{"id":"https://openalex.org/W4390885633","doi":"https://doi.org/10.1080/13543784.2024.2305122","title":"Elinzanetant: a phase III therapy for postmenopausal patients with vasomotor symptoms","display_name":"Elinzanetant: a phase III therapy for postmenopausal patients with vasomotor symptoms","publication_year":2024,"publication_date":"2024-01-02","ids":{"openalex":"https://openalex.org/W4390885633","doi":"https://doi.org/10.1080/13543784.2024.2305122","pmid":"https://pubmed.ncbi.nlm.nih.gov/38224099"},"language":"en","primary_location":{"id":"doi:10.1080/13543784.2024.2305122","doi":"https://doi.org/10.1080/13543784.2024.2305122","is_oa":true,"landing_page_url":"https://doi.org/10.1080/13543784.2024.2305122","pdf_url":"https://www.tandfonline.com/doi/pdf/10.1080/13543784.2024.2305122","source":{"id":"https://openalex.org/S131064935","display_name":"Expert Opinion on Investigational Drugs","issn_l":"1354-3784","issn":["1354-3784","1744-7658"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Expert Opinion on Investigational Drugs","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.tandfonline.com/doi/pdf/10.1080/13543784.2024.2305122","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5020183021","display_name":"Jenifer Sassarini","orcid":"https://orcid.org/0000-0001-8173-3633","observed_orcids":["https://orcid.org/0000-0001-8173-3633"]},"institutions":[{"id":"https://openalex.org/I7882870","display_name":"University of Glasgow","ror":"https://ror.org/00vtgdb53","country_code":"GB","type":"education","lineage":["https://openalex.org/I7882870"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Jenifer Sassarini","raw_affiliation_strings":["School of Medicine, Dentistry & Nursing, University of Glasgow, Glasgow, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medicine, Dentistry & Nursing, University of Glasgow, Glasgow, UK","institution_ids":["https://openalex.org/I7882870"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5046540673","display_name":"Richard Allen Anderson","orcid":"https://orcid.org/0000-0001-6265-8359","observed_orcids":["https://orcid.org/0000-0001-6265-8359"]},"institutions":[{"id":"https://openalex.org/I4210116174","display_name":"MRC Centre for Reproductive Health","ror":"https://ror.org/02f4tsf92","country_code":"GB","type":"facility","lineage":["https://openalex.org/I4210087105","https://openalex.org/I4210116174","https://openalex.org/I90344618","https://openalex.org/I98677209"]},{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Richard A Anderson","raw_affiliation_strings":["Centre for Reproductive Health, Institute for Repair and Regeneration, University of Edinburgh, Edinburgh, UK","Centre for Reproductive Health, Institute for Repair and regeneration, University of Edinburgh, Edinburgh, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Reproductive Health, Institute for Repair and Regeneration, University of Edinburgh, Edinburgh, UK","institution_ids":["https://openalex.org/I4210116174","https://openalex.org/I98677209"]},{"raw_affiliation_string":"Centre for Reproductive Health, Institute for Repair and regeneration, University of Edinburgh, Edinburgh, UK","institution_ids":["https://openalex.org/I4210116174","https://openalex.org/I98677209"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5046540673"],"corresponding_institution_ids":["https://openalex.org/I4210116174","https://openalex.org/I98677209"],"apc_list":null,"apc_paid":null,"fwci":4.3878,"has_fulltext":true,"cited_by_count":16,"citation_normalized_percentile":{"value":0.95110659,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":94,"max":99},"biblio":{"volume":"33","issue":"1","first_page":"19","last_page":"26"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10694","display_name":"Menopause: Health Impacts and Treatments","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10694","display_name":"Menopause: Health Impacts and Treatments","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10459","display_name":"Sexual function and dysfunction studies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/elinzanetant","display_name":"elinzanetant","score":0.8949999809265137},{"id":"https://openalex.org/keywords/menopausal-vasomotor-symptoms","display_name":"menopausal vasomotor symptoms","score":0.9020000100135803},{"id":"https://openalex.org/keywords/hot-flashes","display_name":"hot flashes","score":0.9419999718666077},{"id":"https://openalex.org/keywords/non-hormonal-therapy","display_name":"non-hormonal therapy","score":0.8690000176429749},{"id":"https://openalex.org/keywords/neurokinin-antagonists","display_name":"neurokinin antagonists","score":0.8140000104904175},{"id":"https://openalex.org/keywords/neurokinin-1-receptor","display_name":"neurokinin-1 receptor","score":0.925000011920929},{"id":"https://openalex.org/keywords/nk3-receptor","display_name":"NK3 receptor","score":0.9869999885559082},{"id":"https://openalex.org/keywords/substance-p","display_name":"substance P","score":0.8690000176429749},{"id":"https://openalex.org/keywords/neurokinin-b","display_name":"neurokinin B","score":0.9710000157356262},{"id":"https://openalex.org/keywords/hypothalamic-regulation","display_name":"hypothalamic regulation","score":0.734000027179718},{"id":"https://openalex.org/keywords/breast-cancer-survivors","display_name":"breast cancer survivors","score":0.5820000171661377},{"id":"https://openalex.org/keywords/quality-of-life","display_name":"quality of life","score":0.8769999742507935}],"concepts":[{"id":"https://openalex.org/C2776214587","wikidata":"https://www.wikidata.org/wiki/Q3430227","display_name":"Vasomotor","level":2,"score":0.8940044641494751},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7822163701057434},{"id":"https://openalex.org/C2778562196","wikidata":"https://www.wikidata.org/wiki/Q177708","display_name":"Menopause","level":2,"score":0.5981932282447815},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.5359132885932922},{"id":"https://openalex.org/C2781359426","wikidata":"https://www.wikidata.org/wiki/Q412604","display_name":"Neurokinin B","level":5,"score":0.5158316493034363},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.5000765323638916},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.436170756816864},{"id":"https://openalex.org/C2777088508","wikidata":"https://www.wikidata.org/wiki/Q944777","display_name":"Endometrial cancer","level":3,"score":0.41896969079971313},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.34713780879974365},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3249169588088989},{"id":"https://openalex.org/C2776533618","wikidata":"https://www.wikidata.org/wiki/Q411041","display_name":"Substance P","level":4,"score":0.17839497327804565},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.17178520560264587},{"id":"https://openalex.org/C118303440","wikidata":"https://www.wikidata.org/wiki/Q419968","display_name":"Neuropeptide","level":3,"score":0.06030428409576416}],"mesh":[{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008593","descriptor_name":"Menopause","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008593","descriptor_name":"Menopause","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008593","descriptor_name":"Menopause","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D011788","descriptor_name":"Quality of Life","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011788","descriptor_name":"Quality of Life","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011788","descriptor_name":"Quality of Life","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017698","descriptor_name":"Postmenopause","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D017698","descriptor_name":"Postmenopause","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D017698","descriptor_name":"Postmenopause","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D019584","descriptor_name":"Hot Flashes","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D019584","descriptor_name":"Hot Flashes","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D019584","descriptor_name":"Hot Flashes","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1080/13543784.2024.2305122","doi":"https://doi.org/10.1080/13543784.2024.2305122","is_oa":true,"landing_page_url":"https://doi.org/10.1080/13543784.2024.2305122","pdf_url":"https://www.tandfonline.com/doi/pdf/10.1080/13543784.2024.2305122","source":{"id":"https://openalex.org/S131064935","display_name":"Expert Opinion on Investigational Drugs","issn_l":"1354-3784","issn":["1354-3784","1744-7658"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Expert Opinion on Investigational Drugs","raw_type":"journal-article"},{"id":"pmid:38224099","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38224099","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Expert opinion on investigational drugs","raw_type":"Journal Article"},{"id":"pmh:oai:pure.ed.ac.uk:openaire/d58fb486-e8f1-4bcc-a121-83a6236abb97","doi":null,"is_oa":true,"landing_page_url":"https://www.research.ed.ac.uk/files/412835700/Elinzanetant_a_phase_III_therapy_for_postmenopausal_patients_with_vasomotor_symptoms.pdf","pdf_url":null,"source":{"id":"https://openalex.org/S4306400321","display_name":"Edinburgh Research Explorer (University of Edinburgh)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I98677209","host_organization_name":"University of Edinburgh","host_organization_lineage":["https://openalex.org/I98677209"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Sassarini, J & Anderson, R A 2024, 'Elinzanetant: a phase III therapy for postmenopausal patients with vasomotor symptoms', Expert opinion on investigational drugs, vol. 33, no. 1, pp. 19-26. https://doi.org/10.1080/13543784.2024.2305122","raw_type":"info:eu-repo/semantics/publishedVersion"}],"best_oa_location":{"id":"doi:10.1080/13543784.2024.2305122","doi":"https://doi.org/10.1080/13543784.2024.2305122","is_oa":true,"landing_page_url":"https://doi.org/10.1080/13543784.2024.2305122","pdf_url":"https://www.tandfonline.com/doi/pdf/10.1080/13543784.2024.2305122","source":{"id":"https://openalex.org/S131064935","display_name":"Expert Opinion on Investigational Drugs","issn_l":"1354-3784","issn":["1354-3784","1744-7658"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Expert Opinion on Investigational Drugs","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.8199999928474426,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4390885633.pdf","grobid_xml":"https://content.openalex.org/works/W4390885633.grobid-xml"},"referenced_works_count":59,"referenced_works":["https://openalex.org/W1599716079","https://openalex.org/W1867278424","https://openalex.org/W1979122053","https://openalex.org/W1979924802","https://openalex.org/W1992009754","https://openalex.org/W1995472827","https://openalex.org/W2000088495","https://openalex.org/W2010920434","https://openalex.org/W2026072548","https://openalex.org/W2030521036","https://openalex.org/W2037245831","https://openalex.org/W2040816452","https://openalex.org/W2043842506","https://openalex.org/W2053910827","https://openalex.org/W2061642929","https://openalex.org/W2062438282","https://openalex.org/W2072513181","https://openalex.org/W2073690654","https://openalex.org/W2088224736","https://openalex.org/W2111824942","https://openalex.org/W2117920697","https://openalex.org/W2118749186","https://openalex.org/W2131769837","https://openalex.org/W2142686356","https://openalex.org/W2143506157","https://openalex.org/W2145166201","https://openalex.org/W2152427527","https://openalex.org/W2198736011","https://openalex.org/W2314959750","https://openalex.org/W2399783751","https://openalex.org/W2475721075","https://openalex.org/W2520178405","https://openalex.org/W2533072740","https://openalex.org/W2604269555","https://openalex.org/W2604459583","https://openalex.org/W2613379367","https://openalex.org/W2744283366","https://openalex.org/W2763524947","https://openalex.org/W2786716257","https://openalex.org/W2791855789","https://openalex.org/W2878561547","https://openalex.org/W2912583275","https://openalex.org/W2917664025","https://openalex.org/W2981583996","https://openalex.org/W3008125481","https://openalex.org/W3029770091","https://openalex.org/W3087196123","https://openalex.org/W3092559956","https://openalex.org/W3119652309","https://openalex.org/W3131577210","https://openalex.org/W3139352829","https://openalex.org/W3162519732","https://openalex.org/W3179035487","https://openalex.org/W4283835704","https://openalex.org/W4318013951","https://openalex.org/W4318691761","https://openalex.org/W4324030589","https://openalex.org/W4378744965","https://openalex.org/W4384625903"],"related_works":["https://openalex.org/W2802438622","https://openalex.org/W4380149603","https://openalex.org/W2090072464","https://openalex.org/W1966452808","https://openalex.org/W2527780442","https://openalex.org/W3036314380","https://openalex.org/W2418110596","https://openalex.org/W4321792046","https://openalex.org/W2050354700","https://openalex.org/W2808026525"],"abstract_inverted_index":{"INTRODUCTION:":[0],"Menopausal":[1],"vasomotor":[2,66],"symptoms":[3],"(VMS)":[4],"are":[5,11,110,151,188],"experienced":[6],"by":[7],"most":[8],"women":[9,154],"and":[10,14,34,99,129,137,159,183],"often":[12],"debilitating":[13],"can":[15,36],"last":[16],"for":[17,45,75,82,123,132,143,162],"years.":[18],"While":[19],"hormone":[20],"replacement":[21],"therapy":[22],"is":[23,40,88,168],"effective,":[24],"it":[25,35],"carries":[26],"risks":[27],"that":[28],"have":[29,78],"impacted":[30],"its":[31],"wider":[32],"use,":[33],"be":[37],"contraindicated.":[38],"There":[39],"a":[41,46,89,169,175],"large":[42],"unmet":[43],"need":[44],"safe,":[47],"effective":[48],"non-hormonal":[49,172],"therapy.":[50],"AREAS":[51],"COVERED:":[52],"The":[53],"importance":[54],"of":[55,64,85,135,141],"the":[56,61,65,83,133],"neurokinin":[57],"(NK)":[58],"system":[59],"in":[60,108,118,139,153,191],"hypothalamic":[62],"regulation":[63],"center":[67],"has":[68,115],"become":[69],"clear.":[70],"NK":[71],"antagonists,":[72],"previously":[73],"developed":[74],"other":[76,105],"indications,":[77],"therefore":[79],"been":[80,116],"investigated":[81,117],"treatment":[84,161],"VMS.":[86],"Elinzanetant":[87,114,167],"potent":[90],"antagonist":[91],"at":[92],"both":[93,155],"NK1":[94],"(endogenous":[95],"ligand":[96],"Substance":[97],"P)":[98],"NK3":[100,112],"(neurokinin":[101],"B)":[102],"receptors,":[103],"whereas":[104],"related":[106],"drugs":[107],"development":[109],"selective":[111],"antagonists.":[113],"2":[119],"Phase":[120,148,193],"II":[121],"trials":[122,150],"menopausal":[124],"VMS,":[125],"demonstrating":[126],"rapid":[127,181],"onset":[128,182],"dose-dependant":[130],"efficacy":[131],"relief":[134],"VMS":[136],"improvement":[138],"quality":[140],"life":[142],"up":[144],"to":[145,174],"12":[146],"weeks.":[147],"III":[149,194],"underway":[152],"with":[156,180],"physiological":[157],"menopause":[158],"after":[160],"breast":[163],"cancer.":[164],"EXPERT":[165],"OPINION:":[166],"very":[170],"promising":[171],"approach":[173],"highly":[176],"prevalent":[177],"symptom":[178],"constellation,":[179],"high":[184],"efficacy.":[185],"Wider":[186],"indications":[187],"being":[189],"explored":[190],"current":[192],"trials.":[195]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":10},{"year":2024,"cited_by_count":2}],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2025-10-10T00:00:00"}