{"id":"https://openalex.org/W4390875128","doi":"https://doi.org/10.21203/rs.3.rs-3848573/v1","title":"Patients with Acute Severe Ulcerative Colitis Treated with IV Cyclosporine Who Require Colectomy Within 3 Months of Discharge Have Lower Serum Cyclosporine Levels","display_name":"Patients with Acute Severe Ulcerative Colitis Treated with IV Cyclosporine Who Require Colectomy Within 3 Months of Discharge Have Lower Serum Cyclosporine Levels","publication_year":2024,"publication_date":"2024-01-15","ids":{"openalex":"https://openalex.org/W4390875128","doi":"https://doi.org/10.21203/rs.3.rs-3848573/v1"},"language":"en","primary_location":{"id":"doi:10.21203/rs.3.rs-3848573/v1","doi":"https://doi.org/10.21203/rs.3.rs-3848573/v1","is_oa":true,"landing_page_url":"http://dx.doi.org/10.21203/rs.3.rs-3848573/v1","pdf_url":"https://www.researchsquare.com/article/rs-3848573/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"volume":null,"type":"preprint","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.researchsquare.com/article/rs-3848573/latest.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5019057143","display_name":"Scott Friedberg","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]},{"id":"https://openalex.org/I4210087865","display_name":"University of Chicago Medical Center","ror":"https://ror.org/0076kfe04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087865"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Scott Friedberg","raw_affiliation_strings":["IBD Center, Section of Gastroenterology University of Chicago Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IBD Center, Section of Gastroenterology University of Chicago Medicine","institution_ids":["https://openalex.org/I40347166","https://openalex.org/I4210087865"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033338901","display_name":"Joshua M. Steinberg","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]},{"id":"https://openalex.org/I4210087865","display_name":"University of Chicago Medical Center","ror":"https://ror.org/0076kfe04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087865"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joshua M. Steinberg","raw_affiliation_strings":["IBD Center, Section of Gastroenterology University of Chicago Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IBD Center, Section of Gastroenterology University of Chicago Medicine","institution_ids":["https://openalex.org/I40347166","https://openalex.org/I4210087865"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015144042","display_name":"Jeremy A. Klein","orcid":"https://orcid.org/0000-0001-5229-3413","observed_orcids":["https://orcid.org/0000-0001-5229-3413"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]},{"id":"https://openalex.org/I4210087865","display_name":"University of Chicago Medical Center","ror":"https://ror.org/0076kfe04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087865"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeremy A. Klein","raw_affiliation_strings":["IBD Center, Section of Gastroenterology University of Chicago Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IBD Center, Section of Gastroenterology University of Chicago Medicine","institution_ids":["https://openalex.org/I40347166","https://openalex.org/I4210087865"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031239950","display_name":"Natalie K. Choi","orcid":"https://orcid.org/0000-0003-3637-1543","observed_orcids":["https://orcid.org/0000-0003-3637-1543"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]},{"id":"https://openalex.org/I4210087865","display_name":"University of Chicago Medical Center","ror":"https://ror.org/0076kfe04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087865"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Natalie K. Choi","raw_affiliation_strings":["IBD Center, Section of Gastroenterology University of Chicago Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IBD Center, Section of Gastroenterology University of Chicago Medicine","institution_ids":["https://openalex.org/I40347166","https://openalex.org/I4210087865"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026801185","display_name":"David Choi","orcid":"https://orcid.org/0000-0002-2453-1784","observed_orcids":["https://orcid.org/0000-0002-2453-1784"]},"institutions":[{"id":"https://openalex.org/I183934855","display_name":"Genentech","ror":"https://ror.org/04gndp242","country_code":"US","type":"company","lineage":["https://openalex.org/I118019719","https://openalex.org/I129302853","https://openalex.org/I183934855"]},{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]},{"id":"https://openalex.org/I4210087865","display_name":"University of Chicago Medical Center","ror":"https://ror.org/0076kfe04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087865"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Choi","raw_affiliation_strings":["IBD Center, Section of Gastroenterology University of Chicago Medicine","Arena Pharmaceuticals, Bellatrix Pharmaceuticals, Boehringer Ingelheim Ltd., Bristol -Myers Squibb,","Celgene, Syneos, Dizal","Eli Lilly, Genentech, Gilead Sciences, Hoffman La -Roche, Janssen, P zer, Takeda, and UCB Pharma","Pharmaceutica ls, Genentech/Roche, Gilead Sciences, Ichnos Sciences S.A., InDex Pharmaceuticals, Iterative Scopes, Janssen Pharmaceuticals, Lilly, P zer, Prometheus Laboratories, Reistone,","travel support fr om P zer"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IBD Center, Section of Gastroenterology University of Chicago Medicine","institution_ids":["https://openalex.org/I40347166","https://openalex.org/I4210087865"]},{"raw_affiliation_string":"Arena Pharmaceuticals, Bellatrix Pharmaceuticals, Boehringer Ingelheim Ltd., Bristol -Myers Squibb,","institution_ids":[]},{"raw_affiliation_string":"Celgene, Syneos, Dizal","institution_ids":[]},{"raw_affiliation_string":"Eli Lilly, Genentech, Gilead Sciences, Hoffman La -Roche, Janssen, P zer, Takeda, and UCB Pharma","institution_ids":["https://openalex.org/I183934855"]},{"raw_affiliation_string":"Pharmaceutica ls, Genentech/Roche, Gilead Sciences, Ichnos Sciences S.A., InDex Pharmaceuticals, Iterative Scopes, Janssen Pharmaceuticals, Lilly, P zer, Prometheus Laboratories, Reistone,","institution_ids":[]},{"raw_affiliation_string":"travel support fr om P zer","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066105630","display_name":"Zaheera Shabbir","orcid":"https://orcid.org/0000-0002-2068-7757","observed_orcids":["https://orcid.org/0000-0002-2068-7757"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]},{"id":"https://openalex.org/I4210087865","display_name":"University of Chicago Medical Center","ror":"https://ror.org/0076kfe04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087865"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zaheera Shabbir","raw_affiliation_strings":["IBD Center, Section of Gastroenterology University of Chicago Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IBD Center, Section of Gastroenterology University of Chicago Medicine","institution_ids":["https://openalex.org/I40347166","https://openalex.org/I4210087865"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088377676","display_name":"Tina Rodriguez","orcid":"https://orcid.org/0000-0003-4044-4813","observed_orcids":["https://orcid.org/0000-0003-4044-4813"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]},{"id":"https://openalex.org/I4210087865","display_name":"University of Chicago Medical Center","ror":"https://ror.org/0076kfe04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087865"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tina Rodriguez","raw_affiliation_strings":["IBD Center, Section of Gastroenterology University of Chicago Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IBD Center, Section of Gastroenterology University of Chicago Medicine","institution_ids":["https://openalex.org/I40347166","https://openalex.org/I4210087865"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036858646","display_name":"Cindy Traboulsi","orcid":"https://orcid.org/0000-0001-9868-3687","observed_orcids":["https://orcid.org/0000-0001-9868-3687"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]},{"id":"https://openalex.org/I4210087865","display_name":"University of Chicago Medical Center","ror":"https://ror.org/0076kfe04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087865"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cindy Traboulsi","raw_affiliation_strings":["IBD Center, Section of Gastroenterology University of Chicago Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IBD Center, Section of Gastroenterology University of Chicago Medicine","institution_ids":["https://openalex.org/I40347166","https://openalex.org/I4210087865"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059142660","display_name":"Joel R. Pekow","orcid":"https://orcid.org/0000-0002-4790-8994","observed_orcids":["https://orcid.org/0000-0002-4790-8994"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]},{"id":"https://openalex.org/I4210087865","display_name":"University of Chicago Medical Center","ror":"https://ror.org/0076kfe04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087865"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joel Pekow","raw_affiliation_strings":["IBD Center, Section of Gastroenterology University of Chicago Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IBD Center, Section of Gastroenterology University of Chicago Medicine","institution_ids":["https://openalex.org/I40347166","https://openalex.org/I4210087865"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044048621","display_name":"Dejan Mici\u0107","orcid":"https://orcid.org/0000-0003-2864-1670","observed_orcids":["https://orcid.org/0000-0003-2864-1670"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]},{"id":"https://openalex.org/I4210087865","display_name":"University of Chicago Medical Center","ror":"https://ror.org/0076kfe04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087865"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dejan Micic","raw_affiliation_strings":["IBD Center, Section of Gastroenterology University of Chicago Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IBD Center, Section of Gastroenterology University of Chicago Medicine","institution_ids":["https://openalex.org/I40347166","https://openalex.org/I4210087865"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023182644","display_name":"Russell D. Cohen","orcid":"https://orcid.org/0000-0002-6114-8936","observed_orcids":["https://orcid.org/0000-0002-6114-8936"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]},{"id":"https://openalex.org/I4210087865","display_name":"University of Chicago Medical Center","ror":"https://ror.org/0076kfe04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087865"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Russell D. Cohen","raw_affiliation_strings":["IBD Center, Section of Gastroenterology University of Chicago Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IBD Center, Section of Gastroenterology University of Chicago Medicine","institution_ids":["https://openalex.org/I40347166","https://openalex.org/I4210087865"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061920772","display_name":"Sushila R. Dalal","orcid":"https://orcid.org/0000-0003-1207-0500","observed_orcids":["https://orcid.org/0000-0003-1207-0500"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]},{"id":"https://openalex.org/I4210087865","display_name":"University of Chicago Medical Center","ror":"https://ror.org/0076kfe04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087865"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sushila R. Dalal","raw_affiliation_strings":["IBD Center, Section of Gastroenterology University of Chicago Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IBD Center, Section of Gastroenterology University of Chicago Medicine","institution_ids":["https://openalex.org/I40347166","https://openalex.org/I4210087865"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008206092","display_name":"Nathaniel A. Cohen","orcid":"https://orcid.org/0000-0001-9252-9208","observed_orcids":["https://orcid.org/0000-0001-9252-9208"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]},{"id":"https://openalex.org/I4210087865","display_name":"University of Chicago Medical Center","ror":"https://ror.org/0076kfe04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087865"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nathaniel A. Cohen","raw_affiliation_strings":["IBD Center, Section of Gastroenterology University of Chicago Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IBD Center, Section of Gastroenterology University of Chicago Medicine","institution_ids":["https://openalex.org/I40347166","https://openalex.org/I4210087865"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5049169459","display_name":"David T. Rubin","orcid":"https://orcid.org/0000-0001-5647-1723","observed_orcids":["https://orcid.org/0000-0001-5647-1723"]},"institutions":[{"id":"https://openalex.org/I183934855","display_name":"Genentech","ror":"https://ror.org/04gndp242","country_code":"US","type":"company","lineage":["https://openalex.org/I118019719","https://openalex.org/I129302853","https://openalex.org/I183934855"]},{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]},{"id":"https://openalex.org/I4210087865","display_name":"University of Chicago Medical Center","ror":"https://ror.org/0076kfe04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087865"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David T. Rubin","raw_affiliation_strings":["IBD Center, Section of Gastroenterology University of Chicago Medicine","Arena Pharmaceuticals, Bellatrix Pharmaceuticals, Boehringer Ingelheim Ltd., Bristol -Myers Squibb,","Celgene, Syneos, Dizal","Eli Lilly, Genentech, Gilead Sciences, Hoffman La -Roche, Janssen, P zer, Takeda, and UCB Pharma","Pharmaceutica ls, Genentech/Roche, Gilead Sciences, Ichnos Sciences S.A., InDex Pharmaceuticals, Iterative Scopes, Janssen Pharmaceuticals, Lilly, P zer, Prometheus Laboratories, Reistone,","travel support fr om P zer"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IBD Center, Section of Gastroenterology University of Chicago Medicine","institution_ids":["https://openalex.org/I40347166","https://openalex.org/I4210087865"]},{"raw_affiliation_string":"Arena Pharmaceuticals, Bellatrix Pharmaceuticals, Boehringer Ingelheim Ltd., Bristol -Myers Squibb,","institution_ids":[]},{"raw_affiliation_string":"Celgene, Syneos, Dizal","institution_ids":[]},{"raw_affiliation_string":"Eli Lilly, Genentech, Gilead Sciences, Hoffman La -Roche, Janssen, P zer, Takeda, and UCB Pharma","institution_ids":["https://openalex.org/I183934855"]},{"raw_affiliation_string":"Pharmaceutica ls, Genentech/Roche, Gilead Sciences, Ichnos Sciences S.A., InDex Pharmaceuticals, Iterative Scopes, Janssen Pharmaceuticals, Lilly, P zer, Prometheus Laboratories, Reistone,","institution_ids":[]},{"raw_affiliation_string":"travel support fr om P zer","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11194","display_name":"Ocular Diseases and Beh\u00e7et\u2019s Syndrome","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12518","display_name":"Diverticular Disease and Complications","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acute-severe-ulcerative-colitis","display_name":"acute severe ulcerative colitis","score":0.9589999914169312},{"id":"https://openalex.org/keywords/cyclosporine","display_name":"cyclosporine","score":0.9929999709129333},{"id":"https://openalex.org/keywords/colectomy","display_name":"colectomy","score":0.8930000066757202},{"id":"https://openalex.org/keywords/subtherapeutic-drug-levels","display_name":"subtherapeutic drug levels","score":0.8289999961853027},{"id":"https://openalex.org/keywords/induction-therapy","display_name":"induction therapy","score":0.550000011920929},{"id":"https://openalex.org/keywords/dose-reduction","display_name":"dose reduction","score":0.5289999842643738},{"id":"https://openalex.org/keywords/steroid-refractory-colitis","display_name":"steroid-refractory colitis","score":0.8130000233650208}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8802082538604736},{"id":"https://openalex.org/C2776667177","wikidata":"https://www.wikidata.org/wiki/Q1779148","display_name":"Colectomy","level":4,"score":0.8706491589546204},{"id":"https://openalex.org/C2780479503","wikidata":"https://www.wikidata.org/wiki/Q1477","display_name":"Ulcerative colitis","level":3,"score":0.7559999227523804},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7002192139625549},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.6316721439361572},{"id":"https://openalex.org/C2778715236","wikidata":"https://www.wikidata.org/wiki/Q55622662","display_name":"Discontinuation","level":2,"score":0.6003446578979492},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.5694212913513184},{"id":"https://openalex.org/C195910791","wikidata":"https://www.wikidata.org/wiki/Q1324077","display_name":"Medical record","level":2,"score":0.5244864821434021},{"id":"https://openalex.org/C151956035","wikidata":"https://www.wikidata.org/wiki/Q1132755","display_name":"Logistic regression","level":2,"score":0.48127859830856323},{"id":"https://openalex.org/C2775862500","wikidata":"https://www.wikidata.org/wiki/Q2453464","display_name":"Colitis","level":2,"score":0.4409097731113434},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.32141822576522827},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.21203/rs.3.rs-3848573/v1","doi":"https://doi.org/10.21203/rs.3.rs-3848573/v1","is_oa":true,"landing_page_url":"http://dx.doi.org/10.21203/rs.3.rs-3848573/v1","pdf_url":"https://www.researchsquare.com/article/rs-3848573/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.21203/rs.3.rs-3848573/v1","doi":"https://doi.org/10.21203/rs.3.rs-3848573/v1","is_oa":true,"landing_page_url":"http://dx.doi.org/10.21203/rs.3.rs-3848573/v1","pdf_url":"https://www.researchsquare.com/article/rs-3848573/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4390875128.pdf","grobid_xml":"https://content.openalex.org/works/W4390875128.grobid-xml"},"referenced_works_count":25,"referenced_works":["https://openalex.org/W135528929","https://openalex.org/W1987925515","https://openalex.org/W1998758469","https://openalex.org/W2022435477","https://openalex.org/W2034295073","https://openalex.org/W2060716969","https://openalex.org/W2068255175","https://openalex.org/W2069558624","https://openalex.org/W2086046855","https://openalex.org/W2115020173","https://openalex.org/W2120553039","https://openalex.org/W2159607743","https://openalex.org/W2161815221","https://openalex.org/W2171789845","https://openalex.org/W2528806650","https://openalex.org/W2626370788","https://openalex.org/W2799598867","https://openalex.org/W2980156604","https://openalex.org/W3046366232","https://openalex.org/W3091986443","https://openalex.org/W3110117649","https://openalex.org/W3138845742","https://openalex.org/W3162419183","https://openalex.org/W3195828941","https://openalex.org/W4297855440"],"related_works":["https://openalex.org/W3211043570","https://openalex.org/W2791009013","https://openalex.org/W2977827124","https://openalex.org/W2121222477","https://openalex.org/W4281570288","https://openalex.org/W4235268095","https://openalex.org/W2978536033","https://openalex.org/W2790937520","https://openalex.org/W2361558309","https://openalex.org/W2414148841"],"abstract_inverted_index":{"Abstract":[0],"Background:":[1],"Cyclosporine":[2],"(CYS)":[3],"is":[4],"a":[5],"calcineurin":[6],"inhibitor":[7],"commonly":[8],"used":[9],"as":[10],"induction":[11,59],"therapy":[12,233],"in":[13,205,211],"steroid-refractory":[14],"patients":[15,43,74,82,86,93,98,105,124,134,212],"with":[16,44,162,193,234,243],"acute":[17],"severe":[18],"ulcerative":[19],"colitis":[20],"(ASUC)":[21],"during":[22,77],"hospitalization.":[23],"Aim:":[24],"To":[25],"identify":[26],"the":[27,175],"relationship":[28],"between":[29,60],"post-hospitalization":[30],"CYS":[31,55,58,101,155,188,206,227],"serum":[32,154,226],"levels":[33,189,207,228],"and":[34,96,150],"adverse":[35,89],"clinical":[36,209],"outcomes.":[37],"Methods:":[38],"Electronic":[39],"medical":[40],"records":[41],"of":[42,47,165,180,224,238],"established":[45],"diagnosis":[46],"UC":[48],"hospitalized":[49],"for":[50,144,177],"ASUC":[51],"discharged":[52],"on":[53],"oral":[54,232],"following":[56,229],"IV":[57],"May":[61],"2013":[62],"to":[63,110,231],"December":[64],"2017":[65],"were":[66,83,94,99,106,217],"retrospectively":[67],"analyzed.":[68,84],"Results:":[69],"Of":[70],"thirty-nine":[71],"patients,":[72],"five":[73,92],"underwent":[75,126,135,214],"colectomy":[76,113,127,136,167,195,216],"initial":[78],"hospitalization;":[79],"thirty-four":[80],"remaining":[81],"Twenty":[85],"experienced":[87],"CYS-related":[88],"events":[90],"(AEs);":[91],"dose-reduced":[95,102],"three":[97,115,138],"discontinued.":[100],"or":[103,185,208],"discontinued":[104],"significantly":[107],"more":[108],"likely":[109],"have":[111],"undergone":[112],"within":[114,128,137],"months":[116],"(62.5%":[117],"vs":[118],"11.5%,":[119],"p=0.009).":[120],"Fifteen":[121],"(44%)":[122],"total":[123],"who":[125,213],"one":[129],"year":[130],"post-hospitalization;":[131],"eight":[132],"(23.5%)":[133],"months.":[139],"Logistic":[140],"regression":[141],"analysis":[142],"adjusting":[143],"age,":[145],"sex,":[146],"weight,":[147],"albumin,":[148],"CRP":[149],"AEs":[151,181],"demonstrated":[152],"subtherapeutic":[153,187,225],"level":[156],"(<200":[157],"ng/mL)":[158],"was":[159],"independently":[160,191],"associated":[161,192],"increased":[163,236],"risk":[164,237],"three-month":[166,194,239],"(aHR":[168,196],"20.95,":[169],"95%":[170,198],"CI":[171,199],"1.5-284,":[172],"p=0.02).":[173,201],"Adjusting":[174],"model":[176],"selective":[178],"inclusion":[179],"requiring":[182],"dose":[183],"adjustment":[184],"discontinuation,":[186],"remained":[190],"14.9,":[197],"1.12-198.9,":[200],"No":[202],"significant":[203],"differences":[204],"characteristics":[210],"one-year":[215,244],"observed.":[218],"Conclusions:":[219],"We":[220],"demonstrate":[221],"independent":[222],"association":[223],"conversion":[230],"an":[235],"colectomy,":[240],"but":[241],"not":[242],"colectomy.":[245]},"counts_by_year":[],"updated_date":"2026-10-27T15:51:10.671819","created_date":"2024-01-16T00:00:00"}