{"id":"https://openalex.org/W4390979183","doi":"https://doi.org/10.1111/jop.13508","title":"Ubiquitination, SUMOylation , and NEDDylation related genes serve as prognostic and therapeutic biomarkers for oral squamous cell carcinoma","display_name":"Ubiquitination, SUMOylation , and NEDDylation related genes serve as prognostic and therapeutic biomarkers for oral squamous cell carcinoma","publication_year":2024,"publication_date":"2024-01-17","ids":{"openalex":"https://openalex.org/W4390979183","doi":"https://doi.org/10.1111/jop.13508","pmid":"https://pubmed.ncbi.nlm.nih.gov/38234119"},"language":"en","primary_location":{"id":"doi:10.1111/jop.13508","doi":"https://doi.org/10.1111/jop.13508","is_oa":false,"landing_page_url":"https://doi.org/10.1111/jop.13508","pdf_url":null,"source":{"id":"https://openalex.org/S86809486","display_name":"Journal of Oral Pathology and Medicine","issn_l":"0300-9777","issn":["0300-9777","0904-2512","1600-0714"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Oral Pathology &amp; Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5033673193","display_name":"Shi\u2010Zhou Deng","orcid":"https://orcid.org/0009-0006-7099-1155","observed_orcids":["https://orcid.org/0009-0006-7099-1155"]},"institutions":[{"id":"https://openalex.org/I4210158926","display_name":"Xijing Hospital","ror":"https://ror.org/05cqe9350","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210158926"]},{"id":"https://openalex.org/I9916479","display_name":"Air Force Medical University","ror":"https://ror.org/00ms48f15","country_code":"CN","type":"education","lineage":["https://openalex.org/I9916479"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shi\u2010Zhou Deng","raw_affiliation_strings":["Department of Hepatobiliary Surgery Xi-Jing Hospital, The Fourth Military Medical University Xi'an China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hepatobiliary Surgery Xi-Jing Hospital, The Fourth Military Medical University Xi'an China","institution_ids":["https://openalex.org/I4210158926","https://openalex.org/I9916479"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017149539","display_name":"Xuechen Wu","orcid":"https://orcid.org/0000-0001-7312-5419","observed_orcids":["https://orcid.org/0000-0001-7312-5419"]},"institutions":[{"id":"https://openalex.org/I4210120234","display_name":"Zhongnan Hospital of Wuhan University","ror":"https://ror.org/01v5mqw79","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210120234"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xuechen Wu","raw_affiliation_strings":["Department of Stomatology Zhongnan Hospital of Wuhan University Wuhan China"],"raw_orcid":"https://orcid.org/0000-0001-7312-5419","affiliations":[{"raw_affiliation_string":"Department of Stomatology Zhongnan Hospital of Wuhan University Wuhan China","institution_ids":["https://openalex.org/I4210120234"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108894622","display_name":"Lingshu Kong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lingshu Kong","raw_affiliation_strings":["School of Artificial Intelligence and Automation Huazhong University of Science and Technology Wuhan China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Artificial Intelligence and Automation Huazhong University of Science and Technology Wuhan China","institution_ids":["https://openalex.org/I47720641"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091394591","display_name":"Bo Cheng","orcid":"https://orcid.org/0000-0003-1916-0410","observed_orcids":["https://orcid.org/0000-0003-1916-0410"]},"institutions":[{"id":"https://openalex.org/I4210120234","display_name":"Zhongnan Hospital of Wuhan University","ror":"https://ror.org/01v5mqw79","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210120234"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Bo Cheng","raw_affiliation_strings":["Department of Stomatology Zhongnan Hospital of Wuhan University Wuhan China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Stomatology Zhongnan Hospital of Wuhan University Wuhan China","institution_ids":["https://openalex.org/I4210120234"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101199075","display_name":"Lin Lu Dai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210111998","display_name":"Wuhan No.1 Hospital","ror":"https://ror.org/021ty3131","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210111998"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Lin Dai","raw_affiliation_strings":["Department of Stomatology Wuhan No.1 Hospital Wuhan China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Stomatology Wuhan No.1 Hospital Wuhan China","institution_ids":["https://openalex.org/I4210111998"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5091394591","https://openalex.org/A5101199075"],"corresponding_institution_ids":["https://openalex.org/I4210111998","https://openalex.org/I4210120234"],"apc_list":{"value":4550,"currency":"USD","value_usd":4550},"apc_paid":null,"fwci":0.3317,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.43868335,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":97},"biblio":{"volume":"53","issue":"2","first_page":"114","last_page":"123"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11041","display_name":"Ubiquitin and proteasome pathways","score":0.6187000274658203,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11041","display_name":"Ubiquitin and proteasome pathways","score":0.6187000274658203,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.3125,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11297","display_name":"Ferroptosis and cancer prognosis","score":0.01759999990463257,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/oral-squamous-cell-carcinoma","display_name":"oral squamous cell carcinoma","score":0.9980000257492065},{"id":"https://openalex.org/keywords/ubiquitination","display_name":"ubiquitination","score":0.9940000176429749},{"id":"https://openalex.org/keywords/sumoylation","display_name":"SUMOylation","score":0.9409999847412109},{"id":"https://openalex.org/keywords/neddylation","display_name":"neddylation","score":0.9980000257492065},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.8539999723434448},{"id":"https://openalex.org/keywords/risk-score","display_name":"risk score","score":0.6549999713897705},{"id":"https://openalex.org/keywords/tumor-immune-infiltration","display_name":"tumor immune infiltration","score":0.7639999985694885},{"id":"https://openalex.org/keywords/immune-checkpoint","display_name":"immune checkpoint","score":0.9409999847412109},{"id":"https://openalex.org/keywords/drug-sensitivity","display_name":"drug sensitivity","score":0.8999999761581421},{"id":"https://openalex.org/keywords/docetaxel","display_name":"docetaxel","score":0.7689999938011169},{"id":"https://openalex.org/keywords/doxorubicin","display_name":"doxorubicin","score":0.9980000257492065},{"id":"https://openalex.org/keywords/methotrexate","display_name":"methotrexate","score":0.925000011920929},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.7699999809265137}],"concepts":[{"id":"https://openalex.org/C45005369","wikidata":"https://www.wikidata.org/wiki/Q21115705","display_name":"Neddylation","level":5,"score":0.7530859708786011},{"id":"https://openalex.org/C50382708","wikidata":"https://www.wikidata.org/wiki/Q223218","display_name":"Proportional hazards model","level":2,"score":0.5204637050628662},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5136927962303162},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5003912448883057},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4926803708076477},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4885893762111664},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4569755494594574},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4459899365901947},{"id":"https://openalex.org/C2779231659","wikidata":"https://www.wikidata.org/wiki/Q6953444","display_name":"NEDD8","level":5,"score":0.4424854516983032},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3905988931655884},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.35990267992019653},{"id":"https://openalex.org/C25602115","wikidata":"https://www.wikidata.org/wiki/Q407111","display_name":"Ubiquitin","level":3,"score":0.2850033640861511},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2724975049495697},{"id":"https://openalex.org/C134459356","wikidata":"https://www.wikidata.org/wiki/Q4274835","display_name":"Ubiquitin ligase","level":4,"score":0.14650937914848328},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.081626296043396}],"mesh":[{"descriptor_ui":"D000077195","descriptor_name":"Squamous Cell Carcinoma of Head and Neck","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006258","descriptor_name":"Head and Neck Neoplasms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009062","descriptor_name":"Mouth Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D025801","descriptor_name":"Ubiquitin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D054875","descriptor_name":"Ubiquitination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058207","descriptor_name":"Sumoylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/jop.13508","doi":"https://doi.org/10.1111/jop.13508","is_oa":false,"landing_page_url":"https://doi.org/10.1111/jop.13508","pdf_url":null,"source":{"id":"https://openalex.org/S86809486","display_name":"Journal of Oral Pathology and Medicine","issn_l":"0300-9777","issn":["0300-9777","0904-2512","1600-0714"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Oral Pathology &amp; Medicine","raw_type":"journal-article"},{"id":"pmid:38234119","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38234119","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W1670550591","https://openalex.org/W2016081624","https://openalex.org/W2043904711","https://openalex.org/W2066745745","https://openalex.org/W2072337406","https://openalex.org/W2075294566","https://openalex.org/W2258312727","https://openalex.org/W2557380926","https://openalex.org/W2762079811","https://openalex.org/W2790018833","https://openalex.org/W2806864054","https://openalex.org/W2945765453","https://openalex.org/W2946663348","https://openalex.org/W3004105814","https://openalex.org/W3043246820","https://openalex.org/W3100370100","https://openalex.org/W3111800792","https://openalex.org/W3157033938","https://openalex.org/W3175407259","https://openalex.org/W3176790156","https://openalex.org/W3180993552","https://openalex.org/W3186815806","https://openalex.org/W3200660090","https://openalex.org/W3211600020","https://openalex.org/W4205262307","https://openalex.org/W4221036439","https://openalex.org/W4223494118","https://openalex.org/W4225327431","https://openalex.org/W4290566873"],"related_works":["https://openalex.org/W3176529562","https://openalex.org/W4415651178","https://openalex.org/W4401623412","https://openalex.org/W3180993552","https://openalex.org/W4400319352","https://openalex.org/W3083211453","https://openalex.org/W3155355016","https://openalex.org/W2008828541","https://openalex.org/W7097685913","https://openalex.org/W4413005804"],"abstract_inverted_index":{"BACKGROUND:":[0],"Ubiquitination,":[1],"small":[2],"ubiquitin-related":[3],"modifiers,":[4],"and":[5,37,42,58,83,90,113,121,139,154,166,187,202,217,241],"NEDDylation":[6],"are":[7,196],"now":[8],"found":[9],"to":[10,33,199,219,224],"function":[11,86],"in":[12,18,96,118,129,141,192,234,242],"cancer":[13,21,227],"biology;":[14],"however,":[15],"its":[16],"role":[17,92],"the":[19,35,65,91,130,174,177,180,193],"oral":[20,77,226],"patients":[22,128,155,191,213],"remains":[23],"unclear.":[24],"METHODS:":[25],"A":[26,46,102],"set":[27],"of":[28,40,75,93,104,147,162,170,179],"bioinformatic":[29],"tools":[30],"was":[31,50,99,152,184],"integrated":[32],"analyze":[34],"expression":[36,169],"prognostic":[38,106,145,239],"significance":[39],"ubiquitin":[41],"ubiquitin-like":[43],"(UB/UBL)":[44],"genes.":[45],"UB/UBL-related":[47,94,107,215,230],"risk":[48],"score":[49],"developed":[51],"via":[52],"correlation":[53],"analyses,":[54],"univariate":[55],"Cox":[56,60],"regression,":[57],"multivariate":[59],"regression.":[61],"Nomogram":[62],"analysis":[63],"evaluates":[64],"model's":[66],"prediction":[67],"performance.":[68],"The":[69,144,229],"drug":[70,97],"sensitivity":[71],"analysis,":[72],"immune":[73,164,171],"profiles":[74],"UB/UBL-classified":[76],"squamous":[78],"cell":[79],"carcinoma":[80],"(OSCC)":[81],"patients,":[82],"their":[84],"related":[85],"pathway":[87],"were":[88,109,115],"investigated,":[89],"genes":[95,108,148,216],"therapy":[98],"analyzed.":[100],"RESULTS:":[101],"total":[103],"six":[105],"obtained.":[110],"PSMD3,":[111],"PCGF2,":[112],"H2BC10":[114],"significantly":[116,135],"downregulated":[117],"OSCC":[119,127,212,246],"tissue":[120],"associated":[122,149],"with":[123,150,156,214],"longer":[124],"survival":[125,138,182],"time.":[126],"high-risk":[131,157,194],"group":[132,195],"showed":[133,159],"a":[134,167,208,221],"lower":[136],"overall":[137],"enriched":[140],"cancer-related":[142],"pathways.":[143],"potential":[146],"UB/UBL":[151],"discovered,":[153],"scores":[158],"an":[160],"increase":[161],"protumor":[163],"infiltrates":[165],"high":[168],"checkpoints.":[172],"Moreover,":[173],"area":[175],"under":[176],"curve":[178],"annual":[181],"rate":[183],"0.616,":[185],"0.671,":[186],"0.673,":[188],"respectively.":[189],"Besides,":[190],"more":[197],"sensitive":[198],"docetaxel,":[200],"doxorubicin,":[201],"methotrexate":[203],"therapy.":[204],"CONCLUSIONS:":[205],"We":[206],"construct":[207],"prognosis":[209],"model":[210],"for":[211,245],"try":[218],"find":[220],"new":[222,236],"approach":[223],"treating":[225],"patients.":[228,247],"signature":[231],"is":[232],"helpful":[233],"developing":[235],"tumor":[237],"markers,":[238],"prediction,":[240],"guiding":[243],"treatment":[244]},"counts_by_year":[{"year":2025,"cited_by_count":3}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2024-01-19T00:00:00"}
