{"id":"https://openalex.org/W4390794252","doi":null,"title":"Methylation of the JMJD2B epigenetic regulator differentially affects its ability to coactivate the ETV1 and JUN transcription factors.","display_name":"Methylation of the JMJD2B epigenetic regulator differentially affects its ability to coactivate the ETV1 and JUN transcription factors.","publication_year":2023,"publication_date":"2023-01-01","ids":{"openalex":"https://openalex.org/W4390794252","pmid":"https://pubmed.ncbi.nlm.nih.gov/38213775","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10776875"},"language":"en","primary_location":{"id":"pmh:oai:pubmedcentral.nih.gov:10776875","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10776875","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10776875/pdf/ijbmb0014-0101.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Biochem Mol Biol","raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10776875/pdf/ijbmb0014-0101.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5047189566","display_name":"Tae\u2010Dong Kim","orcid":"https://orcid.org/0000-0002-5442-1885","observed_orcids":["https://orcid.org/0000-0002-5442-1885"]},"institutions":[{"id":"https://openalex.org/I49332381","display_name":"University of Oklahoma Health Sciences Center","ror":"https://ror.org/0457zbj98","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I49332381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tae-Dong Kim","raw_affiliation_strings":["Department of Cell Biology, University of Oklahoma Health Sciences Center Oklahoma, OK, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology, University of Oklahoma Health Sciences Center Oklahoma, OK, USA","institution_ids":["https://openalex.org/I49332381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006896000","display_name":"Ruicai Gu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I49332381","display_name":"University of Oklahoma Health Sciences Center","ror":"https://ror.org/0457zbj98","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I49332381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ruicai Gu","raw_affiliation_strings":["Department of Cell Biology, University of Oklahoma Health Sciences Center Oklahoma, OK, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology, University of Oklahoma Health Sciences Center Oklahoma, OK, USA","institution_ids":["https://openalex.org/I49332381"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5046942450","display_name":"Ralf Janknecht","orcid":"https://orcid.org/0000-0003-1741-1562","observed_orcids":["https://orcid.org/0000-0003-1741-1562"]},"institutions":[{"id":"https://openalex.org/I4390039380","display_name":"OU Health Stephenson Cancer Center","ror":"https://ror.org/02bmcqd02","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039271","https://openalex.org/I4390039380"]},{"id":"https://openalex.org/I49332381","display_name":"University of Oklahoma Health Sciences Center","ror":"https://ror.org/0457zbj98","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I49332381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ralf Janknecht","raw_affiliation_strings":["Department of Cell Biology, University of Oklahoma Health Sciences Center Oklahoma, OK, USA","Stephenson Cancer Center, University of Oklahoma Health Sciences Center Oklahoma, OK, USA","Department of Pathology, University of Oklahoma Health Sciences Center Oklahoma, OK, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology, University of Oklahoma Health Sciences Center Oklahoma, OK, USA","institution_ids":["https://openalex.org/I49332381"]},{"raw_affiliation_string":"Stephenson Cancer Center, University of Oklahoma Health Sciences Center Oklahoma, OK, USA","institution_ids":["https://openalex.org/I4390039380","https://openalex.org/I49332381"]},{"raw_affiliation_string":"Department of Pathology, University of Oklahoma Health Sciences Center Oklahoma, OK, USA","institution_ids":["https://openalex.org/I49332381"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2266,"has_fulltext":true,"cited_by_count":3,"citation_normalized_percentile":{"value":0.36423626,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":97},"biblio":{"volume":"14","issue":"6","first_page":"101","last_page":"115"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13157","display_name":"Cancer-related gene regulation","score":0.7250999808311462,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T13157","display_name":"Cancer-related gene regulation","score":0.7250999808311462,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.23080000281333923,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.027300000190734863,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/jmjd2b","display_name":"JMJD2B","score":1.0},{"id":"https://openalex.org/keywords/lysine-methylation","display_name":"lysine methylation","score":0.8859999775886536},{"id":"https://openalex.org/keywords/set7-9","display_name":"SET7/9","score":0.972000002861023},{"id":"https://openalex.org/keywords/histone-methyltransferase","display_name":"histone methyltransferase","score":0.8180000185966492},{"id":"https://openalex.org/keywords/histone-demethylase","display_name":"histone demethylase","score":0.8429999947547913},{"id":"https://openalex.org/keywords/c-jun","display_name":"c-Jun","score":0.46399998664855957},{"id":"https://openalex.org/keywords/etv1","display_name":"ETV1","score":0.996999979019165},{"id":"https://openalex.org/keywords/transcriptional-coactivation","display_name":"transcriptional coactivation","score":0.921999990940094},{"id":"https://openalex.org/keywords/prostate-cancer","display_name":"prostate cancer","score":0.9229999780654907},{"id":"https://openalex.org/keywords/post-translational-modification","display_name":"post-translational modification","score":0.8690000176429749},{"id":"https://openalex.org/keywords/arginine-substitution","display_name":"arginine substitution","score":0.39800000190734863},{"id":"https://openalex.org/keywords/lncap-cells","display_name":"LNCaP cells","score":0.718999981880188}],"concepts":[{"id":"https://openalex.org/C33288867","wikidata":"https://www.wikidata.org/wiki/Q518328","display_name":"Methylation","level":3,"score":0.6867870092391968},{"id":"https://openalex.org/C2781364455","wikidata":"https://www.wikidata.org/wiki/Q2531584","display_name":"Demethylase","level":4,"score":0.6832557916641235},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.6771113276481628},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.5740785598754883},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.5354127883911133},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.526715099811554},{"id":"https://openalex.org/C64927066","wikidata":"https://www.wikidata.org/wiki/Q36293","display_name":"Histone","level":3,"score":0.5220096707344055},{"id":"https://openalex.org/C22709980","wikidata":"https://www.wikidata.org/wiki/Q4117777","display_name":"Histone methylation","level":5,"score":0.5185320973396301},{"id":"https://openalex.org/C50171091","wikidata":"https://www.wikidata.org/wiki/Q17917770","display_name":"EZH2","level":4,"score":0.5083381533622742},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.46760621666908264},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.39670729637145996},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.38807323575019836},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3495323061943054},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.26019519567489624},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2540191113948822},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.23049715161323547},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.19035133719444275}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:pubmedcentral.nih.gov:10776875","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10776875","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10776875/pdf/ijbmb0014-0101.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Biochem Mol Biol","raw_type":"Text"},{"id":"pmid:38213775","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38213775","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of biochemistry and molecular biology","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:10776875","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10776875","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10776875/pdf/ijbmb0014-0101.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Biochem Mol Biol","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.46810001134872437}],"study_designs":[],"awards":[{"id":"https://openalex.org/G461293425","display_name":"Regulation of KDM4A by Lysine Methylation","funder_award_id":"R03CA223615","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320310179","display_name":"University of Oklahoma","ror":"https://ror.org/02aqsxs83"},{"id":"https://openalex.org/F4320315709","display_name":"Tobacco Settlement Endowment Trust","ror":null},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320333795","display_name":"Stephenson Cancer Center","ror":"https://ror.org/02bmcqd02"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4390794252.pdf","grobid_xml":"https://content.openalex.org/works/W4390794252.grobid-xml"},"referenced_works_count":103,"referenced_works":["https://openalex.org/W1570380442","https://openalex.org/W1628309714","https://openalex.org/W1831392484","https://openalex.org/W1965075655","https://openalex.org/W1974006656","https://openalex.org/W1977995427","https://openalex.org/W1980514987","https://openalex.org/W1982956833","https://openalex.org/W1990014448","https://openalex.org/W1992722664","https://openalex.org/W1992868516","https://openalex.org/W1993582197","https://openalex.org/W1994219871","https://openalex.org/W1998120891","https://openalex.org/W1998944853","https://openalex.org/W2002012961","https://openalex.org/W2005019444","https://openalex.org/W2006285635","https://openalex.org/W2016371780","https://openalex.org/W2020808779","https://openalex.org/W2023913877","https://openalex.org/W2024651117","https://openalex.org/W2026529977","https://openalex.org/W2028898542","https://openalex.org/W2029169609","https://openalex.org/W2035501810","https://openalex.org/W2040004396","https://openalex.org/W2042581231","https://openalex.org/W2044551569","https://openalex.org/W2055086957","https://openalex.org/W2057321383","https://openalex.org/W2062009057","https://openalex.org/W2068157186","https://openalex.org/W2068571186","https://openalex.org/W2070851174","https://openalex.org/W2082683729","https://openalex.org/W2085005232","https://openalex.org/W2088497968","https://openalex.org/W2105718456","https://openalex.org/W2108994842","https://openalex.org/W2115577428","https://openalex.org/W2116721679","https://openalex.org/W2120594989","https://openalex.org/W2120755323","https://openalex.org/W2121158863","https://openalex.org/W2129651872","https://openalex.org/W2138469499","https://openalex.org/W2138650316","https://openalex.org/W2140300092","https://openalex.org/W2144867041","https://openalex.org/W2147454032","https://openalex.org/W2161245944","https://openalex.org/W2228585033","https://openalex.org/W2325780118","https://openalex.org/W2330332539","https://openalex.org/W2341851576","https://openalex.org/W2412898159","https://openalex.org/W2468319890","https://openalex.org/W2483061037","https://openalex.org/W2568232071","https://openalex.org/W2739174192","https://openalex.org/W2741617449","https://openalex.org/W2788835448","https://openalex.org/W2805345163","https://openalex.org/W2887131246","https://openalex.org/W2892375047","https://openalex.org/W2892539008","https://openalex.org/W2913183913","https://openalex.org/W2914136420","https://openalex.org/W2940451799","https://openalex.org/W2940643666","https://openalex.org/W2948925278","https://openalex.org/W2971165642","https://openalex.org/W2982187280","https://openalex.org/W2997224050","https://openalex.org/W3000984028","https://openalex.org/W3032787166","https://openalex.org/W3039442292","https://openalex.org/W3082632066","https://openalex.org/W3092953074","https://openalex.org/W3102740077","https://openalex.org/W3108111879","https://openalex.org/W3134382291","https://openalex.org/W3162117965","https://openalex.org/W3184466940","https://openalex.org/W3187808633","https://openalex.org/W3197286854","https://openalex.org/W4205375279","https://openalex.org/W4210598026","https://openalex.org/W4221062521","https://openalex.org/W4224865306","https://openalex.org/W4283278171","https://openalex.org/W4285028504","https://openalex.org/W4285086494","https://openalex.org/W4295756787","https://openalex.org/W4309660098","https://openalex.org/W4310793981","https://openalex.org/W4321375687","https://openalex.org/W4321793367","https://openalex.org/W4360609162","https://openalex.org/W4383371486","https://openalex.org/W4385442292","https://openalex.org/W7112879309"],"related_works":["https://openalex.org/W4387858946","https://openalex.org/W4388763914","https://openalex.org/W7214250787","https://openalex.org/W2228585033","https://openalex.org/W2080954244","https://openalex.org/W7131629749","https://openalex.org/W7151602777","https://openalex.org/W2788835448","https://openalex.org/W3048518710","https://openalex.org/W2778765825"],"abstract_inverted_index":{"OBJECTIVES:":[0],"Jumonji":[1],"C":[2],"domain-containing":[3,117],"(JMJD)":[4],"2B":[5],"(JMJD2B)":[6],"is":[7,15,25,97,150],"a":[8,82,151,189,269],"transcriptional":[9,78],"cofactor":[10],"and":[11,50,72,196,215],"histone":[12],"demethylase":[13],"that":[14,95,273],"involved":[16],"in":[17,46,86,134,155,198,205,235],"prostate":[18,89,156,176,199,207,236,246],"cancer":[19,90,237],"formation.":[20],"However,":[21],"how":[22],"its":[23,167,228,261],"function":[24],"regulated":[26,40],"by":[27,41,277],"posttranslational":[28,128],"modification":[29],"has":[30],"remained":[31],"elusive.":[32],"Hence,":[33],"we":[34,57,107],"examined":[35],"if":[36],"JMJD2B":[37,77,96,135,162,204,224,244,251,279],"would":[38],"be":[39,275],"lysine":[42,59,65,104],"methylation.":[43],"METHODS:":[44],"Through":[45],"vitro":[47],"methylation":[48,60,132,160,222,249],"assays":[49],"Western":[51],"blotting":[52],"with":[53,81,175,188,212,230],"methyl-lysine":[54],"specific":[55],"antibodies,":[56],"analyzed":[58],"within":[61],"JMJD2B.":[62],"Identified":[63],"methylated":[64,98],"residues":[66,71,138],"were":[67],"mutated":[68],"to":[69,101,136,140,169,226],"arginine":[70,137],"the":[73,109,122,131,144,178,201,240,255],"respective":[74],"impact":[75,165,227],"on":[76,99,166],"activity":[79],"measured":[80],"reporter":[83],"gene":[84],"assay":[85],"human":[87,206],"LNCaP":[88],"cells.":[91,238],"RESULTS:":[92],"We":[93],"discovered":[94],"up":[100],"six":[102],"different":[103],"residues.":[105],"Further,":[106],"identified":[108,220],"suppressor":[110],"of":[111,114,143,161,193,203,223,243,250,257],"variegation":[112],"3-9/enhancer":[113],"zeste/trithorax":[115],"(SET)":[116],"protein":[118,154,180],"7/9":[119],"(SET7/9)":[120],"as":[121],"methyltransferase":[123],"being":[124],"responsible":[125],"for":[126,266],"this":[127],"modification.":[129],"Mutating":[130],"sites":[133],"led":[139],"diminished":[141],"coactivation":[142],"Ju-nana":[145],"(JUN)":[146],"transcription":[147,172,233],"factor,":[148],"which":[149],"known":[152],"oncogenic":[153],"tumors.":[157],"In":[158],"contrast,":[159],"had":[163],"no":[164],"ability":[168],"coactivate":[170],"another":[171],"factor":[173],"associated":[174],"cancer,":[177,200],"DNA-binding":[179],"E26":[181],"transformation-specific":[182],"(ETS)":[183],"variant":[184],"1":[185],"(ETV1).":[186],"Consistent":[187],"potential":[190],"joint":[191],"action":[192],"JMJD2B,":[194],"SET7/9":[195,214],"JUN":[197,216],"expression":[202],"tumors":[208],"was":[209],"positively":[210],"correlated":[211],"both":[213],"levels.":[217],"CONCLUSIONS:":[218],"The":[219],"SET7/9-mediated":[221,248],"appears":[225],"cooperation":[229],"selected":[231],"interacting":[232],"factors":[234],"Given":[239],"implicated":[241],"roles":[242],"beyond":[245],"tumorigenesis,":[247],"possibly":[252],"also":[253],"influences":[254],"development":[256],"other":[258],"cancers,":[259],"while":[260],"impairment":[262],"might":[263],"have":[264],"relevance":[265],"obesity":[267],"or":[268],"global":[270],"developmental":[271],"delay":[272],"can":[274],"elicited":[276],"reduced":[278],"activity.":[280]},"counts_by_year":[{"year":2025,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2024-01-13T00:00:00"}