{"id":"https://openalex.org/W4390915149","doi":"https://doi.org/10.1158/1538-7445.panca2023-a056","title":"Abstract A056: Targeting the mevalonate biosynthesis pathway in gemcitabine resistant pancreatic cancer","display_name":"Abstract A056: Targeting the mevalonate biosynthesis pathway in gemcitabine resistant pancreatic cancer","publication_year":2024,"publication_date":"2024-01-16","ids":{"openalex":"https://openalex.org/W4390915149","doi":"https://doi.org/10.1158/1538-7445.panca2023-a056"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.panca2023-a056","doi":"https://doi.org/10.1158/1538-7445.panca2023-a056","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1158/1538-7445.panca2023-a056","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108824338","display_name":"Alica K. Beutel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alica K. Beutel","raw_affiliation_strings":["1University of California Irvine, Irvine, CA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1University of California Irvine, Irvine, CA,","institution_ids":["https://openalex.org/I204250578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111643219","display_name":"Sabrina E. Calderon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sabrina Calderon","raw_affiliation_strings":["1University of California Irvine, Irvine, CA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1University of California Irvine, Irvine, CA,","institution_ids":["https://openalex.org/I204250578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5093689427","display_name":"Ethan Nghiem","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ethan Nghiem","raw_affiliation_strings":["1University of California Irvine, Irvine, CA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1University of California Irvine, Irvine, CA,","institution_ids":["https://openalex.org/I204250578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047870893","display_name":"Rima Singh","orcid":"https://orcid.org/0000-0002-6822-7987","observed_orcids":["https://orcid.org/0000-0002-6822-7987"]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rima Singh","raw_affiliation_strings":["1University of California Irvine, Irvine, CA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1University of California Irvine, Irvine, CA,","institution_ids":["https://openalex.org/I204250578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087129661","display_name":"Cecily Anaraki","orcid":"https://orcid.org/0009-0000-3172-3365","observed_orcids":["https://orcid.org/0009-0000-3172-3365"]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cecily Anaraki","raw_affiliation_strings":["1University of California Irvine, Irvine, CA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1University of California Irvine, Irvine, CA,","institution_ids":["https://openalex.org/I204250578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041073957","display_name":"Kevin Christian Montecillo Gulay","orcid":"https://orcid.org/0000-0002-9568-3590","observed_orcids":["https://orcid.org/0000-0002-9568-3590"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I4390039236","display_name":"Moores Cancer Center","ror":"https://ror.org/01qkmtm61","country_code":null,"type":"healthcare","lineage":["https://openalex.org/I2800935791","https://openalex.org/I36258959","https://openalex.org/I4390039236"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kevin Gulay","raw_affiliation_strings":["2Moores Cancer Center UC San Diego, San Diego, CA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Moores Cancer Center UC San Diego, San Diego, CA,","institution_ids":["https://openalex.org/I36258959","https://openalex.org/I4390039236"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013005773","display_name":"Herv\u00e9 Tiriac","orcid":"https://orcid.org/0000-0001-5039-6750","observed_orcids":["https://orcid.org/0000-0001-5039-6750"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I4390039236","display_name":"Moores Cancer Center","ror":"https://ror.org/01qkmtm61","country_code":null,"type":"healthcare","lineage":["https://openalex.org/I2800935791","https://openalex.org/I36258959","https://openalex.org/I4390039236"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Herve Tiriac","raw_affiliation_strings":["2Moores Cancer Center UC San Diego, San Diego, CA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Moores Cancer Center UC San Diego, San Diego, CA,","institution_ids":["https://openalex.org/I36258959","https://openalex.org/I4390039236"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055082801","display_name":"Alexander Kleger","orcid":"https://orcid.org/0000-0003-0592-5232","observed_orcids":["https://orcid.org/0000-0003-0592-5232"]},"institutions":[{"id":"https://openalex.org/I4210155144","display_name":"University Hospital Ulm","ror":"https://ror.org/05emabm63","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210155144"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Alexander Kleger","raw_affiliation_strings":["3University Hospital Ulm, Ulm, Germany,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3University Hospital Ulm, Ulm, Germany,","institution_ids":["https://openalex.org/I4210155144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062163674","display_name":"Thomas Theodor Werner Seufferlein","orcid":"https://orcid.org/0000-0003-3259-0810","observed_orcids":["https://orcid.org/0000-0003-3259-0810"]},"institutions":[{"id":"https://openalex.org/I4210155144","display_name":"University Hospital Ulm","ror":"https://ror.org/05emabm63","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210155144"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Thomas Seufferlein","raw_affiliation_strings":["3University Hospital Ulm, Ulm, Germany,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3University Hospital Ulm, Ulm, Germany,","institution_ids":["https://openalex.org/I4210155144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090228463","display_name":"Alexander Muir","orcid":"https://orcid.org/0000-0003-3811-3054","observed_orcids":["https://orcid.org/0000-0003-3811-3054"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexander Muir","raw_affiliation_strings":["4University of Chicago, Chicago, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4University of Chicago, Chicago, IL","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008816660","display_name":"Cholsoon Jang","orcid":"https://orcid.org/0000-0001-6651-4213","observed_orcids":["https://orcid.org/0000-0001-6651-4213"]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cholsoon Jang","raw_affiliation_strings":["1University of California Irvine, Irvine, CA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1University of California Irvine, Irvine, CA,","institution_ids":["https://openalex.org/I204250578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004426625","display_name":"Dennis Juarez","orcid":"https://orcid.org/0000-0002-2458-8879","observed_orcids":["https://orcid.org/0000-0002-2458-8879"]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dennis Juarez","raw_affiliation_strings":["1University of California Irvine, Irvine, CA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1University of California Irvine, Irvine, CA,","institution_ids":["https://openalex.org/I204250578"]}]},{"author_position":"middle","author":{"id":null,"display_name":"David Fruman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Fruman","raw_affiliation_strings":["1University of California Irvine, Irvine, CA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1University of California Irvine, Irvine, CA,","institution_ids":["https://openalex.org/I204250578"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5005221333","display_name":"Christopher J. Halbrook","orcid":"https://orcid.org/0000-0002-3376-3114","observed_orcids":["https://orcid.org/0000-0002-3376-3114"]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher Halbrook","raw_affiliation_strings":["1University of California Irvine, Irvine, CA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1University of California Irvine, Irvine, CA,","institution_ids":["https://openalex.org/I204250578"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"84","issue":"2_Supplement","first_page":"A056","last_page":"A056"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12465","display_name":"Cancer, Lipids, and Metabolism","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12465","display_name":"Cancer, Lipids, and Metabolism","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.006300000008195639,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gemcitabine-resistance","display_name":"gemcitabine resistance","score":0.9160000085830688},{"id":"https://openalex.org/keywords/pancreatic-ductal-adenocarcinoma","display_name":"pancreatic ductal adenocarcinoma","score":0.9990000128746033},{"id":"https://openalex.org/keywords/hmg-coa-reductase","display_name":"HMG-CoA reductase","score":0.972000002861023},{"id":"https://openalex.org/keywords/statins","display_name":"statins","score":0.9229999780654907},{"id":"https://openalex.org/keywords/pitavastatin","display_name":"pitavastatin","score":0.9950000047683716},{"id":"https://openalex.org/keywords/geranylgeranyl-pyrophosphate","display_name":"geranylgeranyl pyrophosphate","score":0.9380000233650208},{"id":"https://openalex.org/keywords/metabolic-vulnerability","display_name":"metabolic vulnerability","score":0.8289999961853027},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.7009999752044678},{"id":"https://openalex.org/keywords/patient-derived-organoids","display_name":"patient-derived organoids","score":0.7440000176429749},{"id":"https://openalex.org/keywords/chemoresistance","display_name":"chemoresistance","score":0.7360000014305115},{"id":"https://openalex.org/keywords/tumor-growth-inhibition","display_name":"tumor growth inhibition","score":0.6330000162124634}],"concepts":[{"id":"https://openalex.org/C2780258809","wikidata":"https://www.wikidata.org/wiki/Q414143","display_name":"Gemcitabine","level":3,"score":0.8942282199859619},{"id":"https://openalex.org/C2779982574","wikidata":"https://www.wikidata.org/wiki/Q14913010","display_name":"Mevalonate pathway","level":4,"score":0.8135300874710083},{"id":"https://openalex.org/C2780210213","wikidata":"https://www.wikidata.org/wiki/Q212961","display_name":"Pancreatic cancer","level":3,"score":0.5988680720329285},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5954064130783081},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.5173346400260925},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.46558135747909546},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4454857110977173},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3762578070163727},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3449632525444031},{"id":"https://openalex.org/C134651460","wikidata":"https://www.wikidata.org/wiki/Q3100717","display_name":"Reductase","level":3,"score":0.3357822895050049},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.31189459562301636},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.13545158505439758},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.13443875312805176},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.panca2023-a056","doi":"https://doi.org/10.1158/1538-7445.panca2023-a056","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1158/1538-7445.panca2023-a056","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.7599999904632568,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2126322332","https://openalex.org/W4205828341","https://openalex.org/W3031675857","https://openalex.org/W2596055884","https://openalex.org/W2885862304","https://openalex.org/W3031244932","https://openalex.org/W4281720666","https://openalex.org/W1965851372","https://openalex.org/W2038866393","https://openalex.org/W2413610125"],"abstract_inverted_index":{"Abstract":[0],"Pancreatic":[1,366],"ductal":[2],"adenocarcinoma":[3],"(PDA)":[4],"is":[5,37,213,271,276],"a":[6,10,34,38,46,76,115,142,244,272,304],"lethal":[7],"malignancy":[8],"with":[9,158,243],"low":[11,109],"survival":[12,309],"rate.":[13],"A":[14],"lack":[15],"of":[16,54,117,131,135,187,207,217,259,284,358],"durable":[17],"responses":[18],"to":[19,29,59,83,86,146,155,185,301],"chemotherapy":[20],"renders":[21],"its":[22,123],"treatment":[23,251],"particularly":[24],"challenging":[25],"and":[26,103,122,220,254,291,307],"largely":[27],"contributes":[28],"the":[30,118,129,188,204,209,250,268,282,346,359],"devastating":[31],"prognosis.":[32],"Gemcitabine,":[33],"pyrimidine":[35],"anti-metabolite,":[36],"cornerstone":[39],"in":[40,49,63,72,92,169,175,228,278,297,310,350,363],"PDA":[41,64,100,172,235,279],"therapy,":[42],"but":[43],"resistance":[44,74,144],"remains":[45],"major":[47],"hurdle":[48],"clinical":[50,305],"care.":[51],"Multiple":[52],"mechanisms":[53],"chemoresistance":[55],"have":[56],"been":[57,139],"attributed":[58],"rewired":[60],"metabolic":[61,90,273],"pathways":[62],"cells.":[65],"Accordingly,":[66,160],"we":[67,95,161,230],"hypothesized":[68],"that":[69,79,151,163,203,240,266,275],"altered":[70],"metabolism":[71],"gemcitabine":[73,93,97,106,132,170,232,253,285,290,351],"represents":[75],"therapeutic":[77],"vulnerability":[78,274],"can":[80],"be":[81,166],"targeted":[82],"improve":[84,308],"response":[85],"treatment.":[87],"To":[88,224],"investigate":[89],"vulnerabilities":[91],"resistance,":[94],"generated":[96],"resistant":[98,171,180,233,260,352],"murine":[99,234],"cell":[101],"lines":[102],"assembled":[104],"patient-derived":[105],"high":[107],"versus":[108],"responder":[110],"organoids.":[111],"Transcriptomic":[112],"profiling":[113],"revealed":[114],"downregulation":[116],"mevalonate":[119,189,210,347],"biosynthesis":[120,211,348],"pathway":[121,137,212,349],"rate-limiting":[124],"enzyme,":[125],"HMG-CoA":[126,148,269],"reductase,":[127],"upon":[128,281],"acquisition":[130,283],"resistance.":[133,286],"Upregulation":[134],"this":[136,311],"has":[138,299],"proposed":[140],"as":[141],"primary":[143],"mechanism":[145],"statins,":[147],"reductase":[149,270],"inhibitors":[150],"are":[152],"frequently":[153],"prescribed":[154],"treat":[156],"patients":[157],"hyperlipidemia.":[159],"postulated":[162],"statins":[164],"would":[165],"more":[167],"potent":[168],"cells":[173,181,236,280],"than":[174],"their":[176],"sensitive":[177],"counterparts.":[178],"Indeed,":[179],"were":[182,241],"exquisitely":[183],"susceptible":[184],"inhibition":[186],"pathway,":[190],"an":[191],"observation":[192],"consistent":[193],"across":[194],"multiple":[195],"clinically":[196],"available":[197],"statins.":[198],"Downstream":[199],"rescue":[200],"experiments":[201],"suggested":[202],"main":[205],"impact":[206],"blocking":[208],"through":[214],"lowered":[215],"levels":[216],"geranylgeranyl":[218],"pyrophosphate":[219],"reduced":[221],"protein":[222],"geranylation.":[223],"validate":[225],"our":[226],"findings":[227],"vivo,":[229],"implanted":[231],"into":[237,303],"syngeneic":[238],"mice":[239],"fed":[242],"modified":[245],"diet":[246],"precluding":[247],"geranylgeraniol.":[248],"Here,":[249],"combination":[252,288],"pitavastatin":[255],"inhibited":[256],"tumor":[257],"growth":[258],"allografts.":[261],"Collectively,":[262],"these":[263],"data":[264],"suggest":[265],"targeting":[267],"gained":[277],"The":[287],"therapy":[289],"pitavastatin,":[292],"two":[293],"widely":[294],"used":[295],"compounds":[296],"patients,":[298],"potential":[300],"translate":[302],"benefit":[306],"deadly":[312],"disease.":[313],"Citation":[314],"Format:":[315],"Alica":[316],"K.":[317],"Beutel,":[318],"Sabrina":[319],"Calderon,":[320],"Ethan":[321],"Nghiem,":[322],"Rima":[323],"Singh,":[324],"Cecily":[325],"Anaraki,":[326],"Kevin":[327],"Gulay,":[328],"Herve":[329],"Tiriac,":[330],"Alexander":[331,335],"Kleger,":[332],"Thomas":[333],"Seufferlein,":[334],"Muir,":[336],"Cholsoon":[337],"Jang,":[338],"Dennis":[339],"Juarez,":[340],"David":[341],"Fruman,":[342],"Christopher":[343],"Halbrook.":[344],"Targeting":[345],"pancreatic":[353],"cancer":[354],"[abstract].":[355],"In:":[356],"Proceedings":[357],"AACR":[360],"Special":[361],"Conference":[362],"Cancer":[364,376],"Research:":[365],"Cancer;":[367],"2023":[368],"Sep":[369],"27-30;":[370],"Boston,":[371],"Massachusetts.":[372],"Philadelphia":[373],"(PA):":[374],"AACR;":[375],"Res":[377],"2024;84(2":[378],"Suppl):Abstract":[379],"nr":[380],"A056.":[381]},"counts_by_year":[],"updated_date":"2026-10-08T09:06:37.294493","created_date":"2025-10-10T00:00:00"}