{"id":"https://openalex.org/W4390948824","doi":"https://doi.org/10.1016/j.drup.2024.101054","title":"Inhibition of SIRT7 overcomes sorafenib acquired resistance by suppressing ERK1/2 phosphorylation via the DDX3X-mediated NLRP3 inflammasome in hepatocellular carcinoma","display_name":"Inhibition of SIRT7 overcomes sorafenib acquired resistance by suppressing ERK1/2 phosphorylation via the DDX3X-mediated NLRP3 inflammasome in hepatocellular carcinoma","publication_year":2024,"publication_date":"2024-01-17","ids":{"openalex":"https://openalex.org/W4390948824","doi":"https://doi.org/10.1016/j.drup.2024.101054","pmid":"https://pubmed.ncbi.nlm.nih.gov/38277756","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10935544"},"language":"en","primary_location":{"id":"doi:10.1016/j.drup.2024.101054","doi":"https://doi.org/10.1016/j.drup.2024.101054","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.drup.2024.101054","pdf_url":"https://ars.els-cdn.com/content/image/1-s2.0-S1368764624000128-ga1_lrg.jpg","source":{"id":"https://openalex.org/S47159833","display_name":"Drug Resistance Updates","issn_l":"1368-7646","issn":["1368-7646","1532-2084"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug Resistance Updates","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://ars.els-cdn.com/content/image/1-s2.0-S1368764624000128-ga1_lrg.jpg","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100653825","display_name":"Yuna Kim","orcid":"https://orcid.org/0000-0002-9190-0340","observed_orcids":["https://orcid.org/0000-0002-9190-0340"]},"institutions":[{"id":"https://openalex.org/I4921948","display_name":"Pusan National University","ror":"https://ror.org/01an57a31","country_code":"KR","type":"education","lineage":["https://openalex.org/I4921948"]},{"id":"https://openalex.org/I848706","display_name":"Sungkyunkwan University","ror":"https://ror.org/04q78tk20","country_code":"KR","type":"education","lineage":["https://openalex.org/I848706"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Yuna Kim","raw_affiliation_strings":["Department of Anatomy, School of Medicine, Pusan National University, Yangsan, Republic of Korea; Department of Biomedical Informatics, School of Medicine, Pusan National University, Yangsan, Republic of Korea","Department of Molecular Cell Biology, Sungkyunkwan University School of Medicine, Suwon, Republic of Korea. Electronic address: yuna716@skku.edu","Department of Molecular Cell Biology, Sungkyunkwan University School of Medicine, Suwon, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy, School of Medicine, Pusan National University, Yangsan, Republic of Korea; Department of Biomedical Informatics, School of Medicine, Pusan National University, Yangsan, Republic of Korea","institution_ids":["https://openalex.org/I4921948"]},{"raw_affiliation_string":"Department of Molecular Cell Biology, Sungkyunkwan University School of Medicine, Suwon, Republic of Korea. Electronic address: yuna716@skku.edu","institution_ids":["https://openalex.org/I848706"]},{"raw_affiliation_string":"Department of Molecular Cell Biology, Sungkyunkwan University School of Medicine, Suwon, Republic of Korea","institution_ids":["https://openalex.org/I848706"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112475612","display_name":"Kwan\u2010Young Jung","orcid":"https://orcid.org/0000-0002-5631-8814","observed_orcids":["https://orcid.org/0000-0002-5631-8814"]},"institutions":[{"id":"https://openalex.org/I4210151417","display_name":"Korea Research Institute of Chemical Technology","ror":"https://ror.org/043k4kk20","country_code":"KR","type":"facility","lineage":["https://openalex.org/I4210151417"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Kwan-Young Jung","raw_affiliation_strings":["Therapeutics & Biotechnology Division, Korea Research Institute of Chemical Technology, Daejeon, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Therapeutics & Biotechnology Division, Korea Research Institute of Chemical Technology, Daejeon, Republic of Korea","institution_ids":["https://openalex.org/I4210151417"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058349680","display_name":"Yun Hak Kim","orcid":"https://orcid.org/0000-0002-9796-8266","observed_orcids":["https://orcid.org/0000-0002-9796-8266"]},"institutions":[{"id":"https://openalex.org/I4921948","display_name":"Pusan National University","ror":"https://ror.org/01an57a31","country_code":"KR","type":"education","lineage":["https://openalex.org/I4921948"]},{"id":"https://openalex.org/I848706","display_name":"Sungkyunkwan University","ror":"https://ror.org/04q78tk20","country_code":"KR","type":"education","lineage":["https://openalex.org/I848706"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Yun Hak Kim","raw_affiliation_strings":["Department of Anatomy, School of Medicine, Pusan National University, Yangsan, Republic of Korea; Department of Biomedical Informatics, School of Medicine, Pusan National University, Yangsan, Republic of Korea","Department of Molecular Cell Biology, Sungkyunkwan University School of Medicine, Suwon, Republic of Korea. Electronic address: yuna716@skku.edu","Department of Anatomy, School of Medicine, Pusan National University, Yangsan, Republic of Korea","Department of Biomedical Informatics"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy, School of Medicine, Pusan National University, Yangsan, Republic of Korea; Department of Biomedical Informatics, School of Medicine, Pusan National University, Yangsan, Republic of Korea","institution_ids":["https://openalex.org/I4921948"]},{"raw_affiliation_string":"Department of Molecular Cell Biology, Sungkyunkwan University School of Medicine, Suwon, Republic of Korea. Electronic address: yuna716@skku.edu","institution_ids":["https://openalex.org/I848706"]},{"raw_affiliation_string":"Department of Anatomy, School of Medicine, Pusan National University, Yangsan, Republic of Korea","institution_ids":["https://openalex.org/I4921948"]},{"raw_affiliation_string":"Department of Biomedical Informatics","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Pan Xu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I5124864","display_name":"\u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne","ror":"https://ror.org/02s376052","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I5124864"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Pan Xu","raw_affiliation_strings":["Laboratory of Integrative Systems Physiology, Institute of Bioengineering, Ecole Polytechnique Federale de Lausanne, Lausanne, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Integrative Systems Physiology, Institute of Bioengineering, Ecole Polytechnique Federale de Lausanne, Lausanne, Switzerland","institution_ids":["https://openalex.org/I5124864"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056262952","display_name":"Baeki E. Kang","orcid":"https://orcid.org/0000-0002-7747-404X","observed_orcids":["https://orcid.org/0000-0002-7747-404X"]},"institutions":[{"id":"https://openalex.org/I848706","display_name":"Sungkyunkwan University","ror":"https://ror.org/04q78tk20","country_code":"KR","type":"education","lineage":["https://openalex.org/I848706"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Baeki E. Kang","raw_affiliation_strings":["Department of Molecular Cell Biology, Sungkyunkwan University School of Medicine, Suwon, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Cell Biology, Sungkyunkwan University School of Medicine, Suwon, Republic of Korea","institution_ids":["https://openalex.org/I848706"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048909928","display_name":"Yunju Jo","orcid":"https://orcid.org/0000-0002-6305-3324","observed_orcids":["https://orcid.org/0000-0002-6305-3324"]},"institutions":[{"id":"https://openalex.org/I39534123","display_name":"Gwangju Institute of Science and Technology","ror":"https://ror.org/024kbgz78","country_code":"KR","type":"education","lineage":["https://openalex.org/I39534123"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Yunju Jo","raw_affiliation_strings":["Department of Biomedical Science and Engineering, Gwangju Institute of Science and Technology, Gwangju, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Science and Engineering, Gwangju Institute of Science and Technology, Gwangju, Republic of Korea","institution_ids":["https://openalex.org/I39534123"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072489422","display_name":"Navin Pandit","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210151417","display_name":"Korea Research Institute of Chemical Technology","ror":"https://ror.org/043k4kk20","country_code":"KR","type":"facility","lineage":["https://openalex.org/I4210151417"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Navin Pandit","raw_affiliation_strings":["Therapeutics & Biotechnology Division, Korea Research Institute of Chemical Technology, Daejeon, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Therapeutics & Biotechnology Division, Korea Research Institute of Chemical Technology, Daejeon, Republic of Korea","institution_ids":["https://openalex.org/I4210151417"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006553006","display_name":"Jeongho Kwon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I848706","display_name":"Sungkyunkwan University","ror":"https://ror.org/04q78tk20","country_code":"KR","type":"education","lineage":["https://openalex.org/I848706"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jeongho Kwon","raw_affiliation_strings":["Department of Molecular Cell Biology, Sungkyunkwan University School of Medicine, Suwon, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Cell Biology, Sungkyunkwan University School of Medicine, Suwon, Republic of Korea","institution_ids":["https://openalex.org/I848706"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028737784","display_name":"Karim Gariani","orcid":"https://orcid.org/0000-0001-8089-4785","observed_orcids":["https://orcid.org/0000-0001-8089-4785"]},"institutions":[{"id":"https://openalex.org/I4210106256","display_name":"University Hospital of Geneva","ror":"https://ror.org/01m1pv723","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I4210106256"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Karim Gariani","raw_affiliation_strings":["Service of Endocrinology, Diabetes, Nutrition and Therapeutic Patient Education, Geneva University Hospitals, Geneva, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Service of Endocrinology, Diabetes, Nutrition and Therapeutic Patient Education, Geneva University Hospitals, Geneva, Switzerland","institution_ids":["https://openalex.org/I4210106256"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013588739","display_name":"Joanna Gariani","orcid":"https://orcid.org/0000-0002-8905-5838","observed_orcids":["https://orcid.org/0000-0002-8905-5838"]},"institutions":[{"id":"https://openalex.org/I4210121971","display_name":"Hirslanden Clinique des Grangettes","ror":"https://ror.org/035a07q19","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I4210110334","https://openalex.org/I4210121971"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Joanna Gariani","raw_affiliation_strings":["Department of radiology, Hirslanden Grangettes Clinic, Geneva, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of radiology, Hirslanden Grangettes Clinic, Geneva, Switzerland","institution_ids":["https://openalex.org/I4210121971"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045394429","display_name":"Junguee Lee","orcid":"https://orcid.org/0000-0002-1477-1418","observed_orcids":["https://orcid.org/0000-0002-1477-1418"]},"institutions":[{"id":"https://openalex.org/I4210111267","display_name":"The Catholic University of Korea Daejeon St. Mary's Hospital","ror":"https://ror.org/01tck1990","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I4210111267","https://openalex.org/I4405260414","https://openalex.org/I87111246"]},{"id":"https://openalex.org/I87111246","display_name":"Catholic University of Korea","ror":"https://ror.org/01fpnj063","country_code":"KR","type":"education","lineage":["https://openalex.org/I87111246"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Junguee Lee","raw_affiliation_strings":["Department of Pathology, Daejeon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Daejeon, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Daejeon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Daejeon, Republic of Korea","institution_ids":["https://openalex.org/I4210111267","https://openalex.org/I87111246"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040939282","display_name":"Jef Verbeek","orcid":"https://orcid.org/0000-0002-1549-8003","observed_orcids":["https://orcid.org/0000-0002-1549-8003"]},"institutions":[{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Jef Verbeek","raw_affiliation_strings":["Laboratory of Hepatology, Department of Chronic Diseases and Metabolism (CHROMETA), KU Leuven, Belgium; Department of Gastroenterology and Hepatology, University Hospitals KU Leuven, Leuven, Belgium","Department of Gastroenterology and Hepatology, University Hospitals KU Leuven, Leuven, Belgium","Laboratory of Hepatology, Department of Chronic Diseases and Metabolism (CHROMETA), KU Leuven, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Hepatology, Department of Chronic Diseases and Metabolism (CHROMETA), KU Leuven, Belgium; Department of Gastroenterology and Hepatology, University Hospitals KU Leuven, Leuven, Belgium","institution_ids":["https://openalex.org/I99464096"]},{"raw_affiliation_string":"Department of Gastroenterology and Hepatology, University Hospitals KU Leuven, Leuven, Belgium","institution_ids":["https://openalex.org/I99464096"]},{"raw_affiliation_string":"Laboratory of Hepatology, Department of Chronic Diseases and Metabolism (CHROMETA), KU Leuven, Belgium","institution_ids":["https://openalex.org/I99464096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081771012","display_name":"Seungyoon Nam","orcid":"https://orcid.org/0000-0002-0966-7915","observed_orcids":["https://orcid.org/0000-0002-0966-7915"]},"institutions":[{"id":"https://openalex.org/I12832649","display_name":"Gachon University","ror":"https://ror.org/03ryywt80","country_code":"KR","type":"education","lineage":["https://openalex.org/I12832649"]},{"id":"https://openalex.org/I4210088426","display_name":"Gachon University Gil Medical Center","ror":"https://ror.org/005nteb15","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I12832649","https://openalex.org/I4210088426"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Seungyoon Nam","raw_affiliation_strings":["Department of Genome Medicine and Science, AI Convergence Center for Medical Science, Gachon Institute of Genome Medicine and Science, Gachon University Gil Medical Center, Gachon University College of Medicine, Incheon, Republic of Korea; Department of Health Sciences and Technology, Gachon Advanced Institute for Health Sciences and Technology (GAIHST), Republic of Korea","Department of Genome Medicine and Science, AI Convergence Center for Medical Science, Gachon Institute of Genome Medicine and Science, Gachon University Gil Medical Center, Gachon University College of Medicine, Incheon, Republic of Korea","Department of Health Sciences and Technology, Gachon Advanced Institute for Health Sciences and Technology (GAIHST)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genome Medicine and Science, AI Convergence Center for Medical Science, Gachon Institute of Genome Medicine and Science, Gachon University Gil Medical Center, Gachon University College of Medicine, Incheon, Republic of Korea; Department of Health Sciences and Technology, Gachon Advanced Institute for Health Sciences and Technology (GAIHST), Republic of Korea","institution_ids":["https://openalex.org/I4210088426"]},{"raw_affiliation_string":"Department of Genome Medicine and Science, AI Convergence Center for Medical Science, Gachon Institute of Genome Medicine and Science, Gachon University Gil Medical Center, Gachon University College of Medicine, Incheon, Republic of Korea","institution_ids":["https://openalex.org/I4210088426"]},{"raw_affiliation_string":"Department of Health Sciences and Technology, Gachon Advanced Institute for Health Sciences and Technology (GAIHST)","institution_ids":["https://openalex.org/I12832649"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043231970","display_name":"Sung\u2010Jin Bae","orcid":"https://orcid.org/0000-0001-8975-0876","observed_orcids":["https://orcid.org/0000-0001-8975-0876"]},"institutions":[{"id":"https://openalex.org/I90735388","display_name":"Kosin University","ror":"https://ror.org/024b57v39","country_code":"KR","type":"education","lineage":["https://openalex.org/I90735388"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Sung-Jin Bae","raw_affiliation_strings":["Department of Molecular Biology and Immunology, Kosin University College of Medicine, Busan, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology and Immunology, Kosin University College of Medicine, Busan, Republic of Korea","institution_ids":["https://openalex.org/I90735388"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041269113","display_name":"Ki\u2010Tae Ha","orcid":"https://orcid.org/0000-0001-6283-0171","observed_orcids":["https://orcid.org/0000-0001-6283-0171"]},"institutions":[{"id":"https://openalex.org/I4921948","display_name":"Pusan National University","ror":"https://ror.org/01an57a31","country_code":"KR","type":"education","lineage":["https://openalex.org/I4921948"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Ki-Tae Ha","raw_affiliation_strings":["Department of Korean Medical Science, Pusan National University School of Korean Medicine, Yangsan, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Korean Medical Science, Pusan National University School of Korean Medicine, Yangsan, Republic of Korea","institution_ids":["https://openalex.org/I4921948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031789193","display_name":"Hyon\u2010Seung Yi","orcid":"https://orcid.org/0000-0002-3767-1954","observed_orcids":["https://orcid.org/0000-0002-3767-1954"]},"institutions":[{"id":"https://openalex.org/I196345858","display_name":"Chungnam National University","ror":"https://ror.org/0227as991","country_code":"KR","type":"education","lineage":["https://openalex.org/I196345858"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Hyon-Seung Yi","raw_affiliation_strings":["Laboratory of Endocrinology and Immune System, Chungnam National University School of Medicine, Daejeon, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Endocrinology and Immune System, Chungnam National University School of Medicine, Daejeon, Republic of Korea","institution_ids":["https://openalex.org/I196345858"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074131405","display_name":"Minho Shong","orcid":"https://orcid.org/0000-0002-0247-7115","observed_orcids":["https://orcid.org/0000-0002-0247-7115"]},"institutions":[{"id":"https://openalex.org/I196345858","display_name":"Chungnam National University","ror":"https://ror.org/0227as991","country_code":"KR","type":"education","lineage":["https://openalex.org/I196345858"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Minho Shong","raw_affiliation_strings":["Research Center for Endocrine and Metabolic Diseases, Chungnam National University School of Medicine, Daejeon, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Center for Endocrine and Metabolic Diseases, Chungnam National University School of Medicine, Daejeon, Republic of Korea","institution_ids":["https://openalex.org/I196345858"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013290027","display_name":"Kyun\u2010Hwan Kim","orcid":"https://orcid.org/0000-0001-5266-072X","observed_orcids":["https://orcid.org/0000-0001-5266-072X"]},"institutions":[{"id":"https://openalex.org/I4210151417","display_name":"Korea Research Institute of Chemical Technology","ror":"https://ror.org/043k4kk20","country_code":"KR","type":"facility","lineage":["https://openalex.org/I4210151417"]},{"id":"https://openalex.org/I848706","display_name":"Sungkyunkwan University","ror":"https://ror.org/04q78tk20","country_code":"KR","type":"education","lineage":["https://openalex.org/I848706"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Kyun-Hwan Kim","raw_affiliation_strings":["Department of Molecular Cell Biology, Sungkyunkwan University School of Medicine, Suwon, Republic of Korea","Therapeutics & Biotechnology Division, Korea Research Institute of Chemical Technology, Daejeon, Republic of Korea. Electronic address: kkrok@krict.re.kr"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Cell Biology, Sungkyunkwan University School of Medicine, Suwon, Republic of Korea","institution_ids":["https://openalex.org/I848706"]},{"raw_affiliation_string":"Therapeutics & Biotechnology Division, Korea Research Institute of Chemical Technology, Daejeon, Republic of Korea. Electronic address: kkrok@krict.re.kr","institution_ids":["https://openalex.org/I4210151417"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083233378","display_name":"Doyoun Kim","orcid":"https://orcid.org/0000-0002-6036-8996","observed_orcids":["https://orcid.org/0000-0002-6036-8996"]},"institutions":[{"id":"https://openalex.org/I4210151417","display_name":"Korea Research Institute of Chemical Technology","ror":"https://ror.org/043k4kk20","country_code":"KR","type":"facility","lineage":["https://openalex.org/I4210151417"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Doyoun Kim","raw_affiliation_strings":["Therapeutics & Biotechnology Division, Korea Research Institute of Chemical Technology, Daejeon, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Therapeutics & Biotechnology Division, Korea Research Institute of Chemical Technology, Daejeon, Republic of Korea","institution_ids":["https://openalex.org/I4210151417"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111965851","display_name":"Hee Jung Jung","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210151417","display_name":"Korea Research Institute of Chemical Technology","ror":"https://ror.org/043k4kk20","country_code":"KR","type":"facility","lineage":["https://openalex.org/I4210151417"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Hee Jung Jung","raw_affiliation_strings":["Therapeutics & Biotechnology Division, Korea Research Institute of Chemical Technology, Daejeon, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Therapeutics & Biotechnology Division, Korea Research Institute of Chemical Technology, Daejeon, Republic of Korea","institution_ids":["https://openalex.org/I4210151417"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Chang-Woo Lee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210111267","display_name":"The Catholic University of Korea Daejeon St. Mary's Hospital","ror":"https://ror.org/01tck1990","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I4210111267","https://openalex.org/I4405260414","https://openalex.org/I87111246"]},{"id":"https://openalex.org/I848706","display_name":"Sungkyunkwan University","ror":"https://ror.org/04q78tk20","country_code":"KR","type":"education","lineage":["https://openalex.org/I848706"]},{"id":"https://openalex.org/I87111246","display_name":"Catholic University of Korea","ror":"https://ror.org/01fpnj063","country_code":"KR","type":"education","lineage":["https://openalex.org/I87111246"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Chang-Woo Lee","raw_affiliation_strings":["Department of Molecular Cell Biology, Sungkyunkwan University School of Medicine, Suwon, Republic of Korea","Department of Pathology, Daejeon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Daejeon, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Cell Biology, Sungkyunkwan University School of Medicine, Suwon, Republic of Korea","institution_ids":["https://openalex.org/I848706"]},{"raw_affiliation_string":"Department of Pathology, Daejeon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Daejeon, Republic of Korea","institution_ids":["https://openalex.org/I4210111267","https://openalex.org/I87111246"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103102735","display_name":"Kwang Rok Kim","orcid":"https://orcid.org/0000-0002-1401-8418","observed_orcids":["https://orcid.org/0000-0002-1401-8418"]},"institutions":[{"id":"https://openalex.org/I4210151417","display_name":"Korea Research Institute of Chemical Technology","ror":"https://ror.org/043k4kk20","country_code":"KR","type":"facility","lineage":["https://openalex.org/I4210151417"]},{"id":"https://openalex.org/I848706","display_name":"Sungkyunkwan University","ror":"https://ror.org/04q78tk20","country_code":"KR","type":"education","lineage":["https://openalex.org/I848706"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Kwang Rok Kim","raw_affiliation_strings":["Department of Molecular Cell Biology, Sungkyunkwan University School of Medicine, Suwon, Republic of Korea","Therapeutics & Biotechnology Division, Korea Research Institute of Chemical Technology, Daejeon, Republic of Korea. Electronic address: kkrok@krict.re.kr","Therapeutics & Biotechnology Division, Korea Research Institute of Chemical Technology, Daejeon, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Cell Biology, Sungkyunkwan University School of Medicine, Suwon, Republic of Korea","institution_ids":["https://openalex.org/I848706"]},{"raw_affiliation_string":"Therapeutics & Biotechnology Division, Korea Research Institute of Chemical Technology, Daejeon, Republic of Korea. Electronic address: kkrok@krict.re.kr","institution_ids":["https://openalex.org/I4210151417"]},{"raw_affiliation_string":"Therapeutics & Biotechnology Division, Korea Research Institute of Chemical Technology, Daejeon, Republic of Korea","institution_ids":["https://openalex.org/I4210151417"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033554852","display_name":"Kristina Schoonjans","orcid":"https://orcid.org/0000-0003-1247-4265","observed_orcids":["https://orcid.org/0000-0003-1247-4265"]},"institutions":[{"id":"https://openalex.org/I5124864","display_name":"\u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne","ror":"https://ror.org/02s376052","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I5124864"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Kristina Schoonjans","raw_affiliation_strings":["Laboratory of Integrative Systems Physiology, Institute of Bioengineering, Ecole Polytechnique Federale de Lausanne, Lausanne, Switzerland. Electronic address: kristina.schoonjans@epfl.ch","Laboratory of Integrative Systems Physiology, Institute of Bioengineering, Ecole Polytechnique Federale de Lausanne, Lausanne, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Integrative Systems Physiology, Institute of Bioengineering, Ecole Polytechnique Federale de Lausanne, Lausanne, Switzerland. Electronic address: kristina.schoonjans@epfl.ch","institution_ids":["https://openalex.org/I5124864"]},{"raw_affiliation_string":"Laboratory of Integrative Systems Physiology, Institute of Bioengineering, Ecole Polytechnique Federale de Lausanne, Lausanne, Switzerland","institution_ids":["https://openalex.org/I5124864"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003154600","display_name":"Johan H. Auwerx","orcid":"https://orcid.org/0000-0002-5065-5393","observed_orcids":["https://orcid.org/0000-0002-5065-5393"]},"institutions":[{"id":"https://openalex.org/I5124864","display_name":"\u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne","ror":"https://ror.org/02s376052","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I5124864"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Johan Auwerx","raw_affiliation_strings":["Laboratory of Integrative Systems Physiology, Institute of Bioengineering, Ecole Polytechnique Federale de Lausanne, Lausanne, Switzerland. Electronic address: admin.auwerx@epfl.ch","Laboratory of Integrative Systems Physiology, Institute of Bioengineering, Ecole Polytechnique Federale de Lausanne, Lausanne, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Integrative Systems Physiology, Institute of Bioengineering, Ecole Polytechnique Federale de Lausanne, Lausanne, Switzerland. Electronic address: admin.auwerx@epfl.ch","institution_ids":["https://openalex.org/I5124864"]},{"raw_affiliation_string":"Laboratory of Integrative Systems Physiology, Institute of Bioengineering, Ecole Polytechnique Federale de Lausanne, Lausanne, Switzerland","institution_ids":["https://openalex.org/I5124864"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5088404150","display_name":"Dongryeol Ryu","orcid":"https://orcid.org/0000-0001-5905-6760","observed_orcids":["https://orcid.org/0000-0001-5905-6760"]},"institutions":[{"id":"https://openalex.org/I39534123","display_name":"Gwangju Institute of Science and Technology","ror":"https://ror.org/024kbgz78","country_code":"KR","type":"education","lineage":["https://openalex.org/I39534123"]},{"id":"https://openalex.org/I848706","display_name":"Sungkyunkwan University","ror":"https://ror.org/04q78tk20","country_code":"KR","type":"education","lineage":["https://openalex.org/I848706"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Dongryeol Ryu","raw_affiliation_strings":["Department of Molecular Cell Biology, Sungkyunkwan University School of Medicine, Suwon, Republic of Korea; Department of Biomedical Science and Engineering, Gwangju Institute of Science and Technology, Gwangju, Republic of Korea. Electronic address: dryu@gist.ac.kr","Department of Biomedical Science and Engineering, Gwangju Institute of Science and Technology, Gwangju, Republic of Korea","Department of Molecular Cell Biology, Sungkyunkwan University School of Medicine, Suwon, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Cell Biology, Sungkyunkwan University School of Medicine, Suwon, Republic of Korea; Department of Biomedical Science and Engineering, Gwangju Institute of Science and Technology, Gwangju, Republic of Korea. Electronic address: dryu@gist.ac.kr","institution_ids":["https://openalex.org/I39534123","https://openalex.org/I848706"]},{"raw_affiliation_string":"Department of Biomedical Science and Engineering, Gwangju Institute of Science and Technology, Gwangju, Republic of Korea","institution_ids":["https://openalex.org/I39534123"]},{"raw_affiliation_string":"Department of Molecular Cell Biology, Sungkyunkwan University School of Medicine, Suwon, Republic of Korea","institution_ids":["https://openalex.org/I848706"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":14,"corresponding_author_ids":["https://openalex.org/A5058349680","https://openalex.org/A5100653825"],"corresponding_institution_ids":["https://openalex.org/I4921948","https://openalex.org/I848706"],"apc_list":{"value":5420,"currency":"USD","value_usd":5420},"apc_paid":{"value":5420,"currency":"USD","value_usd":5420},"fwci":7.1604,"has_fulltext":true,"cited_by_count":27,"citation_normalized_percentile":{"value":0.97938062,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":99},"biblio":{"volume":"73","issue":null,"first_page":"101054","last_page":"101054"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11051","display_name":"Sirtuins and Resveratrol in Medicine","score":0.5,"subfield":{"id":"https://openalex.org/subfields/2717","display_name":"Geriatrics and Gerontology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11051","display_name":"Sirtuins and Resveratrol in Medicine","score":0.5,"subfield":{"id":"https://openalex.org/subfields/2717","display_name":"Geriatrics and Gerontology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.3537999987602234,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12465","display_name":"Cancer, Lipids, and Metabolism","score":0.01080000028014183,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sirt7","display_name":"SIRT7","score":0.996999979019165},{"id":"https://openalex.org/keywords/sorafenib-resistance","display_name":"sorafenib resistance","score":0.8560000061988831},{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"hepatocellular carcinoma","score":0.9679999947547913},{"id":"https://openalex.org/keywords/ddx3x","display_name":"DDX3X","score":0.9700000286102295},{"id":"https://openalex.org/keywords/nlrp3-inflammasome","display_name":"NLRP3 inflammasome","score":0.9990000128746033},{"id":"https://openalex.org/keywords/erk-signaling","display_name":"ERK signaling","score":0.9700000286102295},{"id":"https://openalex.org/keywords/interleukin-1beta","display_name":"IL-1\u03b2","score":0.9279999732971191},{"id":"https://openalex.org/keywords/sirtuin-inhibition","display_name":"sirtuin inhibition","score":0.6190000176429749},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.7609999775886536},{"id":"https://openalex.org/keywords/protein-deacetylation","display_name":"protein deacetylation","score":0.8460000157356262},{"id":"https://openalex.org/keywords/drug-resistance","display_name":"drug resistance","score":0.34700000286102295}],"concepts":[{"id":"https://openalex.org/C2778695046","wikidata":"https://www.wikidata.org/wiki/Q421136","display_name":"Sorafenib","level":3,"score":0.9786417484283447},{"id":"https://openalex.org/C2780561631","wikidata":"https://www.wikidata.org/wiki/Q421331","display_name":"Sirtuin","level":4,"score":0.7892990112304688},{"id":"https://openalex.org/C2777209026","wikidata":"https://www.wikidata.org/wiki/Q412405","display_name":"Inflammasome","level":3,"score":0.6998375058174133},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6368269920349121},{"id":"https://openalex.org/C2778019345","wikidata":"https://www.wikidata.org/wiki/Q1148337","display_name":"Hepatocellular carcinoma","level":2,"score":0.551298201084137},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4558587670326233},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3688165545463562},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3565131723880768},{"id":"https://openalex.org/C119157956","wikidata":"https://www.wikidata.org/wiki/Q796604","display_name":"Acetylation","level":3,"score":0.30175817012786865},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2099381685256958},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.15311124920845032},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.11457276344299316},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.10601839423179626}],"mesh":[{"descriptor_ui":"D000071199","descriptor_name":"NLR Family, Pyrin Domain-Containing 3 Protein","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000071199","descriptor_name":"NLR Family, Pyrin Domain-Containing 3 Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000077157","descriptor_name":"Sorafenib","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000077157","descriptor_name":"Sorafenib","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019008","descriptor_name":"Drug Resistance, Neoplasm","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020935","descriptor_name":"MAP Kinase Signaling System","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D037761","descriptor_name":"Sirtuins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D037761","descriptor_name":"Sirtuins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D037761","descriptor_name":"Sirtuins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053487","descriptor_name":"DEAD-box RNA Helicases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D053487","descriptor_name":"DEAD-box RNA Helicases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D053487","descriptor_name":"DEAD-box RNA Helicases","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D058847","descriptor_name":"Inflammasomes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D058847","descriptor_name":"Inflammasomes","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1016/j.drup.2024.101054","doi":"https://doi.org/10.1016/j.drup.2024.101054","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.drup.2024.101054","pdf_url":"https://ars.els-cdn.com/content/image/1-s2.0-S1368764624000128-ga1_lrg.jpg","source":{"id":"https://openalex.org/S47159833","display_name":"Drug Resistance Updates","issn_l":"1368-7646","issn":["1368-7646","1532-2084"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug Resistance Updates","raw_type":"journal-article"},{"id":"doi:10.1101/2023.03.13.531998","doi":"https://doi.org/10.1101/2023.03.13.531998","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2023.03.13.531998","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2023/03/15/2023.03.13.531998.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmid:38277756","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38277756","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10935544","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/instance/10935544/bin/mmc1.pdf","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug Resist Updat","raw_type":"Text"},{"id":"pmh:oai:infoscience.epfl.ch:310169","doi":null,"is_oa":true,"landing_page_url":"http://infoscience.epfl.ch/record/310169","pdf_url":null,"source":{"id":"https://openalex.org/S4306400487","display_name":"Infoscience (Ecole Polytechnique F\u00e9d\u00e9rale de Lausanne)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I5124864","host_organization_name":"\u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne","host_organization_lineage":["https://openalex.org/I5124864"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"research article"},{"id":"pmh:oai:lirias2repo.kuleuven.be:20.500.12942/736932","doi":null,"is_oa":true,"landing_page_url":"https://lirias.kuleuven.be/handle/20.500.12942/736932","pdf_url":null,"source":{"id":"https://openalex.org/S4306401954","display_name":"Lirias (KU Leuven)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I99464096","host_organization_name":"KU Leuven","host_organization_lineage":["https://openalex.org/I99464096"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Drug Resistance Updates, vol. 73, Art.No. ARTN 101054","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1016/j.drup.2024.101054","doi":"https://doi.org/10.1016/j.drup.2024.101054","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.drup.2024.101054","pdf_url":"https://ars.els-cdn.com/content/image/1-s2.0-S1368764624000128-ga1_lrg.jpg","source":{"id":"https://openalex.org/S47159833","display_name":"Drug Resistance Updates","issn_l":"1368-7646","issn":["1368-7646","1532-2084"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug Resistance Updates","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9922999739646912,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1273016502","display_name":null,"funder_award_id":"RS-2023-00283539","funder_id":"https://openalex.org/F4320322034","funder_display_name":"Ministry of Health and Welfare"},{"id":"https://openalex.org/G2231479445","display_name":null,"funder_award_id":"2023R1A2C3006220","funder_id":"https://openalex.org/F4320322120","funder_display_name":"National Research Foundation of Korea"},{"id":"https://openalex.org/G2517564591","display_name":null,"funder_award_id":"2020R1A2C2010964","funder_id":"https://openalex.org/F4320322120","funder_display_name":"National Research Foundation of Korea"},{"id":"https://openalex.org/G3015853033","display_name":null,"funder_award_id":"KK2431-10","funder_id":"https://openalex.org/F4320322101","funder_display_name":"Korea Research Institute of Chemical Technology"},{"id":"https://openalex.org/G3165649938","display_name":null,"funder_award_id":"2023R1A2C3006220","funder_id":"https://openalex.org/F4320328359","funder_display_name":"Ministry of Science and ICT, South Korea"},{"id":"https://openalex.org/G58727866","display_name":null,"funder_award_id":"NRF-2017K1A1A2013124","funder_id":"https://openalex.org/F4320320924","funder_display_name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung"},{"id":"https://openalex.org/G6127215812","display_name":null,"funder_award_id":"2017K1A1A2013124","funder_id":"https://openalex.org/F4320322120","funder_display_name":"National Research Foundation of Korea"},{"id":"https://openalex.org/G6285774457","display_name":null,"funder_award_id":"RS-2023-00261370","funder_id":"https://openalex.org/F4320322120","funder_display_name":"National Research Foundation of Korea"},{"id":"https://openalex.org/G6369354374","display_name":null,"funder_award_id":"ERC\u2010AdG\u2010787702","funder_id":"https://openalex.org/F4320338335","funder_display_name":"H2020 European Research Council"},{"id":"https://openalex.org/G6778206002","display_name":null,"funder_award_id":"NRF 2017K1A1A2013124","funder_id":"https://openalex.org/F4320322120","funder_display_name":"National Research Foundation of Korea"},{"id":"https://openalex.org/G7657732403","display_name":"Genetic control of NAD+ Metabolism","funder_award_id":"179435","funder_id":"https://openalex.org/F4320320924","funder_display_name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung"},{"id":"https://openalex.org/G7879408376","display_name":null,"funder_award_id":"2021R1A6A3A13044725","funder_id":"https://openalex.org/F4320322120","funder_display_name":"National Research Foundation of Korea"},{"id":"https://openalex.org/G840985363","display_name":null,"funder_award_id":"NRF\u20102020R1A2C2010964","funder_id":"https://openalex.org/F4320322120","funder_display_name":"National Research Foundation of Korea"},{"id":"https://openalex.org/G856060503","display_name":"The Mitochondrial Unfolded Protein Response","funder_award_id":"787702","funder_id":"https://openalex.org/F4320338335","funder_display_name":"H2020 European Research Council"},{"id":"https://openalex.org/G90905576","display_name":null,"funder_award_id":"RS-2023-00283539","funder_id":"https://openalex.org/F4320322120","funder_display_name":"National Research Foundation of Korea"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320320671","display_name":"National Research Foundation","ror":"https://ror.org/05s0g1g46"},{"id":"https://openalex.org/F4320320915","display_name":"\u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne","ror":"https://ror.org/02s376052"},{"id":"https://openalex.org/F4320320924","display_name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","ror":"https://ror.org/00yjd3n13"},{"id":"https://openalex.org/F4320321681","display_name":"Ministry of Trade, Industry and Energy","ror":"https://ror.org/008nkqk13"},{"id":"https://openalex.org/F4320322030","display_name":"Ministry of Science, ICT and Future Planning","ror":"https://ror.org/032e49973"},{"id":"https://openalex.org/F4320322034","display_name":"Ministry of Health and Welfare","ror":"https://ror.org/00vxgjw72"},{"id":"https://openalex.org/F4320322101","display_name":"Korea Research Institute of Chemical Technology","ror":"https://ror.org/043k4kk20"},{"id":"https://openalex.org/F4320322120","display_name":"National Research Foundation of Korea","ror":"https://ror.org/013aysd81"},{"id":"https://openalex.org/F4320322344","display_name":"Korea Drug Development Fund","ror":"https://ror.org/01h8vbd96"},{"id":"https://openalex.org/F4320328359","display_name":"Ministry of Science and ICT, South Korea","ror":"https://ror.org/01wpjm123"},{"id":"https://openalex.org/F4320334678","display_name":"European Research Council","ror":"https://ror.org/0472cxd90"},{"id":"https://openalex.org/F4320338335","display_name":"H2020 European Research Council","ror":"https://ror.org/0472cxd90"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4390948824.pdf","grobid_xml":"https://content.openalex.org/works/W4390948824.grobid-xml"},"referenced_works_count":75,"referenced_works":["https://openalex.org/W1578523240","https://openalex.org/W1934704664","https://openalex.org/W1971837077","https://openalex.org/W1979751618","https://openalex.org/W1986731647","https://openalex.org/W1993741178","https://openalex.org/W2018232327","https://openalex.org/W2028178274","https://openalex.org/W2028846086","https://openalex.org/W2030530506","https://openalex.org/W2031344967","https://openalex.org/W2036710606","https://openalex.org/W2037235549","https://openalex.org/W2043932983","https://openalex.org/W2045336712","https://openalex.org/W2048613470","https://openalex.org/W2050449334","https://openalex.org/W2057559442","https://openalex.org/W2061345986","https://openalex.org/W2061746936","https://openalex.org/W2089524021","https://openalex.org/W2102942095","https://openalex.org/W2104886883","https://openalex.org/W2106715610","https://openalex.org/W2114803943","https://openalex.org/W2117350148","https://openalex.org/W2117674849","https://openalex.org/W2127300984","https://openalex.org/W2134581357","https://openalex.org/W2138358900","https://openalex.org/W2139449514","https://openalex.org/W2155908452","https://openalex.org/W2171723578","https://openalex.org/W2277435680","https://openalex.org/W2337194467","https://openalex.org/W2342599867","https://openalex.org/W2571520146","https://openalex.org/W2589080108","https://openalex.org/W2735411038","https://openalex.org/W2745686360","https://openalex.org/W2751349734","https://openalex.org/W2755342062","https://openalex.org/W2791410480","https://openalex.org/W2883591283","https://openalex.org/W2883781711","https://openalex.org/W2889646458","https://openalex.org/W2890948565","https://openalex.org/W2903416411","https://openalex.org/W2911188335","https://openalex.org/W2937732451","https://openalex.org/W2952776729","https://openalex.org/W2969341306","https://openalex.org/W2972371855","https://openalex.org/W3025022288","https://openalex.org/W3034448267","https://openalex.org/W3075660836","https://openalex.org/W3110414417","https://openalex.org/W3121945144","https://openalex.org/W3168097989","https://openalex.org/W3173879725","https://openalex.org/W3180754516","https://openalex.org/W3190887388","https://openalex.org/W3200355884","https://openalex.org/W4210511126","https://openalex.org/W4210773130","https://openalex.org/W4220671681","https://openalex.org/W4221082631","https://openalex.org/W4281484112","https://openalex.org/W4308891835","https://openalex.org/W4318197608","https://openalex.org/W4324262440","https://openalex.org/W4362678534","https://openalex.org/W6703725322","https://openalex.org/W6704643910","https://openalex.org/W6767201308"],"related_works":["https://openalex.org/W4324349203","https://openalex.org/W2952776729","https://openalex.org/W3098834408","https://openalex.org/W3187023420","https://openalex.org/W6996388949","https://openalex.org/W4392658824","https://openalex.org/W7127368140","https://openalex.org/W2968402683","https://openalex.org/W3016697733","https://openalex.org/W4412433913"],"abstract_inverted_index":{"AIMS:":[0],"Sirtuin":[1],"7":[2],"(SIRT7)":[3],"plays":[4],"an":[5,130],"important":[6],"role":[7],"in":[8,41,87,131,171],"tumor":[9],"development,":[10],"and":[11,33,54,71,120,124,143,186],"has":[12,43],"been":[13,45],"characterized":[14],"as":[15,82],"a":[16,34,83,114],"potent":[17],"regulator":[18],"of":[19,25,52,93,117,141],"cellular":[20],"stress.":[21],"However,":[22],"the":[23,49],"effect":[24,140],"SIRT7":[26,53,81,94,142,151,179],"on":[27],"sorafenib":[28,61,88,159,183,195],"acquired":[29,89,158,184],"resistance":[30,160],"remains":[31],"unclear":[32],"possible":[35],"anti-tumor":[36,139],"mechanism":[37],"beyond":[38],"this":[39],"process":[40],"HCC":[42,69],"not":[44],"clarified.":[46],"We":[47],"examined":[48],"therapeutic":[50,102],"potential":[51,84],"determined":[55],"whether":[56],"it":[57],"functions":[58],"synergistically":[59],"with":[60,106,148,194],"to":[62,79,99,112,137,173],"overcome":[63],"chemoresistance.":[64],"METHODS:":[65],"Cancer":[66],"Genome":[67],"Atlas-liver":[68],"data":[70],"unbiased":[72],"gene":[73],"set":[74],"enrichment":[75],"analyses":[76],"were":[77,97,127],"used":[78,136],"identify":[80],"effector":[85],"molecule":[86],"resistance.":[90],"Two":[91],"types":[92],"chemical":[95,145],"inhibitors":[96,146],"developed":[98],"evaluate":[100],"its":[101,187],"properties":[103],"when":[104,192],"synergized":[105],"sorafenib.":[107,149],"Mass":[108],"spectrometry":[109],"was":[110,135],"performed":[111],"discover":[113],"direct":[115],"target":[116],"SIRT7,":[118],"DDX3X,":[119],"DDX3X":[121,144,154],"deacetylation":[122],"levels":[123],"protein":[125],"stability":[126],"explored.":[128],"Moreover,":[129],"vivo":[132],"xenograft":[133],"model":[134],"confirm":[138],"combined":[147,193],"RESULTS:":[150],"inhibition":[152,188],"mediated":[153],"depletion":[155],"can":[156],"re-sensitize":[157],"by":[161,196],"disrupting":[162],"NLRP3":[163,174],"inflammasome":[164],"assembly,":[165],"finally":[166],"suppressing":[167,197],"hyperactive":[168,198],"ERK1/2":[169,201],"signaling":[170],"response":[172],"inflammasome-mediated":[175],"IL-1\u03b2":[176],"inhibition.":[177],"CONCLUSIONS:":[178],"is":[180],"responsible":[181],"for":[182],"resistance,":[185],"would":[189],"be":[190],"beneficial":[191],"pro-cell":[199],"survival":[200],"signaling.":[202]},"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":15},{"year":2024,"cited_by_count":5}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2024-01-18T00:00:00"}