{"id":"https://openalex.org/W4390929490","doi":"https://doi.org/10.2147/copd.s427770","title":"Real-World Effectiveness of Fluticasone Furoate/Umeclidinium/Vilanterol Once-Daily Single-Inhaler Triple Therapy for Symptomatic COPD: The ELLITHE Non-Interventional Trial","display_name":"Real-World Effectiveness of Fluticasone Furoate/Umeclidinium/Vilanterol Once-Daily Single-Inhaler Triple Therapy for Symptomatic COPD: The ELLITHE Non-Interventional Trial","publication_year":2024,"publication_date":"2024-01-01","ids":{"openalex":"https://openalex.org/W4390929490","doi":"https://doi.org/10.2147/copd.s427770","pmid":"https://pubmed.ncbi.nlm.nih.gov/38249826","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10800114"},"language":"en","primary_location":{"id":"doi:10.2147/copd.s427770","doi":"https://doi.org/10.2147/copd.s427770","is_oa":true,"landing_page_url":"https://doi.org/10.2147/copd.s427770","pdf_url":"https://www.dovepress.com/getfile.php?fileID=96027","source":{"id":"https://openalex.org/S105319247","display_name":"International Journal of COPD","issn_l":"1176-9106","issn":["1176-9106","1178-2005"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320348","host_organization_name":"Dove Medical Press","host_organization_lineage":["https://openalex.org/P4310320348","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Dove Medical Press","Taylor & Francis"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Chronic Obstructive Pulmonary Disease","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.dovepress.com/getfile.php?fileID=96027","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000903205","display_name":"Kai Michael Beeh","orcid":"https://orcid.org/0000-0001-9067-118X","observed_orcids":["https://orcid.org/0000-0001-9067-118X"]},"institutions":[{"id":"https://openalex.org/I4210115328","display_name":"Respiratory Research Institute","ror":"https://ror.org/029rf8d44","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210115328"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Kai-Michael Beeh","raw_affiliation_strings":["Insaf Respiratory Research Institute, Wiesbaden, Germany"],"raw_orcid":"https://orcid.org/0000-0001-9067-118X","affiliations":[{"raw_affiliation_string":"Insaf Respiratory Research Institute, Wiesbaden, Germany","institution_ids":["https://openalex.org/I4210115328"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020159629","display_name":"Karl Scheithe","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405267067","display_name":"GKM Gesellschaft f\u00fcr Therapieforschung mbH (Germany)","ror":"https://ror.org/012peaf20","country_code":"DE","type":"company","lineage":["https://openalex.org/I4405267067"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Karl Scheithe","raw_affiliation_strings":["Department of Biostatistics, GKM Gesellschaft F\u00fcr Therapieforschung mbH, Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics, GKM Gesellschaft F\u00fcr Therapieforschung mbH, Munich, Germany","institution_ids":["https://openalex.org/I4405267067"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108540806","display_name":"H Schmutzler","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405268658","display_name":"Berlin-Chemie AG (Germany)","ror":"https://ror.org/01n4sqg38","country_code":"DE","type":"company","lineage":["https://openalex.org/I4405268658"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Heike Schmutzler","raw_affiliation_strings":["Medical Department, BERLIN-CHEMIE AG, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Department, BERLIN-CHEMIE AG, Berlin, Germany","institution_ids":["https://openalex.org/I4405268658"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5047270851","display_name":"Saskia Kr\u00fcger","orcid":"https://orcid.org/0000-0002-0807-4851","observed_orcids":["https://orcid.org/0000-0002-0807-4851"]},"institutions":[{"id":"https://openalex.org/I4405268658","display_name":"Berlin-Chemie AG (Germany)","ror":"https://ror.org/01n4sqg38","country_code":"DE","type":"company","lineage":["https://openalex.org/I4405268658"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Saskia Kr\u00fcger","raw_affiliation_strings":["Medical Department, BERLIN-CHEMIE AG, Berlin, Germany"],"raw_orcid":"https://orcid.org/0000-0002-0807-4851","affiliations":[{"raw_affiliation_string":"Medical Department, BERLIN-CHEMIE AG, Berlin, Germany","institution_ids":["https://openalex.org/I4405268658"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5000903205"],"corresponding_institution_ids":["https://openalex.org/I4210115328"],"apc_list":{"value":2836,"currency":"USD","value_usd":2836},"apc_paid":{"value":2836,"currency":"USD","value_usd":2836},"fwci":5.4296,"has_fulltext":true,"cited_by_count":21,"citation_normalized_percentile":{"value":0.96627693,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"Volume 19","issue":null,"first_page":"205","last_page":"216"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11651","display_name":"Inhalation and Respiratory Drug Delivery","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chronic-obstructive-pulmonary-disease","display_name":"chronic obstructive pulmonary disease","score":0.8650000095367432},{"id":"https://openalex.org/keywords/fluticasone-furoate","display_name":"fluticasone furoate","score":0.9890000224113464},{"id":"https://openalex.org/keywords/umeclidinium","display_name":"umeclidinium","score":0.9959999918937683},{"id":"https://openalex.org/keywords/vilanterol","display_name":"vilanterol","score":1.0},{"id":"https://openalex.org/keywords/copd-assessment-test","display_name":"COPD Assessment Test","score":0.7419999837875366},{"id":"https://openalex.org/keywords/acute-exacerbation-of-copd","display_name":"COPD exacerbations","score":0.8029999732971191},{"id":"https://openalex.org/keywords/fev1","display_name":"FEV1","score":0.7689999938011169},{"id":"https://openalex.org/keywords/inhaler-adherence","display_name":"inhaler adherence","score":0.9879999756813049},{"id":"https://openalex.org/keywords/usual-care","display_name":"usual care","score":0.7480000257492065},{"id":"https://openalex.org/keywords/real-world-effectiveness","display_name":"real-world effectiveness","score":0.7919999957084656},{"id":"https://openalex.org/keywords/long-acting-muscarinic-antagonist","display_name":"long-acting muscarinic antagonist","score":0.828000009059906},{"id":"https://openalex.org/keywords/inhaled-corticosteroids","display_name":"inhaled corticosteroids","score":0.8700000047683716},{"id":"https://openalex.org/keywords/long-acting-beta-agonists","display_name":"long-acting beta2-agonists","score":0.8949999809265137}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9576942324638367},{"id":"https://openalex.org/C2780261241","wikidata":"https://www.wikidata.org/wiki/Q1394363","display_name":"Inhaler","level":3,"score":0.736716628074646},{"id":"https://openalex.org/C2779028295","wikidata":"https://www.wikidata.org/wiki/Q8564098","display_name":"Fluticasone propionate","level":3,"score":0.7244901061058044},{"id":"https://openalex.org/C2776780178","wikidata":"https://www.wikidata.org/wiki/Q199804","display_name":"COPD","level":2,"score":0.7034412622451782},{"id":"https://openalex.org/C2777419714","wikidata":"https://www.wikidata.org/wiki/Q1334805","display_name":"Dry-powder inhaler","level":4,"score":0.6330044269561768},{"id":"https://openalex.org/C203092338","wikidata":"https://www.wikidata.org/wiki/Q1340863","display_name":"Clinical endpoint","level":3,"score":0.5572839975357056},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5525444149971008},{"id":"https://openalex.org/C2780911369","wikidata":"https://www.wikidata.org/wiki/Q753853","display_name":"Lama","level":3,"score":0.546779990196228},{"id":"https://openalex.org/C1862650","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Physical therapy","level":1,"score":0.4282298982143402},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.4007120430469513},{"id":"https://openalex.org/C2776804153","wikidata":"https://www.wikidata.org/wiki/Q210420","display_name":"Corticosteroid","level":2,"score":0.3929588496685028},{"id":"https://openalex.org/C2776042228","wikidata":"https://www.wikidata.org/wiki/Q35869","display_name":"Asthma","level":2,"score":0.21287226676940918}],"mesh":[{"descriptor_ui":"D000068298","descriptor_name":"Fluticasone","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000730","descriptor_name":"Androstadienes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001592","descriptor_name":"Benzyl Alcohols","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002722","descriptor_name":"Chlorobenzenes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009330","descriptor_name":"Nebulizers and Vaporizers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011812","descriptor_name":"Quinuclidines","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D029424","descriptor_name":"Pulmonary Disease, Chronic Obstructive","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D029424","descriptor_name":"Pulmonary Disease, Chronic Obstructive","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.2147/copd.s427770","doi":"https://doi.org/10.2147/copd.s427770","is_oa":true,"landing_page_url":"https://doi.org/10.2147/copd.s427770","pdf_url":"https://www.dovepress.com/getfile.php?fileID=96027","source":{"id":"https://openalex.org/S105319247","display_name":"International Journal of COPD","issn_l":"1176-9106","issn":["1176-9106","1178-2005"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320348","host_organization_name":"Dove Medical Press","host_organization_lineage":["https://openalex.org/P4310320348","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Dove Medical Press","Taylor & Francis"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Chronic Obstructive Pulmonary Disease","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10800114","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10800114","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10800114/pdf/copd-19-205.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Chron Obstruct Pulmon Dis","raw_type":"Text"},{"id":"pmid:38249826","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38249826","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of chronic obstructive pulmonary disease","raw_type":"Multicenter Study"},{"id":"pmh:oai:dovepress.com/89761","doi":null,"is_oa":true,"landing_page_url":"https://www.dovepress.com/real-world-effectiveness-of-fluticasone-furoateumeclidiniumvilanterol--peer-reviewed-fulltext-article-COPD","pdf_url":"https://www.dovepress.com/article/download/89761","source":{"id":"https://openalex.org/S4306401012","display_name":"Dove Medical Press (Taylor and Francis Group)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:ee84a35e35b2409390a4492066c51e49","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/ee84a35e35b2409390a4492066c51e49","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"International Journal of COPD, Vol Volume 19, Pp 205-216 (2024)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.2147/copd.s427770","doi":"https://doi.org/10.2147/copd.s427770","is_oa":true,"landing_page_url":"https://doi.org/10.2147/copd.s427770","pdf_url":"https://www.dovepress.com/getfile.php?fileID=96027","source":{"id":"https://openalex.org/S105319247","display_name":"International Journal of COPD","issn_l":"1176-9106","issn":["1176-9106","1178-2005"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320348","host_organization_name":"Dove Medical Press","host_organization_lineage":["https://openalex.org/P4310320348","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Dove Medical Press","Taylor & Francis"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Chronic Obstructive Pulmonary Disease","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320337277","display_name":"BERLIN-CHEMIE","ror":"https://ror.org/01n4sqg38"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4390929490.pdf","grobid_xml":"https://content.openalex.org/works/W4390929490.grobid-xml"},"referenced_works_count":45,"referenced_works":["https://openalex.org/W142956752","https://openalex.org/W1860704149","https://openalex.org/W2002726093","https://openalex.org/W2039206076","https://openalex.org/W2077523026","https://openalex.org/W2078552229","https://openalex.org/W2101849970","https://openalex.org/W2107490395","https://openalex.org/W2121612376","https://openalex.org/W2136892596","https://openalex.org/W2138355864","https://openalex.org/W2154204110","https://openalex.org/W2157968241","https://openalex.org/W2167941825","https://openalex.org/W2343928958","https://openalex.org/W2344148139","https://openalex.org/W2365138737","https://openalex.org/W2510919056","https://openalex.org/W2512624858","https://openalex.org/W2604577460","https://openalex.org/W2761298511","https://openalex.org/W2767010890","https://openalex.org/W2785999277","https://openalex.org/W2794418690","https://openalex.org/W2794699839","https://openalex.org/W2802221596","https://openalex.org/W2891482814","https://openalex.org/W2898272122","https://openalex.org/W2912754182","https://openalex.org/W2920797638","https://openalex.org/W2955635155","https://openalex.org/W3007716362","https://openalex.org/W3011621519","https://openalex.org/W3034896332","https://openalex.org/W3037411127","https://openalex.org/W3158385683","https://openalex.org/W3162059233","https://openalex.org/W3177618925","https://openalex.org/W3187388666","https://openalex.org/W4253165656","https://openalex.org/W4285040856","https://openalex.org/W4285732351","https://openalex.org/W4297021616","https://openalex.org/W4311073639","https://openalex.org/W4323923237"],"related_works":["https://openalex.org/W4404097311","https://openalex.org/W4412371960","https://openalex.org/W3164397367","https://openalex.org/W4392648811","https://openalex.org/W2801376904","https://openalex.org/W4312522265","https://openalex.org/W3112576098","https://openalex.org/W4387954676","https://openalex.org/W3162059233","https://openalex.org/W4387954667"],"abstract_inverted_index":{"Purpose:":[0],"Real-life":[1],"effectiveness":[2,74],"data":[3],"on":[4,95],"once-daily":[5,90],"single-inhaler":[6],"triple":[7,196],"therapy":[8],"(odSITT)":[9],"with":[10,33,86,235,276],"the":[11,17,24,81,92,109,112,210,296,303],"inhaled":[12],"corticosteroid":[13],"fluticasone":[14],"furoate":[15],"(FF),":[16],"long-acting":[18,25],"muscarinic":[19],"antagonist":[20],"umeclidinium":[21],"(UMEC),":[22],"and":[23,58,64,78,121,153,158,190,208,239,281,288],"\u03b2":[26],"2":[27],"-agonist":[28],"vilanterol":[29],"(VI)":[30],"in":[31,60,97,102,111,129,141,145,199,233,279,291,310],"patients":[32,160,184,234,311],"chronic":[34],"obstructive":[35],"pulmonary":[36],"disease":[37],"(COPD)":[38],"are":[39],"important":[40],"to":[41,251],"complement":[42],"evidence":[43],"from":[44,187,194],"well-controlled":[45],"randomized":[46],"clinical":[47,98,213],"trials.":[48],"Effectiveness":[49],"of":[50,83,135,172,183,212,285,295,298],"odSITT":[51,277],"was":[52,67,108,257],"quantified":[53],"by":[54,259],"assessing":[55],"health":[56],"status":[57],"symptoms":[59],"usual":[61,273],"care.":[62],"Patients":[63],"Methods:":[65],"ELLITHE":[66],"a":[68],"single-country":[69],"(Germany),":[70],"multicenter,":[71],"open-label,":[72],"non-interventional":[73],"study":[75],"between":[76,119],"2020":[77],"2022,":[79],"evaluating":[80],"effect":[82],"treatment":[84,275,322],"initiation":[85],"FF/UMEC/VI":[87],"100/62.5/25":[88],"\u03bcg":[89],"via":[91],"ELLIPTA":[93],"inhaler":[94,151,241],"improvements":[96,229,284],"outcomes":[99],"versus":[100],"baseline":[101,120,237],"COPD":[103,114,292],"patients.":[104],"The":[105],"primary":[106],"endpoint":[107],"change":[110,128],"total":[113],"Assessment":[115],"Test":[116],"(CAT)":[117],"score":[118,131,201,222,287],"month":[122,138,203],"12.":[123],"Key":[124],"secondary":[125],"endpoints":[126],"included":[127,162],"CAT":[130,175,200,221,228,286,315],"over":[132],"time,":[133],"occurrence":[134,297],"exacerbations":[136],"until":[137],"12,":[139],"changes":[140],"forced":[142],"expiratory":[143],"volume":[144],"one":[146],"second":[147],"(FEV":[148],"1":[149,170,256,290],"),":[150],"adherence,":[152],"safety.":[154],"Results:":[155],"Nine":[156],"hundred":[157],"six":[159],"were":[161,185,192,205,230,246,269],"(age":[163],"66.6":[164],"years,":[165],"55.6%":[166],"male,":[167],"mean":[168,174],"FEV":[169,255,289],"52.6%":[171],"predicted,":[173],"21.5":[176],"units,":[177],"1.4":[178],"exacerbations/year":[179],"pre-study).":[180],"About":[181],"63.9%":[182],"escalated":[186],"dual":[188],"therapies,":[189],"18%":[191],"switched":[193],"multiple-inhaler":[195],"therapies.":[197],"Reductions":[198],"at":[202,225],"12":[204],"statistically":[206],"significant":[207,280],"above":[209],"threshold":[211],"importance":[214],"(\u2212":[215],"2.6":[216],"units;":[217],"p":[218],"<":[219,263],"0.0001).":[220,264],"also":[223],"improved":[224,258],"interim":[226],"visits.":[227],"more":[231],"pronounced":[232],"high":[236],"scores":[238],"better":[240],"adherence.":[242],"Exacerbations":[243],"during":[244],"follow-up":[245],"rare":[247],"(0.2":[248],"events/year)":[249],"compared":[250],"pre-study":[252],"(1.4":[253],"events/year).":[254],"93":[260],"mL":[261],"(p":[262],"No":[265],"new":[266],"safety":[267],"effects":[268],"observed.":[270],"Conclusion:":[271],"In":[272],"care,":[274],"resulted":[278],"clinically":[282],"relevant":[283],"patients,":[293],"regardless":[294],"exacerbations.":[299,313],"These":[300],"findings":[301],"challenge":[302],"current":[304],"guideline":[305],"recommendations":[306],"for":[307],"SITT":[308],"only":[309],"experiencing":[312],"Keywords:":[314],"score,":[316],"real-world":[317],"evidence,":[318],"lung":[319],"function,":[320],"exacerbation,":[321],"adherence":[323]},"counts_by_year":[{"year":2026,"cited_by_count":9},{"year":2025,"cited_by_count":9},{"year":2024,"cited_by_count":3}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2024-01-17T00:00:00"}