{"id":"https://openalex.org/W4390880650","doi":"https://doi.org/10.1038/s41419-024-06439-6","title":"USP30 inhibition induces mitophagy and reduces oxidative stress in parkin-deficient human neurons","display_name":"USP30 inhibition induces mitophagy and reduces oxidative stress in parkin-deficient human neurons","publication_year":2024,"publication_date":"2024-01-15","ids":{"openalex":"https://openalex.org/W4390880650","doi":"https://doi.org/10.1038/s41419-024-06439-6","pmid":"https://pubmed.ncbi.nlm.nih.gov/38225227","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10789816"},"language":"en","primary_location":{"id":"doi:10.1038/s41419-024-06439-6","doi":"https://doi.org/10.1038/s41419-024-06439-6","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41419-024-06439-6","pdf_url":"https://www.nature.com/articles/s41419-024-06439-6.pdf","source":{"id":"https://openalex.org/S185208586","display_name":"Cell Death and Disease","issn_l":"2041-4889","issn":["2041-4889"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Death &amp; Disease","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41419-024-06439-6.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5035519174","display_name":"Justyna Okarmus","orcid":"https://orcid.org/0000-0001-8310-6553","observed_orcids":["https://orcid.org/0000-0001-8310-6553"]},"institutions":[{"id":"https://openalex.org/I177969490","display_name":"University of Southern Denmark","ror":"https://ror.org/03yrrjy16","country_code":"DK","type":"education","lineage":["https://openalex.org/I177969490"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Justyna Okarmus","raw_affiliation_strings":["Department of Neurobiology Research, Institute of Molecular Medicine, University of Southern Denmark, J.B. Winsl\u00f8ws Vej 21, 5000, Odense C, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurobiology Research, Institute of Molecular Medicine, University of Southern Denmark, J.B. Winsl\u00f8ws Vej 21, 5000, Odense C, Denmark","institution_ids":["https://openalex.org/I177969490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008221952","display_name":"Jette Bach Agergaard","orcid":"https://orcid.org/0009-0009-6860-3274","observed_orcids":["https://orcid.org/0009-0009-6860-3274"]},"institutions":[{"id":"https://openalex.org/I177969490","display_name":"University of Southern Denmark","ror":"https://ror.org/03yrrjy16","country_code":"DK","type":"education","lineage":["https://openalex.org/I177969490"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Jette Bach Agergaard","raw_affiliation_strings":["Department of Neurobiology Research, Institute of Molecular Medicine, University of Southern Denmark, J.B. Winsl\u00f8ws Vej 21, 5000, Odense C, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurobiology Research, Institute of Molecular Medicine, University of Southern Denmark, J.B. Winsl\u00f8ws Vej 21, 5000, Odense C, Denmark","institution_ids":["https://openalex.org/I177969490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084055140","display_name":"Tina C. Stummann","orcid":"https://orcid.org/0000-0003-1003-2965","observed_orcids":["https://orcid.org/0000-0003-1003-2965"]},"institutions":[{"id":"https://openalex.org/I133593841","display_name":"Lundbeck (Denmark)","ror":"https://ror.org/0564cd633","country_code":"DK","type":"company","lineage":["https://openalex.org/I133593841"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Tina C. Stummann","raw_affiliation_strings":["Neuroscience, H. Lundbeck A/S, Ottiliavej 9, 2500, Valby, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neuroscience, H. Lundbeck A/S, Ottiliavej 9, 2500, Valby, Denmark","institution_ids":["https://openalex.org/I133593841"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012307947","display_name":"Henriette Haukedal","orcid":"https://orcid.org/0000-0001-5691-095X","observed_orcids":["https://orcid.org/0000-0001-5691-095X"]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Henriette Haukedal","raw_affiliation_strings":["Department of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Gr\u00f8nnegaardsvej 7, 1870, Frederiksberg C, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Gr\u00f8nnegaardsvej 7, 1870, Frederiksberg C, Denmark","institution_ids":["https://openalex.org/I124055696"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014896562","display_name":"Malene Ambj\u00f8rn","orcid":"https://orcid.org/0000-0003-4149-8231","observed_orcids":["https://orcid.org/0000-0003-4149-8231"]},"institutions":[{"id":"https://openalex.org/I133593841","display_name":"Lundbeck (Denmark)","ror":"https://ror.org/0564cd633","country_code":"DK","type":"company","lineage":["https://openalex.org/I133593841"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Malene Ambj\u00f8rn","raw_affiliation_strings":["Neuroscience, H. Lundbeck A/S, Ottiliavej 9, 2500, Valby, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neuroscience, H. Lundbeck A/S, Ottiliavej 9, 2500, Valby, Denmark","institution_ids":["https://openalex.org/I133593841"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090412968","display_name":"Kristine Freude","orcid":"https://orcid.org/0000-0001-9480-2386","observed_orcids":["https://orcid.org/0000-0001-9480-2386"]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Kristine K. Freude","raw_affiliation_strings":["Department of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Gr\u00f8nnegaardsvej 7, 1870, Frederiksberg C, Denmark"],"raw_orcid":"https://orcid.org/0000-0001-9480-2386","affiliations":[{"raw_affiliation_string":"Department of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Gr\u00f8nnegaardsvej 7, 1870, Frederiksberg C, Denmark","institution_ids":["https://openalex.org/I124055696"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038600426","display_name":"Karina Fog","orcid":"https://orcid.org/0000-0003-0106-704X","observed_orcids":["https://orcid.org/0000-0003-0106-704X"]},"institutions":[{"id":"https://openalex.org/I133593841","display_name":"Lundbeck (Denmark)","ror":"https://ror.org/0564cd633","country_code":"DK","type":"company","lineage":["https://openalex.org/I133593841"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Karina Fog","raw_affiliation_strings":["Neuroscience, H. Lundbeck A/S, Ottiliavej 9, 2500, Valby, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neuroscience, H. Lundbeck A/S, Ottiliavej 9, 2500, Valby, Denmark","institution_ids":["https://openalex.org/I133593841"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5034946522","display_name":"Morten Meyer","orcid":"https://orcid.org/0000-0002-9571-1336","observed_orcids":["https://orcid.org/0000-0002-9571-1336"]},"institutions":[{"id":"https://openalex.org/I177969490","display_name":"University of Southern Denmark","ror":"https://ror.org/03yrrjy16","country_code":"DK","type":"education","lineage":["https://openalex.org/I177969490"]},{"id":"https://openalex.org/I2801498763","display_name":"Odense University Hospital","ror":"https://ror.org/00ey0ed83","country_code":"DK","type":"funder","lineage":["https://openalex.org/I2801498763"]}],"countries":["DK"],"is_corresponding":true,"raw_author_name":"Morten Meyer","raw_affiliation_strings":["BRIDGE-Brain Research Inter-Disciplinary Guided Excellence, Department of Clinical Research, University of Southern Denmark, J.B. Winsl\u00f8ws Vej 19, 5000, Odense C, Denmark. mmeyer@health.sdu.dk","Department of Neurobiology Research, Institute of Molecular Medicine, University of Southern Denmark, J.B. Winsl\u00f8ws Vej 21, 5000, Odense C, Denmark. mmeyer@health.sdu.dk","Department of Neurology, Odense University Hospital, J.B. Winsl\u00f8ws Vej 4, 5000, Odense C, Denmark. mmeyer@health.sdu.dk","BRIDGE\u2014Brain Research Inter-Disciplinary Guided Excellence, Department of Clinical Research, University of Southern Denmark, J.B. Winsl\u00f8ws Vej 19, 5000, Odense C, Denmark","Department of Neurology, Odense University Hospital, J.B. Winsl\u00f8ws Vej 4, 5000, Odense C, Denmark"],"raw_orcid":"https://orcid.org/0000-0002-9571-1336","affiliations":[{"raw_affiliation_string":"BRIDGE-Brain Research Inter-Disciplinary Guided Excellence, Department of Clinical Research, University of Southern Denmark, J.B. Winsl\u00f8ws Vej 19, 5000, Odense C, Denmark. mmeyer@health.sdu.dk","institution_ids":["https://openalex.org/I177969490"]},{"raw_affiliation_string":"Department of Neurobiology Research, Institute of Molecular Medicine, University of Southern Denmark, J.B. Winsl\u00f8ws Vej 21, 5000, Odense C, Denmark. mmeyer@health.sdu.dk","institution_ids":["https://openalex.org/I177969490"]},{"raw_affiliation_string":"Department of Neurology, Odense University Hospital, J.B. Winsl\u00f8ws Vej 4, 5000, Odense C, Denmark. mmeyer@health.sdu.dk","institution_ids":["https://openalex.org/I2801498763"]},{"raw_affiliation_string":"BRIDGE\u2014Brain Research Inter-Disciplinary Guided Excellence, Department of Clinical Research, University of Southern Denmark, J.B. Winsl\u00f8ws Vej 19, 5000, Odense C, Denmark","institution_ids":["https://openalex.org/I177969490"]},{"raw_affiliation_string":"Department of Neurology, Odense University Hospital, J.B. Winsl\u00f8ws Vej 4, 5000, Odense C, Denmark","institution_ids":["https://openalex.org/I2801498763"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5034946522"],"corresponding_institution_ids":["https://openalex.org/I177969490","https://openalex.org/I2801498763"],"apc_list":{"value":4790,"currency":"USD","value_usd":4790},"apc_paid":{"value":4790,"currency":"USD","value_usd":4790},"fwci":9.1082,"has_fulltext":true,"cited_by_count":61,"citation_normalized_percentile":{"value":0.99099163,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":100},"biblio":{"volume":"15","issue":"1","first_page":"52","last_page":"52"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":0.5321999788284302,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":0.5321999788284302,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.44679999351501465,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11041","display_name":"Ubiquitin and proteasome pathways","score":0.014999999664723873,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mitophagy","display_name":"mitophagy","score":0.9440000057220459},{"id":"https://openalex.org/keywords/parkin","display_name":"Parkin","score":0.8360000252723694},{"id":"https://openalex.org/keywords/parkinson-s-disease","display_name":"Parkinson's disease","score":0.968999981880188},{"id":"https://openalex.org/keywords/mitochondrial-ubiquitination","display_name":"mitochondrial ubiquitination","score":0.8230000138282776},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.8799999952316284},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.8519999980926514},{"id":"https://openalex.org/keywords/dopaminergic-neurons","display_name":"dopaminergic neurons","score":0.9419999718666077},{"id":"https://openalex.org/keywords/ipsc-derived-neurons","display_name":"iPSC-derived neurons","score":0.9440000057220459},{"id":"https://openalex.org/keywords/e3-ubiquitin-ligase","display_name":"E3 ubiquitin ligase","score":0.8349999785423279}],"concepts":[{"id":"https://openalex.org/C2777668072","wikidata":"https://www.wikidata.org/wiki/Q2472777","display_name":"Parkin","level":4,"score":0.9690484404563904},{"id":"https://openalex.org/C2779324830","wikidata":"https://www.wikidata.org/wiki/Q1806192","display_name":"Mitophagy","level":4,"score":0.9577451944351196},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.8282666206359863},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6482445597648621},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.44898301362991333},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.44897687435150146},{"id":"https://openalex.org/C57600042","wikidata":"https://www.wikidata.org/wiki/Q227564","display_name":"Oxidative phosphorylation","level":2,"score":0.44829487800598145},{"id":"https://openalex.org/C2776804853","wikidata":"https://www.wikidata.org/wiki/Q18045837","display_name":"PINK1","level":5,"score":0.4190274775028229},{"id":"https://openalex.org/C203522944","wikidata":"https://www.wikidata.org/wiki/Q288322","display_name":"Autophagy","level":3,"score":0.39578282833099365},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3629443049430847},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3518776595592499},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.24679669737815857},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.1806352138519287},{"id":"https://openalex.org/C2779734285","wikidata":"https://www.wikidata.org/wiki/Q11085","display_name":"Parkinson's disease","level":3,"score":0.17802956700325012},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.12553787231445312},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.12453386187553406},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D002258","descriptor_name":"Carbonyl Cyanide m-Chlorophenyl Hydrazone","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013869","descriptor_name":"Thiolester Hydrolases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020734","descriptor_name":"Parkinsonian Disorders","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D024101","descriptor_name":"Mitochondrial Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D044767","descriptor_name":"Ubiquitin-Protein Ligases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D057026","descriptor_name":"Induced Pluripotent Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D059290","descriptor_name":"Dopaminergic Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D063306","descriptor_name":"Mitophagy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":8,"locations":[{"id":"doi:10.1038/s41419-024-06439-6","doi":"https://doi.org/10.1038/s41419-024-06439-6","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41419-024-06439-6","pdf_url":"https://www.nature.com/articles/s41419-024-06439-6.pdf","source":{"id":"https://openalex.org/S185208586","display_name":"Cell Death and Disease","issn_l":"2041-4889","issn":["2041-4889"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Death &amp; Disease","raw_type":"journal-article"},{"id":"doi:10.21203/rs.3.rs-2356942/v1","doi":"https://doi.org/10.21203/rs.3.rs-2356942/v1","is_oa":true,"landing_page_url":"http://dx.doi.org/10.21203/rs.3.rs-2356942/v1","pdf_url":"https://www.researchsquare.com/article/rs-2356942/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},{"id":"doi:10.1101/2022.06.29.498100","doi":"https://doi.org/10.1101/2022.06.29.498100","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2022.06.29.498100","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2022/07/02/2022.06.29.498100.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nd","license_id":"https://openalex.org/licenses/cc-by-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:10789816","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10789816","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10789816/pdf/41419_2024_Article_6439.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Death Dis","raw_type":"Text"},{"id":"pmid:38225227","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38225227","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell death & disease","raw_type":"Journal Article"},{"id":"pmh:oai:pure.atira.dk:openaire/8aa2e3b4-f73e-405c-9f66-b01bff8251c4","doi":null,"is_oa":true,"landing_page_url":"https://researchprofiles.ku.dk/da/publications/8aa2e3b4-f73e-405c-9f66-b01bff8251c4","pdf_url":null,"source":{"id":"https://openalex.org/S4306401983","display_name":"Research at the University of Copenhagen (University of Copenhagen)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I124055696","host_organization_name":"University of Copenhagen","host_organization_lineage":["https://openalex.org/I124055696"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Okarmus, J, Agergaard, J B, Stummann, T, Haukedal, H, Ambj\u00f8rn, M, Freude, K, Fog, K & Meyer, M 2024, 'USP30 inhibition induces mitophagy and reduces oxidative stress in parkin-deficient human neurons', Cell Death & Disease, vol. 15, 52. https://doi.org/10.1038/s41419-024-06439-6","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:sdu.dk:openaire/08c5ca76-7a67-4cd6-b38a-c72f3d73de6e","doi":null,"is_oa":true,"landing_page_url":"https://portal.findresearcher.sdu.dk/da/publications/08c5ca76-7a67-4cd6-b38a-c72f3d73de6e","pdf_url":"https://findresearcher.sdu.dk/ws/files/253567863/s41419-024-06439-6.pdf","source":{"id":"https://openalex.org/S4306400423","display_name":"University of Southern Denmark Research Portal (University of Southern Denmark)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I177969490","host_organization_name":"University of Southern Denmark","host_organization_lineage":["https://openalex.org/I177969490"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Okarmus, J, Agergaard, J B, Stummann, T C, Haukedal, H, Ambj\u00f8rn, M, Freude, K K, Fog, K & Meyer, M 2024, 'USP30 inhibition induces mitophagy and reduces oxidative stress in parkin-deficient human neurons', Cell Death and Disease, vol. 15, no. 1, 52. https://doi.org/10.1038/s41419-024-06439-6","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:ba8bf5e0750a40c5b1d19b65ce7c8324","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/ba8bf5e0750a40c5b1d19b65ce7c8324","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cell Death and Disease, Vol 15, Iss 1, Pp 1-13 (2024)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1038/s41419-024-06439-6","doi":"https://doi.org/10.1038/s41419-024-06439-6","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41419-024-06439-6","pdf_url":"https://www.nature.com/articles/s41419-024-06439-6.pdf","source":{"id":"https://openalex.org/S185208586","display_name":"Cell Death and Disease","issn_l":"2041-4889","issn":["2041-4889"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Death &amp; Disease","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4676005117","display_name":null,"funder_award_id":"15-396","funder_id":"https://openalex.org/F4320335119","funder_display_name":"Fonden til L\u00e6gevidenskabens Fremme"},{"id":"https://openalex.org/G5333085907","display_name":null,"funder_award_id":"15-396","funder_id":"https://openalex.org/F4320323411","funder_display_name":"A.P. M\u00f8ller og Hustru Chastine Mc-Kinney M\u00f8llers Fond til almene Formaal"},{"id":"https://openalex.org/G6384693840","display_name":null,"funder_award_id":"14-427","funder_id":"https://openalex.org/F4320323411","funder_display_name":"A.P. M\u00f8ller og Hustru Chastine Mc-Kinney M\u00f8llers Fond til almene Formaal"},{"id":"https://openalex.org/G6874876544","display_name":null,"funder_award_id":"15-396, 14-427","funder_id":"https://openalex.org/F4320335119","funder_display_name":"Fonden til L\u00e6gevidenskabens Fremme"},{"id":"https://openalex.org/G8635736445","display_name":null,"funder_award_id":"14-427","funder_id":"https://openalex.org/F4320335119","funder_display_name":"Fonden til L\u00e6gevidenskabens Fremme"},{"id":"https://openalex.org/G971273228","display_name":null,"funder_award_id":"NNF21OC0071571","funder_id":"https://openalex.org/F4320325957","funder_display_name":"Novo Nordisk Fonden"}],"funders":[{"id":"https://openalex.org/F4320310527","display_name":"Parkinsonforeningen","ror":"https://ror.org/022rxf761"},{"id":"https://openalex.org/F4320312353","display_name":"Jascha Fonden","ror":"https://ror.org/05ykzvv97"},{"id":"https://openalex.org/F4320313796","display_name":"Innovationsfonden","ror":"https://ror.org/00daj4111"},{"id":"https://openalex.org/F4320323411","display_name":"A.P. M\u00f8ller og Hustru Chastine Mc-Kinney M\u00f8llers Fond til almene Formaal","ror":"https://ror.org/02kdrgt12"},{"id":"https://openalex.org/F4320323799","display_name":"Syddansk Universitet","ror":"https://ror.org/03yrrjy16"},{"id":"https://openalex.org/F4320325957","display_name":"Novo Nordisk Fonden","ror":"https://ror.org/04txyc737"},{"id":"https://openalex.org/F4320327918","display_name":"H. Lundbeck A/S","ror":"https://ror.org/0564cd633"},{"id":"https://openalex.org/F4320332679","display_name":"Parkinsonfonden","ror":"https://ror.org/0300wre24"},{"id":"https://openalex.org/F4320335119","display_name":"Fonden til L\u00e6gevidenskabens Fremme","ror":"https://ror.org/02kdrgt12"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4390880650.pdf","grobid_xml":"https://content.openalex.org/works/W4390880650.grobid-xml"},"referenced_works_count":53,"referenced_works":["https://openalex.org/W1518704304","https://openalex.org/W1840395037","https://openalex.org/W2013642338","https://openalex.org/W2014459126","https://openalex.org/W2018133355","https://openalex.org/W2041290559","https://openalex.org/W2053071811","https://openalex.org/W2058065156","https://openalex.org/W2070463829","https://openalex.org/W2082425146","https://openalex.org/W2102694693","https://openalex.org/W2127546245","https://openalex.org/W2130979925","https://openalex.org/W2140679396","https://openalex.org/W2155015733","https://openalex.org/W2158363851","https://openalex.org/W2335833703","https://openalex.org/W2403629665","https://openalex.org/W2586065799","https://openalex.org/W2591870278","https://openalex.org/W2747407286","https://openalex.org/W2762129136","https://openalex.org/W2762641371","https://openalex.org/W2763738314","https://openalex.org/W2801876984","https://openalex.org/W2804669221","https://openalex.org/W2805130622","https://openalex.org/W2807910244","https://openalex.org/W2890021586","https://openalex.org/W2901835592","https://openalex.org/W2904914030","https://openalex.org/W2951831260","https://openalex.org/W2967392900","https://openalex.org/W2969828274","https://openalex.org/W3003042599","https://openalex.org/W3006012411","https://openalex.org/W3009651870","https://openalex.org/W3009966546","https://openalex.org/W3038017964","https://openalex.org/W3042070552","https://openalex.org/W3096776900","https://openalex.org/W3103775593","https://openalex.org/W3115257494","https://openalex.org/W3121008513","https://openalex.org/W3121536984","https://openalex.org/W3156671470","https://openalex.org/W3159899764","https://openalex.org/W3162394609","https://openalex.org/W3165680352","https://openalex.org/W3210519479","https://openalex.org/W3211518125","https://openalex.org/W3214993193","https://openalex.org/W4211044101"],"related_works":["https://openalex.org/W4283789175","https://openalex.org/W4407229133","https://openalex.org/W3210519479","https://openalex.org/W2058065156","https://openalex.org/W3156671470","https://openalex.org/W2051600337","https://openalex.org/W3042070552","https://openalex.org/W4388638467","https://openalex.org/W6906675285","https://openalex.org/W2323679054"],"abstract_inverted_index":{"Ubiquitination":[0],"of":[1,12,36,44,71,77,159,186,197,201,230],"mitochondrial":[2,38,118,146],"proteins":[3,39],"plays":[4],"an":[5,137],"important":[6],"role":[7],"in":[8,53,64,94,154,162,173,222,238],"the":[9,23,34,67,78,122,142,194,198,227],"cellular":[10,219],"regulation":[11],"mitophagy.":[13,42],"The":[14,75],"E3":[15,45],"ubiquitin":[16],"ligase":[17,46],"parkin":[18],"(encoded":[19],"by":[20,87,120,131,182,248],"PARK2)":[21],"and":[22,40,56,104,125,217,225],"ubiquitin-specific":[24],"protease":[25],"30":[26],"(USP30)":[27],"have":[28],"both":[29,54],"been":[30],"reported":[31],"to":[32,50,82,116,141,214,243],"regulate":[33],"ubiquitination":[35,147],"outer":[37],"thereby":[41],"Loss":[43],"activity":[47],"is":[48,210],"thought":[49],"be":[51],"pathogenic":[52],"sporadic":[55],"inherited":[57],"Parkinson's":[58],"disease":[59],"(PD),":[60],"with":[61,103,167,240],"loss-of-function":[62],"mutations":[63],"PARK2":[65,106,155,170],"being":[66],"most":[68],"frequent":[69],"cause":[70],"autosomal":[72],"recessive":[73],"PD.":[74],"aim":[76],"present":[79],"study":[80],"was":[81,129,148],"evaluate":[83],"whether":[84,160],"mitophagy":[85,153,216],"induced":[86,97],"USP30":[88,132,150,176,202,208,231],"inhibition":[89,151,177,209],"provides":[90],"a":[91,211,234,241],"functional":[92],"rescue":[93],"isogenic":[95],"human":[96],"pluripotent":[98],"stem":[99],"cell-derived":[100],"dopaminergic":[101],"neurons":[102,114,135,192],"without":[105],"knockout":[107],"(KO).":[108],"Our":[109,204],"data":[110],"show":[111],"that":[112,126,207],"healthy":[113],"responded":[115],"CCCP-induced":[117],"damage":[119],"clearing":[121],"impaired":[123,138,249],"mitochondria":[124],"this":[127],"process":[128],"accelerated":[130],"inhibition.":[133,203],"Parkin-deficient":[134],"showed":[136],"mitophagic":[139],"response":[140],"CCCP":[143],"challenge,":[144],"although":[145],"enhanced.":[149],"promoted":[152],"KO":[156],"neurons,":[157,175],"independently":[158],"left":[161],"basal":[163],"conditions":[164],"or":[165],"treated":[166],"CCCP.":[168],"In":[169],"KO,":[171],"as":[172,233],"control":[174],"balanced":[178],"oxidative":[179],"stress":[180,246],"levels":[181],"reducing":[183],"excessive":[184],"production":[185],"reactive":[187],"oxygen":[188],"species.":[189],"Interestingly,":[190],"non-dopaminergic":[191],"were":[193],"main":[195],"driver":[196],"beneficial":[199],"effects":[200],"findings":[205],"demonstrate":[206],"promising":[212],"approach":[213,237],"boost":[215],"improve":[218],"health,":[220],"also":[221],"parkin-deficient":[223],"cells,":[224],"support":[226],"potential":[228],"relevance":[229],"inhibitors":[232],"novel":[235],"therapeutic":[236],"diseases":[239],"need":[242],"combat":[244],"neuronal":[245],"mediated":[247],"mitochondria.":[250]},"counts_by_year":[{"year":2026,"cited_by_count":29},{"year":2025,"cited_by_count":27},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":1}],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2024-01-16T00:00:00"}
