137],"deposition":[140],"about":[142,170],"0.921":[143],"\u00b1":[144,172],"0.23":[145],"mg/cm3":[146],"was":[149],"observed.":[150],"RtnTFs-TPs":[151,192],"exhibited":[152],"ideal":[153],"morphological":[154],"characteristics":[155],"scanning":[157],"electron":[158],"microscopic":[159],"images.":[160],"Ex-vivo":[161],"diffusion":[163],"studies":[164],"revealed":[165],"sustained":[167],"98":[171],"0.26":[173],"%":[174],"at":[176],"end":[178],"36":[180],"h":[181],"Skin":[185],"irritancy":[186],"demonstrated":[188],"suitability":[190],"dermal":[194],"delivery":[195,203,220],"stability.":[199],"Hence":[200],"delayed":[205],"enhancing":[210],"solubility":[212],"promising":[216],"strategy":[217],"efficient":[219],"agents.":[223]},"counts_by_year":[{"year":2026,"cited_by_count":13},{"year":2025,"cited_by_count":17},{"year":2024,"cited_by_count":11}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2024-01-20T00:00:00"}