{"id":"https://openalex.org/W4390904552","doi":"https://doi.org/10.26508/lsa.202302257","title":"Nucleolar protein TAAP1/ C22orf46 confers pro-survival signaling in non-small cell lung cancer","display_name":"Nucleolar protein TAAP1/ C22orf46 confers pro-survival signaling in non-small cell lung cancer","publication_year":2024,"publication_date":"2024-01-16","ids":{"openalex":"https://openalex.org/W4390904552","doi":"https://doi.org/10.26508/lsa.202302257","pmid":"https://pubmed.ncbi.nlm.nih.gov/38228372","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10791977"},"language":"en","primary_location":{"id":"doi:10.26508/lsa.202302257","doi":"https://doi.org/10.26508/lsa.202302257","is_oa":true,"landing_page_url":"http://dx.doi.org/10.26508/lsa.202302257","pdf_url":"https://www.life-science-alliance.org/content/lsa/7/4/e202302257.full.pdf","source":{"id":"https://openalex.org/S4210202458","display_name":"Life Science Alliance","issn_l":"2575-1077","issn":["2575-1077"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-40","russia-white-list-1"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Life Science Alliance","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","datacite","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.life-science-alliance.org/content/lsa/7/4/e202302257.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5025866125","display_name":"Marietta D\u00f6ring","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210111460","display_name":"National Center for Tumor Diseases","ror":"https://ror.org/01txwsw02","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I1305996414","https://openalex.org/I17937529","https://openalex.org/I223822909","https://openalex.org/I2802164966","https://openalex.org/I4210111460"]},{"id":"https://openalex.org/I4210162051","display_name":"University Hospital Carl Gustav Carus","ror":"https://ror.org/04za5zm41","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210162051"]},{"id":"https://openalex.org/I4387153526","display_name":"Nationales Centrum f\u00fcr Tumorerkrankungen Dresden","ror":"https://ror.org/01zy07c70","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I1305996414","https://openalex.org/I17937529","https://openalex.org/I2801798921","https://openalex.org/I4210162051","https://openalex.org/I4387153526","https://openalex.org/I78650965"]},{"id":"https://openalex.org/I78650965","display_name":"Technische Universit\u00e4t Dresden","ror":"https://ror.org/042aqky30","country_code":"DE","type":"education","lineage":["https://openalex.org/I78650965"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Marietta D\u00f6ring","raw_affiliation_strings":["National Center for Tumor Diseases/University Cancer Center (NCT/UCC): German Cancer Research Center (DKFZ) Heidelberg, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universit\u00e4t Dresden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Center for Tumor Diseases/University Cancer Center (NCT/UCC): German Cancer Research Center (DKFZ) Heidelberg, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universit\u00e4t Dresden","institution_ids":["https://openalex.org/I4210111460","https://openalex.org/I4210162051","https://openalex.org/I4387153526","https://openalex.org/I78650965"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067554955","display_name":"Melanie Brux","orcid":"https://orcid.org/0009-0003-0946-2332","observed_orcids":["https://orcid.org/0009-0003-0946-2332"]},"institutions":[{"id":"https://openalex.org/I4210111460","display_name":"National Center for Tumor Diseases","ror":"https://ror.org/01txwsw02","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I1305996414","https://openalex.org/I17937529","https://openalex.org/I223822909","https://openalex.org/I2802164966","https://openalex.org/I4210111460"]},{"id":"https://openalex.org/I4210162051","display_name":"University Hospital Carl Gustav Carus","ror":"https://ror.org/04za5zm41","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210162051"]},{"id":"https://openalex.org/I4387153526","display_name":"Nationales Centrum f\u00fcr Tumorerkrankungen Dresden","ror":"https://ror.org/01zy07c70","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I1305996414","https://openalex.org/I17937529","https://openalex.org/I2801798921","https://openalex.org/I4210162051","https://openalex.org/I4387153526","https://openalex.org/I78650965"]},{"id":"https://openalex.org/I78650965","display_name":"Technische Universit\u00e4t Dresden","ror":"https://ror.org/042aqky30","country_code":"DE","type":"education","lineage":["https://openalex.org/I78650965"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Melanie Brux","raw_affiliation_strings":[", Medical Faculty Carl Gustav Carus, Technische Universit\u00e4t Dresden","Medical Systems Biology","National Center for Tumor Diseases/University Cancer Center (NCT/UCC): German Cancer Research Center (DKFZ) Heidelberg, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universit\u00e4t Dresden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":", Medical Faculty Carl Gustav Carus, Technische Universit\u00e4t Dresden","institution_ids":["https://openalex.org/I78650965"]},{"raw_affiliation_string":"Medical Systems Biology","institution_ids":[]},{"raw_affiliation_string":"National Center for Tumor Diseases/University Cancer Center (NCT/UCC): German Cancer Research Center (DKFZ) Heidelberg, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universit\u00e4t Dresden","institution_ids":["https://openalex.org/I4210111460","https://openalex.org/I4210162051","https://openalex.org/I4387153526","https://openalex.org/I78650965"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062316741","display_name":"Maciej Paszkowski\u2010Rogacz","orcid":"https://orcid.org/0000-0002-8245-6006","observed_orcids":["https://orcid.org/0000-0002-8245-6006"]},"institutions":[{"id":"https://openalex.org/I78650965","display_name":"Technische Universit\u00e4t Dresden","ror":"https://ror.org/042aqky30","country_code":"DE","type":"education","lineage":["https://openalex.org/I78650965"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Maciej Paszkowski-Rogacz","raw_affiliation_strings":[", Medical Faculty Carl Gustav Carus, Technische Universit\u00e4t Dresden","Medical Systems Biology"],"raw_orcid":"https://orcid.org/0000-0002-8245-6006","affiliations":[{"raw_affiliation_string":", Medical Faculty Carl Gustav Carus, Technische Universit\u00e4t Dresden","institution_ids":["https://openalex.org/I78650965"]},{"raw_affiliation_string":"Medical Systems Biology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009340778","display_name":"Pedro M. Guillem-Gloria","orcid":"https://orcid.org/0000-0003-0808-0044","observed_orcids":["https://orcid.org/0000-0003-0808-0044"]},"institutions":[{"id":"https://openalex.org/I4405272450","display_name":"Biotechnologisches Zentrum","ror":"https://ror.org/046b28292","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4405272450","https://openalex.org/I4405279746","https://openalex.org/I78650965"]},{"id":"https://openalex.org/I78650965","display_name":"Technische Universit\u00e4t Dresden","ror":"https://ror.org/042aqky30","country_code":"DE","type":"education","lineage":["https://openalex.org/I78650965"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Pedro M Guillem-Gloria","raw_affiliation_strings":["Structural Bioinformatics, BIOTEC, Technische Universit\u00e4t Dresden"],"raw_orcid":"https://orcid.org/0000-0003-0808-0044","affiliations":[{"raw_affiliation_string":"Structural Bioinformatics, BIOTEC, Technische Universit\u00e4t Dresden","institution_ids":["https://openalex.org/I4405272450","https://openalex.org/I78650965"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007947310","display_name":"Frank Buchholz","orcid":"https://orcid.org/0000-0002-4577-3344","observed_orcids":["https://orcid.org/0000-0002-4577-3344"]},"institutions":[{"id":"https://openalex.org/I17937529","display_name":"German Cancer Research Center","ror":"https://ror.org/04cdgtt98","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I17937529"]},{"id":"https://openalex.org/I4210111460","display_name":"National Center for Tumor Diseases","ror":"https://ror.org/01txwsw02","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I1305996414","https://openalex.org/I17937529","https://openalex.org/I223822909","https://openalex.org/I2802164966","https://openalex.org/I4210111460"]},{"id":"https://openalex.org/I4210162051","display_name":"University Hospital Carl Gustav Carus","ror":"https://ror.org/04za5zm41","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210162051"]},{"id":"https://openalex.org/I4387153526","display_name":"Nationales Centrum f\u00fcr Tumorerkrankungen Dresden","ror":"https://ror.org/01zy07c70","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I1305996414","https://openalex.org/I17937529","https://openalex.org/I2801798921","https://openalex.org/I4210162051","https://openalex.org/I4387153526","https://openalex.org/I78650965"]},{"id":"https://openalex.org/I4405269127","display_name":"German Cancer Consortium (DKTK) Dresden","ror":"https://ror.org/036e5z664","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4391767962","https://openalex.org/I4405256427","https://openalex.org/I4405269127"]},{"id":"https://openalex.org/I78650965","display_name":"Technische Universit\u00e4t Dresden","ror":"https://ror.org/042aqky30","country_code":"DE","type":"education","lineage":["https://openalex.org/I78650965"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Frank Buchholz","raw_affiliation_strings":[", Medical Faculty Carl Gustav Carus, Technische Universit\u00e4t Dresden","German Cancer Research Center (DKFZ), Heidelberg and German Cancer Consortium (DKTK) Partner Site, Dresden, Germany","Medical Systems Biology","National Center for Tumor Diseases/University Cancer Center (NCT/UCC): German Cancer Research Center (DKFZ) Heidelberg, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universit\u00e4t Dresden"],"raw_orcid":"https://orcid.org/0000-0002-4577-3344","affiliations":[{"raw_affiliation_string":", Medical Faculty Carl Gustav Carus, Technische Universit\u00e4t Dresden","institution_ids":["https://openalex.org/I78650965"]},{"raw_affiliation_string":"German Cancer Research Center (DKFZ), Heidelberg and German Cancer Consortium (DKTK) Partner Site, Dresden, Germany","institution_ids":["https://openalex.org/I17937529","https://openalex.org/I4405269127"]},{"raw_affiliation_string":"Medical Systems Biology","institution_ids":[]},{"raw_affiliation_string":"National Center for Tumor Diseases/University Cancer Center (NCT/UCC): German Cancer Research Center (DKFZ) Heidelberg, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universit\u00e4t Dresden","institution_ids":["https://openalex.org/I4210111460","https://openalex.org/I4210162051","https://openalex.org/I4387153526","https://openalex.org/I78650965"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021400024","display_name":"Maria Teresa Pisabarro","orcid":"https://orcid.org/0000-0002-5175-9311","observed_orcids":["https://orcid.org/0000-0002-5175-9311"]},"institutions":[{"id":"https://openalex.org/I4405272450","display_name":"Biotechnologisches Zentrum","ror":"https://ror.org/046b28292","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4405272450","https://openalex.org/I4405279746","https://openalex.org/I78650965"]},{"id":"https://openalex.org/I78650965","display_name":"Technische Universit\u00e4t Dresden","ror":"https://ror.org/042aqky30","country_code":"DE","type":"education","lineage":["https://openalex.org/I78650965"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"M Teresa Pisabarro","raw_affiliation_strings":["Structural Bioinformatics, BIOTEC, Technische Universit\u00e4t Dresden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Structural Bioinformatics, BIOTEC, Technische Universit\u00e4t Dresden","institution_ids":["https://openalex.org/I4405272450","https://openalex.org/I78650965"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5081942459","display_name":"Mirko Theis","orcid":"https://orcid.org/0000-0003-3840-6156","observed_orcids":["https://orcid.org/0000-0003-3840-6156"]},"institutions":[{"id":"https://openalex.org/I4210111460","display_name":"National Center for Tumor Diseases","ror":"https://ror.org/01txwsw02","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I1305996414","https://openalex.org/I17937529","https://openalex.org/I223822909","https://openalex.org/I2802164966","https://openalex.org/I4210111460"]},{"id":"https://openalex.org/I4210162051","display_name":"University Hospital Carl Gustav Carus","ror":"https://ror.org/04za5zm41","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210162051"]},{"id":"https://openalex.org/I4387153526","display_name":"Nationales Centrum f\u00fcr Tumorerkrankungen Dresden","ror":"https://ror.org/01zy07c70","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I1305996414","https://openalex.org/I17937529","https://openalex.org/I2801798921","https://openalex.org/I4210162051","https://openalex.org/I4387153526","https://openalex.org/I78650965"]},{"id":"https://openalex.org/I78650965","display_name":"Technische Universit\u00e4t Dresden","ror":"https://ror.org/042aqky30","country_code":"DE","type":"education","lineage":["https://openalex.org/I78650965"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Mirko Theis","raw_affiliation_strings":[", Medical Faculty Carl Gustav Carus, Technische Universit\u00e4t Dresden","Medical Systems Biology","National Center for Tumor Diseases/University Cancer Center (NCT/UCC): German Cancer Research Center (DKFZ) Heidelberg, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universit\u00e4t Dresden"],"raw_orcid":"https://orcid.org/0000-0003-3840-6156","affiliations":[{"raw_affiliation_string":", Medical Faculty Carl Gustav Carus, Technische Universit\u00e4t Dresden","institution_ids":["https://openalex.org/I78650965"]},{"raw_affiliation_string":"Medical Systems Biology","institution_ids":[]},{"raw_affiliation_string":"National Center for Tumor Diseases/University Cancer Center (NCT/UCC): German Cancer Research Center (DKFZ) Heidelberg, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universit\u00e4t Dresden","institution_ids":["https://openalex.org/I4210111460","https://openalex.org/I4210162051","https://openalex.org/I4387153526","https://openalex.org/I78650965"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5081942459"],"corresponding_institution_ids":["https://openalex.org/I4210111460","https://openalex.org/I4210162051","https://openalex.org/I4387153526","https://openalex.org/I78650965"],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":{"value":3500,"currency":"USD","value_usd":3500},"fwci":0.1112,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.29460266,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":95},"biblio":{"volume":"7","issue":"4","first_page":"e202302257","last_page":"e202302257"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.8130000233650208,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.8130000233650208,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.10570000112056732,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.03319999948143959,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/non-small-cell-lung-cancer","display_name":"non-small cell lung cancer","score":0.953000009059906},{"id":"https://openalex.org/keywords/nucleolar-proteins","display_name":"nucleolar proteins","score":0.8659999966621399},{"id":"https://openalex.org/keywords/prosurvival-signaling","display_name":"survival signaling","score":0.8999999761581421},{"id":"https://openalex.org/keywords/apoptosis-resistance","display_name":"apoptosis resistance","score":0.5960000157356262},{"id":"https://openalex.org/keywords/tumor-immune-evasion","display_name":"tumor immune evasion","score":0.6729999780654907},{"id":"https://openalex.org/keywords/bispecific-antibodies","display_name":"bispecific antibodies","score":0.847000002861023},{"id":"https://openalex.org/keywords/cd8-t-cell-cytotoxicity","display_name":"CD8+ T cell cytotoxicity","score":0.902999997138977},{"id":"https://openalex.org/keywords/crispr-cas9-screening","display_name":"CRISPR-Cas9 screen","score":0.9179999828338623},{"id":"https://openalex.org/keywords/genotoxic-stress","display_name":"genotoxic stress","score":0.5550000071525574}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7194169163703918},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.657534122467041},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.6309369802474976},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6197569370269775},{"id":"https://openalex.org/C182615771","wikidata":"https://www.wikidata.org/wiki/Q1369386","display_name":"Lytic cycle","level":3,"score":0.5676063895225525},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.556887686252594},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5553860068321228},{"id":"https://openalex.org/C98108389","wikidata":"https://www.wikidata.org/wiki/Q412563","display_name":"CRISPR","level":3,"score":0.4917767345905304},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.4704769253730774},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.4294581413269043},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.42146626114845276},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4135659635066986},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3496123254299164},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.12758401036262512},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.11034974455833435},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.09303957223892212},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.07008111476898193},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.060309410095214844}],"mesh":[{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009687","descriptor_name":"Nuclear Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018033","descriptor_name":"Antibodies, Bispecific","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true}],"locations_count":6,"locations":[{"id":"doi:10.26508/lsa.202302257","doi":"https://doi.org/10.26508/lsa.202302257","is_oa":true,"landing_page_url":"http://dx.doi.org/10.26508/lsa.202302257","pdf_url":"https://www.life-science-alliance.org/content/lsa/7/4/e202302257.full.pdf","source":{"id":"https://openalex.org/S4210202458","display_name":"Life Science Alliance","issn_l":"2575-1077","issn":["2575-1077"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-40","russia-white-list-1"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Life Science Alliance","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10791977","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10791977","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10791977/pdf/LSA-2023-02257.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Life Sci Alliance","raw_type":"Text"},{"id":"pmid:38228372","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38228372","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Life science alliance","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:f3fd9a49d1474130ab81606a5bb61c99","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/f3fd9a49d1474130ab81606a5bb61c99","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Life Science Alliance, Vol 7, Iss 4, p e202302257 (2024)","raw_type":"article"},{"id":"doi:10.60692/6sqpy-8g813","doi":"https://doi.org/10.60692/6sqpy-8g813","is_oa":true,"landing_page_url":"https://doi.org/10.60692/6sqpy-8g813","pdf_url":null,"source":{"id":"https://openalex.org/S7407051682","display_name":"Greater South Information System","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"},{"id":"doi:10.60692/xmc7t-fae97","doi":"https://doi.org/10.60692/xmc7t-fae97","is_oa":true,"landing_page_url":"https://doi.org/10.60692/xmc7t-fae97","pdf_url":null,"source":{"id":"https://openalex.org/S7407051682","display_name":"Greater South Information System","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"}],"best_oa_location":{"id":"doi:10.26508/lsa.202302257","doi":"https://doi.org/10.26508/lsa.202302257","is_oa":true,"landing_page_url":"http://dx.doi.org/10.26508/lsa.202302257","pdf_url":"https://www.life-science-alliance.org/content/lsa/7/4/e202302257.full.pdf","source":{"id":"https://openalex.org/S4210202458","display_name":"Life Science Alliance","issn_l":"2575-1077","issn":["2575-1077"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-40","russia-white-list-1"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Life Science Alliance","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320310693","display_name":"Deutsches Krebsforschungszentrum","ror":"https://ror.org/04cdgtt98"},{"id":"https://openalex.org/F4320321613","display_name":"Technische Universit\u00e4t Dresden","ror":"https://ror.org/042aqky30"},{"id":"https://openalex.org/F4320336916","display_name":"Medizinische Fakult\u00e4t Carl Gustav Carus, Technische Universit\u00e4t Dresden","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4390904552.pdf","grobid_xml":"https://content.openalex.org/works/W4390904552.grobid-xml"},"referenced_works_count":101,"referenced_works":["https://openalex.org/W1602931439","https://openalex.org/W1607777232","https://openalex.org/W1803102843","https://openalex.org/W1825962579","https://openalex.org/W1829569078","https://openalex.org/W1970108205","https://openalex.org/W1972761833","https://openalex.org/W1978542424","https://openalex.org/W1981188497","https://openalex.org/W1981593008","https://openalex.org/W1985255881","https://openalex.org/W1987134040","https://openalex.org/W1989410548","https://openalex.org/W1994993231","https://openalex.org/W2013658872","https://openalex.org/W2019733630","https://openalex.org/W2032361307","https://openalex.org/W2041086028","https://openalex.org/W2045031211","https://openalex.org/W2054841768","https://openalex.org/W2060617511","https://openalex.org/W2062060771","https://openalex.org/W2062993008","https://openalex.org/W2068427957","https://openalex.org/W2071531866","https://openalex.org/W2076591428","https://openalex.org/W2085419794","https://openalex.org/W2091483784","https://openalex.org/W2099806709","https://openalex.org/W2101683327","https://openalex.org/W2105330984","https://openalex.org/W2107620713","https://openalex.org/W2109956888","https://openalex.org/W2114872225","https://openalex.org/W2123364539","https://openalex.org/W2127132803","https://openalex.org/W2128791472","https://openalex.org/W2130410032","https://openalex.org/W2132165198","https://openalex.org/W2152636515","https://openalex.org/W2160716633","https://openalex.org/W2162560719","https://openalex.org/W2167279371","https://openalex.org/W2170243414","https://openalex.org/W2179438025","https://openalex.org/W2214074259","https://openalex.org/W2252568502","https://openalex.org/W2252711380","https://openalex.org/W2318671945","https://openalex.org/W2323326409","https://openalex.org/W2329974159","https://openalex.org/W2334685455","https://openalex.org/W2336890914","https://openalex.org/W2342536142","https://openalex.org/W2400514548","https://openalex.org/W2620721366","https://openalex.org/W2734530451","https://openalex.org/W2744743363","https://openalex.org/W2759226391","https://openalex.org/W2770893462","https://openalex.org/W2789620675","https://openalex.org/W2791483720","https://openalex.org/W2792200327","https://openalex.org/W2792441487","https://openalex.org/W2800128349","https://openalex.org/W2801298049","https://openalex.org/W2889646458","https://openalex.org/W2893126573","https://openalex.org/W2900245702","https://openalex.org/W2922124059","https://openalex.org/W2988945649","https://openalex.org/W2990427812","https://openalex.org/W2999636349","https://openalex.org/W3024392979","https://openalex.org/W3028304854","https://openalex.org/W3086730128","https://openalex.org/W3093027885","https://openalex.org/W3096016553","https://openalex.org/W3133670891","https://openalex.org/W3135190368","https://openalex.org/W3135882325","https://openalex.org/W3163595068","https://openalex.org/W3165851349","https://openalex.org/W3177828909","https://openalex.org/W3179433157","https://openalex.org/W3203459683","https://openalex.org/W4205247356","https://openalex.org/W4206662285","https://openalex.org/W4207067088","https://openalex.org/W4220724561","https://openalex.org/W4221131693","https://openalex.org/W4292291457","https://openalex.org/W4297348437","https://openalex.org/W4307425304","https://openalex.org/W4308365352","https://openalex.org/W4309506674","https://openalex.org/W4313472507","https://openalex.org/W4327850299","https://openalex.org/W4365479582","https://openalex.org/W4377940638","https://openalex.org/W6700006158"],"related_works":["https://openalex.org/W2490594271","https://openalex.org/W2079524217","https://openalex.org/W4220737105","https://openalex.org/W2960527099","https://openalex.org/W4408537118","https://openalex.org/W4308397829","https://openalex.org/W1981466043","https://openalex.org/W2069914699","https://openalex.org/W3016542498","https://openalex.org/W1966470521"],"abstract_inverted_index":{"Tumor":[0],"cells":[1,50,67,104],"subvert":[2],"immune":[3],"surveillance":[4],"or":[5],"lytic":[6],"stress":[7,117],"by":[8,48,89,118],"harnessing":[9],"inhibitory":[10],"signals.":[11],"Hence,":[12],"bispecific":[13,90],"antibodies":[14],"have":[15],"been":[16],"developed":[17],"to":[18,21,69,78,112,137,152,174],"direct":[19],"CTLs":[20],"the":[22,43,76,80,95,153,163],"tumor":[23,49,103],"site":[24],"and":[25,101,116],"foster":[26],"immune-dependent":[27],"cytotoxicity.":[28],"Although":[29,121],"applied":[30],"with":[31,75,172],"success,":[32],"T":[33,86,113],"cell\u2013based":[34],"immunotherapies":[35],"are":[36],"not":[37],"universally":[38],"effective":[39],"partially":[40],"because":[41],"of":[42,45,83,106,159],"expression":[44,108],"pro-survival":[46,99,170],"factors":[47],"protecting":[51],"them":[52],"from":[53],"apoptosis.":[54],"Here,":[55],"we":[56,127],"report":[57],"a":[58,124,132,169],"CRISPR/Cas9":[59],"screen":[60],"in":[61,145],"human":[62],"non-small":[63],"cell":[64],"lung":[65,146],"cancer":[66],"designed":[68],"identify":[70],"genes":[71],"that":[72,94,102,129],"confer":[73],"tumors":[74],"ability":[77],"evade":[79],"cytotoxic":[81],"effects":[82],"CD8":[84],"+":[85],"lymphocytes":[87],"engaged":[88],"antibodies.":[91],"We":[92],"show":[93],"gene":[96],"C22orf46":[97,107,130,167],"facilitates":[98],"signals":[100],"devoid":[105],"exhibit":[109],"increased":[110],"susceptibility":[111],"cell\u2013induced":[114],"apoptosis":[115,160],"genotoxic":[119],"agents.":[120],"annotated":[122],"as":[123,138,168],"non-coding":[125],"gene,":[126],"demonstrate":[128],"encodes":[131],"nucleolar":[133],"protein,":[134],"hereafter":[135],"referred":[136],"\u201cTumor":[139],"Apoptosis":[140],"Associated":[141],"Protein":[142],"1,\u201d":[143],"up-regulated":[144],"cancer,":[147],"which":[148],"displays":[149],"remote":[150],"homologies":[151],"BH":[154],"domain":[155],"containing":[156],"Bcl-2":[157],"family":[158],"regulators.":[161],"Collectively,":[162],"findings":[164],"establish":[165],"TAAP1/":[166],"oncogene":[171],"implications":[173],"therapy.":[175]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2024-01-17T00:00:00"}