{"id":"https://openalex.org/W4390948686","doi":"https://doi.org/10.1002/chem.202303539","title":"Synthesis and Photophysical Characterization of a pH\u2010Sensitive Quadracyclic Uridine (qU) Analogue","display_name":"Synthesis and Photophysical Characterization of a pH\u2010Sensitive Quadracyclic Uridine (qU) Analogue","publication_year":2024,"publication_date":"2024-01-17","ids":{"openalex":"https://openalex.org/W4390948686","doi":"https://doi.org/10.1002/chem.202303539","pmid":"https://pubmed.ncbi.nlm.nih.gov/38230625"},"language":"en","primary_location":{"id":"doi:10.1002/chem.202303539","doi":"https://doi.org/10.1002/chem.202303539","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1002/chem.202303539","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/chem.202303539","source":{"id":"https://openalex.org/S68911691","display_name":"Chemistry - A European Journal","issn_l":"0947-6539","issn":["0947-6539","1521-3765"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemistry \u2013 A European Journal","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/chem.202303539","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5016108356","display_name":"Hoang\u2010Ngoan Le","orcid":"https://orcid.org/0000-0003-2484-8770","observed_orcids":["https://orcid.org/0000-0003-2484-8770"]},"institutions":[{"id":"https://openalex.org/I4210143795","display_name":"AstraZeneca (Sweden)","ror":"https://ror.org/04wwrrg31","country_code":"SE","type":"company","lineage":["https://openalex.org/I105036370","https://openalex.org/I4210143795"]},{"id":"https://openalex.org/I66862912","display_name":"Chalmers University of Technology","ror":"https://ror.org/040wg7k59","country_code":"SE","type":"education","lineage":["https://openalex.org/I66862912"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Hoang\u2010Ngoan Le","raw_affiliation_strings":["Cell Gene and RNA Therapy Discovery Science BioPharmaceuticals R&D AstraZeneca Pepparedsleden 1 431 50 Gothenburg Sweden","Department of Chemistry and Chemical Engineering Chalmers University of Technology Kemiv\u00e4gen 10 SE-41296 Gothenburg Sweden"],"raw_orcid":"https://orcid.org/0000-0003-2484-8770","affiliations":[{"raw_affiliation_string":"Cell Gene and RNA Therapy Discovery Science BioPharmaceuticals R&D AstraZeneca Pepparedsleden 1 431 50 Gothenburg Sweden","institution_ids":["https://openalex.org/I4210143795"]},{"raw_affiliation_string":"Department of Chemistry and Chemical Engineering Chalmers University of Technology Kemiv\u00e4gen 10 SE-41296 Gothenburg Sweden","institution_ids":["https://openalex.org/I66862912"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080162790","display_name":"Jagannath Kuchlyan","orcid":"https://orcid.org/0000-0002-6296-2032","observed_orcids":["https://orcid.org/0000-0002-6296-2032"]},"institutions":[{"id":"https://openalex.org/I66862912","display_name":"Chalmers University of Technology","ror":"https://ror.org/040wg7k59","country_code":"SE","type":"education","lineage":["https://openalex.org/I66862912"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Jagannath Kuchlyan","raw_affiliation_strings":["Department of Chemistry and Chemical Engineering Chalmers University of Technology Kemiv\u00e4gen 10 SE-41296 Gothenburg Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Chemical Engineering Chalmers University of Technology Kemiv\u00e4gen 10 SE-41296 Gothenburg Sweden","institution_ids":["https://openalex.org/I66862912"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047299428","display_name":"Tom Baladi","orcid":"https://orcid.org/0000-0003-3421-9417","observed_orcids":["https://orcid.org/0000-0003-3421-9417"]},"institutions":[{"id":"https://openalex.org/I4210143795","display_name":"AstraZeneca (Sweden)","ror":"https://ror.org/04wwrrg31","country_code":"SE","type":"company","lineage":["https://openalex.org/I105036370","https://openalex.org/I4210143795"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Tom Baladi","raw_affiliation_strings":["Cell Gene and RNA Therapy Discovery Science BioPharmaceuticals R&D AstraZeneca Pepparedsleden 1 431 50 Gothenburg Sweden"],"raw_orcid":"https://orcid.org/0000-0003-3421-9417","affiliations":[{"raw_affiliation_string":"Cell Gene and RNA Therapy Discovery Science BioPharmaceuticals R&D AstraZeneca Pepparedsleden 1 431 50 Gothenburg Sweden","institution_ids":["https://openalex.org/I4210143795"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063167940","display_name":"Bo Albinsson","orcid":"https://orcid.org/0000-0002-5991-7863","observed_orcids":["https://orcid.org/0000-0002-5991-7863"]},"institutions":[{"id":"https://openalex.org/I66862912","display_name":"Chalmers University of Technology","ror":"https://ror.org/040wg7k59","country_code":"SE","type":"education","lineage":["https://openalex.org/I66862912"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Bo Albinsson","raw_affiliation_strings":["Department of Chemistry and Chemical Engineering Chalmers University of Technology Kemiv\u00e4gen 10 SE-41296 Gothenburg Sweden"],"raw_orcid":"https://orcid.org/0000-0002-5991-7863","affiliations":[{"raw_affiliation_string":"Department of Chemistry and Chemical Engineering Chalmers University of Technology Kemiv\u00e4gen 10 SE-41296 Gothenburg Sweden","institution_ids":["https://openalex.org/I66862912"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018809376","display_name":"Anders Dahl\u00e9n","orcid":"https://orcid.org/0000-0002-2641-7918","observed_orcids":["https://orcid.org/0000-0002-2641-7918"]},"institutions":[{"id":"https://openalex.org/I4210143795","display_name":"AstraZeneca (Sweden)","ror":"https://ror.org/04wwrrg31","country_code":"SE","type":"company","lineage":["https://openalex.org/I105036370","https://openalex.org/I4210143795"]}],"countries":["SE"],"is_corresponding":true,"raw_author_name":"Anders Dahl\u00e9n","raw_affiliation_strings":["Cell Gene and RNA Therapy Discovery Science BioPharmaceuticals R&D AstraZeneca Pepparedsleden 1 431 50 Gothenburg Sweden"],"raw_orcid":"https://orcid.org/0000-0002-2641-7918","affiliations":[{"raw_affiliation_string":"Cell Gene and RNA Therapy Discovery Science BioPharmaceuticals R&D AstraZeneca Pepparedsleden 1 431 50 Gothenburg Sweden","institution_ids":["https://openalex.org/I4210143795"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5091271050","display_name":"L. Marcus Wilhelmsson","orcid":"https://orcid.org/0000-0002-2193-6639","observed_orcids":["https://orcid.org/0000-0002-2193-6639"]},"institutions":[{"id":"https://openalex.org/I66862912","display_name":"Chalmers University of Technology","ror":"https://ror.org/040wg7k59","country_code":"SE","type":"education","lineage":["https://openalex.org/I66862912"]}],"countries":["SE"],"is_corresponding":true,"raw_author_name":"L. Marcus Wilhelmsson","raw_affiliation_strings":["Department of Chemistry and Chemical Engineering Chalmers University of Technology  Kemiv\u00e4gen 10 SE-41296 Gothenburg Sweden"],"raw_orcid":"https://orcid.org/0000-0002-2193-6639","affiliations":[{"raw_affiliation_string":"Department of Chemistry and Chemical Engineering Chalmers University of Technology  Kemiv\u00e4gen 10 SE-41296 Gothenburg Sweden","institution_ids":["https://openalex.org/I66862912"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5018809376","https://openalex.org/A5091271050"],"corresponding_institution_ids":["https://openalex.org/I4210143795","https://openalex.org/I66862912"],"apc_list":{"value":4640,"currency":"USD","value_usd":4640},"apc_paid":{"value":4640,"currency":"USD","value_usd":4640},"fwci":0.6504,"has_fulltext":true,"cited_by_count":6,"citation_normalized_percentile":{"value":0.59229066,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"30","issue":"18","first_page":"e202303539","last_page":"e202303539"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10432","display_name":"DNA and Nucleic Acid Chemistry","score":0.9243000149726868,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10432","display_name":"DNA and Nucleic Acid Chemistry","score":0.9243000149726868,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11129","display_name":"Photochemistry and Electron Transfer Studies","score":0.04179999977350235,"subfield":{"id":"https://openalex.org/subfields/1606","display_name":"Physical and Theoretical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11240","display_name":"Luminescence and Fluorescent Materials","score":0.015799999237060547,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/uracil-analogues","display_name":"uracil analogues","score":0.7919999957084656},{"id":"https://openalex.org/keywords/ph-dependent-fluorescence","display_name":"pH-dependent fluorescence","score":0.6570000052452087},{"id":"https://openalex.org/keywords/dual-band-emission","display_name":"dual-band emission","score":0.7540000081062317},{"id":"https://openalex.org/keywords/excited-state-proton-transfer","display_name":"excited-state proton transfer","score":0.9639999866485596},{"id":"https://openalex.org/keywords/nucleic-acid-labeling","display_name":"nucleic acid labeling","score":0.7009999752044678},{"id":"https://openalex.org/keywords/fluorescence-lifetime","display_name":"fluorescence lifetime","score":0.6639999747276306},{"id":"https://openalex.org/keywords/nucleic-acid-therapeutics","display_name":"nucleic acid therapeutics","score":0.6079999804496765}],"concepts":[{"id":"https://openalex.org/C2779554091","wikidata":"https://www.wikidata.org/wiki/Q182990","display_name":"Uracil","level":3,"score":0.7115358114242554},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6115437150001526},{"id":"https://openalex.org/C91881484","wikidata":"https://www.wikidata.org/wiki/Q191807","display_name":"Fluorescence","level":2,"score":0.5971089601516724},{"id":"https://openalex.org/C2781259782","wikidata":"https://www.wikidata.org/wiki/Q422573","display_name":"Uridine","level":4,"score":0.5345107316970825},{"id":"https://openalex.org/C61234307","wikidata":"https://www.wikidata.org/wiki/Q422960","display_name":"Nucleobase","level":3,"score":0.5166359543800354},{"id":"https://openalex.org/C171001562","wikidata":"https://www.wikidata.org/wiki/Q2856048","display_name":"Quantum yield","level":3,"score":0.5108139514923096},{"id":"https://openalex.org/C24107716","wikidata":"https://www.wikidata.org/wiki/Q123619","display_name":"Nucleic acid","level":2,"score":0.45234620571136475},{"id":"https://openalex.org/C75473681","wikidata":"https://www.wikidata.org/wiki/Q188651","display_name":"Photochemistry","level":1,"score":0.42305877804756165},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.3272436261177063},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.2968515157699585},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.18649375438690186},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1525169014930725},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.09617283940315247},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D005456","descriptor_name":"Fluorescent Dyes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D006863","descriptor_name":"Hydrogen-Ion Concentration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009696","descriptor_name":"Nucleic Acids","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014498","descriptor_name":"Uracil","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014529","descriptor_name":"Uridine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1002/chem.202303539","doi":"https://doi.org/10.1002/chem.202303539","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1002/chem.202303539","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/chem.202303539","source":{"id":"https://openalex.org/S68911691","display_name":"Chemistry - A European Journal","issn_l":"0947-6539","issn":["0947-6539","1521-3765"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemistry \u2013 A European Journal","raw_type":"journal-article"},{"id":"pmid:38230625","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38230625","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemistry (Weinheim an der Bergstrasse, Germany)","raw_type":"Journal Article"},{"id":"pmh:oai:research.chalmers.se:539906","doi":null,"is_oa":true,"landing_page_url":"https://research.chalmers.se/en/publication/539906","pdf_url":"https://research.chalmers.se/publication/539906/file/539906_Fulltext.pdf","source":{"id":"https://openalex.org/S4306402469","display_name":"Chalmers Research (Chalmers University of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I66862912","host_organization_name":"Chalmers University of Technology","host_organization_lineage":["https://openalex.org/I66862912"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"doi:10.1002/chem.202303539","doi":"https://doi.org/10.1002/chem.202303539","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1002/chem.202303539","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/chem.202303539","source":{"id":"https://openalex.org/S68911691","display_name":"Chemistry - A European Journal","issn_l":"0947-6539","issn":["0947-6539","1521-3765"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemistry \u2013 A European Journal","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G3934619281","display_name":"Funktionell leverans av nukleotid-baserade l\u00e4kemedel","funder_award_id":"IRC15-0065","funder_id":"https://openalex.org/F4320320940","funder_display_name":"Stiftelsen f\u00f6r\u00a0Strategisk Forskning"},{"id":"https://openalex.org/G5631245013","display_name":null,"funder_award_id":"IRC15\u20100065","funder_id":"https://openalex.org/F4320327257","funder_display_name":"Stiftelsen f\u00f6r Strategisk Forskning"}],"funders":[{"id":"https://openalex.org/F4320307770","display_name":"AstraZeneca","ror":"https://ror.org/04r9x1a08"},{"id":"https://openalex.org/F4320320940","display_name":"Stiftelsen f\u00f6r\u00a0Strategisk Forskning","ror":"https://ror.org/044wr7g58"},{"id":"https://openalex.org/F4320327257","display_name":"Stiftelsen f\u00f6r Strategisk Forskning","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4390948686.pdf","grobid_xml":"https://content.openalex.org/works/W4390948686.grobid-xml"},"referenced_works_count":65,"referenced_works":["https://openalex.org/W1579716589","https://openalex.org/W1969171882","https://openalex.org/W1970913353","https://openalex.org/W1982652224","https://openalex.org/W1990542275","https://openalex.org/W1994021375","https://openalex.org/W1994693974","https://openalex.org/W2018310119","https://openalex.org/W2021792392","https://openalex.org/W2029443955","https://openalex.org/W2038578123","https://openalex.org/W2058435677","https://openalex.org/W2070908207","https://openalex.org/W2071918883","https://openalex.org/W2074264340","https://openalex.org/W2075096884","https://openalex.org/W2078184681","https://openalex.org/W2089363331","https://openalex.org/W2089575398","https://openalex.org/W2115316940","https://openalex.org/W2120813036","https://openalex.org/W2131914706","https://openalex.org/W2135911486","https://openalex.org/W2146953384","https://openalex.org/W2147588700","https://openalex.org/W2168335282","https://openalex.org/W2168919966","https://openalex.org/W2168921143","https://openalex.org/W2205873299","https://openalex.org/W2264116761","https://openalex.org/W2286747012","https://openalex.org/W2286802360","https://openalex.org/W2324842528","https://openalex.org/W2333962307","https://openalex.org/W2412216997","https://openalex.org/W2516013765","https://openalex.org/W2529989251","https://openalex.org/W2557483441","https://openalex.org/W2581150488","https://openalex.org/W2581449600","https://openalex.org/W2614630372","https://openalex.org/W2766432068","https://openalex.org/W2783172145","https://openalex.org/W2792263257","https://openalex.org/W2808060919","https://openalex.org/W2816780547","https://openalex.org/W2921527886","https://openalex.org/W2942044904","https://openalex.org/W2952072088","https://openalex.org/W3007709539","https://openalex.org/W3035929973","https://openalex.org/W3085457937","https://openalex.org/W3109433756","https://openalex.org/W3115293405","https://openalex.org/W3129916007","https://openalex.org/W3148084463","https://openalex.org/W3148895046","https://openalex.org/W3150802574","https://openalex.org/W3162767976","https://openalex.org/W3164060993","https://openalex.org/W3204963396","https://openalex.org/W4205577317","https://openalex.org/W4281786571","https://openalex.org/W4289948197","https://openalex.org/W6609645346"],"related_works":["https://openalex.org/W7134176937","https://openalex.org/W2161169616","https://openalex.org/W2885660394","https://openalex.org/W2789680039","https://openalex.org/W2168919966","https://openalex.org/W3019679376","https://openalex.org/W2971604533","https://openalex.org/W1964754497","https://openalex.org/W971141903","https://openalex.org/W2008203783"],"abstract_inverted_index":{"Fluorescent":[0],"base":[1,53],"analogues":[2],"(FBAs)":[3],"have":[4],"become":[5],"useful":[6],"tools":[7],"for":[8,50,155],"applications":[9,153],"in":[10,63,84,131,135,149],"biophysical":[11],"chemistry,":[12],"chemical":[13],"biology,":[14],"live-cell":[15],"imaging,":[16],"and":[17,45,70,80,119,138,151,161],"RNA":[18],"therapeutics.":[19,165],"Herein,":[20],"two":[21],"synthetic":[22],"routes":[23],"towards":[24],"a":[25,40,74,81,85],"novel":[26],"FBA":[27],"of":[28,67,77,121,159],"uracil":[29],"named":[30],"qU":[31,37,60,122,142],"(quadracyclic":[32],"uracil/uridine)":[33],"are":[34,123],"described.":[35],"The":[36,128],"nucleobase":[38],"bears":[39],"tetracyclic":[41],"fused":[42],"ring":[43],"system":[44],"is":[46],"designed":[47],"to":[48,126],"allow":[49],"specific":[51],"Watson-Crick":[52],"pairing":[54],"with":[55,73,133],"adenine.":[56],"We":[57],"find":[58,115],"that":[59,100,116],"absorbs":[61],"light":[62],"the":[64,68,136,157],"visible":[65,137],"region":[66],"spectrum":[69],"emits":[71],"brightly":[72],"quantum":[75],"yield":[76],"27":[78],"%":[79],"dual-band":[82],"character":[83],"wide":[86],"pH":[87,139],"range.":[88],"With":[89],"evidence,":[90],"among":[91],"other":[92],"things,":[93],"from":[94,106],"fluorescence":[95],"lifetime":[96],"measurements":[97],"we":[98,114],"suggest":[99],"this":[101],"dual":[102],"emission":[103,120],"feature":[104],"results":[105],"an":[107,143],"excited-state":[108],"proton":[109],"transfer":[110],"(ESPT)":[111],"process.":[112],"Furthermore,":[113],"both":[117],"absorption":[118],"highly":[124],"sensitive":[125],"pH.":[127],"high":[129],"brightness":[130],"combination":[132],"excitation":[134],"responsiveness":[140],"makes":[141],"interesting":[144],"native-like":[145],"nucleic":[146],"acid":[147],"label":[148],"spectroscopy":[150],"microscopy":[152],"in,":[154],"example,":[156],"field":[158],"mRNA":[160],"antisense":[162],"oligonucleotide":[163],"(ASO)":[164]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2024,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2024-01-18T00:00:00"}