{"id":"https://openalex.org/W4390859619","doi":"https://doi.org/10.22271/plants.2024.v12.i1a.1619","title":"Exploration of analgesic, laxative and immunomodulatory effects of leaves and twigs of Euphorbia tirucalli along with in silico analysis","display_name":"Exploration of analgesic, laxative and immunomodulatory effects of leaves and twigs of Euphorbia tirucalli along with in silico analysis","publication_year":2024,"publication_date":"2024-01-01","ids":{"openalex":"https://openalex.org/W4390859619","doi":"https://doi.org/10.22271/plants.2024.v12.i1a.1619"},"language":"en","primary_location":{"id":"doi:10.22271/plants.2024.v12.i1a.1619","doi":"https://doi.org/10.22271/plants.2024.v12.i1a.1619","is_oa":true,"landing_page_url":"http://dx.doi.org/10.22271/plants.2024.v12.i1a.1619","pdf_url":"https://www.plantsjournal.com/archives/2024/vol12issue1/PartA/11-6-25-166.pdf","source":{"id":"https://openalex.org/S2764724089","display_name":"Journal of Medicinal Plants Studies","issn_l":"2320-3862","issn":["2320-3862","2394-0530"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medicinal Plants Studies","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://www.plantsjournal.com/archives/2024/vol12issue1/PartA/11-6-25-166.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Nishat Tasnim","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I124386471","display_name":"Khulna University","ror":"https://ror.org/05pny7s12","country_code":"BD","type":"education","lineage":["https://openalex.org/I124386471"]}],"countries":["BD"],"is_corresponding":false,"raw_author_name":"Nishat Tasnim","raw_affiliation_strings":["Department of Pharmacy Discipline, Life Science School, Khulna University, Khulna, Bangladesh","Pharmacy Discipline Life Science School Khulna University Khulna , Bangladesh"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy Discipline, Life Science School, Khulna University, Khulna, Bangladesh","institution_ids":["https://openalex.org/I124386471"]},{"raw_affiliation_string":"Pharmacy Discipline Life Science School Khulna University Khulna , Bangladesh","institution_ids":["https://openalex.org/I124386471"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040122473","display_name":"Brototi Chakrabarty","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I124386471","display_name":"Khulna University","ror":"https://ror.org/05pny7s12","country_code":"BD","type":"education","lineage":["https://openalex.org/I124386471"]}],"countries":["BD"],"is_corresponding":false,"raw_author_name":"Brototi Chakrabarty","raw_affiliation_strings":["Department of Pharmacy Discipline, Life Science School, Khulna University, Khulna, Bangladesh","Pharmacy Discipline Life Science School Khulna University Khulna , Bangladesh"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy Discipline, Life Science School, Khulna University, Khulna, Bangladesh","institution_ids":["https://openalex.org/I124386471"]},{"raw_affiliation_string":"Pharmacy Discipline Life Science School Khulna University Khulna , Bangladesh","institution_ids":["https://openalex.org/I124386471"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058474375","display_name":"Biswajit Biswas","orcid":"https://orcid.org/0000-0002-2948-2256","observed_orcids":["https://orcid.org/0000-0002-2948-2256"]},"institutions":[{"id":"https://openalex.org/I124386471","display_name":"Khulna University","ror":"https://ror.org/05pny7s12","country_code":"BD","type":"education","lineage":["https://openalex.org/I124386471"]},{"id":"https://openalex.org/I923003605","display_name":"Jashore University of Science and Technology","ror":"https://ror.org/04eqvyq94","country_code":"BD","type":"education","lineage":["https://openalex.org/I923003605"]}],"countries":["BD"],"is_corresponding":false,"raw_author_name":"Biswajit Biswas","raw_affiliation_strings":["Department of Pharmacy,","Faculty of Biological Science and Technology , Jashore University of Science and Technology , Jashore , Bangladesh","Department of Pharmacy Discipline, Life Science School, Khulna University, Khulna, Bangladesh"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy,","institution_ids":[]},{"raw_affiliation_string":"Faculty of Biological Science and Technology , Jashore University of Science and Technology , Jashore , Bangladesh","institution_ids":["https://openalex.org/I923003605"]},{"raw_affiliation_string":"Department of Pharmacy Discipline, Life Science School, Khulna University, Khulna, Bangladesh","institution_ids":["https://openalex.org/I124386471"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061982849","display_name":"Mimi Golder","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I124386471","display_name":"Khulna University","ror":"https://ror.org/05pny7s12","country_code":"BD","type":"education","lineage":["https://openalex.org/I124386471"]},{"id":"https://openalex.org/I923003605","display_name":"Jashore University of Science and Technology","ror":"https://ror.org/04eqvyq94","country_code":"BD","type":"education","lineage":["https://openalex.org/I923003605"]}],"countries":["BD"],"is_corresponding":false,"raw_author_name":"Mimi Golder","raw_affiliation_strings":["Department of Pharmacy Discipline, Life Science School, Khulna University, Khulna, Bangladesh","Pharmacy Discipline Life Science School Khulna University Khulna , Bangladesh","Faculty of Biological Science and Technology, Jashore University of Science and Technology, Jashore, Bangladesh"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy Discipline, Life Science School, Khulna University, Khulna, Bangladesh","institution_ids":["https://openalex.org/I124386471"]},{"raw_affiliation_string":"Pharmacy Discipline Life Science School Khulna University Khulna , Bangladesh","institution_ids":["https://openalex.org/I124386471"]},{"raw_affiliation_string":"Faculty of Biological Science and Technology, Jashore University of Science and Technology, Jashore, Bangladesh","institution_ids":["https://openalex.org/I923003605"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5041749950","display_name":"Pritam Kundu","orcid":"https://orcid.org/0000-0002-3986-2877","observed_orcids":["https://orcid.org/0000-0002-3986-2877"]},"institutions":[{"id":"https://openalex.org/I124386471","display_name":"Khulna University","ror":"https://ror.org/05pny7s12","country_code":"BD","type":"education","lineage":["https://openalex.org/I124386471"]}],"countries":["BD"],"is_corresponding":false,"raw_author_name":"Pritam Kundu","raw_affiliation_strings":["Department of Pharmacy Discipline, Life Science School, Khulna University, Khulna, Bangladesh","Pharmacy Discipline Life Science School Khulna University Khulna , Bangladesh"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy Discipline, Life Science School, Khulna University, Khulna, Bangladesh","institution_ids":["https://openalex.org/I124386471"]},{"raw_affiliation_string":"Pharmacy Discipline Life Science School Khulna University Khulna , Bangladesh","institution_ids":["https://openalex.org/I124386471"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.4106,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.54890434,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":95},"biblio":{"volume":"12","issue":"1","first_page":"01","last_page":"10"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T14521","display_name":"Medicinal Plant Research","score":0.7554000020027161,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T14521","display_name":"Medicinal Plant Research","score":0.7554000020027161,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12298","display_name":"Phytochemicals and Medicinal Plants","score":0.14319999516010284,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12530","display_name":"Bioactive Natural Diterpenoids Research","score":0.024700000882148743,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/euphorbia-tirucalli","display_name":"Euphorbia tirucalli","score":1.0},{"id":"https://openalex.org/keywords/analgesic-activity","display_name":"analgesic activity","score":0.9610000252723694},{"id":"https://openalex.org/keywords/laxative-activity","display_name":"laxative activity","score":0.9670000076293945},{"id":"https://openalex.org/keywords/immunomodulation","display_name":"immunomodulation","score":0.8769999742507935},{"id":"https://openalex.org/keywords/phytochemical-screening","display_name":"phytochemical screening","score":0.7639999985694885},{"id":"https://openalex.org/keywords/total-phenolic-content","display_name":"total phenolic content","score":0.8240000009536743},{"id":"https://openalex.org/keywords/flavonoids","display_name":"flavonoids","score":0.9490000009536743},{"id":"https://openalex.org/keywords/tannins","display_name":"tannins","score":0.9860000014305115},{"id":"https://openalex.org/keywords/acetic-acid-writhing-test","display_name":"acetic acid-induced writhing","score":0.9610000252723694},{"id":"https://openalex.org/keywords/delayed-type-hypersensitivity","display_name":"delayed-type hypersensitivity","score":0.9179999828338623},{"id":"https://openalex.org/keywords/anti-inflammatory-agents","display_name":"anti-inflammatory agents","score":0.6449999809265137},{"id":"https://openalex.org/keywords/traditional-medicine","display_name":"traditional medicine","score":0.5929999947547913},{"id":"https://openalex.org/keywords/medicinal-plants","display_name":"medicinal plants","score":0.5170000195503235}],"concepts":[{"id":"https://openalex.org/C195475562","wikidata":"https://www.wikidata.org/wiki/Q1639139","display_name":"Phytochemical","level":2,"score":0.8823503255844116},{"id":"https://openalex.org/C2778362808","wikidata":"https://www.wikidata.org/wiki/Q375837","display_name":"Gallic acid","level":3,"score":0.7501078844070435},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.7468457221984863},{"id":"https://openalex.org/C2779824472","wikidata":"https://www.wikidata.org/wiki/Q207123","display_name":"Herb","level":3,"score":0.6022404432296753},{"id":"https://openalex.org/C2779880300","wikidata":"https://www.wikidata.org/wiki/Q146567","display_name":"Euphorbia","level":2,"score":0.5708533525466919},{"id":"https://openalex.org/C2781263971","wikidata":"https://www.wikidata.org/wiki/Q409478","display_name":"Quercetin","level":3,"score":0.5513182282447815},{"id":"https://openalex.org/C2779047212","wikidata":"https://www.wikidata.org/wiki/Q156584","display_name":"Euphorbiaceae","level":2,"score":0.515554666519165},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4458669424057007},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4260998070240021},{"id":"https://openalex.org/C206103511","wikidata":"https://www.wikidata.org/wiki/Q426694","display_name":"Terpenoid","level":2,"score":0.415035218000412},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2925418019294739},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2330155372619629},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.22209420800209045},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1673983335494995},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.16472968459129333},{"id":"https://openalex.org/C2991655182","wikidata":"https://www.wikidata.org/wiki/Q188840","display_name":"Medicinal herbs","level":2,"score":0.14145666360855103},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.08325770497322083}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.22271/plants.2024.v12.i1a.1619","doi":"https://doi.org/10.22271/plants.2024.v12.i1a.1619","is_oa":true,"landing_page_url":"http://dx.doi.org/10.22271/plants.2024.v12.i1a.1619","pdf_url":"https://www.plantsjournal.com/archives/2024/vol12issue1/PartA/11-6-25-166.pdf","source":{"id":"https://openalex.org/S2764724089","display_name":"Journal of Medicinal Plants Studies","issn_l":"2320-3862","issn":["2320-3862","2394-0530"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medicinal Plants Studies","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.22271/plants.2024.v12.i1a.1619","doi":"https://doi.org/10.22271/plants.2024.v12.i1a.1619","is_oa":true,"landing_page_url":"http://dx.doi.org/10.22271/plants.2024.v12.i1a.1619","pdf_url":"https://www.plantsjournal.com/archives/2024/vol12issue1/PartA/11-6-25-166.pdf","source":{"id":"https://openalex.org/S2764724089","display_name":"Journal of Medicinal Plants Studies","issn_l":"2320-3862","issn":["2320-3862","2394-0530"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medicinal Plants Studies","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320325297","display_name":"Khulna University","ror":"https://ror.org/05pny7s12"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4390859619.pdf","grobid_xml":"https://content.openalex.org/works/W4390859619.grobid-xml"},"referenced_works_count":23,"referenced_works":["https://openalex.org/W2001634895","https://openalex.org/W2019917976","https://openalex.org/W2067145669","https://openalex.org/W2134736970","https://openalex.org/W2134967712","https://openalex.org/W2149394000","https://openalex.org/W2159305245","https://openalex.org/W2184407378","https://openalex.org/W2404755971","https://openalex.org/W2727943972","https://openalex.org/W2935695342","https://openalex.org/W2997515393","https://openalex.org/W3166824233","https://openalex.org/W3181247207","https://openalex.org/W3200389113","https://openalex.org/W4224251739","https://openalex.org/W4234225854","https://openalex.org/W4236846950","https://openalex.org/W4320159142","https://openalex.org/W4365814727","https://openalex.org/W4385233743","https://openalex.org/W4388049799","https://openalex.org/W6793197678"],"related_works":["https://openalex.org/W2601546966","https://openalex.org/W3115356741","https://openalex.org/W2727943972","https://openalex.org/W4367304857","https://openalex.org/W7119401523","https://openalex.org/W2183747899","https://openalex.org/W7218644200","https://openalex.org/W3200389113","https://openalex.org/W3090523677","https://openalex.org/W2788118902"],"abstract_inverted_index":{"This":[0,80],"study":[1],"was":[2],"conducted":[3],"on":[4,21,150],"Euphorbia":[5],"tirucalli,":[6],"a":[7],"herb":[8],"from":[9],"Euphorbiaceae":[10],"family":[11],"in":[12,42,89,111,128,139],"order":[13],"to":[14,74,87,105,146],"assess":[15],"its":[16,22,137],"some":[17],"pharmacological":[18],"effect":[19,103],"based":[20],"traditional":[23,140],"uses.":[24],"Phytochemical":[25],"analysis":[26],"revealed":[27],"the":[28,70,83,94],"presence":[29],"of":[30,33],"various":[31],"types":[32],"phytochemical":[34],"groups.":[35],"Total":[36],"phenolic,":[37],"flavonoid":[38],"and":[39,55,130,142],"tannin":[40],"contents":[41],"this":[43,67,99,151],"extract":[44,68,81,100],"were":[45],"111.4":[46],"mg":[47,52,57],"gallic":[48,58],"acid":[49,59],"equivalence/g,":[50,60],"105.94":[51],"quercetin":[53],"equivalence/g":[54],"67":[56],"respectively.":[61],"In":[62,93],"acetic":[63],"acid-induced":[64],"writhing":[65,71],"method,":[66],"reduced":[69],"reflex":[72],"up":[73,86,104],"65%":[75],"at":[76],"400":[77,112],"mg/kg":[78,91,113],"dose.":[79,92,114],"increased":[82],"stool":[84],"weight":[85],"64%":[88],"200":[90],"delayed":[95],"type":[96],"hypersensitivity":[97],"assay,":[98],"showed":[101,124],"immunomodulatory":[102],"17.74%":[106],"by":[107],"increasing":[108],"footpad":[109],"thickness":[110],"From":[115],"molecular":[116],"docking":[117],"analysis,":[118],"we":[119],"have":[120],"found":[121],"4":[122],"compounds":[123],"good":[125],"binding":[126],"affinities":[127],"anti-inflammatory":[129],"laxative":[131],"tests.":[132],"These":[133],"experimental":[134],"results":[135],"justify":[136],"uses":[138],"medicine":[141],"these":[143],"will":[144],"help":[145],"conduct":[147],"higher":[148],"researches":[149],"herb.":[152]},"counts_by_year":[{"year":2024,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2024-01-15T00:00:00"}