{"id":"https://openalex.org/W4390914941","doi":"https://doi.org/10.1158/1538-7445.panca2023-pr14","title":"Abstract PR14: Ex vivo models of pancreatic cancer that recapitulate the metabolic tumor microenvironment identify glycine as a chemoresistance-inducing oncometabolite","display_name":"Abstract PR14: Ex vivo models of pancreatic cancer that recapitulate the metabolic tumor microenvironment identify glycine as a chemoresistance-inducing oncometabolite","publication_year":2024,"publication_date":"2024-01-16","ids":{"openalex":"https://openalex.org/W4390914941","doi":"https://doi.org/10.1158/1538-7445.panca2023-pr14"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.panca2023-pr14","doi":"https://doi.org/10.1158/1538-7445.panca2023-pr14","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1158/1538-7445.panca2023-pr14","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5014021738","display_name":"Guillaume Cognet","orcid":"https://orcid.org/0000-0001-5427-8110","observed_orcids":["https://orcid.org/0000-0001-5427-8110"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Guillaume Cognet","raw_affiliation_strings":["1University of Chicago, Chicago, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1University of Chicago, Chicago, IL","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040415861","display_name":"Colin S. Sheehan","orcid":"https://orcid.org/0000-0003-3034-6371","observed_orcids":["https://orcid.org/0000-0003-3034-6371"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Colin Sheehan","raw_affiliation_strings":["1University of Chicago, Chicago, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1University of Chicago, Chicago, IL","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063786407","display_name":"Grace Croley","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Grace Croley","raw_affiliation_strings":["1University of Chicago, Chicago, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1University of Chicago, Chicago, IL","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102605277","display_name":"Lyndon Hu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lyndon Hu","raw_affiliation_strings":["1University of Chicago, Chicago, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1University of Chicago, Chicago, IL","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5090228463","display_name":"Alexander Muir","orcid":"https://orcid.org/0000-0003-3811-3054","observed_orcids":["https://orcid.org/0000-0003-3811-3054"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexander Muir","raw_affiliation_strings":["1University of Chicago, Chicago, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1University of Chicago, Chicago, IL","institution_ids":["https://openalex.org/I40347166"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I40347166"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"84","issue":"2_Supplement","first_page":"PR14","last_page":"PR14"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.9545999765396118,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.9545999765396118,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.03539999946951866,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12465","display_name":"Cancer, Lipids, and Metabolism","score":0.0020000000949949026,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pancreatic-ductal-adenocarcinoma","display_name":"pancreatic ductal adenocarcinoma","score":0.984000027179718},{"id":"https://openalex.org/keywords/glycine","display_name":"glycine","score":0.8019999861717224},{"id":"https://openalex.org/keywords/oncometabolites","display_name":"oncometabolites","score":0.8809999823570251},{"id":"https://openalex.org/keywords/chemoresistance","display_name":"chemoresistance","score":0.878000020980835},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.875},{"id":"https://openalex.org/keywords/interstitial-fluid","display_name":"interstitial fluid","score":0.6060000061988831},{"id":"https://openalex.org/keywords/nutrient-availability","display_name":"nutrient availability","score":0.6769999861717224},{"id":"https://openalex.org/keywords/desmoplasia","display_name":"desmoplasia","score":0.8970000147819519},{"id":"https://openalex.org/keywords/ex-vivo-tumor-model","display_name":"ex vivo tumor model","score":0.6140000224113464},{"id":"https://openalex.org/keywords/cell-death","display_name":"cell death","score":0.6209999918937683},{"id":"https://openalex.org/keywords/metabolomics","display_name":"metabolomics","score":0.609000027179718},{"id":"https://openalex.org/keywords/tumor-perfusion","display_name":"tumor perfusion","score":0.5299999713897705},{"id":"https://openalex.org/keywords/cytoprotection","display_name":"cytoprotection","score":0.6639999747276306},{"id":"https://openalex.org/keywords/cell-culture-medium","display_name":"cell culture media","score":0.31200000643730164},{"id":"https://openalex.org/keywords/transcriptomics","display_name":"transcriptomics","score":0.7210000157356262},{"id":"https://openalex.org/keywords/drug-screening-model","display_name":"drug screening model","score":0.31299999356269836}],"concepts":[{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.8105136156082153},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.6509246230125427},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6195384860038757},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6059272289276123},{"id":"https://openalex.org/C2780210213","wikidata":"https://www.wikidata.org/wiki/Q212961","display_name":"Pancreatic cancer","level":3,"score":0.5014493465423584},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.48058366775512695},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.45980775356292725},{"id":"https://openalex.org/C26291073","wikidata":"https://www.wikidata.org/wiki/Q310484","display_name":"Ex vivo","level":3,"score":0.44645655155181885},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.4340501129627228},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.32787126302719116},{"id":"https://openalex.org/C3020616263","wikidata":"https://www.wikidata.org/wiki/Q1216998","display_name":"Tumor cells","level":2,"score":0.11107340455055237},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.09311917424201965}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.panca2023-pr14","doi":"https://doi.org/10.1158/1538-7445.panca2023-pr14","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1158/1538-7445.panca2023-pr14","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4282982342","https://openalex.org/W4414146949","https://openalex.org/W4378781368","https://openalex.org/W6939240679","https://openalex.org/W4309224174","https://openalex.org/W3139344827","https://openalex.org/W4412403463","https://openalex.org/W4295106687","https://openalex.org/W4409689157","https://openalex.org/W2996169934"],"abstract_inverted_index":{"Abstract":[0],"Pancreatic":[1,375],"adenocarcinoma":[2],"(PDAC)":[3],"tumors":[4,53,292],"are":[5],"poorly":[6],"perfused":[7],"due":[8],"to":[9,19,54,68,109,120,172,187,201,216,227,244,279,296],"intense":[10],"desmoplasia":[11],"and":[12,24,225,321],"dysfunctional":[13],"vasculature.":[14],"This":[15],"limited":[16],"perfusion":[17],"leads":[18],"abnormal":[20],"availability":[21,36,58,128,310],"of":[22,44,51,84,91,184,270,318,330,349,367],"nutrients":[23],"metabolic":[25,355],"substrates":[26],"in":[27,59,106,123,137,143,147,157,167,219,237,277,311,372],"the":[28,45,60,85,89,182,220,234,238,312,354,368],"tumor":[29,324,356],"microenvironment.":[30,62],"To":[31],"understand":[32],"how":[33],"microenvironmetnal":[34],"nutrient":[35,57,81,127,199,309],"impacts":[37],"PDAC":[38,52,61,86,92,103,121,135,141,155,163,185,221,229,239,271,291,319,332],"biology,":[39,320],"we":[40,100,151,195,259,283],"performed":[41],"quantitative":[42],"metabolomics":[43],"interstitial":[46],"fluid":[47],"(the":[48],"local":[49],"perfusate)":[50],"comprehensively":[55],"characterize":[56],"We":[63,175,207],"have":[64],"used":[65],"this":[66,280],"information":[67],"develop":[69],"Tumor":[70],"Interstitial":[71],"Fluid":[72],"Medium":[73],"(TIFM),":[74],"a":[75,115,130,287,361],"cell":[76,149,249,275],"culture":[77,179],"medium":[78],"that":[79,102,140,162,177,209,214,262,290,308,352],"contains":[80],"levels":[82,218],"representative":[83],"microenvironment,":[87,222,240],"enabling":[88,294],"study":[90,329],"biology":[93,136],"under":[94],"physiological":[95],"nutrition.":[96],"By":[97],"transcriptomic":[98],"analysis,":[99],"show":[101,307],"cells":[104,122,142,156,164,186,272],"cultured":[105],"TIFM,":[107],"compared":[108],"standard":[110],"ex":[111],"vivo":[112,347],"models,":[113],"adopt":[114,145],"cellular":[116,254],"state":[117],"more":[118],"similar":[119],"tumors,":[124],"identifying":[125],"TME":[126],"as":[129,170,360],"key":[131],"microenvironmental":[132,198,263],"factor":[133],"regulating":[134],"vivo.":[138],"Given":[139],"TIFM":[144,158,178,191],"an":[146,211,315],"vivo-like":[148],"state,":[150],"next":[152],"asked":[153],"if":[154],"would":[159],"exhibit":[160,166],"phenotypes":[161],"primarily":[165],"vivo,":[168],"such":[169],"resistance":[171,183],"chemotherapeutic":[173,188,268,302],"treatment.":[174],"found":[176,208,236,243],"dramatically":[180],"increases":[181],"challenge.":[189,303],"As":[190],"is":[192,286,314],"chemically":[193],"defined,":[194],"systemically":[196],"screened":[197],"cues":[200],"identify":[202,358],"those":[203],"triggering":[204],"therapy":[205,230],"resistance.":[206,231],"glycine,":[210],"amino":[212],"acid":[213],"accumulates":[215],"high":[217],"was":[223],"necessary":[224],"sufficient":[226],"cause":[228],"Glycine,":[232],"at":[233],"concentrations":[235],"has":[241],"been":[242],"broadly":[245],"cytoprotective":[246],"by":[247,252],"inhibiting":[248],"death":[250,276],"elicited":[251],"diverse":[253,299],"stresses.":[255],"In":[256],"mechanistic":[257,328],"experiments,":[258],"similarly":[260],"find":[261],"glycine":[264,285,359],"does":[265],"not":[266],"prevent":[267],"damage":[269],"but":[273],"blocks":[274],"response":[278],"damage.":[281],"Thus,":[282],"propose":[284],"novel":[288],"oncometabolite":[289,363],"accumulate,":[293],"them":[295],"cope":[297],"with":[298],"stresses,":[300],"including":[301],"Altogether,":[304],"these":[305],"data":[306],"microenvironment":[313,357],"important":[316],"determinant":[317],"models":[322,348],"incorporating":[323],"nutrition":[325],"can":[326],"enable":[327],"microenvironmentally-programmed":[331],"phenotypes.":[333],"Citation":[334],"Format:":[335],"Guillaume":[336],"Cognet,":[337],"Colin":[338],"Sheehan,":[339],"Grace":[340],"Croley,":[341],"Lyndon":[342],"Hu,":[343],"Alexander":[344],"Muir.":[345],"Ex":[346],"pancreatic":[350],"cancer":[351],"recapitulate":[353],"chemoresistance-inducing":[362],"[abstract].":[364],"In:":[365],"Proceedings":[366],"AACR":[369],"Special":[370],"Conference":[371],"Cancer":[373,385],"Research:":[374],"Cancer;":[376],"2023":[377],"Sep":[378],"27-30;":[379],"Boston,":[380],"Massachusetts.":[381],"Philadelphia":[382],"(PA):":[383],"AACR;":[384],"Res":[386],"2024;84(2":[387],"Suppl):Abstract":[388],"nr":[389],"PR14.":[390]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2024-01-17T00:00:00"}