{"id":"https://openalex.org/W4390914903","doi":"https://doi.org/10.1158/1538-7445.panca2023-b057","title":"Abstract B057: An organoids-on-a-chip model to recapitulate and dissect the tumor microenvironment of PDAC","display_name":"Abstract B057: An organoids-on-a-chip model to recapitulate and dissect the tumor microenvironment of PDAC","publication_year":2024,"publication_date":"2024-01-16","ids":{"openalex":"https://openalex.org/W4390914903","doi":"https://doi.org/10.1158/1538-7445.panca2023-b057"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.panca2023-b057","doi":"https://doi.org/10.1158/1538-7445.panca2023-b057","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1158/1538-7445.panca2023-b057","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101527866","display_name":"Lunan Liu","orcid":"https://orcid.org/0000-0001-9758-9170","observed_orcids":["https://orcid.org/0000-0001-9758-9170"]},"institutions":[{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lunan Liu","raw_affiliation_strings":["1Tandon School of Engineering, New York University, Brooklyn, NY,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Tandon School of Engineering, New York University, Brooklyn, NY,","institution_ids":["https://openalex.org/I57206974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030459924","display_name":"Diane M. Simeone","orcid":"https://orcid.org/0000-0001-5142-3087","observed_orcids":["https://orcid.org/0000-0001-5142-3087"]},"institutions":[{"id":"https://openalex.org/I4210086933","display_name":"NYU Langone Health","ror":"https://ror.org/005dvqh91","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210086933"]},{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Diane M. Simeone","raw_affiliation_strings":["2Department of Surgery, New York University Langone Health, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Department of Surgery, New York University Langone Health, New York, NY","institution_ids":["https://openalex.org/I4210086933","https://openalex.org/I57206974"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100739315","display_name":"Weiqiang Chen","orcid":"https://orcid.org/0000-0002-9469-8328","observed_orcids":["https://orcid.org/0000-0002-9469-8328"]},"institutions":[{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Weiqiang Chen","raw_affiliation_strings":["1Tandon School of Engineering, New York University, Brooklyn, NY,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Tandon School of Engineering, New York University, Brooklyn, NY,","institution_ids":["https://openalex.org/I57206974"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"84","issue":"2_Supplement","first_page":"B057","last_page":"B057"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11190","display_name":"3D Printing in Biomedical Research","score":0.9390000104904175,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11190","display_name":"3D Printing in Biomedical Research","score":0.9390000104904175,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.04320000112056732,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.003100000089034438,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pancreatic-ductal-adenocarcinoma","display_name":"pancreatic ductal adenocarcinoma","score":0.9980000257492065},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.9549999833106995},{"id":"https://openalex.org/keywords/organ-on-a-chip","display_name":"organ-on-a-chip","score":0.7829999923706055},{"id":"https://openalex.org/keywords/desmoplasia","display_name":"desmoplasia","score":0.8870000243186951},{"id":"https://openalex.org/keywords/cancer-associated-fibroblasts","display_name":"cancer-associated fibroblasts","score":0.9639999866485596},{"id":"https://openalex.org/keywords/tumor-associated-macrophages","display_name":"tumor-associated macrophages","score":0.9860000014305115},{"id":"https://openalex.org/keywords/immunosuppression","display_name":"immunosuppression","score":0.7039999961853027},{"id":"https://openalex.org/keywords/extracellular-matrix-deposition","display_name":"extracellular matrix deposition","score":0.8489999771118164},{"id":"https://openalex.org/keywords/drug-resistance","display_name":"drug resistance","score":0.5649999976158142},{"id":"https://openalex.org/keywords/microfluidic-organ-models","display_name":"microfluidic organ models","score":0.4519999921321869},{"id":"https://openalex.org/keywords/patient-derived-organoids","display_name":"patient-derived organoids","score":0.6100000143051147}],"concepts":[{"id":"https://openalex.org/C31695470","wikidata":"https://www.wikidata.org/wiki/Q11293125","display_name":"Organoid","level":2,"score":0.7763213515281677},{"id":"https://openalex.org/C2781005279","wikidata":"https://www.wikidata.org/wiki/Q5264825","display_name":"Desmoplasia","level":4,"score":0.7529253959655762},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.7204279899597168},{"id":"https://openalex.org/C16930146","wikidata":"https://www.wikidata.org/wiki/Q4381253","display_name":"Stromal cell","level":2,"score":0.708694577217102},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5483353137969971},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4856392443180084},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.45504748821258545},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3976373076438904},{"id":"https://openalex.org/C52124034","wikidata":"https://www.wikidata.org/wiki/Q557179","display_name":"Stroma","level":3,"score":0.25623250007629395},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2508506178855896},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.13650232553482056},{"id":"https://openalex.org/C3020616263","wikidata":"https://www.wikidata.org/wiki/Q1216998","display_name":"Tumor cells","level":2,"score":0.07005095481872559}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.panca2023-b057","doi":"https://doi.org/10.1158/1538-7445.panca2023-b057","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1158/1538-7445.panca2023-b057","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8100000023841858}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4220755377","https://openalex.org/W7126101334","https://openalex.org/W3198168099","https://openalex.org/W3014020256","https://openalex.org/W4409628477","https://openalex.org/W7149000752","https://openalex.org/W7165620504","https://openalex.org/W4402679703","https://openalex.org/W4414582484","https://openalex.org/W4280506399"],"abstract_inverted_index":{"Abstract":[0,1],"Body:":[2],"Characteristics":[3],"of":[4,58,105,140,152,184,198,216,221,250,253,363,400,430,435],"the":[5,30,51,56,59,66,138,145,156,162,170,174,214,225,239,243,248,262,289,301,319,356,361,386,427,436],"PDAC":[6,33,38,44,90,109,113,141,157,175,244,359,383,387,404,431],"tumor":[7,428],"microenvironment":[8,429],"(TME)":[9],"such":[10],"as":[11,299,394,405,407],"desmoplasia":[12,217],"and":[13,23,28,71,76,93,122,125,133,147,193,208,269,352,369,389,425],"an":[14,81],"immunosuppressive":[15,279],"landscape":[16],"contribute":[17],"to":[18,21,230,340,355,392,397,423],"its":[19],"resistance":[20,92,402],"chemotherapy":[22],"immunotherapy":[24],"approaches.":[25],"To":[26],"recapitulate":[27,424],"dissect":[29,426],"in":[31,60,82,155,161,224,296,318,358,403,440],"vivo":[32,61],"TME,":[34],"we":[35,379],"bioengineered":[36],"a":[37,47,69,107,149,180,194,251,313,382,395],"organoid-on-a-chip":[39,101,384],"model":[40,84,102,422],"by":[41],"integrating":[42],"patient-derived":[43,52,112,115],"organoids":[45,53,323],"on":[46,144,177,189,218,288,345],"microfluidic-based":[48],"organ-on-a-chip.":[49],"While":[50],"(PDOs)":[54],"maintain":[55],"characteristics":[57],"counterparts":[62],"with":[63,74,169,233,238,321],"high":[64],"fidelity,":[65],"organ-on-a-chip":[67],"provides":[68],"controllable":[70],"reproducible":[72],"environment":[73],"stromal":[75,142],"immune":[77],"niche":[78,110,143,159,166,171,176,320,349,374],"cells,":[79],"creating":[80],"vitro":[83],"that":[85,317,335],"may":[86],"providing":[87],"insights":[88],"into":[89],"drug":[91,134,401],"allow":[94],"testing":[95],"for":[96,130],"new":[97],"therapies.":[98,410],"The":[99,278],"multicellular":[100],"is":[103,390],"composed":[104],"1)":[106],"central":[108],"including":[111,256],"organoids,":[114],"cancer-associated":[116],"macrophages":[117,120],"(CAFs),":[118],"tumor-associated":[119],"(TAMs)":[121],"blood":[123],"vessels,":[124],"2)":[126],"surrounding":[127],"vascular":[128],"networks":[129],"nutrient":[131],"transport":[132],"delivery.":[135],"We":[136,332],"reproduced":[137],"hypovasculariy":[139],"chip":[146,178,290],"found":[148,334],"lower":[150],"level":[151,183,315],"CD31":[153],"expression":[154,182],"organoid":[158,165,245],"than":[160,316],"normal":[163,234,322],"pancreatic":[164,235],"(p<0.0001).":[167],"Comparing":[168],"without":[172,373],"PDOs,":[173],"demonstrated":[179],"higher":[181,314],"\u03b1-smooth":[185],"muscle":[186],"actin":[187],"(\u03b1-SMA)":[188],"CAFs":[190],"(fold-change=2.32,":[191],"p<0.0001)":[192],"more":[195],"extensive":[196],"deposition":[197],"ECM":[199],"components":[200],"(e.g.,":[201],"collagen":[202,204,206],"I,":[203],"III,":[205],"IV":[207],"hyaluronic":[209],"acid,":[210],"fold-change>=2.25,":[211],"p\u21d00.0002),":[212],"indicating":[213],"existence":[215],"chip.":[219,346],"Profiling":[220],"cytokine":[222,280,303],"levels":[223],"media":[226],"revealed":[227],"that,":[228],"compared":[229],"models":[231],"used":[232],"epithelial":[236],"cells":[237,350,375],"other":[240],"cellular":[241],"components,":[242],"TME":[246,388],"induced":[247,337],"upregulation":[249],"series":[252],"pro-tumor":[254],"cytokines":[255,264,271,364],"MIP-3\u03b1,":[257],"IL-8,":[258],"CXCL5,":[259],"IL-13":[260],"(fold-change>=5.02),":[261],"inflammation-related":[263],"MIF,":[265],"IL-5,":[266],"MCP-1":[267],"(fold-change>=1.82),":[268],"CAF-derived":[270],"like":[272,365],"CXCL10,":[273],"HGF,":[274],"CXCL1,":[275],"CXCL12":[276],"(fold-change>=1.82).":[277],"TGF-\u03b2":[281],"was":[282,300,310],"increased":[283],"after":[284],"PDOs":[285,336],"were":[286,371],"loaded":[287],"(762.3":[291],"pg/mL":[292,295,306,325,328],"vs.":[293,307,326],"222.6":[294],"conditioned":[297],"medium),":[298],"proinflammatory":[302],"IL-6":[304],"(1089.5":[305],"81.3":[308],"pg/mL),":[309],"maintained":[311],"at":[312,329],"(380.5":[324],"60.4":[327],"day":[330],"13).":[331],"also":[333],"TAMs":[338],"inclined":[339],"be":[341],"M2-like":[342],"(CD68+CD163+)":[343],"phenotype":[344],"In":[347,377],"turn":[348],"(TAMs":[351],"CAFs)":[353],"contributed":[354],"immunosuppression":[357],"TME:":[360],"secretion":[362],"IL-6,":[366],"IL-13,":[367],"MIP-1\u03b2":[368],"HGF":[370],"downregulated":[372],"(fold-change\u21d00.646).":[376],"conclusion,":[378],"have":[380],"developed":[381],"recapitulates":[385],"promising":[391],"serving":[393],"platform":[396],"study":[398],"mechanisms":[399],"well":[406],"test":[408],"novel":[409],"Citation":[411],"Format:":[412],"Lunan":[413],"Liu,":[414],"Diane":[415],"M.":[416],"Simeone,":[417],"Weiqiang":[418],"Chen.":[419],"An":[420],"organoids-on-a-chip":[421],"[abstract].":[432],"In:":[433],"Proceedings":[434],"AACR":[437],"Special":[438],"Conference":[439],"Cancer":[441,453],"Research:":[442],"Pancreatic":[443],"Cancer;":[444],"2023":[445],"Sep":[446],"27-30;":[447],"Boston,":[448],"Massachusetts.":[449],"Philadelphia":[450],"(PA):":[451],"AACR;":[452],"Res":[454],"2024;84(2":[455],"Suppl):Abstract":[456],"nr":[457],"B057.":[458]},"counts_by_year":[],"updated_date":"2026-08-21T09:56:20.448147","created_date":"2024-01-17T00:00:00"}