{"id":"https://openalex.org/W4390909388","doi":"https://doi.org/10.1038/s41375-024-02138-5","title":"Clonal medicine targeting DNA damage response eradicates leukemia","display_name":"Clonal medicine targeting DNA damage response eradicates leukemia","publication_year":2024,"publication_date":"2024-01-16","ids":{"openalex":"https://openalex.org/W4390909388","doi":"https://doi.org/10.1038/s41375-024-02138-5","pmid":"https://pubmed.ncbi.nlm.nih.gov/38228681","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10912018"},"language":"en","primary_location":{"id":"doi:10.1038/s41375-024-02138-5","doi":"https://doi.org/10.1038/s41375-024-02138-5","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41375-024-02138-5","pdf_url":"https://www.nature.com/articles/s41375-024-02138-5.pdf","source":{"id":"https://openalex.org/S149476849","display_name":"Leukemia","issn_l":"0887-6924","issn":["0887-6924","1476-5551"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Leukemia","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.nature.com/articles/s41375-024-02138-5.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5038292704","display_name":"Monika Maria Toma","orcid":"https://orcid.org/0000-0001-8414-253X","observed_orcids":["https://orcid.org/0000-0001-8414-253X"]},"institutions":[{"id":"https://openalex.org/I84392919","display_name":"Temple University","ror":"https://ror.org/00kx1jb78","country_code":"US","type":"education","lineage":["https://openalex.org/I84392919"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Monika M. Toma","raw_affiliation_strings":["Fels Cancer Institute for Personalized Medicine and Department of Cancer and Cellular Biology, Temple University Lewis Katz School of Medicine, Philadelphia, PA, 19140, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fels Cancer Institute for Personalized Medicine and Department of Cancer and Cellular Biology, Temple University Lewis Katz School of Medicine, Philadelphia, PA, 19140, USA","institution_ids":["https://openalex.org/I84392919"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073852871","display_name":"Adam Karami","orcid":"https://orcid.org/0009-0009-1448-9955","observed_orcids":["https://orcid.org/0009-0009-1448-9955"]},"institutions":[{"id":"https://openalex.org/I84392919","display_name":"Temple University","ror":"https://ror.org/00kx1jb78","country_code":"US","type":"education","lineage":["https://openalex.org/I84392919"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Adam Karami","raw_affiliation_strings":["Fels Cancer Institute for Personalized Medicine and Department of Cancer and Cellular Biology, Temple University Lewis Katz School of Medicine, Philadelphia, PA, 19140, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fels Cancer Institute for Personalized Medicine and Department of Cancer and Cellular Biology, Temple University Lewis Katz School of Medicine, Philadelphia, PA, 19140, USA","institution_ids":["https://openalex.org/I84392919"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049450086","display_name":"Margaret Nieborowska-Skorska","orcid":"https://orcid.org/0009-0002-7798-1575","observed_orcids":["https://orcid.org/0009-0002-7798-1575"]},"institutions":[{"id":"https://openalex.org/I84392919","display_name":"Temple University","ror":"https://ror.org/00kx1jb78","country_code":"US","type":"education","lineage":["https://openalex.org/I84392919"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Margaret Nieborowska-Skorska","raw_affiliation_strings":["Fels Cancer Institute for Personalized Medicine and Department of Cancer and Cellular Biology, Temple University Lewis Katz School of Medicine, Philadelphia, PA, 19140, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fels Cancer Institute for Personalized Medicine and Department of Cancer and Cellular Biology, Temple University Lewis Katz School of Medicine, Philadelphia, PA, 19140, USA","institution_ids":["https://openalex.org/I84392919"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108894065","display_name":"Kumaraswamy Naidu Chirtala","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I84392919","display_name":"Temple University","ror":"https://ror.org/00kx1jb78","country_code":"US","type":"education","lineage":["https://openalex.org/I84392919"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kumaraswamy Naidu Chirtala","raw_affiliation_strings":["Fels Cancer Institute for Personalized Medicine and Department of Cancer and Cellular Biology, Temple University Lewis Katz School of Medicine, Philadelphia, PA, 19140, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fels Cancer Institute for Personalized Medicine and Department of Cancer and Cellular Biology, Temple University Lewis Katz School of Medicine, Philadelphia, PA, 19140, USA","institution_ids":["https://openalex.org/I84392919"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059140460","display_name":"Monika P\u0119pek","orcid":"https://orcid.org/0000-0003-3506-8040","observed_orcids":["https://orcid.org/0000-0003-3506-8040"]},"institutions":[{"id":"https://openalex.org/I268303160","display_name":"Medical University of Warsaw","ror":"https://ror.org/04p2y4s44","country_code":"PL","type":"education","lineage":["https://openalex.org/I268303160"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Monika Pepek","raw_affiliation_strings":["Department of Tumor Biology and Genetics, Medical University of Warsaw, Warsaw, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Tumor Biology and Genetics, Medical University of Warsaw, Warsaw, Poland","institution_ids":["https://openalex.org/I268303160"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032243711","display_name":"Emir Hadzijusufovic","orcid":"https://orcid.org/0000-0001-7409-4204","observed_orcids":["https://orcid.org/0000-0001-7409-4204"]},"institutions":[{"id":"https://openalex.org/I150540706","display_name":"University of Veterinary Medicine Vienna","ror":"https://ror.org/01w6qp003","country_code":"AT","type":"education","lineage":["https://openalex.org/I150540706"]},{"id":"https://openalex.org/I4405261830","display_name":"Ludwig Boltzmann Institute for Hematology and Oncology","ror":"https://ror.org/05xfe3w07","country_code":"AT","type":"facility","lineage":["https://openalex.org/I2799334681","https://openalex.org/I4405261830"]},{"id":"https://openalex.org/I76134821","display_name":"Medical University of Vienna","ror":"https://ror.org/05n3x4p02","country_code":"AT","type":"education","lineage":["https://openalex.org/I76134821"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Emir Hadzijusufovic","raw_affiliation_strings":["Department for Companion Animals & Horses, Clinic for Internal Medicine and Infectious Diseases, University of Veterinary Medicine Vienna, Vienna, Austria","Ludwig Boltzmann Institute for Hematology and Oncology and Department of Internal Medicine I, Division of Hematology and Hemostaseology, Medical University of Vienna, Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department for Companion Animals & Horses, Clinic for Internal Medicine and Infectious Diseases, University of Veterinary Medicine Vienna, Vienna, Austria","institution_ids":["https://openalex.org/I150540706"]},{"raw_affiliation_string":"Ludwig Boltzmann Institute for Hematology and Oncology and Department of Internal Medicine I, Division of Hematology and Hemostaseology, Medical University of Vienna, Vienna, Austria","institution_ids":["https://openalex.org/I4405261830","https://openalex.org/I76134821"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074420457","display_name":"Tomasz Stok\u0142osa","orcid":"https://orcid.org/0000-0001-6918-5056","observed_orcids":["https://orcid.org/0000-0001-6918-5056"]},"institutions":[{"id":"https://openalex.org/I268303160","display_name":"Medical University of Warsaw","ror":"https://ror.org/04p2y4s44","country_code":"PL","type":"education","lineage":["https://openalex.org/I268303160"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Tomasz Stoklosa","raw_affiliation_strings":["Department of Tumor Biology and Genetics, Medical University of Warsaw, Warsaw, Poland"],"raw_orcid":"https://orcid.org/0000-0001-6918-5056","affiliations":[{"raw_affiliation_string":"Department of Tumor Biology and Genetics, Medical University of Warsaw, Warsaw, Poland","institution_ids":["https://openalex.org/I268303160"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006306448","display_name":"Peter Valent","orcid":"https://orcid.org/0000-0003-0456-5095","observed_orcids":["https://orcid.org/0000-0003-0456-5095"]},"institutions":[{"id":"https://openalex.org/I4405261830","display_name":"Ludwig Boltzmann Institute for Hematology and Oncology","ror":"https://ror.org/05xfe3w07","country_code":"AT","type":"facility","lineage":["https://openalex.org/I2799334681","https://openalex.org/I4405261830"]},{"id":"https://openalex.org/I76134821","display_name":"Medical University of Vienna","ror":"https://ror.org/05n3x4p02","country_code":"AT","type":"education","lineage":["https://openalex.org/I76134821"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Peter Valent","raw_affiliation_strings":["Ludwig Boltzmann Institute for Hematology and Oncology and Department of Internal Medicine I, Division of Hematology and Hemostaseology, Medical University of Vienna, Vienna, Austria"],"raw_orcid":"https://orcid.org/0000-0003-0456-5095","affiliations":[{"raw_affiliation_string":"Ludwig Boltzmann Institute for Hematology and Oncology and Department of Internal Medicine I, Division of Hematology and Hemostaseology, Medical University of Vienna, Vienna, Austria","institution_ids":["https://openalex.org/I4405261830","https://openalex.org/I76134821"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5063022331","display_name":"Tomasz Sk\u00f3rski","orcid":"https://orcid.org/0000-0002-3809-4538","observed_orcids":["https://orcid.org/0000-0002-3809-4538"]},"institutions":[{"id":"https://openalex.org/I84392919","display_name":"Temple University","ror":"https://ror.org/00kx1jb78","country_code":"US","type":"education","lineage":["https://openalex.org/I84392919"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Tomasz Skorski","raw_affiliation_strings":["Fels Cancer Institute for Personalized Medicine and Department of Cancer and Cellular Biology, Temple University Lewis Katz School of Medicine, Philadelphia, PA, 19140, USA. tskorski@temple.edu","Fels Cancer Institute for Personalized Medicine and Department of Cancer and Cellular Biology, Temple University Lewis Katz School of Medicine, Philadelphia, PA, 19140, USA"],"raw_orcid":"https://orcid.org/0000-0002-3809-4538","affiliations":[{"raw_affiliation_string":"Fels Cancer Institute for Personalized Medicine and Department of Cancer and Cellular Biology, Temple University Lewis Katz School of Medicine, Philadelphia, PA, 19140, USA. tskorski@temple.edu","institution_ids":["https://openalex.org/I84392919"]},{"raw_affiliation_string":"Fels Cancer Institute for Personalized Medicine and Department of Cancer and Cellular Biology, Temple University Lewis Katz School of Medicine, Philadelphia, PA, 19140, USA","institution_ids":["https://openalex.org/I84392919"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5063022331"],"corresponding_institution_ids":["https://openalex.org/I84392919"],"apc_list":{"value":4990,"currency":"USD","value_usd":4990},"apc_paid":{"value":4990,"currency":"USD","value_usd":4990},"fwci":1.857,"has_fulltext":true,"cited_by_count":6,"citation_normalized_percentile":{"value":0.84734589,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":97},"biblio":{"volume":"38","issue":"3","first_page":"671","last_page":"675"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11157","display_name":"Chronic Lymphocytic Leukemia Research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acute-myeloid-leukemia","display_name":"acute myeloid leukemia","score":0.9860000014305115},{"id":"https://openalex.org/keywords/myeloproliferative-neoplasms","display_name":"myeloproliferative neoplasms","score":0.9380000233650208},{"id":"https://openalex.org/keywords/clonal-heterogeneity","display_name":"clonal heterogeneity","score":0.7540000081062317},{"id":"https://openalex.org/keywords/dna-damage-response-inhibitors","display_name":"DNA damage response inhibitors","score":0.8220000267028809},{"id":"https://openalex.org/keywords/double-strand-break-repair","display_name":"DNA double-strand break repair","score":0.8790000081062317},{"id":"https://openalex.org/keywords/parp-inhibitors","display_name":"PARP inhibitors","score":0.9200000166893005},{"id":"https://openalex.org/keywords/parp-inhibitor-resistance","display_name":"PARP inhibitor resistance","score":0.6140000224113464},{"id":"https://openalex.org/keywords/atr-inhibitors","display_name":"ATR inhibitors","score":0.6890000104904175},{"id":"https://openalex.org/keywords/pol-inhibitors","display_name":"Pol\u03b8 inhibitors","score":0.593999981880188},{"id":"https://openalex.org/keywords/flt3-itd-mutation","display_name":"FLT3-ITD","score":0.8040000200271606},{"id":"https://openalex.org/keywords/jak2-v617f-mutation","display_name":"JAK2 V617F mutation","score":0.9639999866485596},{"id":"https://openalex.org/keywords/tet2-mutation","display_name":"TET2 mutation","score":0.5879999995231628},{"id":"https://openalex.org/keywords/dnmt3a-mutation","display_name":"DNMT3A mutation","score":0.8939999938011169}],"concepts":[{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.6472325325012207},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.4864520728588104},{"id":"https://openalex.org/C194409129","wikidata":"https://www.wikidata.org/wiki/Q103824","display_name":"Hematology","level":2,"score":0.4692012667655945},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.46291548013687134},{"id":"https://openalex.org/C2780817109","wikidata":"https://www.wikidata.org/wiki/Q954625","display_name":"Myelodysplastic syndromes","level":3,"score":0.42609351873397827},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4202845096588135},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.39968234300613403},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3773011267185211},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3470064401626587},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2582191228866577},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.1512123942375183}],"mesh":[{"descriptor_ui":"D002999","descriptor_name":"Clone Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004249","descriptor_name":"DNA Damage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004260","descriptor_name":"DNA Repair","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007938","descriptor_name":"Leukemia","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1038/s41375-024-02138-5","doi":"https://doi.org/10.1038/s41375-024-02138-5","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41375-024-02138-5","pdf_url":"https://www.nature.com/articles/s41375-024-02138-5.pdf","source":{"id":"https://openalex.org/S149476849","display_name":"Leukemia","issn_l":"0887-6924","issn":["0887-6924","1476-5551"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Leukemia","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10912018","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10912018","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10912018/pdf/41375_2024_Article_2138.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Leukemia","raw_type":"Text"},{"id":"pmid:38228681","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38228681","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Leukemia","raw_type":"Letter"}],"best_oa_location":{"id":"doi:10.1038/s41375-024-02138-5","doi":"https://doi.org/10.1038/s41375-024-02138-5","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41375-024-02138-5","pdf_url":"https://www.nature.com/articles/s41375-024-02138-5.pdf","source":{"id":"https://openalex.org/S149476849","display_name":"Leukemia","issn_l":"0887-6924","issn":["0887-6924","1476-5551"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Leukemia","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[{"id":"https://openalex.org/G194038528","display_name":null,"funder_award_id":"R01 CA244044","funder_id":"https://openalex.org/F4320306085","funder_display_name":"U.S. Department of Health and Human Services"},{"id":"https://openalex.org/G1980002778","display_name":null,"funder_award_id":"TRP 6628-21","funder_id":"https://openalex.org/F4320308295","funder_display_name":"Leukemia and Lymphoma Society"},{"id":"https://openalex.org/G3626307998","display_name":"AML mutation-guided drugging of DNA repair","funder_award_id":"R01CA237286","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G4794054878","display_name":null,"funder_award_id":"R01CA244707","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G5739139436","display_name":null,"funder_award_id":"R01CA244707","funder_id":"https://openalex.org/F4320306085","funder_display_name":"U.S. Department of Health and Human Services"},{"id":"https://openalex.org/G5847106629","display_name":"Oncogenic tyrosine kinases inhibitors abrogate DNA repair and sensitive leukemias to PARP inhibitors","funder_award_id":"R01CA244044","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G6947585563","display_name":"PolQ as a novel therapeutic target in AML","funder_award_id":"R01CA244179","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G7006446046","display_name":null,"funder_award_id":"R01 CA244179","funder_id":"https://openalex.org/F4320306085","funder_display_name":"U.S. Department of Health and Human Services"},{"id":"https://openalex.org/G7941272330","display_name":null,"funder_award_id":"P30CA042014","funder_id":"https://openalex.org/F4320312218","funder_display_name":"Huntsman Cancer Institute"},{"id":"https://openalex.org/G8235591599","display_name":null,"funder_award_id":"R01CA237286","funder_id":"https://openalex.org/F4320306085","funder_display_name":"U.S. Department of Health and Human Services"},{"id":"https://openalex.org/G8272964340","display_name":"MPN-inducing mutations as biomarkers of synthetic lethality","funder_award_id":"R01CA247707","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000895596","display_name":"Cancer Center Support Grant","funder_award_id":"P30CA042014","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320306085","display_name":"U.S. Department of Health and Human Services","ror":"https://ror.org/033jnv181"},{"id":"https://openalex.org/F4320308295","display_name":"Leukemia and Lymphoma Society","ror":"https://ror.org/04m0xav37"},{"id":"https://openalex.org/F4320309475","display_name":"Northwestern University","ror":"https://ror.org/000e0be47"},{"id":"https://openalex.org/F4320312218","display_name":"Huntsman Cancer Institute","ror":"https://ror.org/03v7tx966"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320333106","display_name":"Robert H. Lurie Comprehensive Cancer Center","ror":"https://ror.org/000e0be47"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4390909388.pdf","grobid_xml":"https://content.openalex.org/works/W4390909388.grobid-xml"},"referenced_works_count":16,"referenced_works":["https://openalex.org/W2027613124","https://openalex.org/W2551286426","https://openalex.org/W2765195183","https://openalex.org/W2808408940","https://openalex.org/W2991449575","https://openalex.org/W3010560555","https://openalex.org/W3093815480","https://openalex.org/W3118071796","https://openalex.org/W3127798333","https://openalex.org/W3177309704","https://openalex.org/W4200418432","https://openalex.org/W4285099086","https://openalex.org/W4310038300","https://openalex.org/W4310946789","https://openalex.org/W4313313022","https://openalex.org/W7073607719"],"related_works":["https://openalex.org/W4389246414","https://openalex.org/W4389248086","https://openalex.org/W4390267839","https://openalex.org/W4283373465","https://openalex.org/W2045105571","https://openalex.org/W2578867121","https://openalex.org/W2481355964","https://openalex.org/W4402616573","https://openalex.org/W2741152418","https://openalex.org/W4417010718"],"abstract_inverted_index":{"Clonal":[0,451,1644],"diversity":[1],"plays":[2],"a":[3,112,198,223,248,530,1243,1257,1780,1902,1910,1938],"key":[4],"role":[5],"in":[6,10,546,648,713,734,900,967,993,1020,1024,1035,1045,1080,1130,1159,1256,1547,1616,1682,1695,1807,1834,1879,1931,1968,1998],"poor":[7],"therapeutic":[8,250,774],"outcomes":[9],"acute":[11],"myeloid":[12,204],"leukemia":[13,861,869,975,1018],"(AML)":[14],"and":[15,74,99,103,133,149,159,173,213,220,227,238,284,290,330,334,350,364,377,381,385,408,426,437,441,445,474,484,561,567,595,614,630,657,671,680,757,878,911,920,935,996,1001,1023,1028,1053,1112,1133,1165,1182,1296,1339,1347,1350,1387,1401,1440,1452,1459,1524,1526,1545,1582,1595,1602,1656,1672,1703,1741,1836,1854,1887,1942,1964,2010,2027],"myeloproliferative":[16],"neoplasm":[17],"(MPN)":[18],"patients":[19,1979],"[":[20,92,120,152,816,953,1063,1843,1892,1986,2003,2034],"1":[21],",":[22,94,154,346,399,407,840,2005,2007],"2":[23],"].":[24,96,122,156,818,955,1065,1845,1894,2036],"Therefore,":[25],"targeting":[26,258,784,1361,1505,1632,1645],"all":[27,85,259,719,1253,1654,1733,1819],"clones":[28,161,307,327,343,392,528,1255,1307,1408,1437,1575,1820,1936,2029],"is":[29,1867],"required":[30],"to":[31,51,58,63,68,143,147,165,179,193,210,246,280,288,328,331,358,371,422,433,456,488,505,598,636,663,686,743,765,835,871,884,946,1039,1143,1251,1301,1312,1354,1382,1409,1428,1449,1521,1529,1549,1565,1592,1653,1669,1732,1754,1773,1795,1814,1841,1858,1861,1877,1890,1905,1916,1954,1977,2031],"eradicate":[32],"these":[33,64,727,752,907,1116,1121,1236,1410,1787],"diseases.":[34],"To":[35,187,956,1357],"achieve":[36],"this":[37,696,725,1696],"goal,":[38],"we":[39,196,698,969,1897],"integrated":[40],"genetic":[41],"clonal":[42,145,189,216,244,517,570,587,783,1360,1504,1543,1631,1793,1914],"landscape":[43,217],"of":[44,79,84,101,218,263,311,325,453,492,501,527,533,542,556,579,591,622,645,715,738,751,778,801,811,849,859,866,868,874,886,894,916,922,929,932,950,989,1011,1017,1026,1056,1059,1073,1115,1120,1140,1146,1174,1229,1242,1263,1265,1336,1406,1466,1480,1492,1503,1608,1620,1630,1699,1743,1792,1805,1817,1848,1901,1912,1925,1934,1940,1950,1960,2025],"individual":[45,60,665,744,796,1475,1511,1638,1715,1755],"patient":[46,269,461,1153,1258,1370,1379,1518,1666,1727],"samples":[47,1371],"with":[48,191,270,305,465,529,538,703,724,888,906,962,977,1041,1047,1099,1205,1215,1246,1282,1438,1576,1779,1812,1839,1980],"the":[49,81,174,180,215,229,323,489,493,515,536,539,543,565,568,615,779,809,843,857,864,872,951,959,987,1009,1113,1138,1141,1239,1247,1261,1313,1325,1329,1404,1407,1419,1464,1488,1496,1744,1803,1829,1851,1856,1913,1923,2023],"response":[50,192,209,274,1548,1685,1794,1915],"DNA":[52,86,201,272,1956],"double-strand":[53],"break":[54],"repair":[55,1782],"(DSBR)":[56],"inhibitors":[57,151,167,195,212,256,276,544,666,745,753,780,797,845,964,1069,1249,1338,1364,1411,1476,1499,1551,1639,1648,1716,1736,1745,1756,1775,1797,1816,1927,1973,1994,2020,2033],"track":[59,144],"clones\u2019":[61,1684],"sensitivity":[62,146,324,452,867,1405],"drugs.":[65,1117],"We":[66,123,235],"decided":[67],"target":[69],"DSBR":[70,108,166,194,211,255,457,844,908,963,1248,1337,1363,1498,1550,1647,1735,1774,1796,1815,1863,1907,1917,1926,1969,2032],"pathways":[71],"because":[72],"AML":[73,102,158,219,237,460,821,966,1254,1655,1664,1725,1761,1808,1835,1941,1985,2026],"MPN":[75,104,160,221,239,1377,1516,1657,1943,2028],"accumulate":[76],"high":[77,1051],"numbers":[78],"DSBs,":[80],"most":[82],"lethal":[83],"lesions":[87],"resulting":[88],"from":[89,267,808,1376,1515,1663,1724,1937],"altered":[90],"metabolism":[91],"3":[93],"4":[95,153],"Thus,":[97,157,1306],"survival":[98,482,848,924],"proliferation":[100],"cells":[105,266,455,462,503,557,594,647,650,740,768,822,851,870,887,897,919,992,1019,1129,1147,1154,1375,1482,1514,1662,1723,1763],"depend":[106],"on":[107,169,520,574,695],"mechanisms":[109],"which":[110,206,846,943],"represent":[111,496,619,1171],"promising":[113],"targetable":[114],"vulnerability":[115],"(Supplementary":[116,231,939,1389,1412,1483,1531,1552,1640,1674,1688,1717,1737,1757,1767,1821],"Fig.":[117,232,449,940,1066,1390,1413,1484,1532,1553,1641,1675,1689,1718,1738,1758,1768,1822],"S1":[118],")":[119,771,942,1164,1278,1677,1740,1770],"5":[121],"reported":[124],"that":[125,700,1148,1308,1872,1899],"AML/MPN":[126],"-":[127,510,524,913,1070],"associated":[128,1778,1811,1838],"somatic":[129,240],"mutations,":[130],"e.g.,":[131],"FLT3(ITD)":[132],"JAK2(V617F)":[134],"accompanied":[135,926],"by":[136,184,297,830,927,998,1125,1157,1193,1293,1317,1362,1395,1538,1646,1786,1869,1922],"TET2mut":[137],"and/or":[138,979,1321],"DNMT3Amut":[139,1874],"can":[140],"be":[141,177,1355,1651,1859,1909],"applied":[142],"PARP":[148,1972],"Pol\u03b8":[150],"6":[155,478,562,1893],"may":[162,1365,1649,1908],"respond":[163],"differently":[164],"depending":[168],"their":[170,773],"mutational":[171],"profile,":[172],"treatment":[175,230,537,566,702,1040,1142,1207,1214,1275,1300,1327],"should":[176,711,2021],"tailored":[178,1071,1250],"mutation":[181,1903],"sets":[182,310],"carried":[183],"malignant":[185,260,1304,1935],"clones.":[186,261,721,1305],"integrate":[188],"composition":[190],"developed":[197,2019],"single-cell":[199,224],"targeted":[200,1785],"sequencing":[202],"(sctDNA-seq)":[203],"panel":[205,547],"illustrated":[207],"clone-by-clone":[208],"unraveled":[214],"at":[222,1828],"resolution":[225],"before":[226,558],"after":[228,535,564,1137],"S2":[233],").":[234,294,315,339,748,983,1007,1169,1271,1392,1416,1486,1534,1556,1643,1692,1720,1760,1824],"used":[236,1976],"mutations":[241,312,534,1826],"as":[242,787],"trackable":[243],"biomarkers":[245],"design":[247],"patient-tailored":[249],"regimen":[251],"(\u201cclonal":[252],"attack\u201d)":[253],"utilizing":[254],"simultaneously":[257],"Incubation":[262],"Lin-CD34":[264],"+":[265,348,352,354,395,397,401,403,405,410,412,414,416,418,705,709,755,759,789,876,880,896,1043,1061,1075,1196,1201,1218,1223,1423,1442,1444,1468,1494,1560,1578,1580,1584,1586,1588,1610,1625,1701,1705],"AML-MD2":[268,454,593,720,739,802,850,918,973,991,1078,1091,1128,1152],"six":[271],"damage":[273],"(DDR)":[275],"were":[277,356,420,463,730,761,1093,1155,1372,1380,1446,1519,1633,1667,1686,1729,1837,1885],"overall":[278,1730],"sensitive":[279,370,421,1381,1427,1448,1520,1528,1564,1668,1860,1889,2030],"PARPi,":[281,332,1383],"ATMi,":[282,854,1384,1495,1522,1670],"ATRi":[283,329,359,423,472,704,708,758,877,912,980,1044,1060,1074,1106,1429,1457,1469,1566,1600,1611,1671,1702],"RAD52i,":[285,1525],"but":[286,368,1678],"resistant":[287,357,1311,1731,1852],"Pol\u03b8i":[289],"DNA-PKi":[291,475,1388,1673,1706],"(Fig.":[292,313,336,746,769,838,981,1004,1269,1276],"1A":[293],"sctDNA-seq":[295,521,575,1393,1536],"followed":[296,1394,1537],"phylogenetic":[298,512],"tree":[299,513],"analysis":[300,318,483,1398,1541],"revealed":[301,1399,1542,1928],"branched":[302],"multi-clonal":[303],"architecture":[304],"eight":[306],"carrying":[308,344,393,1421,1558],"specific":[309],"1B-left":[314],"Fish":[316],"plot":[317,1397,1540],"demonstrated":[319],"staggering":[320],"differences":[321,1402,1546,1681],"between":[322,1403],"various":[326],"ATMi":[333,382,442,470,710,1626,1700,1704],"RAD52i":[335,468,790,881,1386,1433,1450,1467,1493,1624],"1B-right,":[337],"C":[338,550,1006,1168,1415,1691],"For":[340,1417,1659,1801],"example,":[341,1418,1660,1802],"three":[342,390],"EZH2(V679M)":[345,347,351,394,400,409],"TET2(L1721W)":[349,353,396,402,411],"FLT3(D835Y)":[355],"(":[360,373,1162,1167],"~":[361,374],"8%,":[362],"61%":[363],"26%":[365],"survivors,":[366,379,387,428,439,447,1454,1461,1597,1604],"respectively)":[367,380,429,440,1455,1598],"more":[369,732,826,1426,1447,1472,1563,1614,1710],"PARPi":[372,434,466,706,756,788,875,879,910,978,1012,1042,1076,1101,1200,1530,1570,1593,1609,1878,1891],"4%,":[375],"33%":[376],"12%":[378],"(~3%,":[383],"39%":[384],"15%":[386],"respectively).":[388,448,1462,1605],"Conversely,":[389],"other":[391,637,1048,1489],"RUNX1(D160Y)":[398,404,413],"EZH2(E54*)":[406,415],"BCOR1(R1334Tfs*32)":[417],"NRAS(G13R)":[419],"(~1%,":[424],"2%":[425],"0.5%":[427],"while":[430,1873],"less":[431],"responsive":[432],"(~4%,":[435],"44%":[436],"1%":[438,446,1453],"(~2%,":[443],"38%":[444],"1:":[450],"inhibitors.":[458,494,909,1512,1788,1864],"Lin-CD34+":[459,592,1374,1513,1661,1722],"treated":[464,905,970,1094],"olaparib,":[467,601],"6-hydroxy-DL-dopa,":[469,604],"KU-60019,":[471,613],"VE-821":[473],"NU7026":[476],"for":[477,1095],"days":[479,563,1098],"following":[480],"cell":[481,903,923],"sctDNA-seq.":[485],"A":[486,548,891,1082],"Sensitivity":[487,590],"indicated":[490,545,616],"concentrations":[491,541],"Results":[495,618,1170],"mean":[497,620,1172],"%":[498,644],"\u00b1":[499,624,651,1176],"SD":[500],"living":[502,937],"compared":[504,635,662,685,742,834,1753],"vehicle-treated":[506],"control.":[507],"B":[508,1163],"Left":[509],"The":[511,525,551,804,1118,1332,1606,1789],"visualizes":[514],"predicted":[516],"structure":[518],"based":[519,573],"data.":[522,576],"Right":[523],"proportion":[526],"different":[531],"combination":[532,777,952,1010,1072,1114,1465,1491,1607],"red-marked":[540],".":[549],"fish":[552,1396,1539],"plots":[553],"reflect":[554],"number":[555,621,893,988,1173],"(0":[559],"days)":[560],"inferred":[569],"evolution":[571],"pattern":[572,1502,1629],"Chi-Square":[577],"goodness":[578],"fit":[580],"p":[581,627,632,654,659,673,677,682,1179,1184],"-value":[582],"=":[583],"0.01578":[584],"showing":[585,1050],"treatment-induced":[586],"diversity.":[588],"D":[589,1190],"normal":[596,766,836,901,1226],"counterparts":[597,837,1884],"2.5":[599,611],"\u03bcM":[600,603,606,609,612],"30":[602],"0.2":[605],"VE-821,":[607],"25":[608],"ART558,":[610],"combinations.":[617],"colonies":[623,1175],"SD;":[625,652,1177],"***":[626,653,1178],"<":[628,633,655,660,674,678,683,1180,1185],"0.001":[629,656,1181],"**":[631,1183],"0.01":[634,679,1186],"groups":[638,667],"using":[639,668,688,1187,1951],"one-way":[640,669,689,1188],"Anova.":[641,690,1189],"E":[642,1212],"Mean":[643],"\u03b3H2AX-positive":[646,860],"Ki67+":[649],"*":[658],"0.05":[661,684],"corresponding":[664],"Anova":[670],"###":[672],"0.001,":[675],"##":[676],"#":[681],"vehicle":[687],"Full":[691,1232],"size":[692,1233],"image":[693,1234],"Based":[694],"observation,":[697],"hypothesized":[699],"simultaneous":[701,1932],"or":[707,1283],"result":[712,807],"elimination":[714],"numerous,":[716],"if":[717,958,1359],"not":[718,1315,1650,1708,1747,1784],"In":[722,1272,1895],"agreement":[723],"hypothesis,":[726],"drug":[728,1217,1220],"combinations":[729,750,873,1698,1742,1924],"20\u201330\u00d7":[731],"effective":[733,1473,1615],"eliminating":[735],"clonogenic":[736,799,1478,1618],"growth":[737,1479,1619],"when":[741,833,1752],"1D":[747,770],"Remarkably,":[749,1008,1463,1846],"(ATRi":[754],"ATMi)":[760],"only":[762,792,1507,1634],"modestly":[763,1527],"toxic":[764],"hematopoietic":[767,902],"bolstering":[772],"potential.":[775,1231],"Moreover,":[776,863,1721,2017],"displaying":[781,1500,1627],"similar":[782,1501,1628],"specificity":[785],"such":[786],"was":[791,882,898,925,1037,1123,1425,1470,1506,1562,1612,1776,1810],"2\u00d7":[793,1000,1635],"better":[794,1509,1591,1636],"than":[795,1432,1456,1474,1510,1569,1599,1637,1714],"against":[798,1477],"activity":[800,949],"cells.":[803,862],"effect":[805,1713,1751],"might":[806,944],"induction":[810,928],"intracellular":[812],"dual":[813],"synthetic":[814],"lethality":[815],"7":[817],"As":[819,1693],"expected,":[820],"accumulated":[823,1764],"approximately":[824,999],"3\u00d7":[825],"spontaneous":[827,1765],"DSBs":[828,889,1766,1963],"detected":[829,899,1156,1316,1687,1833],"\u03b3H2AX":[831,895],"immunofluorescence":[832,1158],"1E":[839],"Vehicle).":[841],"Only":[842],"reduced":[847,986],"(PARPi,":[852],"ATRi,":[853,1385,1523],"RAD52i)":[855],"increased":[856],"percentage":[858],"magnitude":[865],"proportional":[883],"detection":[885],"(\u03b3H2AX+).":[890],"low":[892,1057],"populations":[904],"mediated":[914],"accumulation":[915],"\u03b3H2AX+":[917],"reduction":[921],"differentiation":[930],"(increased":[931],"CD14+/CD11b+,":[933],"CD11c+,":[934],"HLA-DR+":[936],"cells)":[938],"S3":[941],"contribute":[945],"strong":[947],"anti-leukemia":[948,1712,1750],"8":[954],"determine":[957],"\u201cclonal":[960,1244,1920],"attack\u201d":[961,1192,1245,1921],"eradicates":[965],"vivo,":[968],"mice":[971,1036,1088],"bearing":[972,1089],"primary":[974,1090],"xenografts":[976],"2A":[982],"Individual":[984],"drugs":[985,1122,1209,1342],"hCD45+":[990,1127,1151],"bone":[994,1021,1131,1160],"marrow":[995,1022,1132,1161],"spleen":[997,1025,1134,1166],"3\u00d7,":[1002],"respectively":[1003],"2B,":[1005],"+ATRi":[1013],"eliminated":[1014],">":[1015],"99%":[1016],"7/10":[1027],"10/10":[1029],"mice,":[1030],"respectively.":[1031],"No":[1032],"obvious":[1033],"toxicity":[1034,1055],"attributed":[1038],"concordance":[1046],"studies":[1049],"efficacy":[1052],"tolerable":[1054],"doses":[1058],"PARP1i":[1062],"9":[1064],"2:":[1067],"sctDNA-seq/DSBR":[1068],"eradicated":[1077],"PLX":[1079],"mice.":[1081],"Experimental":[1083],"protocol.":[1084],"Humanized":[1085],"NRGS":[1086],"immunodeficient":[1087],"xenograft":[1092],"14":[1096,2008],"consecutive":[1097],"vehicle,":[1100],"olaparib":[1102],"(30":[1103],"mg/kg":[1104,1109],"i.p.),":[1105],"VE-822":[1107],"(40":[1108],"oral":[1110],"gavage)":[1111],"efficiency":[1119,1241,1930],"evaluated":[1124,1997],"detecting":[1126],"one":[1135],"month":[1136],"end":[1139],"allow":[1144],"regrowth":[1145],"survived":[1149],"treatment.":[1150],"\u201cClonal":[1191],"DDR1":[1194],"inhibitor":[1195,1198,1287,2012],"DDR2":[1197],"(e.g.,":[1199,1221,1343,1827],"ATRi)":[1202],"eventually":[1203],"combined":[1204],"standard":[1206,1274],"(ST)":[1208],"(ST1,":[1210],"ST2).":[1211],"Standard":[1213],"ST1":[1216],"ST2":[1219],"quizartinib":[1222],"azacytidine).":[1224],"Normal/CHIP":[1225],"hematopoiesis/clonal":[1227],"hematopoiesis":[1228],"indeterminate":[1230],"Altogether,":[1235,1919],"results":[1237],"highlight":[1238],"remarkable":[1240,1929],"attack":[1252],"thus":[1259],"reducing":[1260],"probability":[1262],"development":[1264],"time-dependent":[1266],"acquired":[1267],"resistance":[1268,1772,1813,1840,1876],"2D":[1270],"comparison,":[1273],"2E":[1277],"often":[1279],"employs":[1280],"chemotherapeutics":[1281],"without":[1284],"tyrosine":[1285,1344],"kinase":[1286,1345,1993],"(TKi).":[1288],"Chemotherapy":[1289],"dosages":[1290],"are":[1291,1309,1798,1831,1974],"limited":[1292],"side":[1294],"effects":[1295,1335],"TKi":[1297],"requires":[1298],"prolonged":[1299,1326],"effectively":[1302],"eliminate":[1303],"inherently":[1310],"treatment,":[1314],"next":[1318],"generation":[1319],"sequencing,":[1320],"those":[1322],"emerging":[1323],"during":[1324],"cause":[1328],"disease":[1330],"relapse.":[1331],"potential":[1333],"combinatorial":[1334],"FDA":[1340],"approved":[1341],"inhibitors,":[1346],"hypomethylating,":[1348],"genotoxic":[1349,1952],"pro-apoptotic":[1351],"agents)":[1352],"need":[1353],"tested.":[1356,1373],"test":[1358],"have":[1366,1995],"broader":[1367],"applicability,":[1368],"additional":[1369],"P349":[1378,1481,1621],"S4A":[1391],"similarities":[1400,1544],"S4B,":[1414],"clone":[1420,1857],"KMT2A(L2373H)":[1422,1439,1441],"SETBP1(H1100R)":[1424,1443],"(24%":[1430],"survivors)":[1431,1568],"(59%":[1434],"survivors),":[1435,1573],"conversely":[1436],"FLT3(R834L)":[1445],"(~40%":[1451],"(72%":[1458],"4%":[1460],">100\u00d7":[1471],"S4D":[1485],"On":[1487],"hand,":[1490],"two":[1497],"2x":[1508],"P350":[1517],"S4E":[1533],"Again,":[1535],"S4F,":[1554],"G":[1555],"Clone":[1557],"TET2(P363L)":[1559,1577,1583],"NRAS(G12D)":[1561,1579,1585],"(~51%":[1567],"(~":[1571],"79%":[1572],"whereas":[1574,1623],"DNMT3A(W330C)":[1581,1587],"IDH1(R132C)":[1589],"responded":[1590],"(~0.1%":[1594],"0%":[1596],"(~22%":[1601],"3%":[1603],">9x":[1613],"inhibiting":[1617],"cells,":[1622,1881],"S4H":[1642],"applicable":[1652],"samples.":[1658],"V18":[1665],"S5A":[1676],"no":[1679],"significant":[1680,1749],"major":[1683],"S5B,":[1690],"expected":[1694],"context,":[1697],"did":[1707,1746],"exert":[1709,1748],"potent":[1711],"S5D":[1719],"V20":[1726,1762,1809],"sample":[1728],"tested":[1734],"S5E":[1739],"S5F\u2013H":[1759],"S5I":[1769],"therefore":[1771],"likely":[1777],"DSB":[1781],"mechanism(s)":[1783],"mechanistic":[1790],"aspects":[1791],"scarcely":[1799],"available.":[1800],"presence":[1804],"DNMT3A(R882S)":[1806],"almost":[1818],"S5E\u2013H":[1823],"DNMT3A":[1825],"R882)":[1830],"frequently":[1832],"anthracyclines":[1842],"10":[1844],"acquisition":[1847,1900],"TET2(P562Qfs*6)":[1849],"reversed":[1850],"phenotype":[1853],"rendered":[1855],"multiple":[1862],"This":[1865,1945],"observation":[1866],"supported":[1868],"our":[1870],"report":[1871],"promoted":[1875],"FLT3(ITD)-positive":[1880],"DNMT3Amut;TET2mut":[1882],";FLT3(ITD)-positive":[1883],"HR-deficient":[1886],"highly":[1888],"conclusion,":[1896],"postulate":[1898],"known":[1904],"modulate":[1906],"biomarker":[1911],"inhibitor(s).":[1918],"eradication":[1933],"cohort":[1939],"patients.":[1944],"novel":[1946],"approach":[1947],"which,":[1948],"instead":[1949],"agents":[1953],"induce":[1955],"damage,":[1957],"takes":[1958],"advantage":[1959],"metabolic/replication":[1961],"stress-induced":[1962],"targets":[1965],"clone-specific":[1966],"vulnerabilities":[1967],"pathways.":[1970],"While":[1971],"widely":[1975],"treat":[1978],"homologous":[1981],"recombination-deficient":[1982],"tumors":[1983],"including":[1984],"11":[1987],"],":[1988],"ATR,":[1989],"Pol\u03b8,":[1990],"ATM,":[1991],"DNA-PKcs":[1992],"been":[1996],"cancer":[1999],"clinical":[2000,2015],"trials":[2001],"(NCT04991480)":[2002],"12":[2004],"13":[2006],"]":[2009],"RAD52":[2011],"still":[2013],"awaits":[2014],"development.":[2016],"newly":[2018],"broaden":[2022],"spectrum":[2024],"15":[2035]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2024-01-17T00:00:00"}
