{"id":"https://openalex.org/W4391036471","doi":"https://doi.org/10.7324/japs.2024.115259","title":"Evaluation of the antiatherogenic potential of purple sweet potato (Ipomoea batatas L.) extracts in Wistar rats exposed to a high cholesterol diet","display_name":"Evaluation of the antiatherogenic potential of purple sweet potato (Ipomoea batatas L.) extracts in Wistar rats exposed to a high cholesterol diet","publication_year":2024,"publication_date":"2024-01-19","ids":{"openalex":"https://openalex.org/W4391036471","doi":"https://doi.org/10.7324/japs.2024.115259"},"language":"en","primary_location":{"id":"doi:10.7324/japs.2024.115259","doi":"https://doi.org/10.7324/japs.2024.115259","is_oa":true,"landing_page_url":"https://doi.org/10.7324/japs.2024.115259","pdf_url":"https://japsonline.com/admin/php/uploads/4153_pdf.pdf","source":{"id":"https://openalex.org/S2764844132","display_name":"Journal of Applied Pharmaceutical Science","issn_l":"2231-3354","issn":["2231-3354"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4327876862","host_organization_name":"Open Science Publishers LLP","host_organization_lineage":["https://openalex.org/P4327876862"],"host_organization_lineage_names":["Open Science Publishers LLP"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Applied Pharmaceutical Science","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://japsonline.com/admin/php/uploads/4153_pdf.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5027666322","display_name":"I Made Jawi","orcid":"https://orcid.org/0000-0003-3212-262X","observed_orcids":["https://orcid.org/0000-0003-3212-262X","https://orcid.org/0000-0002-1748-2179"]},"institutions":[{"id":"https://openalex.org/I126826664","display_name":"Udayana University","ror":"https://ror.org/035qsg823","country_code":"ID","type":"education","lineage":["https://openalex.org/I126826664"]},{"id":"https://openalex.org/I4387152157","display_name":"Universitas Dhyana Pura","ror":"https://ror.org/02558xx03","country_code":"ID","type":"education","lineage":["https://openalex.org/I4387152157"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"I Made Jawi","raw_affiliation_strings":["Department of Pharmacology, Faculty of Medicine, Udayana University, Denpasar, Indonesia","Study Program of Biology, Faculty of Health, Science, and Technology, Universitas Dhyana Pura, Badung, Indonesia","of of . . "],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Faculty of Medicine, Udayana University, Denpasar, Indonesia","institution_ids":["https://openalex.org/I126826664"]},{"raw_affiliation_string":"Study Program of Biology, Faculty of Health, Science, and Technology, Universitas Dhyana Pura, Badung, Indonesia","institution_ids":["https://openalex.org/I4387152157"]},{"raw_affiliation_string":"of of . . ","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031316894","display_name":"I Wayan Putu Sutirta Yasa","orcid":"https://orcid.org/0000-0003-2494-1553","observed_orcids":["https://orcid.org/0000-0003-2494-1553"]},"institutions":[{"id":"https://openalex.org/I126826664","display_name":"Udayana University","ror":"https://ror.org/035qsg823","country_code":"ID","type":"education","lineage":["https://openalex.org/I126826664"]},{"id":"https://openalex.org/I4387152157","display_name":"Universitas Dhyana Pura","ror":"https://ror.org/02558xx03","country_code":"ID","type":"education","lineage":["https://openalex.org/I4387152157"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"I Wayan Putu Sutirta Yasa","raw_affiliation_strings":["Department of Clinical Pathology, Faculty of Medicine, Udayana University, Denpasar, Indonesia","Study Program of Biology, Faculty of Health, Science, and Technology, Universitas Dhyana Pura, Badung, Indonesia","of of . . "],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Pathology, Faculty of Medicine, Udayana University, Denpasar, Indonesia","institution_ids":["https://openalex.org/I126826664"]},{"raw_affiliation_string":"Study Program of Biology, Faculty of Health, Science, and Technology, Universitas Dhyana Pura, Badung, Indonesia","institution_ids":["https://openalex.org/I4387152157"]},{"raw_affiliation_string":"of of . . ","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5053442367","display_name":"I Gede Widhiantara","orcid":"https://orcid.org/0000-0003-0498-525X","observed_orcids":["https://orcid.org/0000-0003-0498-525X"]},"institutions":[{"id":"https://openalex.org/I4387152157","display_name":"Universitas Dhyana Pura","ror":"https://ror.org/02558xx03","country_code":"ID","type":"education","lineage":["https://openalex.org/I4387152157"]}],"countries":["ID"],"is_corresponding":true,"raw_author_name":"I Gede Widhiantara","raw_affiliation_strings":["Corresponding Author I Gede Widhiantara, Study Program of Biology, Faculty of Health, Science, andTechnology, Universitas Dhyana Pura, Badung, Indonesia","Study Program of Biology, Faculty of Health, Science, and Technology, Universitas Dhyana Pura, Badung, Indonesia","of of . . "],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Corresponding Author I Gede Widhiantara, Study Program of Biology, Faculty of Health, Science, andTechnology, Universitas Dhyana Pura, Badung, Indonesia","institution_ids":["https://openalex.org/I4387152157"]},{"raw_affiliation_string":"Study Program of Biology, Faculty of Health, Science, and Technology, Universitas Dhyana Pura, Badung, Indonesia","institution_ids":["https://openalex.org/I4387152157"]},{"raw_affiliation_string":"of of . . ","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5053442367"],"corresponding_institution_ids":["https://openalex.org/I4387152157"],"apc_list":null,"apc_paid":null,"fwci":0.9471,"has_fulltext":true,"cited_by_count":4,"citation_normalized_percentile":{"value":0.66843231,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":96},"biblio":{"volume":"14","issue":"2","first_page":"152","last_page":"160"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13828","display_name":"Natural Products and Biological Research","score":0.9717000126838684,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T13828","display_name":"Natural Products and Biological Research","score":0.9717000126838684,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12955","display_name":"Atherosclerosis and Cardiovascular Diseases","score":0.014000000432133675,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10445","display_name":"Antioxidant Activity and Oxidative Stress","score":0.003100000089034438,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/purple-sweet-potato","display_name":"purple sweet potato","score":0.8939999938011169},{"id":"https://openalex.org/keywords/sweet-potato","display_name":"Ipomoea batatas","score":0.9980000257492065},{"id":"https://openalex.org/keywords/anti-atherogenic-effects","display_name":"antiatherogenic effects","score":0.7910000085830688},{"id":"https://openalex.org/keywords/high-cholesterol-diet","display_name":"high-cholesterol diet","score":0.921999990940094},{"id":"https://openalex.org/keywords/dyslipidemia","display_name":"dyslipidemia","score":0.9769999980926514},{"id":"https://openalex.org/keywords/atherosclerosis","display_name":"atherosclerosis","score":0.7680000066757202},{"id":"https://openalex.org/keywords/lipid-profile","display_name":"lipid profile","score":0.6399999856948853},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.6819999814033508},{"id":"https://openalex.org/keywords/malondialdehyde","display_name":"malondialdehyde","score":0.9539999961853027},{"id":"https://openalex.org/keywords/superoxide-dismutase","display_name":"superoxide dismutase","score":0.9539999961853027},{"id":"https://openalex.org/keywords/netrin-1","display_name":"netrin-1","score":0.9110000133514404},{"id":"https://openalex.org/keywords/apolipoprotein-e","display_name":"apolipoprotein E","score":0.9940000176429749},{"id":"https://openalex.org/keywords/apolipoprotein-a-i","display_name":"apolipoprotein A-I","score":0.7559999823570251},{"id":"https://openalex.org/keywords/antioxidant-activity","display_name":"antioxidant activity","score":0.5329999923706055},{"id":"https://openalex.org/keywords/dietary-supplementation","display_name":"dietary supplementation","score":0.5009999871253967},{"id":"https://openalex.org/keywords/endothelial-dysfunction","display_name":"endothelial dysfunction","score":0.5759999752044678},{"id":"https://openalex.org/keywords/oxidized-ldl","display_name":"oxidized LDL","score":0.7039999961853027}],"concepts":[{"id":"https://openalex.org/C2778728632","wikidata":"https://www.wikidata.org/wiki/Q161173","display_name":"Ipomoea","level":2,"score":0.9595284461975098},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.6853488683700562},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4953102171421051},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.4514346718788147},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3253748416900635},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.27477744221687317},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1500537395477295}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.7324/japs.2024.115259","doi":"https://doi.org/10.7324/japs.2024.115259","is_oa":true,"landing_page_url":"https://doi.org/10.7324/japs.2024.115259","pdf_url":"https://japsonline.com/admin/php/uploads/4153_pdf.pdf","source":{"id":"https://openalex.org/S2764844132","display_name":"Journal of Applied Pharmaceutical Science","issn_l":"2231-3354","issn":["2231-3354"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4327876862","host_organization_name":"Open Science Publishers LLP","host_organization_lineage":["https://openalex.org/P4327876862"],"host_organization_lineage_names":["Open Science Publishers LLP"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Applied Pharmaceutical Science","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.7324/japs.2024.115259","doi":"https://doi.org/10.7324/japs.2024.115259","is_oa":true,"landing_page_url":"https://doi.org/10.7324/japs.2024.115259","pdf_url":"https://japsonline.com/admin/php/uploads/4153_pdf.pdf","source":{"id":"https://openalex.org/S2764844132","display_name":"Journal of Applied Pharmaceutical Science","issn_l":"2231-3354","issn":["2231-3354"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4327876862","host_organization_name":"Open Science Publishers LLP","host_organization_lineage":["https://openalex.org/P4327876862"],"host_organization_lineage_names":["Open Science Publishers LLP"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Applied Pharmaceutical Science","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320318932","display_name":"Universitas Udayana","ror":"https://ror.org/035qsg823"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4391036471.pdf","grobid_xml":"https://content.openalex.org/works/W4391036471.grobid-xml"},"referenced_works_count":54,"referenced_works":["https://openalex.org/W1608005307","https://openalex.org/W1987790605","https://openalex.org/W2049746695","https://openalex.org/W2056516296","https://openalex.org/W2080777317","https://openalex.org/W2113605797","https://openalex.org/W2159582752","https://openalex.org/W2418748266","https://openalex.org/W2558219170","https://openalex.org/W2558657406","https://openalex.org/W2580722674","https://openalex.org/W2599772444","https://openalex.org/W2739159777","https://openalex.org/W2894778776","https://openalex.org/W2909839337","https://openalex.org/W2924534120","https://openalex.org/W2939976199","https://openalex.org/W2953536521","https://openalex.org/W2955088664","https://openalex.org/W2966613145","https://openalex.org/W2991892454","https://openalex.org/W2998762999","https://openalex.org/W3006116566","https://openalex.org/W3027805975","https://openalex.org/W3046757022","https://openalex.org/W3047812607","https://openalex.org/W3048325813","https://openalex.org/W3048696815","https://openalex.org/W3082284125","https://openalex.org/W3108143107","https://openalex.org/W3120229106","https://openalex.org/W3127216274","https://openalex.org/W3154426821","https://openalex.org/W3162187253","https://openalex.org/W3172526658","https://openalex.org/W3176869572","https://openalex.org/W3178630408","https://openalex.org/W3183696133","https://openalex.org/W3189320557","https://openalex.org/W3191232333","https://openalex.org/W3193218822","https://openalex.org/W3193572465","https://openalex.org/W3196226334","https://openalex.org/W3207964133","https://openalex.org/W3215775808","https://openalex.org/W4200393148","https://openalex.org/W4205627155","https://openalex.org/W4214611285","https://openalex.org/W4293045885","https://openalex.org/W4307940232","https://openalex.org/W4308365150","https://openalex.org/W4310682609","https://openalex.org/W4312322024","https://openalex.org/W4312837267"],"related_works":["https://openalex.org/W7159787871","https://openalex.org/W4280596587","https://openalex.org/W4408138219","https://openalex.org/W4399422570","https://openalex.org/W2982670339","https://openalex.org/W7214918810","https://openalex.org/W2083140746","https://openalex.org/W2760260026","https://openalex.org/W2936485726","https://openalex.org/W2759040707"],"abstract_inverted_index":{"by":[0,10,62,94,199,251,361],"various":[1],"causes,":[2],"one":[3,101],"of":[4,33,41,59,72,102,105,152,207,212,316,338,398],"which":[5,36,84,262],"is":[6,25,100,386,400],"dyslipidemia.Dyslipidemia,":[7],"caused":[8,61,93],"mainly":[9],"an":[11,89,118,311],"increase":[12,312],"in":[13,121,248,268,278,296,305,313,335,346,371,402],"low-density":[14,96],"lipoprotein":[15,43,97,318],"(LDL)":[16],"cholesterol,":[17],"may":[18],"lead":[19],"to":[20,27,79,87,109,231,241,258,388],"endothelial":[21],"dysfunction":[22],"[2]":[23],"and":[24,30,48,149,160,243,289,331,365,368,385],"susceptible":[26],"oxidative":[28,363],"stress":[29,364],"the":[31,80,103,111,146,150,167,193,205,208,210,219,228,249,259,269,297,302,306,314,336,347],"formation":[32],"oxidized":[34],"LDL,":[35],"promotes":[37],"atherosclerosis":[38,394],"[3].The":[39],"levels":[40,52,151,247,291,315,370],"high-density":[42,317],"(HDL),":[44],"apoprotein":[45,49],"A-I":[46],"(ApoA-I),":[47],"E":[50],"(ApoE)":[51],"have":[53],"previously":[54],"been":[55,75],"utilized":[56,68,390],"as":[57,69,117,192,391],"indicators":[58],"inflammation":[60],"dyslipidemia":[63],"[4].Netrin-1,":[64],"a":[65,70,124,171,179,272,358,375,392],"novel":[66],"protein":[67,82,158],"marker":[71],"atherosclerosis,":[73],"has":[74],"discovered":[76],"[5].Netrin-1":[77],"relates":[78],"laminin":[81],"family,":[83],"was":[85,143,215,223,239,263,271,310],"shown":[86,345],"be":[88,190,389],"essential":[90],"ABSTRACT":[91],"Dyslipidemia":[92],"elevated":[95],"cholesterol":[98,246],"(LDL-C)":[99],"causes":[104],"atherosclerosis.This":[106],"study":[107],"aims":[108],"determine":[110],"purple":[112],"sweet":[113],"potato":[114],"extract":[115],"(PSPE)":[116],"antiatherogenic":[119,383],"agent":[120],"rats":[122,132,373],"fed":[123,374],"highcholesterol":[125],"diet.In":[126],"total,":[127],"32":[128],"adult":[129],"male":[130],"Wistar":[131,372],"were":[133,163,197],"separated":[134],"into":[135],"two":[136],"groups.A":[137],"randomized":[138],"pre-and":[139],"posttest":[140,250,339],"control":[141,168,260,303,348],"design":[142],"performed.Before":[144],"treatment,":[145,209],"lipid":[147,359],"profile":[148,360],"malondialdehyde":[153],"(MDA),":[154],"superoxide":[155],"dismutase":[156],"(SOD),":[157],"Netrin-1,":[159],"apolipoprotein-E":[161],"(Apo-E)":[162],"all":[164],"evaluated.Group":[165],"1,":[166],"group,":[169,261,342],"received":[170,178],"high-cholesterol":[172,180,376],"diet":[173,181,235],"(control),":[174],"while":[175],"Group":[176,232],"2":[177,187,233],"supplemented":[182,236],"with":[183,218,237,301],"200":[184,352],"mg/ml":[185,353],"PSPE.Group":[186],"hereafter":[188],"will":[189],"mentioned":[191],"PSPE":[194,298,341,354,381],"group.Both":[195],"groups":[196],"treated":[198],"respective":[200],"treatment":[201,229,355],"for":[202],"3":[203],"months.At":[204],"end":[206],"evaluation":[211],"necessary":[213],"parameters":[214],"carried":[216],"out":[217],"pretest.Paired":[220],"t-test":[221],"data":[222],"obtained.The":[224],"results":[225],"showed":[226],"that":[227,380],"given":[230],"(high-cholesterol":[234],"PSPE)":[238],"able":[240],"reduce":[242],"maintain":[244],"total":[245],"131.02":[252],"\u00b1":[253,265,281,286,293,320,325],"4.3":[254],"mg/dl":[255,267],"when":[256],"compared":[257,300],"261.25":[264],"18.74":[266],"posttest.There":[270],"significant":[273],"decrease":[274],"(p":[275],"<":[276],"0.05)":[277],"triglyceride":[279],"(131.27":[280],"1.9":[282,321],"mg/dl),":[283,288,322],"LDL":[284],"(18.33":[285],"4.6":[287],"MDA":[290],"(0.6":[292],"0.04":[294],"mmol/ml)":[295],"group":[299,304],"same":[307],"parameters.However,":[308],"there":[309],"(86.43":[319],"SOD":[323],"(5.22":[324],"0.14":[326],"U/ml),":[327],"Netrin-1":[328,367],"(115":[329],"ng/l),":[330],"Apo-E":[332,369],"(107.52":[333],"ng/ml)":[334],"serum":[337],"on":[340],"but":[343],"not":[344],"group.Following":[349],"our":[350],"findings,":[351],"successfully":[356],"maintained":[357],"reducing":[362],"increasing":[366],"diet.These":[377],"findings":[378],"indicate":[379],"displays":[382],"effects":[384],"possible":[387],"new":[393],"therapy,":[395],"whose":[396],"mechanism":[397],"action":[399],"described":[401],"this":[403],"study.":[404]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2024,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2024-01-20T00:00:00"}