{"id":"https://openalex.org/W4390944115","doi":"https://doi.org/10.1007/s00415-023-12103-4","title":"Ultra-late response (> 24 weeks) to anti-CGRP monoclonal antibodies in migraine: a multicenter, prospective, observational study","display_name":"Ultra-late response (> 24 weeks) to anti-CGRP monoclonal antibodies in migraine: a multicenter, prospective, observational study","publication_year":2024,"publication_date":"2024-01-17","ids":{"openalex":"https://openalex.org/W4390944115","doi":"https://doi.org/10.1007/s00415-023-12103-4","pmid":"https://pubmed.ncbi.nlm.nih.gov/38231271","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11055785"},"language":"en","primary_location":{"id":"doi:10.1007/s00415-023-12103-4","doi":"https://doi.org/10.1007/s00415-023-12103-4","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s00415-023-12103-4","pdf_url":"https://link.springer.com/content/pdf/10.1007/s00415-023-12103-4.pdf","source":{"id":"https://openalex.org/S175814247","display_name":"Journal of Neurology","issn_l":"0012-1037","issn":["0012-1037","0340-5354","1432-1459"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neurology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://link.springer.com/content/pdf/10.1007/s00415-023-12103-4.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5007223912","display_name":"Piero Barbanti","orcid":"https://orcid.org/0000-0002-5670-3755","observed_orcids":["https://orcid.org/0000-0002-5670-3755"]},"institutions":[{"id":"https://openalex.org/I292310028","display_name":"San Raffaele University of Rome","ror":"https://ror.org/02rwycx38","country_code":"IT","type":"education","lineage":["https://openalex.org/I292310028"]},{"id":"https://openalex.org/I4387155925","display_name":"IRCCS San Raffaele Roma","ror":"https://ror.org/006x48140","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126","https://openalex.org/I4387155925"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Piero Barbanti","raw_affiliation_strings":["Headache and Pain Unit, IRCCS San Raffaele Roma, Via Della Pisana 235, 00163, Rome, Italy. piero.barbanti@sanraffaele.it","San Raffaele University, Rome, Italy. piero.barbanti@sanraffaele.it","Headache and Pain Unit, IRCCS San Raffaele Roma, Via Della Pisana 235, 00163, Rome, Italy"],"raw_orcid":"https://orcid.org/0000-0002-5670-3755","affiliations":[{"raw_affiliation_string":"Headache and Pain Unit, IRCCS San Raffaele Roma, Via Della Pisana 235, 00163, Rome, Italy. piero.barbanti@sanraffaele.it","institution_ids":["https://openalex.org/I4387155925"]},{"raw_affiliation_string":"San Raffaele University, Rome, Italy. piero.barbanti@sanraffaele.it","institution_ids":["https://openalex.org/I292310028"]},{"raw_affiliation_string":"Headache and Pain Unit, IRCCS San Raffaele Roma, Via Della Pisana 235, 00163, Rome, Italy","institution_ids":["https://openalex.org/I4387155925"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004416010","display_name":"Cinzia Aurilia","orcid":"https://orcid.org/0000-0002-2658-2243","observed_orcids":["https://orcid.org/0000-0002-2658-2243","https://orcid.org/0000-0002-2308-2139"]},"institutions":[{"id":"https://openalex.org/I4387155925","display_name":"IRCCS San Raffaele Roma","ror":"https://ror.org/006x48140","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126","https://openalex.org/I4387155925"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Cinzia Aurilia","raw_affiliation_strings":["Headache and Pain Unit, IRCCS San Raffaele Roma, Via Della Pisana 235, 00163, Rome, Italy. cinzia.aurilia@sanraffaele.it","Headache and Pain Unit, IRCCS San Raffaele Roma, Via Della Pisana 235, 00163, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Headache and Pain Unit, IRCCS San Raffaele Roma, Via Della Pisana 235, 00163, Rome, Italy. cinzia.aurilia@sanraffaele.it","institution_ids":["https://openalex.org/I4387155925"]},{"raw_affiliation_string":"Headache and Pain Unit, IRCCS San Raffaele Roma, Via Della Pisana 235, 00163, Rome, Italy","institution_ids":["https://openalex.org/I4387155925"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067104129","display_name":"Gabriella Egeo","orcid":"https://orcid.org/0000-0003-3068-4522","observed_orcids":["https://orcid.org/0000-0003-3068-4522"]},"institutions":[{"id":"https://openalex.org/I4387155925","display_name":"IRCCS San Raffaele Roma","ror":"https://ror.org/006x48140","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126","https://openalex.org/I4387155925"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Gabriella Egeo","raw_affiliation_strings":["Headache and Pain Unit, IRCCS San Raffaele Roma, Via Della Pisana 235, 00163, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Headache and Pain Unit, IRCCS San Raffaele Roma, Via Della Pisana 235, 00163, Rome, Italy","institution_ids":["https://openalex.org/I4387155925"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074163476","display_name":"Stefania Proietti","orcid":"https://orcid.org/0000-0002-9844-1482","observed_orcids":["https://orcid.org/0000-0002-9844-1482"]},"institutions":[{"id":"https://openalex.org/I4387155925","display_name":"IRCCS San Raffaele Roma","ror":"https://ror.org/006x48140","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126","https://openalex.org/I4387155925"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Stefania Proietti","raw_affiliation_strings":["Clinical and Molecular Epidemiology, IRCCS San Raffaele Roma, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical and Molecular Epidemiology, IRCCS San Raffaele Roma, Rome, Italy","institution_ids":["https://openalex.org/I4387155925"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110159853","display_name":"Florindo d\u2019Onofrio","orcid":"https://orcid.org/0009-0007-1647-3389","observed_orcids":["https://orcid.org/0009-0007-1647-3389"]},"institutions":[{"id":"https://openalex.org/I4210111929","display_name":"Azienda Ospedaliera S.Giuseppe Moscati","ror":"https://ror.org/021jxzw96","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210111929"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Florindo D\u2019Onofrio","raw_affiliation_strings":["Headache Center Neurology Unit, San Giuseppe Moscati Hospital, Avellino, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Headache Center Neurology Unit, San Giuseppe Moscati Hospital, Avellino, Italy","institution_ids":["https://openalex.org/I4210111929"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053356945","display_name":"Paola Torelli","orcid":"https://orcid.org/0000-0002-4072-2353","observed_orcids":["https://orcid.org/0000-0002-4072-2353"]},"institutions":[{"id":"https://openalex.org/I124601658","display_name":"University of Parma","ror":"https://ror.org/02k7wn190","country_code":"IT","type":"education","lineage":["https://openalex.org/I124601658"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Paola Torelli","raw_affiliation_strings":["Unit of Neurology, Department of Medicine and Surgery, Headache Center, University of Parma, Parma, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unit of Neurology, Department of Medicine and Surgery, Headache Center, University of Parma, Parma, Italy","institution_ids":["https://openalex.org/I124601658"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055793459","display_name":"Marco Aguggia","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Marco Aguggia","raw_affiliation_strings":["Headache Center Cardinal Massaia, Asti, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Headache Center Cardinal Massaia, Asti, Italy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053336149","display_name":"Davide Bertuzzo","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Davide Bertuzzo","raw_affiliation_strings":["Headache Center Cardinal Massaia, Asti, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Headache Center Cardinal Massaia, Asti, Italy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067585857","display_name":"Cinzia Finocchi","orcid":"https://orcid.org/0000-0003-4385-1203","observed_orcids":["https://orcid.org/0000-0003-4385-1203"]},"institutions":[{"id":"https://openalex.org/I4210090376","display_name":"Ospedale San Paolo","ror":"https://ror.org/00bpn0984","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210090376"]},{"id":"https://openalex.org/I4210149359","display_name":"Azienda Sanitaria Locale N. 2 Savonese","ror":"https://ror.org/04kz5k469","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210149359"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Cinzia Finocchi","raw_affiliation_strings":["Divisione di Neurologia, Ospedale San Paolo, ASL 2 Savonese, Savona, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Divisione di Neurologia, Ospedale San Paolo, ASL 2 Savonese, Savona, Italy","institution_ids":["https://openalex.org/I4210090376","https://openalex.org/I4210149359"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049245235","display_name":"Michele Trimboli","orcid":"https://orcid.org/0000-0001-6058-3912","observed_orcids":["https://orcid.org/0000-0001-6058-3912"]},"institutions":[{"id":"https://openalex.org/I36443711","display_name":"Magna Graecia University","ror":"https://ror.org/0530bdk91","country_code":"IT","type":"education","lineage":["https://openalex.org/I36443711"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Michele Trimboli","raw_affiliation_strings":["University Magna Graecia, Catanzaro, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Magna Graecia, Catanzaro, Italy","institution_ids":["https://openalex.org/I36443711"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014491572","display_name":"Sabina Cevoli","orcid":"https://orcid.org/0000-0003-4668-4295","observed_orcids":["https://orcid.org/0000-0003-4668-4295"]},"institutions":[{"id":"https://openalex.org/I4210123211","display_name":"Istituto delle Scienze Neurologiche di Bologna","ror":"https://ror.org/02mgzgr95","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210119117","https://openalex.org/I4210123211","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Sabina Cevoli","raw_affiliation_strings":["IRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, Italy","institution_ids":["https://openalex.org/I4210123211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082987616","display_name":"Giulia Fiorentini","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4387155925","display_name":"IRCCS San Raffaele Roma","ror":"https://ror.org/006x48140","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126","https://openalex.org/I4387155925"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giulia Fiorentini","raw_affiliation_strings":["Headache and Pain Unit, IRCCS San Raffaele Roma, Via Della Pisana 235, 00163, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Headache and Pain Unit, IRCCS San Raffaele Roma, Via Della Pisana 235, 00163, Rome, Italy","institution_ids":["https://openalex.org/I4387155925"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059277162","display_name":"Bianca Orlando","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4387155925","display_name":"IRCCS San Raffaele Roma","ror":"https://ror.org/006x48140","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126","https://openalex.org/I4387155925"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Bianca Orlando","raw_affiliation_strings":["Headache and Pain Unit, IRCCS San Raffaele Roma, Via Della Pisana 235, 00163, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Headache and Pain Unit, IRCCS San Raffaele Roma, Via Della Pisana 235, 00163, Rome, Italy","institution_ids":["https://openalex.org/I4387155925"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038480583","display_name":"Maurizio Zucco","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210095143","display_name":"Azienda Ospedaliera San Camillo-Forlanini","ror":"https://ror.org/00j707644","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210095143"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Maurizio Zucco","raw_affiliation_strings":["Headache Center, San Camillo-Forlanini Hospital, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Headache Center, San Camillo-Forlanini Hospital, Rome, Italy","institution_ids":["https://openalex.org/I4210095143"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101654413","display_name":"Laura Di Clemente","orcid":"https://orcid.org/0009-0001-7849-9484","observed_orcids":["https://orcid.org/0009-0001-7849-9484"]},"institutions":[{"id":"https://openalex.org/I4210095143","display_name":"Azienda Ospedaliera San Camillo-Forlanini","ror":"https://ror.org/00j707644","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210095143"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Laura Di Clemente","raw_affiliation_strings":["Headache Center, San Camillo-Forlanini Hospital, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Headache Center, San Camillo-Forlanini Hospital, Rome, Italy","institution_ids":["https://openalex.org/I4210095143"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032023638","display_name":"Ilaria Cetta","orcid":"https://orcid.org/0000-0002-9493-3885","observed_orcids":["https://orcid.org/0000-0002-9493-3885"]},"institutions":[{"id":"https://openalex.org/I154387261","display_name":"Vita-Salute San Raffaele University","ror":"https://ror.org/01gmqr298","country_code":"IT","type":"education","lineage":["https://openalex.org/I154387261"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Ilaria Cetta","raw_affiliation_strings":["Neurology Unit, IRCCS San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurology Unit, IRCCS San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy","institution_ids":["https://openalex.org/I154387261"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103021558","display_name":"Bruno Colombo","orcid":"https://orcid.org/0000-0001-8701-7072","observed_orcids":["https://orcid.org/0000-0001-8701-7072","https://orcid.org/0000-0003-2487-3634"]},"institutions":[{"id":"https://openalex.org/I154387261","display_name":"Vita-Salute San Raffaele University","ror":"https://ror.org/01gmqr298","country_code":"IT","type":"education","lineage":["https://openalex.org/I154387261"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Bruno Colombo","raw_affiliation_strings":["Neurology Unit, IRCCS San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurology Unit, IRCCS San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy","institution_ids":["https://openalex.org/I154387261"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104268653","display_name":"Monica Laura Bandettini di Poggio","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210146472","display_name":"Ospedale Policlinico San Martino","ror":"https://ror.org/04d7es448","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210146472","https://openalex.org/I4210153126","https://openalex.org/I4405264730"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Monica Laura Bandettini di Poggio","raw_affiliation_strings":["IRCCS Ospedale Policlinico San Martino, Genoa, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IRCCS Ospedale Policlinico San Martino, Genoa, Italy","institution_ids":["https://openalex.org/I4210146472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033690538","display_name":"Valentina Favoni","orcid":"https://orcid.org/0000-0001-5335-2438","observed_orcids":["https://orcid.org/0000-0001-5335-2438"]},"institutions":[{"id":"https://openalex.org/I4210123211","display_name":"Istituto delle Scienze Neurologiche di Bologna","ror":"https://ror.org/02mgzgr95","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210119117","https://openalex.org/I4210123211","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Valentina Favoni","raw_affiliation_strings":["IRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, Italy","institution_ids":["https://openalex.org/I4210123211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043359650","display_name":"Licia Grazzi","orcid":"https://orcid.org/0000-0001-6535-1109","observed_orcids":["https://orcid.org/0000-0001-6535-1109"]},"institutions":[{"id":"https://openalex.org/I4210164485","display_name":"Fondazione IRCCS Istituto Neurologico Carlo Besta","ror":"https://ror.org/05rbx8m02","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126","https://openalex.org/I4210164485"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Licia Grazzi","raw_affiliation_strings":["Neuroalgology Unit, Headache Center Fondazione, IRCCS Istituto Neurologico\"Carlo Besta\", Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neuroalgology Unit, Headache Center Fondazione, IRCCS Istituto Neurologico\"Carlo Besta\", Milan, Italy","institution_ids":["https://openalex.org/I4210164485"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049977936","display_name":"Antonio Salerno","orcid":"https://orcid.org/0009-0000-2191-6155","observed_orcids":["https://orcid.org/0009-0000-2191-6155"]},"institutions":[{"id":"https://openalex.org/I2799358833","display_name":"Azienda Ospedaliera San Giovanni Addolorata","ror":"https://ror.org/04pr9pz75","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I2799358833"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Antonio Salerno","raw_affiliation_strings":["Headache Center San Giovanni Addolorata Hospital, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Headache Center San Giovanni Addolorata Hospital, Rome, Italy","institution_ids":["https://openalex.org/I2799358833"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110956859","display_name":"Antonio Carnevale","orcid":"https://orcid.org/0009-0005-5665-5780","observed_orcids":["https://orcid.org/0009-0005-5665-5780"]},"institutions":[{"id":"https://openalex.org/I4210097502","display_name":"Ospedale San Filippo Neri","ror":"https://ror.org/00qt4k071","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210097502"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Antonio Carnevale","raw_affiliation_strings":["Headache Center San Filippo Neri Hospital, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Headache Center San Filippo Neri Hospital, Rome, Italy","institution_ids":["https://openalex.org/I4210097502"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008607186","display_name":"Micaela Robotti","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4396570669","display_name":"Azienda Socio Sanitaria Territoriale Santi Paolo e Carlo","ror":"https://ror.org/03dpchx26","country_code":"IT","type":"government","lineage":["https://openalex.org/I4396570669"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Micaela Robotti","raw_affiliation_strings":["Headache Center, ASST Santi Paolo Carlo, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Headache Center, ASST Santi Paolo Carlo, Milan, Italy","institution_ids":["https://openalex.org/I4396570669"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056946355","display_name":"Fabio Frediani","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4396570669","display_name":"Azienda Socio Sanitaria Territoriale Santi Paolo e Carlo","ror":"https://ror.org/03dpchx26","country_code":"IT","type":"government","lineage":["https://openalex.org/I4396570669"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Fabio Frediani","raw_affiliation_strings":["Headache Center, ASST Santi Paolo Carlo, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Headache Center, ASST Santi Paolo Carlo, Milan, Italy","institution_ids":["https://openalex.org/I4396570669"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049277307","display_name":"Claudia Altamura","orcid":"https://orcid.org/0000-0002-5934-5535","observed_orcids":["https://orcid.org/0000-0002-5934-5535"]},"institutions":[{"id":"https://openalex.org/I4210143387","display_name":"Campus Bio Medico University Hospital","ror":"https://ror.org/04gqbd180","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210143387"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Claudia Altamura","raw_affiliation_strings":["Headache and Neurosonology Unit, Policlinico Universitario Campus Bio-Medico, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Headache and Neurosonology Unit, Policlinico Universitario Campus Bio-Medico, Rome, Italy","institution_ids":["https://openalex.org/I4210143387"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003010065","display_name":"Massimo Filippi","orcid":"https://orcid.org/0000-0002-5485-0479","observed_orcids":["https://orcid.org/0000-0002-5485-0479"]},"institutions":[{"id":"https://openalex.org/I154387261","display_name":"Vita-Salute San Raffaele University","ror":"https://ror.org/01gmqr298","country_code":"IT","type":"education","lineage":["https://openalex.org/I154387261"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Massimo Filippi","raw_affiliation_strings":["Neurology Unit, IRCCS San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurology Unit, IRCCS San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy","institution_ids":["https://openalex.org/I154387261"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083240134","display_name":"Fabrizio Vernieri","orcid":"https://orcid.org/0000-0002-9594-9336","observed_orcids":["https://orcid.org/0000-0002-9594-9336"]},"institutions":[{"id":"https://openalex.org/I4210143387","display_name":"Campus Bio Medico University Hospital","ror":"https://ror.org/04gqbd180","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210143387"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Fabrizio Vernieri","raw_affiliation_strings":["Headache and Neurosonology Unit, Policlinico Universitario Campus Bio-Medico, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Headache and Neurosonology Unit, Policlinico Universitario Campus Bio-Medico, Rome, Italy","institution_ids":["https://openalex.org/I4210143387"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028649970","display_name":"Stefano Bonassi","orcid":"https://orcid.org/0000-0003-3833-6717","observed_orcids":["https://orcid.org/0000-0003-3833-6717"]},"institutions":[{"id":"https://openalex.org/I292310028","display_name":"San Raffaele University of Rome","ror":"https://ror.org/02rwycx38","country_code":"IT","type":"education","lineage":["https://openalex.org/I292310028"]},{"id":"https://openalex.org/I4210111929","display_name":"Azienda Ospedaliera S.Giuseppe Moscati","ror":"https://ror.org/021jxzw96","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210111929"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Stefano Bonassi","raw_affiliation_strings":["Headache Center Neurology Unit, San Giuseppe Moscati Hospital, Avellino, Italy","San Raffaele University, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Headache Center Neurology Unit, San Giuseppe Moscati Hospital, Avellino, Italy","institution_ids":["https://openalex.org/I4210111929"]},{"raw_affiliation_string":"San Raffaele University, Rome, Italy","institution_ids":["https://openalex.org/I292310028"]}]},{"author_position":"last","author":{"id":null,"display_name":"ERT; for the Italian Migraine Registry study group","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"ERT; for the Italian Migraine Registry study group","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":16,"corresponding_author_ids":["https://openalex.org/A5004416010","https://openalex.org/A5007223912"],"corresponding_institution_ids":["https://openalex.org/I292310028","https://openalex.org/I4387155925"],"apc_list":{"value":4590,"currency":"USD","value_usd":4590},"apc_paid":{"value":4590,"currency":"USD","value_usd":4590},"fwci":12.1231,"has_fulltext":true,"cited_by_count":52,"citation_normalized_percentile":{"value":0.99280063,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"271","issue":"5","first_page":"2434","last_page":"2443"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10498","display_name":"Migraine and Headache Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10498","display_name":"Migraine and Headache Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10420","display_name":"Intracranial Aneurysms: Treatment and Complications","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/migraine","display_name":"migraine","score":0.43799999356269836},{"id":"https://openalex.org/keywords/anti-cgrp-monoclonal-antibodies","display_name":"CGRP monoclonal antibodies","score":0.9599999785423279},{"id":"https://openalex.org/keywords/late-responders","display_name":"late responders","score":0.7450000047683716},{"id":"https://openalex.org/keywords/treatment-response","display_name":"treatment response","score":0.6129999756813049},{"id":"https://openalex.org/keywords/chronic-migraine","display_name":"chronic migraine","score":0.7429999709129333},{"id":"https://openalex.org/keywords/episodic-migraine","display_name":"episodic migraine","score":0.8889999985694885},{"id":"https://openalex.org/keywords/medication-overuse","display_name":"medication overuse","score":0.6430000066757202},{"id":"https://openalex.org/keywords/body-mass-index","display_name":"body mass index","score":0.6470000147819519},{"id":"https://openalex.org/keywords/hit-6","display_name":"HIT-6","score":0.6679999828338623},{"id":"https://openalex.org/keywords/migraine-disability","display_name":"migraine disability","score":0.46399998664855957},{"id":"https://openalex.org/keywords/real-world-treatment-outcomes","display_name":"real-world treatment outcomes","score":0.4050000011920929},{"id":"https://openalex.org/keywords/treatment-response-biomarkers","display_name":"treatment response biomarkers","score":0.5640000104904175}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8626412153244019},{"id":"https://openalex.org/C2778541695","wikidata":"https://www.wikidata.org/wiki/Q133823","display_name":"Migraine","level":2,"score":0.8181393146514893},{"id":"https://openalex.org/C163170386","wikidata":"https://www.wikidata.org/wiki/Q419432","display_name":"Calcitonin gene-related peptide","level":4,"score":0.8164666891098022},{"id":"https://openalex.org/C2910587157","wikidata":"https://www.wikidata.org/wiki/Q133823","display_name":"Chronic Migraine","level":3,"score":0.6327135562896729},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5656642913818359},{"id":"https://openalex.org/C16568411","wikidata":"https://www.wikidata.org/wiki/Q83042","display_name":"Neurology","level":2,"score":0.5497612357139587},{"id":"https://openalex.org/C2779627488","wikidata":"https://www.wikidata.org/wiki/Q315860","display_name":"Calcitonin","level":2,"score":0.5063563585281372},{"id":"https://openalex.org/C188816634","wikidata":"https://www.wikidata.org/wiki/Q2113324","display_name":"Prospective cohort study","level":2,"score":0.49117323756217957},{"id":"https://openalex.org/C23131810","wikidata":"https://www.wikidata.org/wiki/Q818574","display_name":"Observational study","level":2,"score":0.481696218252182},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.4343968629837036},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.40740224719047546},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.28710198402404785},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2097577154636383},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.07113948464393616},{"id":"https://openalex.org/C118303440","wikidata":"https://www.wikidata.org/wiki/Q419968","display_name":"Neuropeptide","level":3,"score":0.051524847745895386},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008881","descriptor_name":"Migraine Disorders","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008881","descriptor_name":"Migraine Disorders","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015740","descriptor_name":"Calcitonin Gene-Related Peptide","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1007/s00415-023-12103-4","doi":"https://doi.org/10.1007/s00415-023-12103-4","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s00415-023-12103-4","pdf_url":"https://link.springer.com/content/pdf/10.1007/s00415-023-12103-4.pdf","source":{"id":"https://openalex.org/S175814247","display_name":"Journal of Neurology","issn_l":"0012-1037","issn":["0012-1037","0340-5354","1432-1459"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neurology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11055785","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11055785","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11055785/pdf/415_2023_Article_12103.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Neurol","raw_type":"Text"},{"id":"pmid:38231271","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38231271","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of neurology","raw_type":"Multicenter Study"},{"id":"pmh:oai:iris.unisr.it:20.500.11768/156276","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/20.500.11768/156276","pdf_url":"https://iris.unisr.it/bitstream/20.500.11768/156276/5/J%20Neurol%20271_2434.pdf","source":{"id":"https://openalex.org/S7407055348","display_name":"Archivio Istituzionale della Ricerca - Universit\u00e0 Vita-Salute San Raffaele","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:cris.unibo.it:11585/977334","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/11585/977334","pdf_url":null,"source":{"id":"https://openalex.org/S4306402579","display_name":"Archivio istituzionale della ricerca (Alma Mater Studiorum Universit\u00e0 di Bologna)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210117483","host_organization_name":"Istituto di Ematologia di Bologna","host_organization_lineage":["https://openalex.org/I4210117483"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1007/s00415-023-12103-4","doi":"https://doi.org/10.1007/s00415-023-12103-4","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s00415-023-12103-4","pdf_url":"https://link.springer.com/content/pdf/10.1007/s00415-023-12103-4.pdf","source":{"id":"https://openalex.org/S175814247","display_name":"Journal of Neurology","issn_l":"0012-1037","issn":["0012-1037","0340-5354","1432-1459"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neurology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320307758","display_name":"Eli Lilly and Company","ror":"https://ror.org/01qat3289"},{"id":"https://openalex.org/F4320307781","display_name":"Sanofi","ror":"https://ror.org/027vj4x92"},{"id":"https://openalex.org/F4320308604","display_name":"Biogen","ror":"https://ror.org/02jqkb192"},{"id":"https://openalex.org/F4320308970","display_name":"Teva Pharmaceutical Industries","ror":"https://ror.org/01wfv3m53"},{"id":"https://openalex.org/F4320309725","display_name":"Fondazione Italiana Sclerosi Multipla","ror":"https://ror.org/006z1y950"},{"id":"https://openalex.org/F4320321781","display_name":"Ministero della Salute","ror":"https://ror.org/00789fa95"},{"id":"https://openalex.org/F4320324698","display_name":"Fondazione Italiana di Ricerca per la Sclerosi Laterale Amiotrofica","ror":"https://ror.org/058f84k27"},{"id":"https://openalex.org/F4320332585","display_name":"Allergan","ror":"https://ror.org/00wthd003"},{"id":"https://openalex.org/F4320333587","display_name":"Sanofi Genzyme","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4390944115.pdf","grobid_xml":"https://content.openalex.org/works/W4390944115.grobid-xml"},"referenced_works_count":23,"referenced_works":["https://openalex.org/W73775937","https://openalex.org/W1963591991","https://openalex.org/W1973378154","https://openalex.org/W1992307523","https://openalex.org/W2026443662","https://openalex.org/W2088850685","https://openalex.org/W2122311626","https://openalex.org/W2122612489","https://openalex.org/W2275048719","https://openalex.org/W2785395436","https://openalex.org/W2969957804","https://openalex.org/W2996149780","https://openalex.org/W3030102664","https://openalex.org/W3035231691","https://openalex.org/W3166381176","https://openalex.org/W3177316434","https://openalex.org/W4210696369","https://openalex.org/W4282822738","https://openalex.org/W4282934967","https://openalex.org/W4307742097","https://openalex.org/W4320710015","https://openalex.org/W4366248393","https://openalex.org/W4382403544"],"related_works":["https://openalex.org/W4366248393","https://openalex.org/W4413395886","https://openalex.org/W4414979553","https://openalex.org/W7134236135","https://openalex.org/W4400547437","https://openalex.org/W4398761433","https://openalex.org/W4307742097","https://openalex.org/W4364352667","https://openalex.org/W3139684698","https://openalex.org/W4323539414"],"abstract_inverted_index":{"OBJECTIVE:":[0],"Nearly":[1],"60%":[2],"of":[3,38,61,158,166,264,283,318,332,343,372,378,391],"migraine":[4,25,93,100,160,373],"patients":[5,40,62,120,161,239,333,344],"treated":[6,108],"with":[7,102,109,121,133,300,334],"monoclonal":[8],"antibodies":[9],"(mAbs)":[10],"targeting":[11],"the":[12,39,192,220,370,376,386],"calcitonin":[13],"gene-related":[14],"peptide":[15],"(CGRP)":[16],"pathway":[17],"experience":[18],"a":[19,122,134,147,329],"\u2265":[20,95,103,114,123,135,148,163,193,221,226,335],"50%":[21,124,136,149,194,222],"reduction":[22],"in":[23,298],"monthly":[24],"days":[26],"(MMD)":[27],"at":[28,225,244],"12":[29,47,128],"weeks":[30,48,53,70,165,352,360],"compared":[31],"to":[32,43,64,347,368],"baseline":[33],"(responders).":[34],"However,":[35],"approximately":[36],"half":[37],"not":[41,242,345],"responding":[42,63,346],"anti-CGRP":[44,65,111,167,348],"mAbs":[45,66,112,168,349],"\u2264":[46,51,127,139,248,350,358],"do":[49,353],"respond":[50,243,354],"24":[52,69,140,153,351],"(late":[54],"responders).":[55,72],"We":[56,117],"assessed":[57],"frequency":[58,282],"and":[59,142,180,208,210,231,275,311,328,375,380],"characteristics":[60],"only":[67,151],">":[68,152],"(ultra-late":[71],"METHODS:":[73],"In":[74],"this":[75],"multicenter":[76],"(n":[77],"=":[78,260,273,279,287,295,303,307,314,321,326,339],"16),":[79],"prospective,":[80],"observational,":[81],"real-life":[82],"study,":[83],"we":[84],"enrolled":[85],"all":[86,198],"consecutive":[87],"adults":[88],"affected":[89],"by":[90],"high-frequency":[91],"episodic":[92],"(HFEM:":[94],"8":[96],"days/month)":[97],"or":[98,297,309],"chronic":[99],"(CM),":[101],"3":[104],"prior":[105],"therapeutic":[106],"failures,":[107],"any":[110,245],"for":[113,172,177,183,256],"48":[115,164,249,359],"weeks.":[116,154,250],"defined":[118],"responders":[119,131,144,176,182,252,255],"response":[125,137,150,195,223,387],"rate":[126,138,196,224],"weeks,":[129,141],"late":[130,175],"those":[132,145],"ultra-late":[143,181,187,214,236],"achieving":[146],"RESULTS:":[155],"A":[156],"total":[157],"572":[159],"completed":[162],"treatment.":[169,392],"Responders":[170],"accounted":[171],"60.5%":[173],"(346/572),":[174],"15%":[178],"(86/572),":[179],"15.7%":[184],"(90/572).":[185],"Among":[186],"responders,":[188,215],"7.3%":[189],"(42/572)":[190],"maintained":[191],"across":[197],"subsequent":[199,228],"time":[200,229,246],"intervals":[201],"(weeks":[202],"28,":[203],"32,":[204],"36,":[205],"40,":[206],"44,":[207],"48)":[209],"were":[211,232],"considered":[212],"persistent":[213],"while":[216,356],"8.4%":[217],"(48/572)":[218],"missed":[219],"1":[227,336],"interval":[230,247],"classified":[233],"as":[234],"fluctuating":[235],"responders.":[237],"Fifty":[238],"(8.7%)":[240],"did":[241],"Ultra-late":[251],"differed":[253],"from":[254],"higher":[257,281,316,330],"BMI":[258],"(p":[259,267,272,278,286,294,302,306,313,320,325,338],"0.033),":[261],"longer":[262],"duration":[263,371],"medication":[265],"overuse":[266],"<":[268],"0.001),":[269],"lower":[270],"NRS":[271],"0.017)":[274],"HIT-6":[276],"scores":[277],"0.002),":[280,288],"dopaminergic":[284],"symptoms":[285],"less":[289],"common":[290],"unilateral":[291],"pain-either":[292],"alone":[293],"0.010)":[296,327],"combination":[299],"UAS":[301,310],"0.023),":[304],"allodynia":[305,312],"0.043),":[308],"0.012)-a":[315],"number":[317],"comorbidities":[319,324],"0.012),":[322],"psychiatric":[323],"proportion":[331],"comorbidity":[337],"0.020).":[340],"CONCLUSION:":[341],"Two-thirds":[342],"later,":[355],"non-responders":[357],"are":[361],"quite":[362],"rare":[363],"(8.7%).":[364],"These":[365],"findings":[366],"suggest":[367],"rethink":[369],"prophylaxis":[374],"definition":[377],"resistant":[379],"refractory":[381],"migraine,":[382],"currently":[383],"based":[384],"on":[385],"after":[388],"2-3":[389],"months":[390]},"counts_by_year":[{"year":2026,"cited_by_count":25},{"year":2025,"cited_by_count":19},{"year":2024,"cited_by_count":8}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2024-01-18T00:00:00"}