{"id":"https://openalex.org/W4390967194","doi":"https://doi.org/10.1200/po.23.00127","title":"Tumor-Informed Circulating Tumor DNA for Minimal Residual Disease Detection in the Management of Colorectal Cancer","display_name":"Tumor-Informed Circulating Tumor DNA for Minimal Residual Disease Detection in the Management of Colorectal Cancer","publication_year":2024,"publication_date":"2024-01-18","ids":{"openalex":"https://openalex.org/W4390967194","doi":"https://doi.org/10.1200/po.23.00127","pmid":"https://pubmed.ncbi.nlm.nih.gov/38237099","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10805428"},"language":"en","primary_location":{"id":"doi:10.1200/po.23.00127","doi":"https://doi.org/10.1200/po.23.00127","is_oa":false,"landing_page_url":"https://doi.org/10.1200/po.23.00127","pdf_url":null,"source":{"id":"https://openalex.org/S4210227748","display_name":"JCO Precision Oncology","issn_l":"2473-4284","issn":["2473-4284"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-20","russia-white-list-2"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JCO Precision Oncology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10805428/pdf/po-8-e2300127.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5045527493","display_name":"Oluwadunni Eunice Emiloju","orcid":"https://orcid.org/0009-0003-1173-7593","observed_orcids":["https://orcid.org/0009-0003-1173-7593","https://orcid.org/0000-0002-6884-4010"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Oluwadunni E. Emiloju","raw_affiliation_strings":["Division of Oncology, Mayo Clinic, Rochester, MN"],"raw_orcid":"https://orcid.org/0009-0003-1173-7593","affiliations":[{"raw_affiliation_string":"Division of Oncology, Mayo Clinic, Rochester, MN","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017352332","display_name":"Michael Harrison Storandt","orcid":"https://orcid.org/0000-0002-1266-7393","observed_orcids":["https://orcid.org/0000-0002-1266-7393"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael Storandt","raw_affiliation_strings":["Department of Medicine, Mayo Clinic, Rochester, MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Mayo Clinic, Rochester, MN","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026163032","display_name":"Tyler Zemla","orcid":"https://orcid.org/0009-0005-2390-3557","observed_orcids":["https://orcid.org/0009-0005-2390-3557"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tyler Zemla","raw_affiliation_strings":["Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041256351","display_name":"Nguyen H. Tran","orcid":"https://orcid.org/0000-0002-6104-6489","observed_orcids":["https://orcid.org/0000-0002-6104-6489"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nguyen Tran","raw_affiliation_strings":["Division of Oncology, Mayo Clinic, Rochester, MN"],"raw_orcid":"https://orcid.org/0000-0002-6104-6489","affiliations":[{"raw_affiliation_string":"Division of Oncology, Mayo Clinic, Rochester, MN","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083871900","display_name":"Krishan R. Jethwa","orcid":"https://orcid.org/0000-0002-7590-558X","observed_orcids":["https://orcid.org/0000-0002-7590-558X"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Krishan Jethwa","raw_affiliation_strings":["Department of Radiation Oncology, Mayo Clinic, Rochester, MN"],"raw_orcid":"https://orcid.org/0000-0002-7590-558X","affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, Mayo Clinic, Rochester, MN","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002142386","display_name":"Amit Mahipal","orcid":"https://orcid.org/0000-0002-1111-8333","observed_orcids":["https://orcid.org/0000-0002-1111-8333"]},"institutions":[{"id":"https://openalex.org/I2799343972","display_name":"University Hospitals of Cleveland","ror":"https://ror.org/0130jk839","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799343972"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amit Mahipal","raw_affiliation_strings":["Department of Hematology and Oncology, University Hospitals, Cleveland, OH"],"raw_orcid":"https://orcid.org/0000-0002-1111-8333","affiliations":[{"raw_affiliation_string":"Department of Hematology and Oncology, University Hospitals, Cleveland, OH","institution_ids":["https://openalex.org/I2799343972"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103003131","display_name":"Jessica L. Mitchell","orcid":"https://orcid.org/0000-0002-7438-6626","observed_orcids":["https://orcid.org/0000-0002-7438-6626"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jessica Mitchell","raw_affiliation_strings":["Department of Medicine, Mayo Clinic, Rochester, MN"],"raw_orcid":"https://orcid.org/0000-0002-7438-6626","affiliations":[{"raw_affiliation_string":"Department of Medicine, Mayo Clinic, Rochester, MN","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047120387","display_name":"Cornelius A. Thiels","orcid":"https://orcid.org/0000-0003-3654-8601","observed_orcids":["https://orcid.org/0000-0003-3654-8601"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cornelius Thiels","raw_affiliation_strings":["Department of Surgery, Mayo Clinic, Rochester, MN"],"raw_orcid":"https://orcid.org/0000-0003-3654-8601","affiliations":[{"raw_affiliation_string":"Department of Surgery, Mayo Clinic, Rochester, MN","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080560489","display_name":"Kellie Leanne Mathis","orcid":"https://orcid.org/0000-0002-2547-5606","observed_orcids":["https://orcid.org/0000-0002-2547-5606"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kellie Mathis","raw_affiliation_strings":["Department of Surgery, Mayo Clinic, Rochester, MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Mayo Clinic, Rochester, MN","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006194799","display_name":"Robert R. McWilliams","orcid":"https://orcid.org/0000-0002-8199-5040","observed_orcids":["https://orcid.org/0000-0002-8199-5040"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert McWilliams","raw_affiliation_strings":["Department of Medicine, Mayo Clinic, Rochester, MN"],"raw_orcid":"https://orcid.org/0000-0002-8199-5040","affiliations":[{"raw_affiliation_string":"Department of Medicine, Mayo Clinic, Rochester, MN","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018405630","display_name":"Joleen Marie Hubbard","orcid":"https://orcid.org/0000-0001-8250-4920","observed_orcids":["https://orcid.org/0000-0001-8250-4920"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joleen Hubbard","raw_affiliation_strings":["Department of Medicine, Mayo Clinic, Rochester, MN"],"raw_orcid":"https://orcid.org/0000-0001-8250-4920","affiliations":[{"raw_affiliation_string":"Department of Medicine, Mayo Clinic, Rochester, MN","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069073626","display_name":"Frank A. Sinicrope","orcid":"https://orcid.org/0000-0002-2907-1000","observed_orcids":["https://orcid.org/0000-0002-2907-1000"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Frank Sinicrope","raw_affiliation_strings":["Department of Medicine, Mayo Clinic, Rochester, MN","Division of Oncology, Mayo Clinic, Rochester, MN"],"raw_orcid":"https://orcid.org/0000-0002-2907-1000","affiliations":[{"raw_affiliation_string":"Department of Medicine, Mayo Clinic, Rochester, MN","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Division of Oncology, Mayo Clinic, Rochester, MN","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049291606","display_name":"Qian Shi","orcid":"https://orcid.org/0000-0002-4640-8832","observed_orcids":["https://orcid.org/0000-0002-4640-8832"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Qian Shi","raw_affiliation_strings":["Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN"],"raw_orcid":"https://orcid.org/0000-0002-4640-8832","affiliations":[{"raw_affiliation_string":"Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101829310","display_name":"Zhaohui Jin","orcid":"https://orcid.org/0000-0001-7844-5833","observed_orcids":["https://orcid.org/0000-0001-7844-5833"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zhaohui Jin","raw_affiliation_strings":["Division of Oncology, Mayo Clinic, Rochester, MN"],"raw_orcid":"https://orcid.org/0000-0001-7844-5833","affiliations":[{"raw_affiliation_string":"Division of Oncology, Mayo Clinic, Rochester, MN","institution_ids":["https://openalex.org/I1330342723"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.1044,"has_fulltext":true,"cited_by_count":15,"citation_normalized_percentile":{"value":0.87276858,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"8","issue":"8","first_page":"e2300127","last_page":"e2300127"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.7148000001907349,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.7148000001907349,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.18479999899864197,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10335","display_name":"Colorectal Cancer Surgical Treatments","score":0.031700000166893005,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/circulating-tumor-dna","display_name":"circulating tumor DNA","score":0.9350000023841858},{"id":"https://openalex.org/keywords/measurable-residual-disease","display_name":"minimal residual disease","score":0.9589999914169312},{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":0.9959999918937683},{"id":"https://openalex.org/keywords/tumor-recurrence","display_name":"tumor recurrence","score":0.4429999887943268},{"id":"https://openalex.org/keywords/liquid-biopsy","display_name":"liquid biopsy","score":0.7160000205039978},{"id":"https://openalex.org/keywords/carcinoembryonic-antigen","display_name":"carcinoembryonic antigen","score":0.8799999952316284},{"id":"https://openalex.org/keywords/clinical-decision-making","display_name":"clinical decision-making","score":0.6110000014305115}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8853606581687927},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.7205305695533752},{"id":"https://openalex.org/C2777387746","wikidata":"https://www.wikidata.org/wiki/Q769706","display_name":"Carcinoembryonic antigen","level":3,"score":0.687474250793457},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.683356523513794},{"id":"https://openalex.org/C146357865","wikidata":"https://www.wikidata.org/wiki/Q1123245","display_name":"Stage (stratigraphy)","level":2,"score":0.6542693972587585},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5702280402183533},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5548045039176941},{"id":"https://openalex.org/C2779823535","wikidata":"https://www.wikidata.org/wiki/Q6865356","display_name":"Minimal residual disease","level":3,"score":0.5304360389709473},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4735007882118225},{"id":"https://openalex.org/C2781335228","wikidata":"https://www.wikidata.org/wiki/Q19596321","display_name":"Circulating tumor DNA","level":3,"score":0.4655471742153168},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.44683319330215454},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.4441562294960022},{"id":"https://openalex.org/C195910791","wikidata":"https://www.wikidata.org/wiki/Q1324077","display_name":"Medical record","level":2,"score":0.4286143183708191},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.3455321788787842},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000073888","descriptor_name":"Cell-Free Nucleic Acids","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000074141","descriptor_name":"Circulating Tumor DNA","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D004273","descriptor_name":"DNA, Neoplasm","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D018365","descriptor_name":"Neoplasm, Residual","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D018365","descriptor_name":"Neoplasm, Residual","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1200/po.23.00127","doi":"https://doi.org/10.1200/po.23.00127","is_oa":false,"landing_page_url":"https://doi.org/10.1200/po.23.00127","pdf_url":null,"source":{"id":"https://openalex.org/S4210227748","display_name":"JCO Precision Oncology","issn_l":"2473-4284","issn":["2473-4284"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-20","russia-white-list-2"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JCO Precision Oncology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10805428","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10805428","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10805428/pdf/po-8-e2300127.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JCO Precis Oncol","raw_type":"Text"},{"id":"pmid:38237099","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38237099","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JCO precision oncology","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:10805428","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10805428","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10805428/pdf/po-8-e2300127.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JCO Precis Oncol","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G9000861174","display_name":"Working to Eliminate Care Disparities in Liver Cancer in Southeast Asian Americans: Transportation and Other Social Determinants of Health.","funder_award_id":"K23MD017217","funder_id":"https://openalex.org/F4320337534","funder_display_name":"National Institute on Minority Health and Health Disparities"}],"funders":[{"id":"https://openalex.org/F4320307758","display_name":"Eli Lilly and Company","ror":"https://ror.org/01qat3289"},{"id":"https://openalex.org/F4320307773","display_name":"GlaxoSmithKline","ror":"https://ror.org/01xsqw823"},{"id":"https://openalex.org/F4320309086","display_name":"Celgene","ror":"https://ror.org/0527yg379"},{"id":"https://openalex.org/F4320332193","display_name":"Genentech","ror":"https://ror.org/04gndp242"},{"id":"https://openalex.org/F4320337534","display_name":"National Institute on Minority Health and Health Disparities","ror":"https://ror.org/0493hgw16"},{"id":"https://openalex.org/F4320338262","display_name":"Daiichi Sankyo Europe","ror":"https://ror.org/01qhj1g70"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4390967194.pdf","grobid_xml":"https://content.openalex.org/works/W4390967194.grobid-xml"},"referenced_works_count":28,"referenced_works":["https://openalex.org/W2084470612","https://openalex.org/W2087225672","https://openalex.org/W2097428152","https://openalex.org/W2100471896","https://openalex.org/W2101815035","https://openalex.org/W2119938514","https://openalex.org/W2138235363","https://openalex.org/W2144326782","https://openalex.org/W2157093199","https://openalex.org/W2460179076","https://openalex.org/W2607200433","https://openalex.org/W2767597469","https://openalex.org/W2899311685","https://openalex.org/W2944044607","https://openalex.org/W2982349045","https://openalex.org/W3131468764","https://openalex.org/W3159598242","https://openalex.org/W3187047625","https://openalex.org/W3200901082","https://openalex.org/W4206046655","https://openalex.org/W4211121451","https://openalex.org/W4220837551","https://openalex.org/W4224884268","https://openalex.org/W4280584035","https://openalex.org/W4281738617","https://openalex.org/W4285492196","https://openalex.org/W4307401860","https://openalex.org/W4315754639"],"related_works":["https://openalex.org/W4317891385","https://openalex.org/W7221075899","https://openalex.org/W4411541138","https://openalex.org/W3088777217","https://openalex.org/W7202073883","https://openalex.org/W3031421676","https://openalex.org/W3030855893","https://openalex.org/W7162651831","https://openalex.org/W7203672983","https://openalex.org/W7128490711"],"abstract_inverted_index":{"PURPOSE:":[0],"Recurrence":[1,84],"after":[2],"curative-intent":[3],"treatment":[4],"occurs":[5],"in":[6,44,48,151,169,172,181,217,229,232,253],"20%-50%":[7],"of":[8,22,37,39,62,65,90,94,163,222,249],"patients":[9,66,108,128,152,186],"with":[10,67,195,204],"stage":[11,130,133,136,140],"II-IV":[12],"colorectal":[13],"cancer":[14],"(CRC),":[15],"underscoring":[16],"the":[17,35,95,106,110,161,237],"need":[18,238],"for":[19,211,239],"early":[20],"detection":[21,213],"minimal":[23],"residual":[24],"disease":[25,156],"(MRD)":[26],"using":[27],"circulating":[28],"tumor":[29],"DNA":[30],"(ctDNA).":[31],"Here,":[32],"we":[33],"examined":[34],"pattern":[36],"use":[38,248],"a":[40,59,170,230],"tumor-informed":[41,74],"ctDNA":[42,75,97,145,200,209,223,250],"assay":[43,76],"CRC":[45,68],"MRD":[46,212,251],"monitoring":[47,210],"routine":[49,246],"clinical":[50,173,218,233,241,247],"practice":[51],"at":[52,71,113],"Mayo":[53],"Clinic,":[54],"Rochester.":[55],"METHODS:":[56],"We":[57],"conducted":[58],"retrospective":[60],"analysis":[61],"health":[63],"records":[64],"who":[69,153],"had":[70,129,154],"least":[72],"one":[73,190],"from":[77],"May":[78],"2019":[79],"through":[80],"July":[81],"1,":[82],"2022.":[83],"was":[85,115],"defined":[86],"as":[87,184],"radiographic":[88],"evidence":[89],"disease.":[91,142],"Descriptive":[92],"characteristics":[93],"cohort,":[96],"results,":[98],"and":[99,121,138,166],"subsequent":[100],"interventions":[101,165],"were":[102,119,123,149,177],"recorded.":[103],"RESULTS:":[104],"Of":[105,143],"120":[107],"included,":[109],"median":[111],"age":[112],"diagnosis":[114],"67":[116],"years,":[117],"46%":[118],"female,":[120],"94%":[122],"White.":[124],"At":[125],"diagnosis,":[126],"10":[127],"I,":[131],"23":[132],"II,":[134],"60":[135],"III,":[137],"25":[139],"IV":[141],"476":[144],"assays":[146,224],"performed,":[147],"70%":[148],"performed":[150,225],"recurrent":[155],"most":[157],"commonly":[158],"to":[159,244],"monitor":[160],"effectiveness":[162],"therapeutic":[164],"16%":[167],"resulted":[168],"change":[171,231],"decision":[174],"making.":[175],"There":[176],"110":[178],"recurrences":[179],"identified":[180],"62":[182],"patients,":[183],"some":[185],"experienced":[187],"more":[188],"than":[189],"recurrence":[191],"over":[192],"time.":[193],"Compared":[194],"serum":[196],"carcinoembryonic":[197],"antigen":[198],"levels,":[199],"results":[201],"correlated":[202],"better":[203],"radiologic":[205],"imaging.":[206],"CONCLUSION:":[207],"Routine":[208],"has":[214],"been":[215],"adopted":[216],"practice;":[219],"however,":[220],"84%":[221],"did":[226],"not":[227],"result":[228],"management.":[234],"This":[235],"suggests":[236],"further":[240],"research":[242],"data":[243],"guide":[245],"testing":[252],"CRC.":[254]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2024-01-19T00:00:00"}