{"id":"https://openalex.org/W4390789294","doi":"https://doi.org/10.1038/s41598-024-51689-1","title":"Investigation of the effects of T-2 toxin in chicken-derived three-dimensional hepatic cell cultures","display_name":"Investigation of the effects of T-2 toxin in chicken-derived three-dimensional hepatic cell cultures","publication_year":2024,"publication_date":"2024-01-12","ids":{"openalex":"https://openalex.org/W4390789294","doi":"https://doi.org/10.1038/s41598-024-51689-1","pmid":"https://pubmed.ncbi.nlm.nih.gov/38216675","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10786837"},"language":"en","primary_location":{"id":"doi:10.1038/s41598-024-51689-1","doi":"https://doi.org/10.1038/s41598-024-51689-1","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-024-51689-1","pdf_url":"https://www.nature.com/articles/s41598-024-51689-1.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41598-024-51689-1.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5090298540","display_name":"J\u00falia V\u00f6r\u00f6sh\u00e1zi","orcid":"https://orcid.org/0000-0003-0706-7972","observed_orcids":["https://orcid.org/0000-0003-0706-7972"]},"institutions":[{"id":"https://openalex.org/I4210136554","display_name":"University of Veterinary Medicine","ror":"https://ror.org/03vayv672","country_code":"HU","type":"education","lineage":["https://openalex.org/I4210136554"]}],"countries":["HU"],"is_corresponding":true,"raw_author_name":"J\u00falia V\u00f6r\u00f6sh\u00e1zi","raw_affiliation_strings":["Division of Biochemistry, Department of Physiology and Biochemistry, University of Veterinary Medicine, Budapest, 1078, Hungary. Voroshazi.julia@univet.hu","Division of Biochemistry, Department of Physiology and Biochemistry, University of Veterinary Medicine, Budapest, 1078, Hungary"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Biochemistry, Department of Physiology and Biochemistry, University of Veterinary Medicine, Budapest, 1078, Hungary. Voroshazi.julia@univet.hu","institution_ids":["https://openalex.org/I4210136554"]},{"raw_affiliation_string":"Division of Biochemistry, Department of Physiology and Biochemistry, University of Veterinary Medicine, Budapest, 1078, Hungary","institution_ids":["https://openalex.org/I4210136554"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000824682","display_name":"M\u00e1t\u00e9 Mackei","orcid":"https://orcid.org/0000-0001-5992-6797","observed_orcids":["https://orcid.org/0000-0001-5992-6797"]},"institutions":[{"id":"https://openalex.org/I4210136554","display_name":"University of Veterinary Medicine","ror":"https://ror.org/03vayv672","country_code":"HU","type":"education","lineage":["https://openalex.org/I4210136554"]}],"countries":["HU"],"is_corresponding":false,"raw_author_name":"M\u00e1t\u00e9 Mackei","raw_affiliation_strings":["Division of Biochemistry, Department of Physiology and Biochemistry, University of Veterinary Medicine, Budapest, 1078, Hungary","National Laboratory of Infectious Animal Diseases, Antimicrobial Resistance, Veterinary Public Health and Food Chain Safety, University of Veterinary Medicine, Budapest, 1078, Hungary"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Biochemistry, Department of Physiology and Biochemistry, University of Veterinary Medicine, Budapest, 1078, Hungary","institution_ids":["https://openalex.org/I4210136554"]},{"raw_affiliation_string":"National Laboratory of Infectious Animal Diseases, Antimicrobial Resistance, Veterinary Public Health and Food Chain Safety, University of Veterinary Medicine, Budapest, 1078, Hungary","institution_ids":["https://openalex.org/I4210136554"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072850056","display_name":"Csilla Seb\u0151k","orcid":"https://orcid.org/0000-0003-1498-3127","observed_orcids":["https://orcid.org/0000-0003-1498-3127"]},"institutions":[{"id":"https://openalex.org/I4210136554","display_name":"University of Veterinary Medicine","ror":"https://ror.org/03vayv672","country_code":"HU","type":"education","lineage":["https://openalex.org/I4210136554"]}],"countries":["HU"],"is_corresponding":false,"raw_author_name":"Csilla Seb\u0151k","raw_affiliation_strings":["Division of Biochemistry, Department of Physiology and Biochemistry, University of Veterinary Medicine, Budapest, 1078, Hungary"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Biochemistry, Department of Physiology and Biochemistry, University of Veterinary Medicine, Budapest, 1078, Hungary","institution_ids":["https://openalex.org/I4210136554"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047647397","display_name":"Patrik Tr\u00e1j","orcid":"https://orcid.org/0000-0002-2323-9634","observed_orcids":["https://orcid.org/0000-0002-2323-9634"]},"institutions":[{"id":"https://openalex.org/I4210136554","display_name":"University of Veterinary Medicine","ror":"https://ror.org/03vayv672","country_code":"HU","type":"education","lineage":["https://openalex.org/I4210136554"]}],"countries":["HU"],"is_corresponding":false,"raw_author_name":"Patrik Tr\u00e1j","raw_affiliation_strings":["Division of Biochemistry, Department of Physiology and Biochemistry, University of Veterinary Medicine, Budapest, 1078, Hungary"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Biochemistry, Department of Physiology and Biochemistry, University of Veterinary Medicine, Budapest, 1078, Hungary","institution_ids":["https://openalex.org/I4210136554"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023693525","display_name":"Rege Anna M\u00e1rton","orcid":"https://orcid.org/0009-0006-2463-2311","observed_orcids":["https://orcid.org/0009-0006-2463-2311"]},"institutions":[{"id":"https://openalex.org/I4210136554","display_name":"University of Veterinary Medicine","ror":"https://ror.org/03vayv672","country_code":"HU","type":"education","lineage":["https://openalex.org/I4210136554"]}],"countries":["HU"],"is_corresponding":false,"raw_author_name":"Rege Anna M\u00e1rton","raw_affiliation_strings":["Division of Biochemistry, Department of Physiology and Biochemistry, University of Veterinary Medicine, Budapest, 1078, Hungary","National Laboratory of Infectious Animal Diseases, Antimicrobial Resistance, Veterinary Public Health and Food Chain Safety, University of Veterinary Medicine, Budapest, 1078, Hungary"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Biochemistry, Department of Physiology and Biochemistry, University of Veterinary Medicine, Budapest, 1078, Hungary","institution_ids":["https://openalex.org/I4210136554"]},{"raw_affiliation_string":"National Laboratory of Infectious Animal Diseases, Antimicrobial Resistance, Veterinary Public Health and Food Chain Safety, University of Veterinary Medicine, Budapest, 1078, Hungary","institution_ids":["https://openalex.org/I4210136554"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030063885","display_name":"D\u00e1vid G\u00e9za Horv\u00e1th","orcid":"https://orcid.org/0000-0003-4844-4543","observed_orcids":["https://orcid.org/0000-0003-4844-4543"]},"institutions":[{"id":"https://openalex.org/I4210136554","display_name":"University of Veterinary Medicine","ror":"https://ror.org/03vayv672","country_code":"HU","type":"education","lineage":["https://openalex.org/I4210136554"]}],"countries":["HU"],"is_corresponding":false,"raw_author_name":"D\u00e1vid G\u00e9za Horv\u00e1th","raw_affiliation_strings":["Department of Pathology, University of Veterinary Medicine, Budapest, 1078, Hungary"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, University of Veterinary Medicine, Budapest, 1078, Hungary","institution_ids":["https://openalex.org/I4210136554"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038100921","display_name":"Korinna Huber","orcid":"https://orcid.org/0000-0002-1293-8472","observed_orcids":["https://orcid.org/0000-0002-1293-8472"]},"institutions":[{"id":"https://openalex.org/I110079840","display_name":"University of Hohenheim","ror":"https://ror.org/00b1c9541","country_code":"DE","type":"education","lineage":["https://openalex.org/I110079840"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Korinna Huber","raw_affiliation_strings":["Institute of Animal Science, University of Hohenheim, 70599, Stuttgart, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Animal Science, University of Hohenheim, 70599, Stuttgart, Germany","institution_ids":["https://openalex.org/I110079840"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033275024","display_name":"Zsuzsanna Neogr\u00e1dy","orcid":"https://orcid.org/0000-0002-0139-1942","observed_orcids":["https://orcid.org/0000-0002-0139-1942"]},"institutions":[{"id":"https://openalex.org/I4210136554","display_name":"University of Veterinary Medicine","ror":"https://ror.org/03vayv672","country_code":"HU","type":"education","lineage":["https://openalex.org/I4210136554"]}],"countries":["HU"],"is_corresponding":false,"raw_author_name":"Zsuzsanna Neogr\u00e1dy","raw_affiliation_strings":["Division of Biochemistry, Department of Physiology and Biochemistry, University of Veterinary Medicine, Budapest, 1078, Hungary"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Biochemistry, Department of Physiology and Biochemistry, University of Veterinary Medicine, Budapest, 1078, Hungary","institution_ids":["https://openalex.org/I4210136554"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5003945909","display_name":"G\u00e1bor M\u00e1tis","orcid":"https://orcid.org/0000-0001-7371-9444","observed_orcids":["https://orcid.org/0000-0001-7371-9444"]},"institutions":[{"id":"https://openalex.org/I4210136554","display_name":"University of Veterinary Medicine","ror":"https://ror.org/03vayv672","country_code":"HU","type":"education","lineage":["https://openalex.org/I4210136554"]}],"countries":["HU"],"is_corresponding":false,"raw_author_name":"G\u00e1bor M\u00e1tis","raw_affiliation_strings":["Division of Biochemistry, Department of Physiology and Biochemistry, University of Veterinary Medicine, Budapest, 1078, Hungary","National Laboratory of Infectious Animal Diseases, Antimicrobial Resistance, Veterinary Public Health and Food Chain Safety, University of Veterinary Medicine, Budapest, 1078, Hungary"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Biochemistry, Department of Physiology and Biochemistry, University of Veterinary Medicine, Budapest, 1078, Hungary","institution_ids":["https://openalex.org/I4210136554"]},{"raw_affiliation_string":"National Laboratory of Infectious Animal Diseases, Antimicrobial Resistance, Veterinary Public Health and Food Chain Safety, University of Veterinary Medicine, Budapest, 1078, Hungary","institution_ids":["https://openalex.org/I4210136554"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5090298540"],"corresponding_institution_ids":["https://openalex.org/I4210136554"],"apc_list":{"value":2590,"currency":"USD","value_usd":2590},"apc_paid":{"value":2590,"currency":"USD","value_usd":2590},"fwci":1.8669,"has_fulltext":true,"cited_by_count":9,"citation_normalized_percentile":{"value":0.8346114,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"14","issue":"1","first_page":"1195","last_page":"1195"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10520","display_name":"Mycotoxins in Agriculture and Food","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10520","display_name":"Mycotoxins in Agriculture and Food","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14072","display_name":"Immunotoxicology and immune responses","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/t-2-toxin","display_name":"T-2 toxin","score":0.996999979019165},{"id":"https://openalex.org/keywords/mycotoxin-toxicity","display_name":"mycotoxin toxicity","score":0.8759999871253967},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.8330000042915344},{"id":"https://openalex.org/keywords/antioxidant-response","display_name":"antioxidant response","score":0.6349999904632568},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.7350000143051147},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.9190000295639038},{"id":"https://openalex.org/keywords/interleukin-8","display_name":"interleukin-8","score":1.0},{"id":"https://openalex.org/keywords/lipid-metabolism","display_name":"lipid metabolism","score":0.6639999747276306},{"id":"https://openalex.org/keywords/amino-acid-metabolism","display_name":"amino acid metabolism","score":1.0},{"id":"https://openalex.org/keywords/hepatocyte-viability","display_name":"hepatocyte viability","score":0.5770000219345093},{"id":"https://openalex.org/keywords/poultry-feed-contamination","display_name":"poultry feed contamination","score":0.7450000047683716}],"concepts":[{"id":"https://openalex.org/C2777367657","wikidata":"https://www.wikidata.org/wiki/Q184651","display_name":"Toxin","level":2,"score":0.8515641093254089},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.6161051988601685},{"id":"https://openalex.org/C2777318727","wikidata":"https://www.wikidata.org/wiki/Q409464","display_name":"Lactate dehydrogenase","level":3,"score":0.6097234487533569},{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.584854781627655},{"id":"https://openalex.org/C2778401633","wikidata":"https://www.wikidata.org/wiki/Q418661","display_name":"Malondialdehyde","level":3,"score":0.5684384703636169},{"id":"https://openalex.org/C53227056","wikidata":"https://www.wikidata.org/wiki/Q189152","display_name":"Viability assay","level":3,"score":0.49082478880882263},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.4703778624534607},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4249362647533417},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4191981256008148},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.40890267491340637},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.39361444115638733},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.36022132635116577},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.10421252250671387}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002645","descriptor_name":"Chickens","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013605","descriptor_name":"T-2 Toxin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013605","descriptor_name":"T-2 Toxin","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018929","descriptor_name":"Cell Culture Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1038/s41598-024-51689-1","doi":"https://doi.org/10.1038/s41598-024-51689-1","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-024-51689-1","pdf_url":"https://www.nature.com/articles/s41598-024-51689-1.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10786837","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10786837","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10786837/pdf/41598_2024_Article_51689.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sci Rep","raw_type":"Text"},{"id":"pmid:38216675","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38216675","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific reports","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:e6f355a2b03042289cd993836379a19f","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/e6f355a2b03042289cd993836379a19f","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Scientific Reports, Vol 14, Iss 1, Pp 1-16 (2024)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1038/s41598-024-51689-1","doi":"https://doi.org/10.1038/s41598-024-51689-1","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-024-51689-1","pdf_url":"https://www.nature.com/articles/s41598-024-51689-1.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[{"id":"https://openalex.org/G8308698986","display_name":null,"funder_award_id":"OTKA FK 134940","funder_id":"https://openalex.org/F4320326762","funder_display_name":"Nemzeti Kutat\u00e1si Fejleszt\u00e9si \u00e9s Innov\u00e1ci\u00f3s Hivatal"}],"funders":[{"id":"https://openalex.org/F4320311402","display_name":"Universit\u00e4t Hohenheim","ror":"https://ror.org/00b1c9541"},{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"},{"id":"https://openalex.org/F4320326762","display_name":"Nemzeti Kutat\u00e1si Fejleszt\u00e9si \u00e9s Innov\u00e1ci\u00f3s Hivatal","ror":null},{"id":"https://openalex.org/F6460977599","display_name":"\u00c1llatorvostudom\u00e1nyi Egyetem","ror":"https://ror.org/03vayv672"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4390789294.pdf","grobid_xml":"https://content.openalex.org/works/W4390789294.grobid-xml"},"referenced_works_count":90,"referenced_works":["https://openalex.org/W1508080975","https://openalex.org/W1531237901","https://openalex.org/W1963632309","https://openalex.org/W1965540205","https://openalex.org/W1970121621","https://openalex.org/W1974915274","https://openalex.org/W1980851826","https://openalex.org/W1985137513","https://openalex.org/W1990815615","https://openalex.org/W1992750787","https://openalex.org/W1993370376","https://openalex.org/W2002207827","https://openalex.org/W2003246080","https://openalex.org/W2005855703","https://openalex.org/W2008593502","https://openalex.org/W2012052968","https://openalex.org/W2013697353","https://openalex.org/W2014344801","https://openalex.org/W2015095581","https://openalex.org/W2017202952","https://openalex.org/W2018183596","https://openalex.org/W2024584462","https://openalex.org/W2026632576","https://openalex.org/W2028331558","https://openalex.org/W2028619725","https://openalex.org/W2028943470","https://openalex.org/W2037831532","https://openalex.org/W2044116574","https://openalex.org/W2047253953","https://openalex.org/W2048493065","https://openalex.org/W2061169138","https://openalex.org/W2066804807","https://openalex.org/W2080627209","https://openalex.org/W2087821048","https://openalex.org/W2095295709","https://openalex.org/W2106172943","https://openalex.org/W2115179369","https://openalex.org/W2118371701","https://openalex.org/W2126914275","https://openalex.org/W2129775839","https://openalex.org/W2130222980","https://openalex.org/W2132737853","https://openalex.org/W2141667823","https://openalex.org/W2143777550","https://openalex.org/W2146180618","https://openalex.org/W2182405985","https://openalex.org/W2213201605","https://openalex.org/W2241377065","https://openalex.org/W2251658869","https://openalex.org/W2327204928","https://openalex.org/W2522454612","https://openalex.org/W2589618728","https://openalex.org/W2593341591","https://openalex.org/W2604695785","https://openalex.org/W2614198225","https://openalex.org/W2615924507","https://openalex.org/W2739502069","https://openalex.org/W2766142559","https://openalex.org/W2774928962","https://openalex.org/W2789893155","https://openalex.org/W2795681973","https://openalex.org/W2805716713","https://openalex.org/W2808274868","https://openalex.org/W2894585751","https://openalex.org/W2898153869","https://openalex.org/W2907953604","https://openalex.org/W2915280035","https://openalex.org/W2949120942","https://openalex.org/W2954477018","https://openalex.org/W2978671410","https://openalex.org/W2983803719","https://openalex.org/W2999870391","https://openalex.org/W3003458343","https://openalex.org/W3009424702","https://openalex.org/W3046039466","https://openalex.org/W3093725611","https://openalex.org/W3117628944","https://openalex.org/W3120195292","https://openalex.org/W3128950184","https://openalex.org/W3139442710","https://openalex.org/W3169829812","https://openalex.org/W3173208004","https://openalex.org/W3175798988","https://openalex.org/W3185481341","https://openalex.org/W3197616850","https://openalex.org/W3206216003","https://openalex.org/W3212864281","https://openalex.org/W4282001730","https://openalex.org/W4306294633","https://openalex.org/W4321169779"],"related_works":["https://openalex.org/W7128475025","https://openalex.org/W2999870391","https://openalex.org/W4403348947","https://openalex.org/W2068194495","https://openalex.org/W7213441809","https://openalex.org/W7167614573","https://openalex.org/W4413121628","https://openalex.org/W2210050562","https://openalex.org/W2612454309","https://openalex.org/W2990877963"],"abstract_inverted_index":{"Despite":[0],"being":[1],"one":[2],"of":[3,8,14,20,36,64,101,119,146,153,167,196],"the":[4,11,18,21,34,42,81,112,120,123,142,147,150,160,193,197],"most":[5],"common":[6],"contaminants":[7],"poultry":[9],"feed,":[10],"molecular":[12],"effects":[13,35,190],"T-2":[15,37,65,96,138,175],"toxin":[16,38,66,97,139,176],"on":[17,172],"liver":[19,169],"exposed":[22],"animals":[23],"are":[24],"still":[25],"not":[26],"fully":[27],"elucidated.":[28],"To":[29],"gain":[30],"more":[31],"accurate":[32],"understanding,":[33],"were":[39,55,109],"investigated":[40],"in":[41,45,74],"present":[43],"study":[44],"chicken-derived":[46],"three-dimensional":[47],"(3D)":[48],"primary":[49],"hepatic":[50,154],"cell":[51,178],"cultures.":[52],"3D":[53],"spheroids":[54,155],"treated":[56,76],"with":[57],"three":[58],"concentrations":[59],"(100,":[60],"500,":[61],"1000":[62],"nM)":[63],"for":[67],"24":[68],"h.":[69],"Cellular":[70],"metabolic":[71,151],"activity":[72,90],"declined":[73],"all":[75],"groups":[77],"as":[78],"reflected":[79],"by":[80,111,135,191],"Cell":[82],"Counting":[83],"Kit-8":[84],"assay,":[85],"while":[86,130],"extracellular":[87],"lactate":[88],"dehydrogenase":[89],"was":[91,128,133,156],"increased":[92,134],"after":[93],"500":[94],"nM":[95,137],"exposure.":[98],"The":[99],"levels":[100],"oxidative":[102,194],"stress":[103],"markers":[104],"malondialdehyde":[105],"and":[106,163,182],"protein":[107],"carbonyl":[108],"reduced":[110],"toxin,":[113],"suggesting":[114],"effective":[115],"antioxidant":[116],"compensatory":[117],"mechanisms":[118],"liver.":[121],"Concerning":[122],"pro-inflammatory":[124],"cytokines,":[125],"IL-6":[126],"concentration":[127,132],"decreased,":[129],"IL-8":[131],"100":[136],"exposure,":[140],"indicating":[141],"multifaceted":[143],"immunomodulatory":[144],"action":[145],"toxin.":[148],"Further,":[149],"profile":[152],"also":[157],"modulated,":[158],"confirming":[159],"altered":[161],"lipid":[162],"amino":[164],"acid":[165],"metabolism":[166,181],"toxin-exposed":[168],"cells.":[170,198],"Based":[171],"these":[173],"results,":[174],"affected":[177],"viability,":[179],"hepatocellular":[180],"inflammatory":[183],"response,":[184],"likely":[185],"carried":[186],"out":[187],"its":[188],"toxic":[189],"affecting":[192],"homeostasis":[195]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":1}],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2024-01-13T00:00:00"}