{"id":"https://openalex.org/W4390944590","doi":"https://doi.org/10.2174/0122115366266024240101075745","title":"Downregulation of Serum miR-133b and miR-206 Associate with Clinical Outcomes of Progression as Monitoring Biomarkers for Metastasis Colorectal Cancer Patients","display_name":"Downregulation of Serum miR-133b and miR-206 Associate with Clinical Outcomes of Progression as Monitoring Biomarkers for Metastasis Colorectal Cancer Patients","publication_year":2024,"publication_date":"2024-01-17","ids":{"openalex":"https://openalex.org/W4390944590","doi":"https://doi.org/10.2174/0122115366266024240101075745","pmid":"https://pubmed.ncbi.nlm.nih.gov/38231064","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11275315"},"language":"en","primary_location":{"id":"doi:10.2174/0122115366266024240101075745","doi":"https://doi.org/10.2174/0122115366266024240101075745","is_oa":true,"landing_page_url":"https://doi.org/10.2174/0122115366266024240101075745","pdf_url":null,"source":{"id":"https://openalex.org/S4210218714","display_name":"MicroRNA","issn_l":"2211-5366","issn":["2211-5366","2211-5374"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-40"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"MicroRNA","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.2174/0122115366266024240101075745","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5052001421","display_name":"Surasak Wanram","orcid":"https://orcid.org/0000-0002-1866-0723","observed_orcids":["https://orcid.org/0000-0002-1866-0723"]},"institutions":[{"id":"https://openalex.org/I72091625","display_name":"Ubon Ratchathani University","ror":"https://ror.org/045nemn19","country_code":"TH","type":"education","lineage":["https://openalex.org/I72091625"]}],"countries":["TH"],"is_corresponding":true,"raw_author_name":"Surasak Wanram","raw_affiliation_strings":["Biomedical Science Research Unit, Ubon Ratchathani University, Ubon Ratchathani, 34190, Thailand","College of Medicine and Public Health, Ubon Ratchathani University, Ubon Ratchathani, 34190, Thailand"],"raw_orcid":"https://orcid.org/0000-0002-1866-0723","affiliations":[{"raw_affiliation_string":"Biomedical Science Research Unit, Ubon Ratchathani University, Ubon Ratchathani, 34190, Thailand","institution_ids":["https://openalex.org/I72091625"]},{"raw_affiliation_string":"College of Medicine and Public Health, Ubon Ratchathani University, Ubon Ratchathani, 34190, Thailand","institution_ids":["https://openalex.org/I72091625"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5093730107","display_name":"Namphon Klaewkla","orcid":"https://orcid.org/0000-0002-1448-2966","observed_orcids":["https://orcid.org/0000-0002-1448-2966"]},"institutions":[{"id":"https://openalex.org/I72091625","display_name":"Ubon Ratchathani University","ror":"https://ror.org/045nemn19","country_code":"TH","type":"education","lineage":["https://openalex.org/I72091625"]}],"countries":["TH"],"is_corresponding":false,"raw_author_name":"Namphon Klaewkla","raw_affiliation_strings":["College of Medicine and Public Health, Ubon Ratchathani University, Ubon Ratchathani, 34190, Thailand"],"raw_orcid":"https://orcid.org/0000-0002-1448-2966","affiliations":[{"raw_affiliation_string":"College of Medicine and Public Health, Ubon Ratchathani University, Ubon Ratchathani, 34190, Thailand","institution_ids":["https://openalex.org/I72091625"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5093730108","display_name":"Parichart Pinyosri","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I72091625","display_name":"Ubon Ratchathani University","ror":"https://ror.org/045nemn19","country_code":"TH","type":"education","lineage":["https://openalex.org/I72091625"]}],"countries":["TH"],"is_corresponding":false,"raw_author_name":"Parichart Pinyosri","raw_affiliation_strings":["Biomedical Science Research Unit, Ubon Ratchathani University, Ubon Ratchathani, 34190, Thailand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical Science Research Unit, Ubon Ratchathani University, Ubon Ratchathani, 34190, Thailand","institution_ids":["https://openalex.org/I72091625"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5052001421"],"corresponding_institution_ids":["https://openalex.org/I72091625"],"apc_list":null,"apc_paid":null,"fwci":0.6797,"has_fulltext":true,"cited_by_count":5,"citation_normalized_percentile":{"value":0.62092248,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"13","issue":"1","first_page":"56","last_page":"62"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11765","display_name":"Circular RNAs in diseases","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":0.972000002861023},{"id":"https://openalex.org/keywords/circulating-micrornas","display_name":"circulating microRNAs","score":0.8550000190734863},{"id":"https://openalex.org/keywords/mir-133b","display_name":"miR-133b","score":0.9279999732971191},{"id":"https://openalex.org/keywords/mir-206","display_name":"miR-206","score":1.0},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.7360000014305115},{"id":"https://openalex.org/keywords/serum-biomarkers","display_name":"serum biomarkers","score":0.7329999804496765},{"id":"https://openalex.org/keywords/kras","display_name":"KRAS","score":0.5490000247955322},{"id":"https://openalex.org/keywords/egfr","display_name":"EGFR","score":0.9959999918937683},{"id":"https://openalex.org/keywords/mirna-target-prediction","display_name":"miRNA target prediction","score":0.7059999704360962},{"id":"https://openalex.org/keywords/disease-progression-monitoring","display_name":"disease progression monitoring","score":0.6759999990463257},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.8309999704360962},{"id":"https://openalex.org/keywords/mir-30-family","display_name":"miR-30 family","score":0.6399999856948853},{"id":"https://openalex.org/keywords/mir-155-5p","display_name":"miR-155-5p","score":0.9039999842643738},{"id":"https://openalex.org/keywords/mir-143-3p","display_name":"miR-143-3p","score":0.9359999895095825}],"concepts":[{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.862977921962738},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.7078965902328491},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.6917847394943237},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6618462204933167},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.5530383586883545},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5320464372634888},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5006074905395508},{"id":"https://openalex.org/C2779256057","wikidata":"https://www.wikidata.org/wiki/Q16909647","display_name":"Tumor progression","level":3,"score":0.42911767959594727},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.42452800273895264},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4045841693878174},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.11451253294944763},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.05397757887840271},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009362","descriptor_name":"Neoplasm Metastasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.2174/0122115366266024240101075745","doi":"https://doi.org/10.2174/0122115366266024240101075745","is_oa":true,"landing_page_url":"https://doi.org/10.2174/0122115366266024240101075745","pdf_url":null,"source":{"id":"https://openalex.org/S4210218714","display_name":"MicroRNA","issn_l":"2211-5366","issn":["2211-5366","2211-5374"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-40"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"MicroRNA","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11275315","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11275315","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11275315/pdf/MIRNA-13-56.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Microrna","raw_type":"Text"},{"id":"pmid:38231064","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38231064","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"MicroRNA (Shariqah, United Arab Emirates)","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.2174/0122115366266024240101075745","doi":"https://doi.org/10.2174/0122115366266024240101075745","is_oa":true,"landing_page_url":"https://doi.org/10.2174/0122115366266024240101075745","pdf_url":null,"source":{"id":"https://openalex.org/S4210218714","display_name":"MicroRNA","issn_l":"2211-5366","issn":["2211-5366","2211-5374"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-40"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"MicroRNA","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4390944590.pdf","grobid_xml":"https://content.openalex.org/works/W4390944590.grobid-xml"},"referenced_works_count":76,"referenced_works":["https://openalex.org/W1496125310","https://openalex.org/W1744006947","https://openalex.org/W1975476791","https://openalex.org/W1995319698","https://openalex.org/W2016106370","https://openalex.org/W2024859904","https://openalex.org/W2029449177","https://openalex.org/W2038920886","https://openalex.org/W2062067050","https://openalex.org/W2066534523","https://openalex.org/W2097233439","https://openalex.org/W2105632406","https://openalex.org/W2147691089","https://openalex.org/W2168555507","https://openalex.org/W2256104903","https://openalex.org/W2282846405","https://openalex.org/W2403347976","https://openalex.org/W2489835174","https://openalex.org/W2518006691","https://openalex.org/W2538990466","https://openalex.org/W2598298046","https://openalex.org/W2612051395","https://openalex.org/W2728095235","https://openalex.org/W2763431583","https://openalex.org/W2788280364","https://openalex.org/W2794479713","https://openalex.org/W2797032383","https://openalex.org/W2802609344","https://openalex.org/W2809714622","https://openalex.org/W2884620854","https://openalex.org/W2891913229","https://openalex.org/W2902351112","https://openalex.org/W2902435726","https://openalex.org/W2911790056","https://openalex.org/W2912751388","https://openalex.org/W2943002680","https://openalex.org/W2969232121","https://openalex.org/W2970115840","https://openalex.org/W2979482964","https://openalex.org/W2997492439","https://openalex.org/W3006618175","https://openalex.org/W3009226610","https://openalex.org/W3027210562","https://openalex.org/W3037731585","https://openalex.org/W3045398807","https://openalex.org/W3080648871","https://openalex.org/W3084267815","https://openalex.org/W3088240313","https://openalex.org/W3091822548","https://openalex.org/W3092448592","https://openalex.org/W3095254310","https://openalex.org/W3110692374","https://openalex.org/W3114583637","https://openalex.org/W3127410786","https://openalex.org/W3128235136","https://openalex.org/W3128248976","https://openalex.org/W3128646645","https://openalex.org/W3192466505","https://openalex.org/W3200581984","https://openalex.org/W3213334042","https://openalex.org/W4200043367","https://openalex.org/W4200350261","https://openalex.org/W4205428700","https://openalex.org/W4213353827","https://openalex.org/W4220677690","https://openalex.org/W4283724601","https://openalex.org/W4296710377","https://openalex.org/W4297540219","https://openalex.org/W4308449789","https://openalex.org/W4311496676","https://openalex.org/W4312066024","https://openalex.org/W4322719806","https://openalex.org/W4360861681","https://openalex.org/W4368618195","https://openalex.org/W4385553506","https://openalex.org/W4385876782"],"related_works":["https://openalex.org/W2175752441","https://openalex.org/W3009226610","https://openalex.org/W3027210562","https://openalex.org/W2098327927","https://openalex.org/W2495293224","https://openalex.org/W2219573808","https://openalex.org/W4290774104","https://openalex.org/W3198894875","https://openalex.org/W3202126507","https://openalex.org/W53332993"],"abstract_inverted_index":{"BACKGROUND:":[0],"mutation":[1],"are":[2],"associated":[3,236],"with":[4,194,228,237],"CRC":[5,30,51,69,195,230,234],"development":[6],"playing":[7],"a":[8,105,181],"role":[9],"in":[10,50,104,130],"controlling":[11],"the":[12,116,127,174,223],"cellular":[13],"process":[14],"as":[15,31,124,189,191,218],"epigenetic":[16],"events.":[17],"Circulating":[18],"serum":[19,46,70,81,97,187,212],"miRs":[20,137,155,171],"can":[21,216],"serve":[22,217],"for":[23,86,221],"early":[24],"diagnosis,":[25],"monitoring,":[26],"and":[27,48,66,78,91,99,119,166,198,214],"prognosis":[28],"of":[29,44,56,138,156,185,226],"biomarkers":[32,43,220],"but":[33],"it":[34],"is":[35],"still":[36],"unclear,":[37],"clinically.":[38,245],"OBJECTIVE:":[39],"To":[40],"determine":[41],"potential":[42],"circulating":[45,96,186,211],"miR-133b":[47,98,188,213],"miR-206":[49,100,192,215],"patients":[52,196,235],"Methods:":[53],"Bioinformatic":[54],"prediction":[55,176],"microRNA":[57],"was":[58,113],"screened":[59],"followed":[60],"by":[61,172],"TargetScanHuman7.2,":[62],"miRTar2GO,":[63],"miRDB,":[64],"MiRanda,":[65],"DIANA-microT-CDS.":[67],"Forty-four":[68],"(19":[71],"locally":[72],"advanced,":[73],"23":[74],"distant":[75],"advanced":[76,199],"CRC)":[77],"12":[79],"normal":[80,122,204],"samples":[82,123],"were":[83,101],"subsequently":[84],"extracted":[85],"RNA":[87],"isolation,":[88],"cDNA":[89],"synthesis,":[90],"miR":[92],"validation.":[93],"The":[94,210],"candidate":[95],"validated":[102],"resulting":[103],"relative":[106],"expression":[107,112,183],"via":[108],"quantitative":[109],"RT-PCR.":[110],"Relative":[111],"normalized":[114],"to":[115,121,150,169,203],"spike-internal":[117],"control":[118],"compared":[120,202],"1":[125],"using":[126,173],"-2\u0394\u0394Ct":[128],"method":[129],"principle.":[131],"RESULTS:":[132],"Our":[133,178],"results":[134,179],"represented":[135],"9":[136,154],"miR-206,":[139],"miR-155-5p,":[140],"miR-143-3p,":[141],"miR-193a-3p,":[142],"miR-30a-":[143],"5p,":[144],"miR-30d-5p,":[145],"miR-30e-5p,":[146],"miR-543,":[147],"miR-877-5p":[148],"relate":[149],"KRAS-specific":[151],"miRs,":[152],"whereas,":[153],"miR-133b,":[157],"miR-302a-3p,":[158],"miR-302b-3p,":[159],"miR-302d-3p,":[160],"miR-302e,":[161],"miR-520a-3p,":[162],"miR-520b,":[163],"miR-520c-":[164],"3p":[165],"miR-7-5p":[167],"relevance":[168],"EGFR-specific":[170],"bioinformatic":[175],"tools.":[177],"showed":[180],"decreased":[182],"level":[184],"well":[190],"associating":[193],"(local":[197],"metastasis)":[200],"when":[201],"(P":[205],"<":[206],"0.05),":[207],"significantly.":[208],"CONCLUSION:":[209],"significant":[219],"monitoring":[222],"clinical":[224],"outcome":[225],"progression":[227],"metastatic":[229],"patients.":[231],"Increased":[232],"drug-responsive":[233],"crucial":[238],"molecular":[239],"intervention":[240],"should":[241],"be":[242],"further":[243],"explored,":[244]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2024-01-18T00:00:00"}
