{"id":"https://openalex.org/W4390914914","doi":"https://doi.org/10.1158/1538-7445.panca2023-c039","title":"Abstract C039: Disruption of ADAM17-dependent cellular crosstalk inhibits tumor progression of pancreatic ductal adenocarcinoma","display_name":"Abstract C039: Disruption of ADAM17-dependent cellular crosstalk inhibits tumor progression of pancreatic ductal adenocarcinoma","publication_year":2024,"publication_date":"2024-01-16","ids":{"openalex":"https://openalex.org/W4390914914","doi":"https://doi.org/10.1158/1538-7445.panca2023-c039"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.panca2023-c039","doi":"https://doi.org/10.1158/1538-7445.panca2023-c039","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1158/1538-7445.panca2023-c039","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Hui-Ju Wen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154057602","display_name":"Henry Ford Health","ror":"https://ror.org/02kwnkm68","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I154057602"]},{"id":"https://openalex.org/I2803043754","display_name":"Henry Ford Hospital","ror":"https://ror.org/0193sb042","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I154057602","https://openalex.org/I2803043754"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hui-Ju Wen","raw_affiliation_strings":["1Henry Ford Pancreatic Cancer Center, Detroit, MI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Henry Ford Pancreatic Cancer Center, Detroit, MI","institution_ids":["https://openalex.org/I154057602","https://openalex.org/I2803043754"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5054373028","display_name":"Howard C. Crawford","orcid":"https://orcid.org/0000-0001-9360-3019","observed_orcids":["https://orcid.org/0000-0001-9360-3019"]},"institutions":[{"id":"https://openalex.org/I154057602","display_name":"Henry Ford Health","ror":"https://ror.org/02kwnkm68","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I154057602"]},{"id":"https://openalex.org/I2803043754","display_name":"Henry Ford Hospital","ror":"https://ror.org/0193sb042","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I154057602","https://openalex.org/I2803043754"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Howard Crawford","raw_affiliation_strings":["1Henry Ford Pancreatic Cancer Center, Detroit, MI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Henry Ford Pancreatic Cancer Center, Detroit, MI","institution_ids":["https://openalex.org/I154057602","https://openalex.org/I2803043754"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"84","issue":"2_Supplement","first_page":"C039","last_page":"C039"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.9541000127792358,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.9541000127792358,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.03480000048875809,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10760","display_name":"Pancreatitis Pathology and Treatment","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/adam17","display_name":"ADAM17","score":1.0},{"id":"https://openalex.org/keywords/pancreatic-ductal-adenocarcinoma","display_name":"pancreatic ductal adenocarcinoma","score":0.9940000176429749},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.7540000081062317},{"id":"https://openalex.org/keywords/egfr-activation","display_name":"EGFR activation","score":0.8019999861717224},{"id":"https://openalex.org/keywords/macrophages","display_name":"macrophages","score":0.7739999890327454},{"id":"https://openalex.org/keywords/myeloid-cells","display_name":"myeloid cells","score":0.9380000233650208},{"id":"https://openalex.org/keywords/ccl21","display_name":"CCL21","score":0.8109999895095825},{"id":"https://openalex.org/keywords/dendritic-cells","display_name":"dendritic cells","score":0.859000027179718},{"id":"https://openalex.org/keywords/cytotoxic-t-lymphocytes","display_name":"cytotoxic T lymphocytes","score":0.9729999899864197},{"id":"https://openalex.org/keywords/tumor-immunology","display_name":"tumor immunology","score":0.5989999771118164},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.5070000290870667}],"concepts":[{"id":"https://openalex.org/C7876069","wikidata":"https://www.wikidata.org/wiki/Q14873666","display_name":"Paracrine signalling","level":3,"score":0.7229052186012268},{"id":"https://openalex.org/C128240485","wikidata":"https://www.wikidata.org/wiki/Q786998","display_name":"Autocrine signalling","level":3,"score":0.712040364742279},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6856062412261963},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.6388993263244629},{"id":"https://openalex.org/C2780210213","wikidata":"https://www.wikidata.org/wiki/Q212961","display_name":"Pancreatic cancer","level":3,"score":0.5704790353775024},{"id":"https://openalex.org/C16930146","wikidata":"https://www.wikidata.org/wiki/Q4381253","display_name":"Stromal cell","level":2,"score":0.5685825943946838},{"id":"https://openalex.org/C2777996000","wikidata":"https://www.wikidata.org/wiki/Q7130412","display_name":"Pancreatic tumor","level":4,"score":0.5437738299369812},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.503292977809906},{"id":"https://openalex.org/C2779256057","wikidata":"https://www.wikidata.org/wiki/Q16909647","display_name":"Tumor progression","level":3,"score":0.4989166259765625},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.44953304529190063},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.4261566996574402},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3212682604789734},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.28081297874450684},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2271614372730255},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.207511305809021},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.19376131892204285},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.panca2023-c039","doi":"https://doi.org/10.1158/1538-7445.panca2023-c039","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1158/1538-7445.panca2023-c039","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9940000176429749}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4309187745","https://openalex.org/W4282965033","https://openalex.org/W4417526694","https://openalex.org/W3029710243","https://openalex.org/W2620111536","https://openalex.org/W2731893911","https://openalex.org/W2277133700","https://openalex.org/W1446168949","https://openalex.org/W2063629426","https://openalex.org/W1982021610"],"abstract_inverted_index":{"Abstract":[0],"Activation":[1],"of":[2,60,66,120,130,148,151,166,201,219,254,264,271,278],"cellular":[3,28,266],"signaling":[4,29,59],"pathways":[5,30],"by":[6,31,110,204,230],"crosstalk":[7,267],"between":[8],"tumor":[9,101,145,161,173,202,228,238,269],"cells":[10,93,109,125,232,236],"and":[11,36,57,134,175,233],"their":[12],"microenvironment":[13],"is":[14,40,52,69,80,206],"an":[15,135,216],"essential":[16],"mechanism":[17],"supporting":[18],"pancreatic":[19,74,100,255,272],"carcinogenesis.":[20],"In":[21],"this":[22],"study,":[23],"we":[24,97,214],"aim":[25],"to":[26,169],"disrupt":[27],"targeting":[32],"ADAM17":[33,39,105,121,152,167,241,249],"(a":[34],"disintegrin":[35],"metalloprotease":[37],"17).":[38],"a":[41,70,83,99,112,128,170,176,244,251],"membrane":[42],"bound":[43],"enzyme":[44],"which":[45,68],"cleaves":[46],"cell":[47,132],"surface":[48],"proteins.":[49],"Its":[50],"function":[51],"closely":[53],"linked":[54],"with":[55,104],"autocrine":[56],"paracrine":[58,84],"immunomodulation":[61],"as":[62,64,250],"well":[63],"activation":[65],"EGFR,":[67],"central":[71],"molecule":[72],"for":[73,237],"tumorigenesis.":[75],"To":[76,141],"investigate":[77],"whether":[78],"EGFR":[79,139,180],"activated":[81],"via":[82],"manner":[85],"from":[86],"macrophages,":[87],"the":[88,123,144,188,194,210,222,279],"most":[89],"abundant":[90],"immune-related":[91],"stromal":[92],"in":[94,107,122,127,138,159,172,179,187,193,221,226,283],"pancreas":[95],"cancers,":[96],"generated":[98],"mouse":[102],"model":[103],"deletion":[106],"myeloid":[108,124],"using":[111,153],"dual":[113],"recombinase":[114],"strategy.":[115],"We":[116],"observed":[117,185],"that":[118,199],"lack":[119],"resulted":[126],"delay":[129],"acinar":[131],"transformation":[133],"associated":[136],"decrease":[137,178],"activation.":[140,181],"further":[142],"examine":[143],"supportive":[146],"role":[147],"ADAM17,":[149],"inhibition":[150,165,200],"anti-ADAM17":[154],"antibody,":[155],"MEDI3622,":[156],"was":[157],"tested":[158],"orthotopic":[160],"bearing":[162],"mice.":[163],"systemic":[164],"led":[168],"reduction":[171],"burden":[174],"concomitant":[177],"These":[182],"effects":[183],"were":[184],"exclusively":[186],"immunocompetent":[189],"animals,":[190],"but":[191],"not":[192],"immunodeficient":[195],"animals.":[196],"It":[197],"implicates":[198],"growth":[203],"MEDI3622":[205],"highly":[207],"dependent":[208],"on":[209],"immune":[211],"response.":[212],"Furthermore,":[213],"found":[215],"elevated":[217],"level":[218],"CCL21":[220],"MEDI3622-treated":[223],"tumors":[224],"resulting":[225],"increased":[227],"infiltration":[229],"dendritic":[231],"cytotoxic":[234],"T":[235],"killing.":[239],"Altogether,":[240],"blockade":[242],"displays":[243],"pronounced":[245],"anti-tumor":[246],"effect,":[247],"suggesting":[248],"therapeutic":[252],"target":[253],"cancer.":[256],"Citation":[257],"Format:":[258],"Hui-Ju":[259],"Wen,":[260],"Howard":[261],"Crawford.":[262],"Disruption":[263],"ADAM17-dependent":[265],"inhibits":[268],"progression":[270],"ductal":[273],"adenocarcinoma":[274],"[abstract].":[275],"In:":[276],"Proceedings":[277],"AACR":[280],"Special":[281],"Conference":[282],"Cancer":[284,296],"Research:":[285],"Pancreatic":[286],"Cancer;":[287],"2023":[288],"Sep":[289],"27-30;":[290],"Boston,":[291],"Massachusetts.":[292],"Philadelphia":[293],"(PA):":[294],"AACR;":[295],"Res":[297],"2024;84(2":[298],"Suppl):Abstract":[299],"nr":[300],"C039.":[301]},"counts_by_year":[],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2024-01-17T00:00:00"}
