{"id":"https://openalex.org/W4390789596","doi":"https://doi.org/10.1158/2159-8290.c.7022645","title":"Data from Xaluritamig, a STEAP1 \u00d7 CD3 XmAb 2+1 Immune Therapy for Metastatic Castration-Resistant Prostate Cancer: Results from Dose Exploration in a First-in-Human Study","display_name":"Data from Xaluritamig, a STEAP1 \u00d7 CD3 XmAb 2+1 Immune Therapy for Metastatic Castration-Resistant Prostate Cancer: Results from Dose Exploration in a First-in-Human Study","publication_year":2024,"publication_date":"2024-01-12","ids":{"openalex":"https://openalex.org/W4390789596","doi":"https://doi.org/10.1158/2159-8290.c.7022645"},"language":"en","primary_location":{"id":"doi:10.1158/2159-8290.c.7022645","doi":"https://doi.org/10.1158/2159-8290.c.7022645","is_oa":true,"landing_page_url":"https://doi.org/10.1158/2159-8290.c.7022645","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/2159-8290.c.7022645","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5063435994","display_name":"William Kevin Kelly","orcid":"https://orcid.org/0000-0003-2629-672X","observed_orcids":["https://orcid.org/0000-0003-2629-672X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"William K. Kelly","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-2629-672X","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036310901","display_name":"Daniel Costin Danila","orcid":"https://orcid.org/0000-0002-7647-0741","observed_orcids":["https://orcid.org/0000-0002-7647-0741"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Daniel C. Danila","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-7647-0741","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036446086","display_name":"Chia\u2010Chi Lin","orcid":"https://orcid.org/0000-0002-2573-5789","observed_orcids":["https://orcid.org/0000-0002-2573-5789"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Chia-Chi Lin","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-2573-5789","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063838757","display_name":"Jae\u2010Lyun Lee","orcid":"https://orcid.org/0000-0002-9420-7162","observed_orcids":["https://orcid.org/0000-0002-9420-7162"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jae-Lyun Lee","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-9420-7162","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014625956","display_name":"Nobuaki Matsubara","orcid":"https://orcid.org/0000-0002-9203-4245","observed_orcids":["https://orcid.org/0000-0002-9203-4245"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nobuaki Matsubara","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-9203-4245","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062468425","display_name":"Patrick J. Ward","orcid":"https://orcid.org/0000-0002-7800-4840","observed_orcids":["https://orcid.org/0000-0002-7800-4840"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Patrick J. Ward","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-7800-4840","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038489185","display_name":"Andrew J. Armstrong","orcid":"https://orcid.org/0000-0001-7012-1754","observed_orcids":["https://orcid.org/0000-0001-7012-1754"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Andrew J. Armstrong","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-7012-1754","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090641762","display_name":"David William Pook","orcid":"https://orcid.org/0000-0002-1744-3022","observed_orcids":["https://orcid.org/0000-0002-1744-3022"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David Pook","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-1744-3022","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100726133","display_name":"Miso Kim","orcid":"https://orcid.org/0000-0002-4064-4199","observed_orcids":["https://orcid.org/0000-0002-4064-4199"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Miso Kim","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-4064-4199","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091696839","display_name":"Tanya Barauskas Dorff","orcid":"https://orcid.org/0000-0001-5990-298X","observed_orcids":["https://orcid.org/0000-0001-5990-298X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tanya B. Dorff","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-5990-298X","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027035277","display_name":"Stefanie Fischer","orcid":"https://orcid.org/0000-0001-9609-3640","observed_orcids":["https://orcid.org/0000-0001-9609-3640"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Stefanie Fischer","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-9609-3640","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030330847","display_name":"Yung\u2010Chang Lin","orcid":"https://orcid.org/0000-0002-2084-5348","observed_orcids":["https://orcid.org/0000-0002-2084-5348"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yung-Chang Lin","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-2084-5348","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084855225","display_name":"Lisa Glen Horvath","orcid":"https://orcid.org/0000-0001-6842-9223","observed_orcids":["https://orcid.org/0000-0001-6842-9223"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lisa G. Horvath","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-6842-9223","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016875639","display_name":"Christopher Joseph Sumey","orcid":"https://orcid.org/0000-0002-9288-2236","observed_orcids":["https://orcid.org/0000-0002-9288-2236"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Christopher Sumey","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-9288-2236","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030908830","display_name":"Zhao Yang","orcid":"https://orcid.org/0000-0002-1199-1052","observed_orcids":["https://orcid.org/0000-0002-1199-1052"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zhao Yang","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-1199-1052","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004082394","display_name":"Gabor Jurida","orcid":"https://orcid.org/0009-0000-8003-1269","observed_orcids":["https://orcid.org/0009-0000-8003-1269"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gabor Jurida","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0000-8003-1269","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006727597","display_name":"Kristen M. Smith","orcid":"https://orcid.org/0000-0003-0960-0937","observed_orcids":["https://orcid.org/0000-0003-0960-0937"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kristen M. Smith","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-0960-0937","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085456274","display_name":"Jamie N. Connarn","orcid":"https://orcid.org/0000-0001-7112-7357","observed_orcids":["https://orcid.org/0000-0001-7112-7357"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jamie N. Connarn","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-7112-7357","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024288749","display_name":"Hweixian Leong Penny","orcid":"https://orcid.org/0009-0000-3212-0275","observed_orcids":["https://orcid.org/0009-0000-3212-0275"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hweixian L. Penny","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0000-3212-0275","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058424325","display_name":"Julia Stieglmaier","orcid":"https://orcid.org/0009-0009-7035-5855","observed_orcids":["https://orcid.org/0009-0009-7035-5855"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Julia Stieglmaier","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0009-7035-5855","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5012316179","display_name":"Leonard Joseph Appleman","orcid":"https://orcid.org/0000-0003-4951-7388","observed_orcids":["https://orcid.org/0000-0003-4951-7388"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Leonard J. Appleman","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-4951-7388","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.9814000129699707,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.9814000129699707,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.007899999618530273,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12534","display_name":"Protein Degradation and Inhibitors","score":0.0024999999441206455,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/steap1","display_name":"STEAP1","score":0.996999979019165},{"id":"https://openalex.org/keywords/t-cell-engagers","display_name":"T-cell engagers","score":0.8880000114440918},{"id":"https://openalex.org/keywords/cd3","display_name":"CD3","score":0.5080000162124634},{"id":"https://openalex.org/keywords/metastatic-castration-resistant-prostate-cancer","display_name":"metastatic castration-resistant prostate cancer","score":0.9549999833106995},{"id":"https://openalex.org/keywords/dose-escalation","display_name":"dose escalation","score":0.5830000042915344},{"id":"https://openalex.org/keywords/maximum-tolerated-dose","display_name":"maximum tolerated dose","score":0.9580000042915344},{"id":"https://openalex.org/keywords/cytokine-release-syndrome","display_name":"cytokine release syndrome","score":0.9810000061988831},{"id":"https://openalex.org/keywords/psa-response","display_name":"PSA response","score":0.9129999876022339},{"id":"https://openalex.org/keywords/recist-response","display_name":"RECIST response","score":0.8679999709129333},{"id":"https://openalex.org/keywords/immunotherapy","display_name":"immunotherapy","score":0.5479999780654907}],"concepts":[{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.9006052017211914},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8017020225524902},{"id":"https://openalex.org/C2777511904","wikidata":"https://www.wikidata.org/wiki/Q425227","display_name":"Taxane","level":4,"score":0.740478515625},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5426685214042664},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5050047039985657},{"id":"https://openalex.org/C2776235491","wikidata":"https://www.wikidata.org/wiki/Q9625","display_name":"Prostate","level":3,"score":0.5034295916557312},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.48808467388153076},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4754083752632141},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.4392070174217224},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.37906700372695923},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.12075942754745483}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1158/2159-8290.c.7022645","doi":"https://doi.org/10.1158/2159-8290.c.7022645","is_oa":true,"landing_page_url":"https://doi.org/10.1158/2159-8290.c.7022645","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},{"id":"doi:10.1158/2159-8290.c.7022645.v1","doi":"https://doi.org/10.1158/2159-8290.c.7022645.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/2159-8290.c.7022645.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/2159-8290.c.7022645","doi":"https://doi.org/10.1158/2159-8290.c.7022645","is_oa":true,"landing_page_url":"https://doi.org/10.1158/2159-8290.c.7022645","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4387798677","https://openalex.org/W4389280670","https://openalex.org/W4387810329","https://openalex.org/W4410809399","https://openalex.org/W4390819144","https://openalex.org/W7162660031","https://openalex.org/W4387797966","https://openalex.org/W4402560265","https://openalex.org/W4409690745","https://openalex.org/W7162545775"],"abstract_inverted_index":{"Abstract":[0],"Xaluritamig":[1,137,154],"(AMG":[2],"509)":[3],"is":[4,138,223],"a":[5,75,139,181,190],"six-transmembrane":[6],"epithelial":[7],"antigen":[8,109],"of":[9,20,175,197],"the":[10],"prostate":[11,29,43,143,185,200],"1":[12,100],"(STEAP1)\u2013targeted":[13],"T-cell":[14,178],"engager":[15],"designed":[16],"to":[17,58],"facilitate":[18],"lysis":[19],"STEAP1-expressing":[21],"cancer":[22,44,144],"cells,":[23],"such":[24],"as":[25,69,180,189],"those":[26],"in":[27,199,225],"advanced":[28],"cancer.":[30,201],"This":[31,171,221,229],"first-in-human":[32],"study":[33,172],"reports":[34],"monotherapy":[35],"dose":[36,54],"exploration":[37],"for":[38,142,166,177,184],"patients":[39,50,167],"with":[40,103,125,162,168],"metastatic":[41],"castration-resistant":[42],"(mCRPC),":[45],"primarily":[46,97],"taxane":[47],"pretreated.":[48],"Ninety-seven":[49],"received":[51],"\u22651":[52],"intravenous":[53],"ranging":[55],"from":[56,228],"0.001":[57],"2.0":[59],"mg":[60,71,132],"weekly":[61,73],"or":[62],"every":[63],"2":[64],"weeks.":[65],"MTD":[66],"was":[67],"identified":[68],"1.5":[70],"i.v.":[72],"via":[74],"3-step":[76],"dose.":[77],"The":[78],"most":[79],"common":[80],"treatment-related":[81],"adverse":[82],"events":[83],"were":[84,116],"cytokine":[85],"release":[86],"syndrome":[87],"(CRS;":[88],"72%),":[89],"fatigue":[90],"(45%),":[91],"and":[92,101,105,111,159,192],"myalgia":[93],"(34%).":[94],"CRS":[95],"occurred":[96],"during":[98],"cycle":[99],"improved":[102],"premedication":[104],"step":[106],"dosing.":[107],"Prostate-specific":[108],"(PSA)":[110],"RECIST":[112],"responses":[113,157],"across":[114],"cohorts":[115],"encouraging":[117,148,156],"[49%":[118],"PSA50;":[119,134],"24%":[120],"objective":[121],"response":[122],"rate":[123],"(ORR)],":[124],"greater":[126],"frequency":[127],"at":[128],"target":[129],"doses":[130],"\u22650.75":[131],"(59%":[133],"41%":[135],"ORR).":[136],"novel":[140],"immunotherapy":[141],"that":[145],"has":[146],"shown":[147],"results":[149],"supporting":[150],"further":[151,194],"development.":[152],"Significance:":[153],"demonstrated":[155],"(PSA":[158],"RECIST)":[160],"compared":[161],"historical":[163],"established":[164],"treatments":[165],"late-line":[169],"mCRPC.":[170],"provides":[173],"proof":[174],"concept":[176],"engagers":[179],"potential":[182],"treatment":[183],"cancer,":[186],"validates":[187],"STEAP1":[188],"target,":[191],"supports":[193],"clinical":[195],"investigation":[196],"xaluritamig":[198],"See":[202,212],"related":[203,213],"commentary":[204],"by":[205,215],"Hage":[206],"Chehade":[207],"et":[208,217],"al.,":[209,218],"p.":[210,219,231],"20.":[211],"article":[214,222],"Nolan-Stevaux":[216],"90.":[220],"featured":[224],"Selected":[226],"Articles":[227],"Issue,":[230],"5":[232]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2024-01-13T00:00:00"}