{"id":"https://openalex.org/W4390989753","doi":"https://doi.org/10.1111/aos.16038","title":"In\u2010depth study of the mucoadhesive and lubricating properties of Hyalistil SYNFO and other sodium hyaluronate\u2010based eye drops","display_name":"In\u2010depth study of the mucoadhesive and lubricating properties of Hyalistil SYNFO and other sodium hyaluronate\u2010based eye drops","publication_year":2024,"publication_date":"2024-01-01","ids":{"openalex":"https://openalex.org/W4390989753","doi":"https://doi.org/10.1111/aos.16038"},"language":"en","primary_location":{"id":"doi:10.1111/aos.16038","doi":"https://doi.org/10.1111/aos.16038","is_oa":false,"landing_page_url":"https://doi.org/10.1111/aos.16038","pdf_url":null,"source":{"id":"https://openalex.org/S21165490","display_name":"Acta Ophthalmologica","issn_l":"0001-639X","issn":["0001-639X","1755-375X","1755-3768"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Ophthalmologica","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5041041424","display_name":"Ilenia Abbate","orcid":"https://orcid.org/0000-0001-6382-4857","observed_orcids":["https://orcid.org/0000-0001-6382-4857"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ilenia Abbate","raw_affiliation_strings":["SIFI S.p.A., Innovation and Medical Science, Lavinaio-Aci S. Antonio (CT), Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"SIFI S.p.A., Innovation and Medical Science, Lavinaio-Aci S. Antonio (CT), Italy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085569775","display_name":"Angelo Pricoco","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Angelo Pricoco","raw_affiliation_strings":["SIFI S.p.A., Innovation and Medical Science, Lavinaio-Aci S. Antonio (CT), Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"SIFI S.p.A., Innovation and Medical Science, Lavinaio-Aci S. Antonio (CT), Italy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104230868","display_name":"Donato Spina","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Donato Spina","raw_affiliation_strings":["SIFI S.p.A., Innovation and Medical Science, Lavinaio-Aci S. Antonio (CT), Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"SIFI S.p.A., Innovation and Medical Science, Lavinaio-Aci S. Antonio (CT), Italy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071251338","display_name":"Giuseppe De Pasquale","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Giuseppe De Pasquale","raw_affiliation_strings":["SIFI S.p.A., Innovation and Medical Science, Lavinaio-Aci S. Antonio (CT), Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"SIFI S.p.A., Innovation and Medical Science, Lavinaio-Aci S. Antonio (CT), Italy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043570436","display_name":"Cristina Zappulla","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Cristina Zappulla","raw_affiliation_strings":["SIFI S.p.A., Innovation and Medical Science, Lavinaio-Aci S. Antonio (CT), Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"SIFI S.p.A., Innovation and Medical Science, Lavinaio-Aci S. Antonio (CT), Italy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039377376","display_name":"Maria Cristina Curatolo","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Maria Cristina Curatolo","raw_affiliation_strings":["SIFI S.p.A., Innovation and Medical Science, Lavinaio-Aci S. Antonio (CT), Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"SIFI S.p.A., Innovation and Medical Science, Lavinaio-Aci S. Antonio (CT), Italy","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5044361839","display_name":"Santa Viola","orcid":"https://orcid.org/0009-0008-9198-9665","observed_orcids":["https://orcid.org/0009-0008-9198-9665"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Santa Viola","raw_affiliation_strings":["SIFI S.p.A., Innovation and Medical Science, Lavinaio-Aci S. Antonio (CT), Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"SIFI S.p.A., Innovation and Medical Science, Lavinaio-Aci S. Antonio (CT), Italy","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4840,"currency":"USD","value_usd":4840},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"102","issue":"S279","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10997","display_name":"Ocular Surface and Contact Lens","score":0.8769999742507935,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10997","display_name":"Ocular Surface and Contact Lens","score":0.8769999742507935,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.12049999833106995,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11826","display_name":"Ocular Infections and Treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sodium-hyaluronate","display_name":"sodium hyaluronate","score":0.9729999899864197},{"id":"https://openalex.org/keywords/eye-drops","display_name":"eye drops","score":0.8399999737739563},{"id":"https://openalex.org/keywords/dry-eye-disease","display_name":"dry eye","score":0.9509999752044678},{"id":"https://openalex.org/keywords/mucoadhesion","display_name":"mucoadhesion","score":0.9929999709129333},{"id":"https://openalex.org/keywords/xanthan-gum","display_name":"xanthan gum","score":0.9620000123977661},{"id":"https://openalex.org/keywords/osmoprotectants","display_name":"osmoprotectants","score":0.8679999709129333},{"id":"https://openalex.org/keywords/glycine","display_name":"glycine","score":0.8330000042915344},{"id":"https://openalex.org/keywords/betaine","display_name":"betaine","score":0.996999979019165},{"id":"https://openalex.org/keywords/viscoelasticity","display_name":"viscoelasticity","score":0.8040000200271606},{"id":"https://openalex.org/keywords/shear-thinning","display_name":"shear thinning","score":0.6539999842643738},{"id":"https://openalex.org/keywords/zeta-potential","display_name":"zeta potential","score":0.7820000052452087},{"id":"https://openalex.org/keywords/residence-time","display_name":"residence time","score":0.6129999756813049}],"concepts":[{"id":"https://openalex.org/C2780020223","wikidata":"https://www.wikidata.org/wiki/Q25323681","display_name":"Mucoadhesion","level":4,"score":0.7722904086112976},{"id":"https://openalex.org/C86181022","wikidata":"https://www.wikidata.org/wiki/Q196823","display_name":"Zeta potential","level":3,"score":0.5987585783004761},{"id":"https://openalex.org/C179264091","wikidata":"https://www.wikidata.org/wiki/Q410862","display_name":"Mucin","level":2,"score":0.5783095955848694},{"id":"https://openalex.org/C2777917749","wikidata":"https://www.wikidata.org/wiki/Q3143635","display_name":"Sodium hyaluronate","level":2,"score":0.5759467482566833},{"id":"https://openalex.org/C200990466","wikidata":"https://www.wikidata.org/wiki/Q271707","display_name":"Rheology","level":2,"score":0.5640039443969727},{"id":"https://openalex.org/C2780100132","wikidata":"https://www.wikidata.org/wiki/Q410768","display_name":"Xanthan gum","level":3,"score":0.5355273485183716},{"id":"https://openalex.org/C186541917","wikidata":"https://www.wikidata.org/wiki/Q910483","display_name":"Viscoelasticity","level":2,"score":0.5199350714683533},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5040789842605591},{"id":"https://openalex.org/C191717309","wikidata":"https://www.wikidata.org/wiki/Q902458","display_name":"Shear thinning","level":3,"score":0.45486611127853394},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.38890355825424194},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.38177990913391113},{"id":"https://openalex.org/C118487528","wikidata":"https://www.wikidata.org/wiki/Q161437","display_name":"Ophthalmology","level":1,"score":0.3620636463165283},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.23624271154403687},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.16803675889968872},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.15675640106201172},{"id":"https://openalex.org/C521977710","wikidata":"https://www.wikidata.org/wiki/Q81163","display_name":"Polymer","level":2,"score":0.12615638971328735},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.09730756282806396},{"id":"https://openalex.org/C2776634624","wikidata":"https://www.wikidata.org/wiki/Q4914690","display_name":"Bioadhesive","level":3,"score":0.0},{"id":"https://openalex.org/C155672457","wikidata":"https://www.wikidata.org/wiki/Q61231","display_name":"Nanoparticle","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1111/aos.16038","doi":"https://doi.org/10.1111/aos.16038","is_oa":false,"landing_page_url":"https://doi.org/10.1111/aos.16038","pdf_url":null,"source":{"id":"https://openalex.org/S21165490","display_name":"Acta Ophthalmologica","issn_l":"0001-639X","issn":["0001-639X","1755-375X","1755-3768"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Ophthalmologica","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8048999905586243}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2886720986","https://openalex.org/W2502217397","https://openalex.org/W2185742817","https://openalex.org/W2969762263","https://openalex.org/W3204571073","https://openalex.org/W4376620042","https://openalex.org/W2897656515","https://openalex.org/W3198838965","https://openalex.org/W3213037177","https://openalex.org/W2079100014"],"abstract_inverted_index":{"Purpose:":[0],"Several":[1],"sodium":[2],"hyaluronate":[3],"(SH)":[4],"eye":[5,16,23,56,116,281],"drops":[6,24,117,204],"formulations":[7,155],"are":[8],"widely":[9],"used":[10,101],"for":[11],"the":[12,65,104,161,195,202,246,265,271,276],"management":[13],"of":[14,38,48,76,85,107,150,153,160,248,261,273],"dry":[15],"disease":[17],"(DED).":[18],"Hyalistil":[19,49,108,130,166,221,262],"SYNFO":[20,50,109,131,167,263],"is":[21],"an":[22,257],"based":[25],"on":[26,118,216,264],"SH":[27,250],"and":[28,31,34,45,58,78,91,171,180,189,240,251,283],"xanthan":[29,252],"gum":[30],"osmoprotectants":[32],"(glycine":[33],"betaine).":[35],"The":[36,71,125,184,212,237],"aim":[37],"our":[39],"study":[40,215],"was":[41,100,191,227],"to":[42,53,59,63,102,111,144,178,207,224,229,245,256],"evaluate":[43],"viscosity":[44],"mucoadhesion":[46,173],"profiles":[47,127],"with":[51],"respect":[52],"other":[54,112,181],"SH\u2010based":[55,115,182],"drops,":[57],"investigate":[60],"their":[61],"ability":[62],"protect":[64,230],"corneal":[66,120,231,266,284],"surface":[67],"from":[68,234],"dehydration.":[69,235],"Methods:":[70],"physicochemical":[72],"properties,":[73],"in":[74,96,157,197,213],"term":[75],"viscoelastic":[77,134],"mucoadhesive":[79,242],"behaviour,":[80],"were":[81],"evaluated":[82],"by":[83,194,201],"means":[84],"a":[86,133,140,158,169],"rheometer,":[87],"TA\u2010XT2":[88],"texture":[89],"analyzer":[90],"zeta":[92,198],"potential":[93,199],"determination.":[94],"An":[95],"vitro":[97,214],"dehydration":[98,279],"model":[99],"demonstrate":[103],"lubricant":[105],"effect":[106,277],"compared":[110,177,206,223],"commercially":[113],"available":[114],"human":[119],"epithelial":[121,232],"cells":[122,218,233],"(HCE).":[123],"Results:":[124],"rheological":[126],"indicated":[128],"that":[129,165,220],"exhibits":[132],"behaviour":[135],"under":[136],"shear":[137],"strain":[138],"showing":[139],"characteristic":[141],"curve":[142],"owing":[143],"its":[145],"specific":[146],"molecular":[147],"properties.":[148],"Evaluations":[149],"detachment":[151],"force":[152],"tested":[154],"resulting":[156],"strengthening":[159],"mucin\u2010formulation":[162],"interface":[163],"showed":[164],"exhibited":[168],"stronger":[170],"significant":[172],"calculated":[174],"as":[175],"percentage":[176],"mucin":[179,190,208],"products.":[183],"occurring":[185],"interaction":[186],"between":[187],"formulation":[188],"also":[192],"demonstrated":[193,219],"variations":[196],"measured":[200],"mucin\u2010eye":[203],"mixture":[205],"or":[209],"product":[210],"alone.":[211],"HCE":[217],"SYNFO,":[222],"others":[225],"formulation,":[226],"able":[228],"Conclusions:":[236],"pseudoplastic":[238],"profile":[239],"increased":[241],"strength,":[243],"due":[244],"presence":[247],"both":[249],"gum,":[253],"may":[254],"lead":[255],"improved":[258],"residence":[259],"time":[260],"epithelium":[267],"ensuring":[268],"relief":[269],"during":[270],"treatment":[272],"DED.":[274],"Moreover,":[275],"against":[278],"improves":[280],"lubrication":[282],"cell":[285],"protection.":[286]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2024-01-19T00:00:00"}
