{"id":"https://openalex.org/W4390939008","doi":"https://doi.org/10.1021/acs.analchem.3c04958","title":"Facile Method for Determining Lanthipeptide Stereochemistry","display_name":"Facile Method for Determining Lanthipeptide Stereochemistry","publication_year":2024,"publication_date":"2024-01-17","ids":{"openalex":"https://openalex.org/W4390939008","doi":"https://doi.org/10.1021/acs.analchem.3c04958","pmid":"https://pubmed.ncbi.nlm.nih.gov/38232355","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10831782"},"language":"en","primary_location":{"id":"doi:10.1021/acs.analchem.3c04958","doi":"https://doi.org/10.1021/acs.analchem.3c04958","is_oa":true,"landing_page_url":"https://doi.org/10.1021/acs.analchem.3c04958","pdf_url":null,"source":{"id":"https://openalex.org/S191963794","display_name":"Analytical Chemistry","issn_l":"0003-2700","issn":["0003-2700","1520-6882"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Analytical Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1021/acs.analchem.3c04958","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5072248918","display_name":"Youran Luo","orcid":"https://orcid.org/0000-0002-8033-2472","observed_orcids":["https://orcid.org/0000-0002-8033-2472"]},"institutions":[{"id":"https://openalex.org/I157725225","display_name":"University of Illinois Urbana-Champaign","ror":"https://ror.org/047426m28","country_code":"US","type":"education","lineage":["https://openalex.org/I157725225"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Youran Luo","raw_affiliation_strings":["Department of Chemistry, University of Illinois at Urbana\u2013Champaign, Urbana, Illinois 61801, United States"],"raw_orcid":"https://orcid.org/0000-0002-8033-2472","affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of Illinois at Urbana\u2013Champaign, Urbana, Illinois 61801, United States","institution_ids":["https://openalex.org/I157725225"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103101392","display_name":"Shuyun Xu","orcid":"https://orcid.org/0009-0008-8443-3984","observed_orcids":["https://orcid.org/0009-0008-8443-3984"]},"institutions":[{"id":"https://openalex.org/I157725225","display_name":"University of Illinois Urbana-Champaign","ror":"https://ror.org/047426m28","country_code":"US","type":"education","lineage":["https://openalex.org/I157725225"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shuyun Xu","raw_affiliation_strings":["Department of Chemistry, University of Illinois at Urbana\u2013Champaign, Urbana, Illinois 61801, United States"],"raw_orcid":"https://orcid.org/0009-0008-8443-3984","affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of Illinois at Urbana\u2013Champaign, Urbana, Illinois 61801, United States","institution_ids":["https://openalex.org/I157725225"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057286464","display_name":"Autumn M. Frerk","orcid":"https://orcid.org/0000-0002-0273-7108","observed_orcids":["https://orcid.org/0000-0002-0273-7108"]},"institutions":[{"id":"https://openalex.org/I157725225","display_name":"University of Illinois Urbana-Champaign","ror":"https://ror.org/047426m28","country_code":"US","type":"education","lineage":["https://openalex.org/I157725225"]},{"id":"https://openalex.org/I4405271866","display_name":"Carl R. Woese Institute for Genomic Biology","ror":"https://ror.org/036j6yj81","country_code":"US","type":"facility","lineage":["https://openalex.org/I4405271866"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Autumn M. Frerk","raw_affiliation_strings":["Carl R. Woese Institute for Genomic Biology, University of Illinois at Urbana\u2013Champaign, Urbana, Illinois 61801, United States","Department of Chemistry, University of Illinois at Urbana\u2013Champaign, Urbana, Illinois 61801, United States"],"raw_orcid":"https://orcid.org/0000-0002-0273-7108","affiliations":[{"raw_affiliation_string":"Carl R. Woese Institute for Genomic Biology, University of Illinois at Urbana\u2013Champaign, Urbana, Illinois 61801, United States","institution_ids":["https://openalex.org/I157725225","https://openalex.org/I4405271866"]},{"raw_affiliation_string":"Department of Chemistry, University of Illinois at Urbana\u2013Champaign, Urbana, Illinois 61801, United States","institution_ids":["https://openalex.org/I157725225"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5067523147","display_name":"Wilfred A. van der Donk","orcid":"https://orcid.org/0000-0002-5467-7071","observed_orcids":["https://orcid.org/0000-0002-5467-7071"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I157725225","display_name":"University of Illinois Urbana-Champaign","ror":"https://ror.org/047426m28","country_code":"US","type":"education","lineage":["https://openalex.org/I157725225"]},{"id":"https://openalex.org/I4405271866","display_name":"Carl R. Woese Institute for Genomic Biology","ror":"https://ror.org/036j6yj81","country_code":"US","type":"facility","lineage":["https://openalex.org/I4405271866"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Wilfred A. van der Donk","raw_affiliation_strings":["Carl R. Woese Institute for Genomic Biology, University of Illinois at Urbana\u2013Champaign, Urbana, Illinois 61801, United States","Department of Chemistry, University of Illinois at Urbana\u2013Champaign, Urbana, Illinois 61801, United States","Howard Hughes Medical Institute, University of Illinois at Urbana\u2013Champaign, Urbana, Illinois 61801, United States"],"raw_orcid":"https://orcid.org/0000-0002-5467-7071","affiliations":[{"raw_affiliation_string":"Carl R. Woese Institute for Genomic Biology, University of Illinois at Urbana\u2013Champaign, Urbana, Illinois 61801, United States","institution_ids":["https://openalex.org/I157725225","https://openalex.org/I4405271866"]},{"raw_affiliation_string":"Department of Chemistry, University of Illinois at Urbana\u2013Champaign, Urbana, Illinois 61801, United States","institution_ids":["https://openalex.org/I157725225"]},{"raw_affiliation_string":"Howard Hughes Medical Institute, University of Illinois at Urbana\u2013Champaign, Urbana, Illinois 61801, United States","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I157725225"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5067523147"],"corresponding_institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I157725225","https://openalex.org/I4405271866"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":{"value":4500,"currency":"USD","value_usd":4500},"fwci":3.4098,"has_fulltext":true,"cited_by_count":13,"citation_normalized_percentile":{"value":0.92390575,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"96","issue":"4","first_page":"1767","last_page":"1773"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10252","display_name":"Microbial Natural Products and Biosynthesis","score":0.5615000128746033,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10252","display_name":"Microbial Natural Products and Biosynthesis","score":0.5615000128746033,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":0.18930000066757202,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10908","display_name":"Analytical Chemistry and Chromatography","score":0.1014999970793724,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lanthipeptides","display_name":"lanthipeptides","score":0.9980000257492065},{"id":"https://openalex.org/keywords/stereochemistry-determination","display_name":"stereochemistry determination","score":0.8930000066757202},{"id":"https://openalex.org/keywords/lanthionine","display_name":"lanthionine","score":0.800000011920929},{"id":"https://openalex.org/keywords/marfey-s-analysis","display_name":"Marfey's analysis","score":0.8759999871253967},{"id":"https://openalex.org/keywords/ribosomally-synthesized-and-post-translationally-modified-peptides","display_name":"ribosomally synthesized and post-translationally modified peptides","score":0.9020000100135803},{"id":"https://openalex.org/keywords/antimicrobial-peptides","display_name":"antimicrobial peptides","score":0.6890000104904175},{"id":"https://openalex.org/keywords/genome-mining","display_name":"genome mining","score":0.8529999852180481},{"id":"https://openalex.org/keywords/natural-products","display_name":"natural products","score":0.5270000100135803}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.9907532930374146},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.4218023121356964},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.35749393701553345},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.3375348448753357}],"mesh":[{"descriptor_ui":"D000409","descriptor_name":"Alanine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D000409","descriptor_name":"Alanine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002853","descriptor_name":"Chromatography, Liquid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D013440","descriptor_name":"Sulfides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1021/acs.analchem.3c04958","doi":"https://doi.org/10.1021/acs.analchem.3c04958","is_oa":true,"landing_page_url":"https://doi.org/10.1021/acs.analchem.3c04958","pdf_url":null,"source":{"id":"https://openalex.org/S191963794","display_name":"Analytical Chemistry","issn_l":"0003-2700","issn":["0003-2700","1520-6882"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Analytical Chemistry","raw_type":"journal-article"},{"id":"doi:10.1101/2023.10.26.564210","doi":"https://doi.org/10.1101/2023.10.26.564210","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2023.10.26.564210","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2023/11/03/2023.10.26.564210.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:10831782","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10831782","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10831782/pdf/ac3c04958.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anal Chem","raw_type":"Text"},{"id":"pmid:38232355","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38232355","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Analytical chemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1021/acs.analchem.3c04958","doi":"https://doi.org/10.1021/acs.analchem.3c04958","is_oa":true,"landing_page_url":"https://doi.org/10.1021/acs.analchem.3c04958","pdf_url":null,"source":{"id":"https://openalex.org/S191963794","display_name":"Analytical Chemistry","issn_l":"0003-2700","issn":["0003-2700","1520-6882"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Analytical Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G9000912183","display_name":"A Next-Generation Scalable Platform to Discover Antimicrobials of Ribosomal Origin","funder_award_id":"R01AI144967","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320306082","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4390939008.pdf","grobid_xml":"https://content.openalex.org/works/W4390939008.grobid-xml"},"referenced_works_count":57,"referenced_works":["https://openalex.org/W1869253421","https://openalex.org/W1983703411","https://openalex.org/W1987063095","https://openalex.org/W1995399470","https://openalex.org/W2022162043","https://openalex.org/W2044601830","https://openalex.org/W2050428291","https://openalex.org/W2051668777","https://openalex.org/W2053819820","https://openalex.org/W2062932139","https://openalex.org/W2091732247","https://openalex.org/W2142696585","https://openalex.org/W2167332415","https://openalex.org/W2169643092","https://openalex.org/W2322532412","https://openalex.org/W2326842020","https://openalex.org/W2328635643","https://openalex.org/W2415991929","https://openalex.org/W2429194438","https://openalex.org/W2581893128","https://openalex.org/W2592527354","https://openalex.org/W2593189583","https://openalex.org/W2901111985","https://openalex.org/W2977984311","https://openalex.org/W2985979606","https://openalex.org/W2986937238","https://openalex.org/W2991551069","https://openalex.org/W3011920353","https://openalex.org/W3031896406","https://openalex.org/W3037766603","https://openalex.org/W3043773617","https://openalex.org/W3087348949","https://openalex.org/W3117886555","https://openalex.org/W3117945984","https://openalex.org/W3122611304","https://openalex.org/W3159344977","https://openalex.org/W3165083676","https://openalex.org/W4220828637","https://openalex.org/W4220975403","https://openalex.org/W4221094539","https://openalex.org/W4221113615","https://openalex.org/W4283312800","https://openalex.org/W4293102559","https://openalex.org/W4294146847","https://openalex.org/W4295904750","https://openalex.org/W4306409651","https://openalex.org/W4308053336","https://openalex.org/W4313219486","https://openalex.org/W4322493733","https://openalex.org/W4323660987","https://openalex.org/W4327901951","https://openalex.org/W4365810872","https://openalex.org/W4380291692","https://openalex.org/W4383069899","https://openalex.org/W4384663787","https://openalex.org/W4386191644","https://openalex.org/W4388721902"],"related_works":["https://openalex.org/W4221094539","https://openalex.org/W2521783917","https://openalex.org/W4293102559","https://openalex.org/W4413286088","https://openalex.org/W3021726468","https://openalex.org/W2587918325","https://openalex.org/W3153768332","https://openalex.org/W4320487803","https://openalex.org/W2953855243","https://openalex.org/W3210721182"],"abstract_inverted_index":{"Lanthipeptides":[0,20],"make":[1],"up":[2],"a":[3,57,101,108,147,155,170],"large":[4],"group":[5],"of":[6,33,86,94,97,125,169],"natural":[7],"products":[8],"that":[9,27,45,136],"belong":[10],"to":[11,90,121,158],"the":[12,92,126],"ribosomally":[13],"synthesized":[14],"and":[15,23,60,131,153],"post-translationally":[16],"modified":[17],"peptides":[18],"(RiPPs).":[19],"contain":[21],"lanthionine":[22,134],"methyllanthionine":[24,129],"bis-amino":[25],"acids":[26],"have":[28,137],"varying":[29],"stereochemistry.":[30],"The":[31,143],"stereochemistry":[32,93,99],"new":[34],"lanthipeptides":[35],"is":[36,46,88,107],"often":[37],"not":[38,47],"determined":[39],"because":[40],"current":[41,114],"methods":[42,120],"require":[43],"equipment":[44],"standard":[48],"in":[49,140],"most":[50],"laboratories.":[51],"In":[52,116],"this":[53],"study,":[54],"we":[55,118],"developed":[56,144],"facile,":[58],"efficient,":[59],"user-friendly":[61],"method":[62],"for":[63],"detecting":[64],"lanthipeptide":[65,171],"stereochemistry,":[66],"utilizing":[67],"advanced":[68],"Marfey's":[69],"analysis":[70],"with":[71,77,166],"detection":[72,111],"by":[73,173],"liquid":[74,103],"chromatography":[75,104],"coupled":[76],"mass":[78],"spectrometry":[79],"(LC-MS).":[80],"Under":[81],"optimized":[82],"conditions,":[83],"0.05":[84],"mg":[85],"peptide":[87],"sufficient":[89],"characterize":[91],"five":[95],"(methyl)lanthionines":[96],"different":[98,128,133],"using":[100],"simple":[102],"setup,":[105],"which":[106],"much":[109],"lower":[110],"limit":[112],"than":[113],"methods.":[115],"addition,":[117],"describe":[119],"readily":[122],"access":[123],"standards":[124],"three":[127],"stereoisomers":[130,135],"two":[132],"been":[138],"reported":[139],"known":[141],"lanthipeptides.":[142],"workflow":[145],"uses":[146],"commonly":[148],"used":[149],"nonchiral":[150],"column":[151],"system":[152],"offers":[154],"scalable":[156],"platform":[157],"assist":[159],"antimicrobial":[160],"discovery.":[161],"We":[162],"illustrate":[163],"its":[164],"utility":[165],"an":[167],"example":[168],"discovered":[172],"genome":[174],"mining.":[175]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2024-01-18T00:00:00"}