{"id":"https://openalex.org/W4390813086","doi":"https://doi.org/10.3389/fonc.2023.1188017","title":"Association between serum \u03b3-glutamyl transferase and advanced colorectal adenoma among inpatients: a case-control study","display_name":"Association between serum \u03b3-glutamyl transferase and advanced colorectal adenoma among inpatients: a case-control study","publication_year":2024,"publication_date":"2024-01-12","ids":{"openalex":"https://openalex.org/W4390813086","doi":"https://doi.org/10.3389/fonc.2023.1188017","pmid":"https://pubmed.ncbi.nlm.nih.gov/38282678","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10816217"},"language":"en","primary_location":{"id":"doi:10.3389/fonc.2023.1188017","doi":"https://doi.org/10.3389/fonc.2023.1188017","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fonc.2023.1188017","pdf_url":null,"source":{"id":"https://openalex.org/S2596394214","display_name":"Frontiers in Oncology","issn_l":"2234-943X","issn":["2234-943X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Oncology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3389/fonc.2023.1188017","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101536828","display_name":"Huijie Wang","orcid":"https://orcid.org/0000-0003-1091-2583","observed_orcids":["https://orcid.org/0000-0003-1091-2583"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Huijie Wang","raw_affiliation_strings":["Department of Endoscopy, Shijiazhuang Traditional Chinese Medicine Hospital, Shijiazhuang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Endoscopy, Shijiazhuang Traditional Chinese Medicine Hospital, Shijiazhuang, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113763299","display_name":"Huanwei Zheng","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Huanwei Zheng","raw_affiliation_strings":["Department of Gastroenterology, Shijiazhuang Traditional Chinese Medicine Hospital, Shijiazhuang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Shijiazhuang Traditional Chinese Medicine Hospital, Shijiazhuang, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033976412","display_name":"Xu Cao","orcid":"https://orcid.org/0000-0002-9927-6802","observed_orcids":["https://orcid.org/0000-0002-9927-6802"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xu Cao","raw_affiliation_strings":["Department of Endoscopy, Shijiazhuang Traditional Chinese Medicine Hospital, Shijiazhuang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Endoscopy, Shijiazhuang Traditional Chinese Medicine Hospital, Shijiazhuang, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Ping Meng","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ping Meng","raw_affiliation_strings":["Department of Gastroenterology, Shijiazhuang Traditional Chinese Medicine Hospital, Shijiazhuang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Shijiazhuang Traditional Chinese Medicine Hospital, Shijiazhuang, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101795102","display_name":"Jinli Liu","orcid":"https://orcid.org/0000-0002-4167-1578","observed_orcids":["https://orcid.org/0000-0002-4167-1578"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jinli Liu","raw_affiliation_strings":["Department of Endoscopy, Shijiazhuang Traditional Chinese Medicine Hospital, Shijiazhuang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Endoscopy, Shijiazhuang Traditional Chinese Medicine Hospital, Shijiazhuang, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002104276","display_name":"Haiying Zuo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I169071405","display_name":"Hebei North University","ror":"https://ror.org/03hqwnx39","country_code":"CN","type":"education","lineage":["https://openalex.org/I169071405"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Haiying Zuo","raw_affiliation_strings":["Graduate School, Hebei North University, Zhangjiakou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate School, Hebei North University, Zhangjiakou, China","institution_ids":["https://openalex.org/I169071405"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100372489","display_name":"Teng Zhang","orcid":"https://orcid.org/0000-0001-7733-2917","observed_orcids":["https://orcid.org/0000-0001-7733-2917"]},"institutions":[{"id":"https://openalex.org/I137506752","display_name":"North China University of Science and Technology","ror":"https://ror.org/04z4wmb81","country_code":"CN","type":"education","lineage":["https://openalex.org/I137506752"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Teng Zhang","raw_affiliation_strings":["Institute of Traditional Chinese Medicine, North China University of Science and Technology, Tangshan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Traditional Chinese Medicine, North China University of Science and Technology, Tangshan, China","institution_ids":["https://openalex.org/I137506752"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100398362","display_name":"Zhichao Wang","orcid":"https://orcid.org/0000-0002-0612-0658","observed_orcids":["https://orcid.org/0000-0002-0612-0658"]},"institutions":[{"id":"https://openalex.org/I169071405","display_name":"Hebei North University","ror":"https://ror.org/03hqwnx39","country_code":"CN","type":"education","lineage":["https://openalex.org/I169071405"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhichao Wang","raw_affiliation_strings":["Graduate School, Hebei North University, Zhangjiakou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate School, Hebei North University, Zhangjiakou, China","institution_ids":["https://openalex.org/I169071405"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5113763299"],"corresponding_institution_ids":[],"apc_list":{"value":3295,"currency":"USD","value_usd":3295},"apc_paid":{"value":3295,"currency":"USD","value_usd":3295},"fwci":1.4546,"has_fulltext":true,"cited_by_count":9,"citation_normalized_percentile":{"value":0.83776615,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":97},"biblio":{"volume":"13","issue":null,"first_page":"1188017","last_page":"1188017"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10552","display_name":"Colorectal Cancer Screening and Detection","score":0.98580002784729,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10552","display_name":"Colorectal Cancer Screening and Detection","score":0.98580002784729,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11369","display_name":"Genetic factors in colorectal cancer","score":0.00430000014603138,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11355","display_name":"Inflammatory Biomarkers in Disease Prognosis","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gamma-glutamyl-transferase","display_name":"gamma-glutamyl transferase","score":0.9210000038146973},{"id":"https://openalex.org/keywords/advanced-adenoma","display_name":"advanced adenoma","score":0.9980000257492065},{"id":"https://openalex.org/keywords/colorectal-cancer-precursor-lesions","display_name":"colorectal cancer precursor lesions","score":0.8230000138282776},{"id":"https://openalex.org/keywords/serum-biomarkers","display_name":"serum biomarkers","score":0.8379999995231628},{"id":"https://openalex.org/keywords/diagnostic-biomarkers","display_name":"diagnostic biomarkers","score":0.5490000247955322},{"id":"https://openalex.org/keywords/colorectal-cancer-screening","display_name":"colorectal cancer screening","score":0.968999981880188},{"id":"https://openalex.org/keywords/hospitalized-patients","display_name":"hospitalized patients","score":0.5619999766349792}],"concepts":[{"id":"https://openalex.org/C2776861080","wikidata":"https://www.wikidata.org/wiki/Q2825480","display_name":"Colorectal adenoma","level":4,"score":0.8576035499572754},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7796156406402588},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.7670536041259766},{"id":"https://openalex.org/C77350462","wikidata":"https://www.wikidata.org/wiki/Q1125472","display_name":"Confounding","level":2,"score":0.7515673637390137},{"id":"https://openalex.org/C2777428134","wikidata":"https://www.wikidata.org/wiki/Q272741","display_name":"Adenoma","level":2,"score":0.7332112789154053},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6773726940155029},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.5868264436721802},{"id":"https://openalex.org/C151956035","wikidata":"https://www.wikidata.org/wiki/Q1132755","display_name":"Logistic regression","level":2,"score":0.5682253837585449},{"id":"https://openalex.org/C156957248","wikidata":"https://www.wikidata.org/wiki/Q1862216","display_name":"Odds ratio","level":2,"score":0.5640011429786682},{"id":"https://openalex.org/C146304588","wikidata":"https://www.wikidata.org/wiki/Q961652","display_name":"Case-control study","level":2,"score":0.46908560395240784},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.40622878074645996},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2072131335735321}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3389/fonc.2023.1188017","doi":"https://doi.org/10.3389/fonc.2023.1188017","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fonc.2023.1188017","pdf_url":null,"source":{"id":"https://openalex.org/S2596394214","display_name":"Frontiers in Oncology","issn_l":"2234-943X","issn":["2234-943X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Oncology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10816217","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10816217","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10816217/pdf/fonc-13-1188017.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Oncol","raw_type":"Text"},{"id":"pmid:38282678","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38282678","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in oncology","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:689b7fd36fd542178e989390f182c915","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/689b7fd36fd542178e989390f182c915","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Oncology, Vol 13 (2024)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fonc.2023.1188017","doi":"https://doi.org/10.3389/fonc.2023.1188017","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fonc.2023.1188017","pdf_url":null,"source":{"id":"https://openalex.org/S2596394214","display_name":"Frontiers in Oncology","issn_l":"2234-943X","issn":["2234-943X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9940000176429749,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4390813086.pdf","grobid_xml":"https://content.openalex.org/works/W4390813086.grobid-xml"},"referenced_works_count":43,"referenced_works":["https://openalex.org/W183752289","https://openalex.org/W1567936707","https://openalex.org/W1914193268","https://openalex.org/W1970452249","https://openalex.org/W1974150445","https://openalex.org/W1990790927","https://openalex.org/W2002424467","https://openalex.org/W2011870094","https://openalex.org/W2033069695","https://openalex.org/W2052387402","https://openalex.org/W2082465243","https://openalex.org/W2082964350","https://openalex.org/W2097903769","https://openalex.org/W2110267763","https://openalex.org/W2140965288","https://openalex.org/W2146122808","https://openalex.org/W2146430570","https://openalex.org/W2147072570","https://openalex.org/W2157224977","https://openalex.org/W2157343124","https://openalex.org/W2165201727","https://openalex.org/W2368690534","https://openalex.org/W2369386906","https://openalex.org/W2414289400","https://openalex.org/W2417090450","https://openalex.org/W2461986395","https://openalex.org/W2483014046","https://openalex.org/W2510191342","https://openalex.org/W2518132675","https://openalex.org/W2551573318","https://openalex.org/W3002898669","https://openalex.org/W3012545288","https://openalex.org/W3091880717","https://openalex.org/W3119064916","https://openalex.org/W3126498241","https://openalex.org/W3128646645","https://openalex.org/W3130591609","https://openalex.org/W3134553072","https://openalex.org/W3140801180","https://openalex.org/W3168737135","https://openalex.org/W4211038303","https://openalex.org/W4211247697","https://openalex.org/W4281756216"],"related_works":["https://openalex.org/W3091880717","https://openalex.org/W4409390833","https://openalex.org/W4404568861","https://openalex.org/W4403920756","https://openalex.org/W4406469905","https://openalex.org/W3126498241","https://openalex.org/W2977484154","https://openalex.org/W2115858158","https://openalex.org/W2945233253","https://openalex.org/W2561991028"],"abstract_inverted_index":{"Emerging":[0],"evidence":[1],"suggests":[2],"a":[3,21,38,125,179],"link":[4],"between":[5,15,84],"\u03b3-glutamyl":[6],"transferase":[7],"(GGT)":[8],"and":[9,17,54,69,77,86],"various":[10],"malignancies.":[11],"However,":[12],"the":[13,61,82,104,147],"relationship":[14,83],"GGT":[16,85,120,138,158,174],"advanced":[18,87,107,130,166,184],"colorectal":[19,25,88,108,131,167,185],"adenoma,":[20,186],"critical":[22],"precursor":[23],"to":[24,32,45,134],"cancer,":[26],"remains":[27],"unclear.":[28],"This":[29],"study":[30,41],"aimed":[31],"elucidate":[33],"this":[34],"relationship.":[35],"We":[36],"conducted":[37],"single-center":[39],"retrospective":[40],"from":[42,60],"April":[43],"2015":[44],"June":[46],"2022,":[47],"enrolling":[48],"3534":[49],"inpatients":[50],"including":[51],"525":[52],"cases":[53],"3009":[55],"controls.":[56],"Data":[57],"were":[58,160],"extracted":[59],"electronic":[62],"medical":[63],"records,":[64],"encompassing":[65],"clinicodemographic":[66],"characteristics,":[67],"co-morbidities,":[68],"several":[70],"blood":[71],"biochemical":[72],"indicators.":[73],"Utilizing":[74],"logistic":[75],"regression":[76],"curve":[78],"fitting,":[79],"we":[80,95],"explored":[81],"adenoma.":[89,168],"After":[90],"adjustment":[91],"for":[92,98,183],"confounding":[93],"factors,":[94],"found":[96],"that":[97,172],"each":[99],"20-unit":[100],"increase":[101],"in":[102],"GGT,":[103],"risk":[105,128],"of":[106,129,149,165],"adenoma":[109,132],"increased":[110],"by":[111],"6%":[112],"(OR=":[113],"1.06":[114],"[1.01-1.12]).":[115],"Moreover,":[116],"individuals":[117],"with":[118,136,154,162],"high":[119],"levels":[121,139,159,175],"(\u226550":[122],"U/L)":[123,141],"had":[124],"61%":[126],"higher":[127,163],"compared":[133],"those":[135],"low":[137],"(<50":[140],"(OR=1.61":[142],"[1.13-2.31]).":[143],"Subgroup":[144],"analysis":[145],"demonstrated":[146],"robustness":[148],"these":[150],"findings":[151,170],"across":[152],"subjects":[153],"different":[155],"characteristics.":[156],"High":[157],"associated":[161],"odds":[164],"Our":[169],"suggest":[171],"elevated":[173],"may":[176],"serve":[177],"as":[178],"potential":[180],"diagnostic":[181],"marker":[182],"providing":[187],"new":[188],"insights":[189],"into":[190],"its":[191],"screening":[192],"strategies.":[193]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":2}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2024-01-13T00:00:00"}