{"id":"https://openalex.org/W4390908055","doi":"https://doi.org/10.1136/ard-2023-224699","title":"Comparison of the effect of treatment with NSAIDs added to anti-TNF therapy versus anti-TNF therapy alone on the progression of structural damage in the spine over 2 years in patients with radiographic axial spondyloarthritis from the randomised-controlled CONSUL trial","display_name":"Comparison of the effect of treatment with NSAIDs added to anti-TNF therapy versus anti-TNF therapy alone on the progression of structural damage in the spine over 2 years in patients with radiographic axial spondyloarthritis from the randomised-controlled CONSUL trial","publication_year":2024,"publication_date":"2024-01-16","ids":{"openalex":"https://openalex.org/W4390908055","doi":"https://doi.org/10.1136/ard-2023-224699","pmid":"https://pubmed.ncbi.nlm.nih.gov/38228361","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11041582"},"language":"en","primary_location":{"id":"doi:10.1136/ard-2023-224699","doi":"https://doi.org/10.1136/ard-2023-224699","is_oa":true,"landing_page_url":"https://doi.org/10.1136/ard-2023-224699","pdf_url":"https://ard.bmj.com/content/annrheumdis/early/2024/01/15/ard-2023-224699.full.pdf","source":{"id":"https://openalex.org/S25650217","display_name":"Annals of the Rheumatic Diseases","issn_l":"0003-4967","issn":["0003-4967","1468-2060"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of the Rheumatic Diseases","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://ard.bmj.com/content/annrheumdis/early/2024/01/15/ard-2023-224699.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5048211544","display_name":"Fabian Nikolai Proft","orcid":"https://orcid.org/0000-0003-4306-033X","observed_orcids":["https://orcid.org/0000-0003-4306-033X"]},"institutions":[{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Fabian Proft","raw_affiliation_strings":["Department of Gastroenterology, Infectiology and Rheumatology (including Nutrition Medicine), Charite Universitatsmedizin Berlin, Berlin, Germany Fabian.Proft@charite.de","Department of Gastroenterology, Infectiology and Rheumatology (including Nutrition Medicine), Charite Universitatsmedizin Berlin, Berlin 12203, Germany"],"raw_orcid":"https://orcid.org/0000-0003-4306-033X","affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Infectiology and Rheumatology (including Nutrition Medicine), Charite Universitatsmedizin Berlin, Berlin, Germany Fabian.Proft@charite.de","institution_ids":["https://openalex.org/I7877124"]},{"raw_affiliation_string":"Department of Gastroenterology, Infectiology and Rheumatology (including Nutrition Medicine), Charite Universitatsmedizin Berlin, Berlin 12203, Germany","institution_ids":["https://openalex.org/I7877124"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084697737","display_name":"Murat Tor\u011futalp","orcid":"https://orcid.org/0000-0003-4600-9484","observed_orcids":["https://orcid.org/0000-0003-4600-9484"]},"institutions":[{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Murat Torgutalp","raw_affiliation_strings":["Department of Gastroenterology, Infectiology and Rheumatology (including Nutrition Medicine), Charite Universitatsmedizin Berlin, Berlin, Germany"],"raw_orcid":"https://orcid.org/0000-0003-4600-9484","affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Infectiology and Rheumatology (including Nutrition Medicine), Charite Universitatsmedizin Berlin, Berlin, Germany","institution_ids":["https://openalex.org/I7877124"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003130991","display_name":"Burkhard Muche","orcid":"https://orcid.org/0000-0003-4104-5080","observed_orcids":["https://orcid.org/0000-0003-4104-5080"]},"institutions":[{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Burkhard Muche","raw_affiliation_strings":["Department of Gastroenterology, Infectiology and Rheumatology (including Nutrition Medicine), Charite Universitatsmedizin Berlin, Berlin, Germany","Department of Rheumatology CCM, Charite Universitatsmedizin Berlin, Berlin, Germany"],"raw_orcid":"https://orcid.org/0000-0003-4104-5080","affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Infectiology and Rheumatology (including Nutrition Medicine), Charite Universitatsmedizin Berlin, Berlin, Germany","institution_ids":["https://openalex.org/I7877124"]},{"raw_affiliation_string":"Department of Rheumatology CCM, Charite Universitatsmedizin Berlin, Berlin, Germany","institution_ids":["https://openalex.org/I7877124"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011986838","display_name":"Valeria R\u00edos Rodr\u00edguez","orcid":"https://orcid.org/0000-0001-5612-043X","observed_orcids":["https://orcid.org/0000-0001-5612-043X"]},"institutions":[{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Valeria Rios Rodriguez","raw_affiliation_strings":["Department of Gastroenterology, Infectiology and Rheumatology (including Nutrition Medicine), Charite Universitatsmedizin Berlin, Berlin, Germany"],"raw_orcid":"https://orcid.org/0000-0001-5612-043X","affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Infectiology and Rheumatology (including Nutrition Medicine), Charite Universitatsmedizin Berlin, Berlin, Germany","institution_ids":["https://openalex.org/I7877124"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044290696","display_name":"Joachim Listing","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210095248","display_name":"German Rheumatism Research Centre","ror":"https://ror.org/00shv0x82","country_code":"DE","type":"facility","lineage":["https://openalex.org/I315704651","https://openalex.org/I4210095248"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Joachim Listing","raw_affiliation_strings":["German Rheumatism Research Center Berlin, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"German Rheumatism Research Center Berlin, Berlin, Germany","institution_ids":["https://openalex.org/I4210095248"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038256968","display_name":"Mikhail Protopopov","orcid":"https://orcid.org/0000-0003-4840-5069","observed_orcids":["https://orcid.org/0000-0003-4840-5069"]},"institutions":[{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Mikhail Protopopov","raw_affiliation_strings":["Department of Gastroenterology, Infectiology and Rheumatology (including Nutrition Medicine), Charite Universitatsmedizin Berlin, Berlin, Germany"],"raw_orcid":"https://orcid.org/0000-0003-4840-5069","affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Infectiology and Rheumatology (including Nutrition Medicine), Charite Universitatsmedizin Berlin, Berlin, Germany","institution_ids":["https://openalex.org/I7877124"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089879558","display_name":"Judith Rademacher","orcid":"https://orcid.org/0000-0001-7442-2570","observed_orcids":["https://orcid.org/0000-0001-7442-2570"]},"institutions":[{"id":"https://openalex.org/I4210139777","display_name":"Berlin Institute of Health at Charit\u00e9 - Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/0493xsw21","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210139777","https://openalex.org/I7877124"]},{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Judith Rademacher","raw_affiliation_strings":["BIH, Berlin, Germany","Department of Gastroenterology, Infectiology and Rheumatology (including Nutrition Medicine), Charite Universitatsmedizin Berlin, Berlin, Germany"],"raw_orcid":"https://orcid.org/0000-0001-7442-2570","affiliations":[{"raw_affiliation_string":"BIH, Berlin, Germany","institution_ids":["https://openalex.org/I4210139777"]},{"raw_affiliation_string":"Department of Gastroenterology, Infectiology and Rheumatology (including Nutrition Medicine), Charite Universitatsmedizin Berlin, Berlin, Germany","institution_ids":["https://openalex.org/I7877124"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020029860","display_name":"Hildrun Haibel","orcid":"https://orcid.org/0000-0002-5180-1831","observed_orcids":["https://orcid.org/0000-0002-5180-1831"]},"institutions":[{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Hildrun Haibel","raw_affiliation_strings":["Department of Gastroenterology, Infectiology and Rheumatology (including Nutrition Medicine), Charite Universitatsmedizin Berlin, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Infectiology and Rheumatology (including Nutrition Medicine), Charite Universitatsmedizin Berlin, Berlin, Germany","institution_ids":["https://openalex.org/I7877124"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108373403","display_name":"Laura Collazos Spiller","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Laura Spiller","raw_affiliation_strings":["Department of Gastroenterology, Infectiology and Rheumatology (including Nutrition Medicine), Charite Universitatsmedizin Berlin, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Infectiology and Rheumatology (including Nutrition Medicine), Charite Universitatsmedizin Berlin, Berlin, Germany","institution_ids":["https://openalex.org/I7877124"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006464787","display_name":"Anne-Katrin Weber","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Anne-Katrin Weber","raw_affiliation_strings":["Department of Gastroenterology, Infectiology and Rheumatology (including Nutrition Medicine), Charite Universitatsmedizin Berlin, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Infectiology and Rheumatology (including Nutrition Medicine), Charite Universitatsmedizin Berlin, Berlin, Germany","institution_ids":["https://openalex.org/I7877124"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087260810","display_name":"Maryna Verba","orcid":"https://orcid.org/0009-0005-7789-4027","observed_orcids":["https://orcid.org/0009-0005-7789-4027"]},"institutions":[{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Maryna Verba","raw_affiliation_strings":["Department of Gastroenterology, Infectiology and Rheumatology (including Nutrition Medicine), Charite Universitatsmedizin Berlin, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Infectiology and Rheumatology (including Nutrition Medicine), Charite Universitatsmedizin Berlin, Berlin, Germany","institution_ids":["https://openalex.org/I7877124"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060626069","display_name":"J. Brandt-Juergens","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jan Brandt-Juergens","raw_affiliation_strings":["Rheumatology, Private Practice, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rheumatology, Private Practice, Berlin, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001947020","display_name":"Uta Kiltz","orcid":"https://orcid.org/0000-0001-5668-4497","observed_orcids":["https://orcid.org/0000-0001-5668-4497"]},"institutions":[{"id":"https://openalex.org/I4210091869","display_name":"Rheumazentrum Ruhrgebiet","ror":"https://ror.org/00e03sj10","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2799784675","https://openalex.org/I4210088550","https://openalex.org/I4210091869"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Uta Kiltz","raw_affiliation_strings":["Rheumazentrum Ruhrgebiet, Herne, Germany"],"raw_orcid":"https://orcid.org/0000-0001-5668-4497","affiliations":[{"raw_affiliation_string":"Rheumazentrum Ruhrgebiet, Herne, Germany","institution_ids":["https://openalex.org/I4210091869"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064909947","display_name":"Maren Sieburg","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Maren Sieburg","raw_affiliation_strings":["Rheumatologische Facharztpraxis, Magdeburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rheumatologische Facharztpraxis, Magdeburg, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074284517","display_name":"Swen Jacki","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Swen Jacki","raw_affiliation_strings":["Rheumatologische Schwerpunktpraxis, T\u00fcbingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rheumatologische Schwerpunktpraxis, T\u00fcbingen, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085745432","display_name":"Joachim Sieper","orcid":"https://orcid.org/0000-0003-0285-9890","observed_orcids":["https://orcid.org/0000-0003-0285-9890"]},"institutions":[{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Joachim Sieper","raw_affiliation_strings":["Department of Gastroenterology, Infectiology and Rheumatology (including Nutrition Medicine), Charite Universitatsmedizin Berlin, Berlin, Germany"],"raw_orcid":"https://orcid.org/0000-0003-0285-9890","affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Infectiology and Rheumatology (including Nutrition Medicine), Charite Universitatsmedizin Berlin, Berlin, Germany","institution_ids":["https://openalex.org/I7877124"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5029965399","display_name":"Denis Poddubnyy","orcid":"https://orcid.org/0000-0002-4537-6015","observed_orcids":["https://orcid.org/0000-0002-4537-6015"]},"institutions":[{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Denis Poddubnyy","raw_affiliation_strings":["Department of Gastroenterology, Infectiology and Rheumatology (including Nutrition Medicine), Charite Universitatsmedizin Berlin, Berlin, Germany"],"raw_orcid":"https://orcid.org/0000-0002-4537-6015","affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Infectiology and Rheumatology (including Nutrition Medicine), Charite Universitatsmedizin Berlin, Berlin, Germany","institution_ids":["https://openalex.org/I7877124"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5048211544"],"corresponding_institution_ids":["https://openalex.org/I7877124"],"apc_list":{"value":4870,"currency":"USD","value_usd":4870},"apc_paid":{"value":4870,"currency":"USD","value_usd":4870},"fwci":7.342,"has_fulltext":true,"cited_by_count":24,"citation_normalized_percentile":{"value":0.97969109,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":99},"biblio":{"volume":"83","issue":"5","first_page":"599","last_page":"607"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11092","display_name":"Spondyloarthritis Studies and Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11092","display_name":"Spondyloarthritis Studies and Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11030","display_name":"Scoliosis diagnosis and treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13328","display_name":"Osteomyelitis and Bone Disorders Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/radiographic-axial-spondyloarthritis","display_name":"radiographic axial spondyloarthritis","score":0.984000027179718},{"id":"https://openalex.org/keywords/golimumab","display_name":"golimumab","score":0.6779999732971191},{"id":"https://openalex.org/keywords/celecoxib","display_name":"celecoxib","score":0.9940000176429749},{"id":"https://openalex.org/keywords/tumor-necrosis-factor-inhibitors","display_name":"tumor necrosis factor inhibitors","score":0.8140000104904175},{"id":"https://openalex.org/keywords/nonsteroidal-anti-inflammatory-drugs","display_name":"nonsteroidal anti-inflammatory drugs","score":0.6660000085830688},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.8130000233650208},{"id":"https://openalex.org/keywords/syndesmophytes","display_name":"syndesmophytes","score":0.984000027179718},{"id":"https://openalex.org/keywords/msasss","display_name":"mSASSS","score":0.9459999799728394},{"id":"https://openalex.org/keywords/ankylosing-spondylitis","display_name":"ankylosing spondylitis","score":0.8899999856948853}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9820932149887085},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7106478810310364},{"id":"https://openalex.org/C2777402515","wikidata":"https://www.wikidata.org/wiki/Q52849","display_name":"Ankylosing spondylitis","level":2,"score":0.6826483011245728},{"id":"https://openalex.org/C2781290027","wikidata":"https://www.wikidata.org/wiki/Q413879","display_name":"Golimumab","level":4,"score":0.6503178477287292},{"id":"https://openalex.org/C2776999253","wikidata":"https://www.wikidata.org/wiki/Q1304270","display_name":"Combination therapy","level":2,"score":0.6210602521896362},{"id":"https://openalex.org/C203092338","wikidata":"https://www.wikidata.org/wiki/Q1340863","display_name":"Clinical endpoint","level":3,"score":0.5457950234413147},{"id":"https://openalex.org/C2780132546","wikidata":"https://www.wikidata.org/wiki/Q348260","display_name":"Adalimumab","level":3,"score":0.5096020698547363},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.4716165363788605},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.45363765954971313},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.42342543601989746},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.40783265233039856},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.34273993968963623},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.25897443294525146},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000068579","descriptor_name":"Celecoxib","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000079424","descriptor_name":"Tumor Necrosis Factor Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000894","descriptor_name":"Anti-Inflammatory Agents, Non-Steroidal","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011859","descriptor_name":"Radiography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013131","descriptor_name":"Spine","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D013131","descriptor_name":"Spine","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D013167","descriptor_name":"Spondylitis, Ankylosing","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D025242","descriptor_name":"Spondylarthropathies","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1136/ard-2023-224699","doi":"https://doi.org/10.1136/ard-2023-224699","is_oa":true,"landing_page_url":"https://doi.org/10.1136/ard-2023-224699","pdf_url":"https://ard.bmj.com/content/annrheumdis/early/2024/01/15/ard-2023-224699.full.pdf","source":{"id":"https://openalex.org/S25650217","display_name":"Annals of the Rheumatic Diseases","issn_l":"0003-4967","issn":["0003-4967","1468-2060"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of the Rheumatic Diseases","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11041582","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11041582","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11041582/pdf/ard-2023-224699.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Ann Rheum Dis","raw_type":"Text"},{"id":"pmid:38228361","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38228361","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of the rheumatic diseases","raw_type":"Randomized Controlled Trial"},{"id":"pmh:oai:open-archive.highwire.org:annrheumdis:83/5/599","doi":null,"is_oa":false,"landing_page_url":"http://ard.bmj.com/cgi/content/short/83/5/599","pdf_url":null,"source":{"id":"https://openalex.org/S4406923041","display_name":"HighWire Press Open Archive","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"TEXT"}],"best_oa_location":{"id":"doi:10.1136/ard-2023-224699","doi":"https://doi.org/10.1136/ard-2023-224699","is_oa":true,"landing_page_url":"https://doi.org/10.1136/ard-2023-224699","pdf_url":"https://ard.bmj.com/content/annrheumdis/early/2024/01/15/ard-2023-224699.full.pdf","source":{"id":"https://openalex.org/S25650217","display_name":"Annals of the Rheumatic Diseases","issn_l":"0003-4967","issn":["0003-4967","1468-2060"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of the Rheumatic Diseases","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4190349554","display_name":"Studie zu Morbus Bechterew: Vergleich einer einfachen TNF-Blocker-Therapie und einer Kombinationstherapie mit NSAR","funder_award_id":"01KG1603","funder_id":"https://openalex.org/F4320321114","funder_display_name":"Bundesministerium f\u00fcr Bildung und Forschung"}],"funders":[{"id":"https://openalex.org/F4320307105","display_name":"Amgen","ror":"https://ror.org/03g03ge92"},{"id":"https://openalex.org/F4320307758","display_name":"Eli Lilly and Company","ror":"https://ror.org/01qat3289"},{"id":"https://openalex.org/F4320307765","display_name":"Pfizer","ror":"https://ror.org/01xdqrp08"},{"id":"https://openalex.org/F4320309086","display_name":"Celgene","ror":"https://ror.org/0527yg379"},{"id":"https://openalex.org/F4320321114","display_name":"Bundesministerium f\u00fcr Bildung und Forschung","ror":"https://ror.org/04pz7b180"},{"id":"https://openalex.org/F6817826280","display_name":"MSD Sharp and Dohme","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4390908055.pdf","grobid_xml":"https://content.openalex.org/works/W4390908055.grobid-xml"},"referenced_works_count":33,"referenced_works":["https://openalex.org/W179140423","https://openalex.org/W1621490964","https://openalex.org/W1801885993","https://openalex.org/W1966756689","https://openalex.org/W1969914594","https://openalex.org/W2012643422","https://openalex.org/W2058882501","https://openalex.org/W2092734189","https://openalex.org/W2100284451","https://openalex.org/W2110917772","https://openalex.org/W2114419814","https://openalex.org/W2121308402","https://openalex.org/W2128084341","https://openalex.org/W2129012958","https://openalex.org/W2133816416","https://openalex.org/W2142527891","https://openalex.org/W2143071958","https://openalex.org/W2161187200","https://openalex.org/W2179418451","https://openalex.org/W2336936581","https://openalex.org/W2342957666","https://openalex.org/W2622873710","https://openalex.org/W2760718433","https://openalex.org/W2766693443","https://openalex.org/W2793025543","https://openalex.org/W3041438351","https://openalex.org/W3042486720","https://openalex.org/W3127767345","https://openalex.org/W3135506742","https://openalex.org/W4211203343","https://openalex.org/W4282562331","https://openalex.org/W4282945243","https://openalex.org/W4307091386"],"related_works":["https://openalex.org/W4283584857","https://openalex.org/W2622873710","https://openalex.org/W6889951061","https://openalex.org/W2896407267","https://openalex.org/W2973213844","https://openalex.org/W4283582137","https://openalex.org/W4416774804","https://openalex.org/W7024864167","https://openalex.org/W4282562331","https://openalex.org/W2743000536"],"abstract_inverted_index":{"OBJECTIVES:":[0],"The":[1,109,170],"study":[2],"aimed":[3],"to":[4,17,96,152,182,192],"evaluate":[5],"the":[6,78,129,141,168,185,195,208,215,221,236],"effect":[7],"of":[8,135,205,212],"adding":[9],"a":[10,18,66,86],"non-steroidal":[11],"anti-inflammatory":[12],"drug":[13],"(NSAID),":[14],"celecoxib":[15],"(CEL),":[16],"tumour":[19],"necrosis":[20],"factor":[21],"inhibitor":[22],"(TNFi),":[23],"golimumab":[24],"(GOL),":[25],"compared":[26],"with":[27,36,70,85,241],"TNFi":[28],"monotherapy":[29,153,186,209,251],"on":[30],"radiographic":[31,37,51,113,254],"spinal":[32,255],"progression":[33,52,114,256],"in":[34,128,140,172,184,194,203,207,214,226,252,260],"patients":[35,84,137,146,166,206,213],"axial":[38],"spondyloarthritis":[39],"(r-axSpA)":[40],"over":[41,249,257],"2":[42,258],"years.":[43],"METHODS:":[44],"R-axSpA":[45],"patients,":[46],"having":[47],"risk":[48],"factors":[49],"for":[50],"(high":[53],"disease":[54],"activity":[55],"plus":[56],"C":[57],"reactive":[58],"protein":[59],">5":[60],"mg/L":[61],"and/or":[62],"\u22651":[63],"syndesmophyte(s)),":[64],"underwent":[65],"12-week":[67],"run-in":[68,142],"phase":[69,80],"GOL":[71,107,250],"50":[72],"mg":[73,99],"every":[74],"4":[75],"weeks.":[76],"In":[77],"core":[79],"(96":[81],"weeks),":[82],"only":[83],"good":[87],"clinical":[88],"response":[89],"at":[90,125,149,174],"week":[91,126,150,160,175],"12":[92,151],"were":[93,138,147,233],"randomised":[94,148],"(1:1)":[95],"GOL+CEL":[97,242],"200":[98],"two":[100],"times":[101],"per":[102],"day":[103],"(combination":[104],"therapy)":[105],"or":[106,155],"monotherapy.":[108],"primary":[110],"endpoint":[111],"was":[112,177],"assessed":[115],"by":[116],"modified":[117],"Stoke":[118],"Ankylosing":[119],"Spondylitis":[120],"Spinal":[121],"Score":[122],"(mSASSS)":[123],"change":[124,171],"108":[127,176],"intent-to-treat":[130],"population.":[131],"RESULTS:":[132],"A":[133],"total":[134],"128":[136],"enrolled":[139],"phase;":[143],"and":[144,229],"109":[145],"(n=55)":[154],"combination":[156,196,216],"therapy":[157,197,217,240],"(n=54).":[158],"At":[159],"108,":[161],"97":[162],"(52":[163],"vs":[164,187,210],"45)":[165],"completed":[167],"study.":[169],"mSASSS":[173],"1.7":[178],"(95%":[179,189],"CI":[180,190],"0.8":[181],"2.6)":[183],"1.1":[188],"0.4":[191],"1.8)":[193],"groups":[198,218],"(p=0.79).":[199],"New":[200],"syndesmophytes":[201],"occurred":[202],"25%":[204],"11%":[211],"(p=0.12).":[219],"During":[220],"study,":[222],"no":[223],"significant":[224,247],"differences":[225],"adverse":[227,231],"events":[228,232],"serious":[230],"observed":[234],"between":[235],"groups.":[237],"CONCLUSIONS:":[238],"Combination":[239],"did":[243],"not":[244],"demonstrate":[245],"statistically":[246],"superiority":[248],"retarding":[253],"years":[259],"r-axSpA.":[261]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":10},{"year":2024,"cited_by_count":8}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2024-01-17T00:00:00"}