{"id":"https://openalex.org/W4390971663","doi":"https://doi.org/10.1371/journal.ppat.1011871","title":"Exposure to Mycobacterium remodels alveolar macrophages and the early innate response to Mycobacterium tuberculosis infection","display_name":"Exposure to Mycobacterium remodels alveolar macrophages and the early innate response to Mycobacterium tuberculosis infection","publication_year":2024,"publication_date":"2024-01-18","ids":{"openalex":"https://openalex.org/W4390971663","doi":"https://doi.org/10.1371/journal.ppat.1011871","pmid":"https://pubmed.ncbi.nlm.nih.gov/38236787"},"language":"en","primary_location":{"id":"doi:10.1371/journal.ppat.1011871","doi":"https://doi.org/10.1371/journal.ppat.1011871","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.ppat.1011871","pdf_url":"https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1011871&type=printable","source":{"id":"https://openalex.org/S2004986","display_name":"PLoS Pathogens","issn_l":"1553-7366","issn":["1553-7366","1553-7374"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Pathogens","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","datacite","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1011871&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5044616877","display_name":"Dat Mai","orcid":"https://orcid.org/0000-0002-3781-8151","observed_orcids":["https://orcid.org/0000-0002-3781-8151"]},"institutions":[{"id":"https://openalex.org/I4405262941","display_name":"Seattle Children's Research Institute","ror":"https://ror.org/00cz0md82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1295499534","https://openalex.org/I4405262941"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dat Mai","raw_affiliation_strings":["Center for Global Infectious Disease Research, Seattle Children\u2019s Research Institute, Seattle, WA 98109","Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, Washington, United States of America"],"raw_orcid":"https://orcid.org/0000-0002-3781-8151","affiliations":[{"raw_affiliation_string":"Center for Global Infectious Disease Research, Seattle Children\u2019s Research Institute, Seattle, WA 98109","institution_ids":["https://openalex.org/I4405262941"]},{"raw_affiliation_string":"Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, Washington, United States of America","institution_ids":["https://openalex.org/I4405262941"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074454517","display_name":"Ana N. Jahn","orcid":"https://orcid.org/0000-0003-4891-8198","observed_orcids":["https://orcid.org/0000-0003-4891-8198"]},"institutions":[{"id":"https://openalex.org/I4405262941","display_name":"Seattle Children's Research Institute","ror":"https://ror.org/00cz0md82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1295499534","https://openalex.org/I4405262941"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ana Jahn","raw_affiliation_strings":["Center for Global Infectious Disease Research, Seattle Children\u2019s Research Institute, Seattle, WA 98109","Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, Washington, United States of America"],"raw_orcid":"https://orcid.org/0000-0003-4891-8198","affiliations":[{"raw_affiliation_string":"Center for Global Infectious Disease Research, Seattle Children\u2019s Research Institute, Seattle, WA 98109","institution_ids":["https://openalex.org/I4405262941"]},{"raw_affiliation_string":"Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, Washington, United States of America","institution_ids":["https://openalex.org/I4405262941"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087362634","display_name":"Tara A. Murray","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405262941","display_name":"Seattle Children's Research Institute","ror":"https://ror.org/00cz0md82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1295499534","https://openalex.org/I4405262941"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tara Murray","raw_affiliation_strings":["Center for Global Infectious Disease Research, Seattle Children\u2019s Research Institute, Seattle, WA 98109","Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, Washington, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Global Infectious Disease Research, Seattle Children\u2019s Research Institute, Seattle, WA 98109","institution_ids":["https://openalex.org/I4405262941"]},{"raw_affiliation_string":"Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, Washington, United States of America","institution_ids":["https://openalex.org/I4405262941"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021863355","display_name":"Michael Morikubo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405262941","display_name":"Seattle Children's Research Institute","ror":"https://ror.org/00cz0md82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1295499534","https://openalex.org/I4405262941"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael Morikubo","raw_affiliation_strings":["Center for Global Infectious Disease Research, Seattle Children\u2019s Research Institute, Seattle, WA 98109","Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, Washington, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Global Infectious Disease Research, Seattle Children\u2019s Research Institute, Seattle, WA 98109","institution_ids":["https://openalex.org/I4405262941"]},{"raw_affiliation_string":"Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, Washington, United States of America","institution_ids":["https://openalex.org/I4405262941"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010116884","display_name":"Pamelia N. Lim","orcid":"https://orcid.org/0000-0002-1905-8785","observed_orcids":["https://orcid.org/0000-0002-1905-8785"]},"institutions":[{"id":"https://openalex.org/I24603500","display_name":"University of Massachusetts Amherst","ror":"https://ror.org/0072zz521","country_code":"US","type":"education","lineage":["https://openalex.org/I24603500"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pamelia N. Lim","raw_affiliation_strings":["Department of Veterinary and Animal Sciences, University of Massachusetts Amherst, Amherst, Massachusetts, United States of America","Molecular and Cellular Biology Graduate Program, University of Massachusetts Amherst, Amherst, Massachusetts, United States of America"],"raw_orcid":"https://orcid.org/0000-0002-1905-8785","affiliations":[{"raw_affiliation_string":"Department of Veterinary and Animal Sciences, University of Massachusetts Amherst, Amherst, Massachusetts, United States of America","institution_ids":["https://openalex.org/I24603500"]},{"raw_affiliation_string":"Molecular and Cellular Biology Graduate Program, University of Massachusetts Amherst, Amherst, Massachusetts, United States of America","institution_ids":["https://openalex.org/I24603500"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062363781","display_name":"Maritza M. Cervantes","orcid":"https://orcid.org/0000-0002-5535-3300","observed_orcids":["https://orcid.org/0000-0002-5535-3300"]},"institutions":[{"id":"https://openalex.org/I24603500","display_name":"University of Massachusetts Amherst","ror":"https://ror.org/0072zz521","country_code":"US","type":"education","lineage":["https://openalex.org/I24603500"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maritza M. Cervantes","raw_affiliation_strings":["Department of Veterinary and Animal Sciences, University of Massachusetts Amherst, Amherst, Massachusetts, United States of America"],"raw_orcid":"https://orcid.org/0000-0002-5535-3300","affiliations":[{"raw_affiliation_string":"Department of Veterinary and Animal Sciences, University of Massachusetts Amherst, Amherst, Massachusetts, United States of America","institution_ids":["https://openalex.org/I24603500"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058342816","display_name":"Linh K. Pham","orcid":"https://orcid.org/0000-0002-0589-0423","observed_orcids":["https://orcid.org/0000-0002-0589-0423"]},"institutions":[{"id":"https://openalex.org/I24603500","display_name":"University of Massachusetts Amherst","ror":"https://ror.org/0072zz521","country_code":"US","type":"education","lineage":["https://openalex.org/I24603500"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Linh K. Pham","raw_affiliation_strings":["Animal Biotechnology and Biomedical Sciences Graduate Program, University of Massachusetts Amherst, Amherst, Massachusetts, United States of America","Department of Veterinary and Animal Sciences, University of Massachusetts Amherst, Amherst, Massachusetts, United States of America"],"raw_orcid":"https://orcid.org/0000-0002-0589-0423","affiliations":[{"raw_affiliation_string":"Animal Biotechnology and Biomedical Sciences Graduate Program, University of Massachusetts Amherst, Amherst, Massachusetts, United States of America","institution_ids":["https://openalex.org/I24603500"]},{"raw_affiliation_string":"Department of Veterinary and Animal Sciences, University of Massachusetts Amherst, Amherst, Massachusetts, United States of America","institution_ids":["https://openalex.org/I24603500"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022749604","display_name":"Johannes Nemeth","orcid":"https://orcid.org/0000-0003-0683-456X","observed_orcids":["https://orcid.org/0000-0003-0683-456X"]},"institutions":[{"id":"https://openalex.org/I202697423","display_name":"University of Zurich","ror":"https://ror.org/02crff812","country_code":"CH","type":"education","lineage":["https://openalex.org/I202697423"]},{"id":"https://openalex.org/I4210100468","display_name":"University Hospital Zurich","ror":"https://ror.org/01462r250","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I4210100468"]},{"id":"https://openalex.org/I4405262941","display_name":"Seattle Children's Research Institute","ror":"https://ror.org/00cz0md82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1295499534","https://openalex.org/I4405262941"]}],"countries":["CH","US"],"is_corresponding":false,"raw_author_name":"Johannes Nemeth","raw_affiliation_strings":["Center for Global Infectious Disease Research, Seattle Children\u2019s Research Institute, Seattle, WA 98109","University Hospital Zurich, University of Zurich, Division of Infectious, Diseases and Hospital Epidemiology, Raemistrasse 100, 8091 Z\u00fcrich, Switzerland","Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, Washington, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Global Infectious Disease Research, Seattle Children\u2019s Research Institute, Seattle, WA 98109","institution_ids":["https://openalex.org/I4405262941"]},{"raw_affiliation_string":"University Hospital Zurich, University of Zurich, Division of Infectious, Diseases and Hospital Epidemiology, Raemistrasse 100, 8091 Z\u00fcrich, Switzerland","institution_ids":["https://openalex.org/I202697423","https://openalex.org/I4210100468"]},{"raw_affiliation_string":"Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, Washington, United States of America","institution_ids":["https://openalex.org/I4405262941"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075715453","display_name":"Kevin B. Urdahl","orcid":"https://orcid.org/0000-0003-0088-1066","observed_orcids":["https://orcid.org/0000-0003-0088-1066"]},"institutions":[{"id":"https://openalex.org/I4405262941","display_name":"Seattle Children's Research Institute","ror":"https://ror.org/00cz0md82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1295499534","https://openalex.org/I4405262941"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kevin Urdahl","raw_affiliation_strings":["Center for Global Infectious Disease Research, Seattle Children\u2019s Research Institute, Seattle, WA 98109","Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, Washington, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Global Infectious Disease Research, Seattle Children\u2019s Research Institute, Seattle, WA 98109","institution_ids":["https://openalex.org/I4405262941"]},{"raw_affiliation_string":"Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, Washington, United States of America","institution_ids":["https://openalex.org/I4405262941"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066147484","display_name":"Alan H. Diercks","orcid":"https://orcid.org/0000-0002-5236-6130","observed_orcids":["https://orcid.org/0000-0002-5236-6130"]},"institutions":[{"id":"https://openalex.org/I4405262941","display_name":"Seattle Children's Research Institute","ror":"https://ror.org/00cz0md82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1295499534","https://openalex.org/I4405262941"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alan H. Diercks","raw_affiliation_strings":["Center for Global Infectious Disease Research, Seattle Children\u2019s Research Institute, Seattle, WA 98109","Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, Washington, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Global Infectious Disease Research, Seattle Children\u2019s Research Institute, Seattle, WA 98109","institution_ids":["https://openalex.org/I4405262941"]},{"raw_affiliation_string":"Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, Washington, United States of America","institution_ids":["https://openalex.org/I4405262941"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063227404","display_name":"Alan A. Aderem","orcid":"https://orcid.org/0000-0003-4031-5499","observed_orcids":["https://orcid.org/0000-0003-4031-5499"]},"institutions":[{"id":"https://openalex.org/I4405262941","display_name":"Seattle Children's Research Institute","ror":"https://ror.org/00cz0md82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1295499534","https://openalex.org/I4405262941"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alan Aderem","raw_affiliation_strings":["Center for Global Infectious Disease Research, Seattle Children\u2019s Research Institute, Seattle, WA 98109","Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, Washington, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Global Infectious Disease Research, Seattle Children\u2019s Research Institute, Seattle, WA 98109","institution_ids":["https://openalex.org/I4405262941"]},{"raw_affiliation_string":"Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, Washington, United States of America","institution_ids":["https://openalex.org/I4405262941"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5045215070","display_name":"Alissa C. Rothchild","orcid":"https://orcid.org/0000-0001-7484-1193","observed_orcids":["https://orcid.org/0000-0001-7484-1193"]},"institutions":[{"id":"https://openalex.org/I24603500","display_name":"University of Massachusetts Amherst","ror":"https://ror.org/0072zz521","country_code":"US","type":"education","lineage":["https://openalex.org/I24603500"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Alissa C. Rothchild","raw_affiliation_strings":["Department of Veterinary and Animal Sciences, University of Massachusetts Amherst, Amherst, MA 01003","Department of Veterinary and Animal Sciences, University of Massachusetts Amherst, Amherst, Massachusetts, United States of America"],"raw_orcid":"https://orcid.org/0000-0001-7484-1193","affiliations":[{"raw_affiliation_string":"Department of Veterinary and Animal Sciences, University of Massachusetts Amherst, Amherst, MA 01003","institution_ids":["https://openalex.org/I24603500"]},{"raw_affiliation_string":"Department of Veterinary and Animal Sciences, University of Massachusetts Amherst, Amherst, Massachusetts, United States of America","institution_ids":["https://openalex.org/I24603500"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5045215070"],"corresponding_institution_ids":["https://openalex.org/I24603500"],"apc_list":{"value":2926,"currency":"USD","value_usd":2926},"apc_paid":{"value":2926,"currency":"USD","value_usd":2926},"fwci":16.7064,"has_fulltext":true,"cited_by_count":54,"citation_normalized_percentile":{"value":0.99587367,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":100},"biblio":{"volume":"20","issue":"1","first_page":"e1011871","last_page":"e1011871"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.9160000085830688,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.9160000085830688,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13410","display_name":"Immune responses and vaccinations","score":0.08229999989271164,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alveolar-macrophages","display_name":"alveolar macrophages","score":0.9710000157356262},{"id":"https://openalex.org/keywords/mycobacterium-tuberculosis","display_name":"Mycobacterium tuberculosis","score":0.9079999923706055},{"id":"https://openalex.org/keywords/coinfection","display_name":"co-infection","score":0.6119999885559082},{"id":"https://openalex.org/keywords/innate-immune-response","display_name":"innate immune response","score":0.7710000276565552},{"id":"https://openalex.org/keywords/interferon-response","display_name":"interferon response","score":0.6880000233650208},{"id":"https://openalex.org/keywords/interferon-stimulated-genes","display_name":"interferon-stimulated genes","score":0.8629999756813049},{"id":"https://openalex.org/keywords/macrophage-plasticity","display_name":"macrophage plasticity","score":0.9319999814033508},{"id":"https://openalex.org/keywords/lung-microenvironment","display_name":"lung microenvironment","score":0.7749999761581421},{"id":"https://openalex.org/keywords/macrophage-activation","display_name":"macrophage activation","score":0.5070000290870667},{"id":"https://openalex.org/keywords/host-directed-therapy","display_name":"host-directed therapy","score":0.492000013589859},{"id":"https://openalex.org/keywords/t-cells","display_name":"T cells","score":0.39899998903274536},{"id":"https://openalex.org/keywords/dendritic-cells","display_name":"dendritic cells","score":1.0}],"concepts":[{"id":"https://openalex.org/C2777975735","wikidata":"https://www.wikidata.org/wiki/Q130971","display_name":"Mycobacterium tuberculosis","level":3,"score":0.7617835998535156},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.6571487784385681},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.6477512121200562},{"id":"https://openalex.org/C26291073","wikidata":"https://www.wikidata.org/wiki/Q310484","display_name":"Ex vivo","level":3,"score":0.6067897081375122},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5846338868141174},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.574704110622406},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.5417234897613525},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.49079903960227966},{"id":"https://openalex.org/C2776178377","wikidata":"https://www.wikidata.org/wiki/Q188269","display_name":"Interferon","level":2,"score":0.4768287241458893},{"id":"https://openalex.org/C2781069245","wikidata":"https://www.wikidata.org/wiki/Q12204","display_name":"Tuberculosis","level":2,"score":0.4618386924266815},{"id":"https://openalex.org/C2778012055","wikidata":"https://www.wikidata.org/wiki/Q448687","display_name":"Alveolar macrophage","level":4,"score":0.4475921094417572},{"id":"https://openalex.org/C2778497218","wikidata":"https://www.wikidata.org/wiki/Q133447","display_name":"Mycobacterium bovis","level":4,"score":0.42213377356529236},{"id":"https://openalex.org/C2779244956","wikidata":"https://www.wikidata.org/wiki/Q184204","display_name":"Macrophage","level":3,"score":0.41437527537345886},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2366950511932373},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.18954849243164062},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.09088072180747986},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007372","descriptor_name":"Interferons","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007372","descriptor_name":"Interferons","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007372","descriptor_name":"Interferons","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007372","descriptor_name":"Interferons","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007372","descriptor_name":"Interferons","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007372","descriptor_name":"Interferons","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007372","descriptor_name":"Interferons","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008070","descriptor_name":"Lipopolysaccharides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008070","descriptor_name":"Lipopolysaccharides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008070","descriptor_name":"Lipopolysaccharides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008070","descriptor_name":"Lipopolysaccharides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008070","descriptor_name":"Lipopolysaccharides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008070","descriptor_name":"Lipopolysaccharides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008070","descriptor_name":"Lipopolysaccharides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009169","descriptor_name":"Mycobacterium tuberculosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009169","descriptor_name":"Mycobacterium tuberculosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009169","descriptor_name":"Mycobacterium tuberculosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009169","descriptor_name":"Mycobacterium tuberculosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009169","descriptor_name":"Mycobacterium tuberculosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009169","descriptor_name":"Mycobacterium tuberculosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009169","descriptor_name":"Mycobacterium tuberculosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014376","descriptor_name":"Tuberculosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014376","descriptor_name":"Tuberculosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014376","descriptor_name":"Tuberculosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014376","descriptor_name":"Tuberculosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014376","descriptor_name":"Tuberculosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014376","descriptor_name":"Tuberculosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014376","descriptor_name":"Tuberculosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016676","descriptor_name":"Macrophages, Alveolar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016676","descriptor_name":"Macrophages, Alveolar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016676","descriptor_name":"Macrophages, Alveolar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016676","descriptor_name":"Macrophages, Alveolar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016676","descriptor_name":"Macrophages, Alveolar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016676","descriptor_name":"Macrophages, Alveolar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016676","descriptor_name":"Macrophages, Alveolar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":9,"locations":[{"id":"doi:10.1371/journal.ppat.1011871","doi":"https://doi.org/10.1371/journal.ppat.1011871","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.ppat.1011871","pdf_url":"https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1011871&type=printable","source":{"id":"https://openalex.org/S2004986","display_name":"PLoS Pathogens","issn_l":"1553-7366","issn":["1553-7366","1553-7374"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Pathogens","raw_type":"journal-article"},{"id":"doi:10.1101/2022.09.19.507309","doi":"https://doi.org/10.1101/2022.09.19.507309","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2022.09.19.507309","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2022/09/19/2022.09.19.507309.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmid:38236787","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38236787","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS pathogens","raw_type":"Journal Article"},{"id":"pmh:oai:www.zora.uzh.ch:258847","doi":null,"is_oa":true,"landing_page_url":"https://www.zora.uzh.ch/id/eprint/258847/1/ZORA_journal_ppat_1011871.pdf","pdf_url":"https://www.zora.uzh.ch/id/eprint/258847/1/ZORA_journal_ppat_1011871.pdf","source":{"id":"https://openalex.org/S4306401281","display_name":"Zurich Open Repository and Archive (University of Zurich)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I202697423","host_organization_name":"University of Zurich","host_organization_lineage":["https://openalex.org/I202697423"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Mai, Dat; Jahn, Ana; Murray, Tara; Morikubo, Michael; Lim, Pamelia N; Cervantes, Maritza M; Pham, Linh K; Nemeth, Johannes; Urdahl, Kevin; Diercks, Alan H; Aderem, Alan; Rothchild, Alissa C (2024). Exposure to Mycobacterium remodels alveolar macrophages and the early innate response to Mycobacterium tuberculosis infection. PLoS Pathogens, 20(1):e1011871.","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10796046","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10796046","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10796046/pdf/ppat.1011871.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Pathog","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:143a4d81cff74ae386b052dafa929cea","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/143a4d81cff74ae386b052dafa929cea","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Pathogens, Vol 20, Iss 1, p e1011871 (2024)","raw_type":"article"},{"id":"pmh:oai:doaj.org/article:a8b5eeaaa33d439183f3c3f68c960c42","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/a8b5eeaaa33d439183f3c3f68c960c42","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Pathogens, Vol 20, Iss 1 (2024)","raw_type":"article"},{"id":"pmh:oai:www.zora.uzh.ch:20.500.14742/218693","doi":null,"is_oa":true,"landing_page_url":"https://www.zora.uzh.ch/handle/20.500.14742/218693","pdf_url":null,"source":{"id":"https://openalex.org/S4306401281","display_name":"Zurich Open Repository and Archive (University of Zurich)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I202697423","host_organization_name":"University of Zurich","host_organization_lineage":["https://openalex.org/I202697423"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Mai, D., Jahn, A., Murray, T., Morikubo, M., Lim, P. N., Cervantes, M. M., Pham, L. K., Nemeth, J., Urdahl, K., Diercks, A. H., Aderem, A., & Rothchild, A. C. (2024). Exposure to Mycobacterium remodels alveolar macrophages and the early innate response to Mycobacterium tuberculosis infection. PLoS Pathogens, 20, e1011871. https://doi.org/10.1371/journal.ppat.1011871","raw_type":"Journal Article"},{"id":"doi:10.5167/uzh-258847","doi":"https://doi.org/10.5167/uzh-258847","is_oa":true,"landing_page_url":"https://doi.org/10.5167/uzh-258847","pdf_url":null,"source":{"id":"https://openalex.org/S4306401281","display_name":"Zurich Open Repository and Archive (University of Zurich)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I202697423","host_organization_name":"University of Zurich","host_organization_lineage":["https://openalex.org/I202697423"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":null,"raw_source_name":null,"raw_type":"JournalArticle"}],"best_oa_location":{"id":"doi:10.1371/journal.ppat.1011871","doi":"https://doi.org/10.1371/journal.ppat.1011871","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.ppat.1011871","pdf_url":"https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1011871&type=printable","source":{"id":"https://openalex.org/S2004986","display_name":"PLoS Pathogens","issn_l":"1553-7366","issn":["1553-7366","1553-7374"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Pathogens","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G3054802909","display_name":null,"funder_award_id":"75N93019C00070","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G406634028","display_name":null,"funder_award_id":"T32-GM135096","funder_id":"https://openalex.org/F4320332749","funder_display_name":"University of Massachusetts Amherst"},{"id":"https://openalex.org/G5001766","display_name":null,"funder_award_id":"T32GM135096","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G5005746390","display_name":"Exploring the role of myeloid cells in persisting Mycobacterium tuberculosis infection in vitro and in vivo","funder_award_id":"200407","funder_id":"https://openalex.org/F4320320924","funder_display_name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung"},{"id":"https://openalex.org/G501624161","display_name":null,"funder_award_id":"R21AI163809","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G5292295948","display_name":null,"funder_award_id":"75N93019C00070","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G5597899865","display_name":"LPS Signaling in Macrophages: The Roll of Toll","funder_award_id":"R01AI032972","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G7908745547","display_name":null,"funder_award_id":"U19AI135976, R01AI032972","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G9000006243","display_name":null,"funder_award_id":"U19AI135976","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000186017","display_name":null,"funder_award_id":"T32GM135096","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000275040","display_name":null,"funder_award_id":"GM135096","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000285987","display_name":null,"funder_award_id":"R21AI163809","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G916267468","display_name":null,"funder_award_id":"U19AI135976","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320311684","display_name":"Seattle Children's Research Institute","ror":"https://ror.org/01njes783"},{"id":"https://openalex.org/F4320312687","display_name":"Children\u2019s Hospital of Wisconsin Research Institute","ror":"https://ror.org/058g1h315"},{"id":"https://openalex.org/F4320320924","display_name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","ror":"https://ror.org/00yjd3n13"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332749","display_name":"University of Massachusetts Amherst","ror":"https://ror.org/0072zz521"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4390971663.pdf","grobid_xml":"https://content.openalex.org/works/W4390971663.grobid-xml"},"referenced_works_count":71,"referenced_works":["https://openalex.org/W1516509805","https://openalex.org/W1553456249","https://openalex.org/W1977099733","https://openalex.org/W2009522156","https://openalex.org/W2010318115","https://openalex.org/W2021340905","https://openalex.org/W2023478821","https://openalex.org/W2062147513","https://openalex.org/W2096441981","https://openalex.org/W2099778380","https://openalex.org/W2100646399","https://openalex.org/W2106682613","https://openalex.org/W2109543073","https://openalex.org/W2114104545","https://openalex.org/W2121499583","https://openalex.org/W2130388912","https://openalex.org/W2130410032","https://openalex.org/W2139984355","https://openalex.org/W2150037895","https://openalex.org/W2151119895","https://openalex.org/W2156261200","https://openalex.org/W2214074259","https://openalex.org/W2259139274","https://openalex.org/W2310773425","https://openalex.org/W2467308937","https://openalex.org/W2566211375","https://openalex.org/W2783642412","https://openalex.org/W2783711120","https://openalex.org/W2789367247","https://openalex.org/W2885821180","https://openalex.org/W2888406753","https://openalex.org/W2889537407","https://openalex.org/W2898375074","https://openalex.org/W2907514116","https://openalex.org/W2916020270","https://openalex.org/W2945315710","https://openalex.org/W2949177718","https://openalex.org/W2950199265","https://openalex.org/W2952038178","https://openalex.org/W2959177108","https://openalex.org/W2966718046","https://openalex.org/W2972255989","https://openalex.org/W2983406765","https://openalex.org/W3000597097","https://openalex.org/W3009920944","https://openalex.org/W3028360800","https://openalex.org/W3035663015","https://openalex.org/W3043097371","https://openalex.org/W3075977357","https://openalex.org/W3090227199","https://openalex.org/W3097788036","https://openalex.org/W3101697142","https://openalex.org/W3113032581","https://openalex.org/W3120857229","https://openalex.org/W3159507093","https://openalex.org/W3165160504","https://openalex.org/W3179787169","https://openalex.org/W3185416158","https://openalex.org/W3196745917","https://openalex.org/W3198857396","https://openalex.org/W3199175189","https://openalex.org/W3201207399","https://openalex.org/W3214890989","https://openalex.org/W4207056927","https://openalex.org/W4210368582","https://openalex.org/W4210830935","https://openalex.org/W4220836245","https://openalex.org/W4220928107","https://openalex.org/W4310588974","https://openalex.org/W4311875158","https://openalex.org/W4384666758"],"related_works":["https://openalex.org/W2133939009","https://openalex.org/W2914484697","https://openalex.org/W4205550511","https://openalex.org/W2602761843","https://openalex.org/W2131249659","https://openalex.org/W4225904185","https://openalex.org/W2559207392","https://openalex.org/W4391788169","https://openalex.org/W2115172975","https://openalex.org/W3121894466"],"abstract_inverted_index":{"Abstract":[0],"Alveolar":[1,379],"macrophages":[2,158,380],"(AMs)":[3],"play":[4,386],"a":[5,36,71,104,124,134,300,421],"critical":[6],"role":[7,389],"during":[8,390],"Mycobacterium":[9,66,306],"tuberculosis":[10,307],"(Mtb)":[11],"infection":[12,74,227,392,426],"as":[13,393],"the":[14,18,43,46,83,115,152,233,267,273,279,284,304,320,352,372,398,401,428,441,456,464,484],"first":[15,402],"cells":[16,181,184,384,404],"in":[17,32,110,228,283,397],"lung":[19,116,234,269,399,458],"to":[20,30,58,108,151,207,221,256,288,339,347,351,405,407,445,482,487],"encounter":[21],"bacteria.":[22],"We":[23,88,435],"previously":[24],"showed":[25],"that":[26,76,90,138,198,211,218,356,385,437,453,463],"AMs":[27,118,129,191,253,282],"initially":[28],"respond":[29,406],"Mtb":[31,73,109,196,210,226,341,391,425,446],"vivo":[33,111,188,229,242],"by":[34,86,112,142,303,326,432],"mounting":[35],"cell-protective,":[37],"rather":[38],"than":[39],"pro-inflammatory":[40,106,168],"response.":[41],"However,":[42,215,365],"plasticity":[44,280],"of":[45,79,156,170,190,252,281,319,323,333,423],"initial":[47,84],"AM":[48,216],"response":[49,85,107,137,355,375,431,444,468,486],"was":[50],"unknown.":[51],"Here,":[52,409],"we":[53,148,410],"characterize":[54],"how":[55,366,412],"previous":[56],"exposure":[57,223,255,338,439],"mycobacterium":[59,160,414],",":[60],"either":[61,340,416],"through":[62,70,292,417,447,472],"subcutaneous":[63],"vaccination":[64,293,419,473],"with":[65,162,192,258],"bovis":[67,344],"(scBCG)":[68],"or":[69,294,342,420,474],"contained":[72,424],"(coMtb)":[75],"mimics":[77],"aspects":[78],"concomitant":[80],"immunity,":[81],"impacts":[82,427],"AMs.":[87,113,171],"find":[89,436],"both":[91,165,261,448],"scBCG":[92,120,199,274],"and":[93,100,102,154,167,182,195,200,209,236,249,264,275,286,400,451,477],"coMtb":[94,131,201,276],"accelerate":[95],"early":[96,429,465],"innate":[97,373,394,430,466],"cell":[98],"activation":[99],"recruitment":[101],"generate":[103,203],"stronger":[105,204],"Within":[114],"environment,":[117],"from":[119,130,266],"vaccinated":[121],"mice":[122,132],"mount":[123],"robust":[125],"interferon-associated":[126,166,205],"response,":[127],"while":[128],"produce":[133],"broader":[135],"inflammatory":[136],"is":[139,376],"not":[140,238],"dominated":[141],"Interferon":[143],"Stimulated":[144],"Genes.":[145],"Using":[146],"scRNAseq,":[147],"identify":[149],"changes":[150,175,263,350,450],"frequency":[153],"phenotype":[155],"airway-resident":[157,179],"following":[159,225,240,254],"exposure,":[161,415],"enrichment":[163],"for":[164,178,260],"populations":[169],"In":[172],"contrast,":[173],"minimal":[174],"were":[176,219],"found":[177],"T":[180],"dendritic":[183],"after":[185],"exposures.":[186],"Ex":[187],"stimulation":[189],"Pam3Cys,":[193],"LPS":[194,208],"reveal":[197,247],"exposures":[202,368],"responses":[206],"are":[212,230,381],"cell-intrinsic":[213,449],"changes.":[214],"profiles":[217],"unique":[220],"each":[222,314],"modality":[224],"dependent":[231],"on":[232,331,455],"environment":[235],"do":[237],"emerge":[239],"ex":[241],"stimulation.":[243],"Overall,":[244],"our":[245],"studies":[246],"significant":[248],"durable":[250],"remodeling":[251],"mycobacterium,":[257],"evidence":[259],"AM-intrinsic":[262],"contributions":[265],"altered":[268,457],"microenvironments.":[270],"Comparisons":[271],"between":[272],"models":[277],"highlight":[278],"airway":[285],"opportunities":[287],"target":[289],"their":[290],"function":[291],"host-directed":[295,475],"therapies.":[296],"Author":[297],"Summary":[298],"Tuberculosis,":[299],"disease":[301],"caused":[302],"bacteria":[305],"(Mtb),":[308],"claims":[309],"around":[310],"1.6":[311],"million":[312],"lives":[313],"year,":[315],"making":[316],"it":[317],"one":[318],"leading":[321],"causes":[322],"death":[324],"worldwide":[325],"an":[327,387],"infectious":[328],"agent.":[329],"Based":[330],"principles":[332],"conventional":[334],"immunological":[335],"memory,":[336],"prior":[337,413,438],"M.":[343],"BCG":[345,418],"leads":[346],"antigen-specific":[348],"long-lasting":[349],"adaptive":[353],"immune":[354,374,395,467],"can":[357],"be":[358,470],"effective":[359],"at":[360],"protecting":[361],"against":[362],"subsequent":[363],"challenge.":[364],"these":[367],"may":[369],"also":[370],"impact":[371],"less":[377],"understood.":[378],"tissue-resident":[382],"myeloid":[383],"important":[388],"sentinels":[396],"host":[403,485],"infection.":[408],"examined":[411],"model":[422],"alveolar":[433,442],"macrophages.":[434],"remodels":[440],"macrophage":[443],"signals":[452],"depend":[454],"environment.":[459],"These":[460],"findings":[461],"suggest":[462],"could":[469,478],"targeted":[471],"therapy":[476],"complement":[479],"existing":[480],"strategies":[481],"enhance":[483],"Mtb.":[488]},"counts_by_year":[{"year":2026,"cited_by_count":18},{"year":2025,"cited_by_count":24},{"year":2024,"cited_by_count":11},{"year":2023,"cited_by_count":1}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2025-10-10T00:00:00"}