{"id":"https://openalex.org/W4390777595","doi":"https://doi.org/10.21926/obm.neurobiol.2401207","title":"Neuroprotective Effects and Cognitive Enhancement of Allomargaritarine in 5xFAD Alzheimer's Disease Mice Model","display_name":"Neuroprotective Effects and Cognitive Enhancement of Allomargaritarine in 5xFAD Alzheimer's Disease Mice Model","publication_year":2024,"publication_date":"2024-01-09","ids":{"openalex":"https://openalex.org/W4390777595","doi":"https://doi.org/10.21926/obm.neurobiol.2401207"},"language":"en","primary_location":{"id":"doi:10.21926/obm.neurobiol.2401207","doi":"https://doi.org/10.21926/obm.neurobiol.2401207","is_oa":true,"landing_page_url":"https://doi.org/10.21926/obm.neurobiol.2401207","pdf_url":"https://www.lidsen.com/journals/neurobiology/neurobiology-08-01-207/obm.neurobiol.2401207.pdf","source":{"id":"https://openalex.org/S4210221663","display_name":"OBM Neurobiology","issn_l":"2573-4407","issn":["2573-4407"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1","poland-20","russia-white-list-4"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"OBM Neurobiology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://www.lidsen.com/journals/neurobiology/neurobiology-08-01-207/obm.neurobiol.2401207.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5033413678","display_name":"Yulia R. Aleksandrova","orcid":"https://orcid.org/0000-0002-5370-3370","observed_orcids":["https://orcid.org/0000-0002-5370-3370"]},"institutions":[{"id":"https://openalex.org/I1313323035","display_name":"Russian Academy of Sciences","ror":"https://ror.org/05qrfxd25","country_code":"RU","type":"government","lineage":["https://openalex.org/I1313323035"]},{"id":"https://openalex.org/I4210162996","display_name":"Institute of Physiologically Active Compounds","ror":"https://ror.org/05xw3yj26","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210145551","https://openalex.org/I4210162996"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Yulia Aleksandrova","raw_affiliation_strings":[". Institute of Physiologically Active Compounds at Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences, 142432, Chernogolovka, Russia;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":". Institute of Physiologically Active Compounds at Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences, 142432, Chernogolovka, Russia;","institution_ids":["https://openalex.org/I1313323035","https://openalex.org/I4210162996"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067878943","display_name":"\u0410. \u0412. \u0421\u0435\u043c\u0430\u043a\u043e\u0432","orcid":"https://orcid.org/0000-0002-6434-8976","observed_orcids":["https://orcid.org/0000-0002-6434-8976"]},"institutions":[{"id":"https://openalex.org/I1313323035","display_name":"Russian Academy of Sciences","ror":"https://ror.org/05qrfxd25","country_code":"RU","type":"government","lineage":["https://openalex.org/I1313323035"]},{"id":"https://openalex.org/I4210162996","display_name":"Institute of Physiologically Active Compounds","ror":"https://ror.org/05xw3yj26","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210145551","https://openalex.org/I4210162996"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Alexey Semakov","raw_affiliation_strings":[". Institute of Physiologically Active Compounds at Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences, 142432, Chernogolovka, Russia;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":". Institute of Physiologically Active Compounds at Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences, 142432, Chernogolovka, Russia;","institution_ids":["https://openalex.org/I1313323035","https://openalex.org/I4210162996"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006984146","display_name":"Dmitry O. Tsypyshev","orcid":"https://orcid.org/0000-0003-4551-0226","observed_orcids":["https://orcid.org/0000-0003-4551-0226"]},"institutions":[{"id":"https://openalex.org/I4210096179","display_name":"Novosibirsk Institute of Organic Chemistry","ror":"https://ror.org/00tgps059","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210096179","https://openalex.org/I4210145551"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Dmitry Tsypyshev","raw_affiliation_strings":[". Department of Medicinal Chemistry, Novosibirsk Institute of Organic Chemistry, Lavrentiev av. 9, Novosibirsk, 630090, Russia;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":". Department of Medicinal Chemistry, Novosibirsk Institute of Organic Chemistry, Lavrentiev av. 9, Novosibirsk, 630090, Russia;","institution_ids":["https://openalex.org/I4210096179"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001684239","display_name":"Kirill Chaprov","orcid":"https://orcid.org/0000-0002-0258-1879","observed_orcids":["https://orcid.org/0000-0002-0258-1879"]},"institutions":[{"id":"https://openalex.org/I1313323035","display_name":"Russian Academy of Sciences","ror":"https://ror.org/05qrfxd25","country_code":"RU","type":"government","lineage":["https://openalex.org/I1313323035"]},{"id":"https://openalex.org/I4210162996","display_name":"Institute of Physiologically Active Compounds","ror":"https://ror.org/05xw3yj26","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210145551","https://openalex.org/I4210162996"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Kirill Chaprov","raw_affiliation_strings":[". Institute of Physiologically Active Compounds at Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences, 142432, Chernogolovka, Russia;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":". Institute of Physiologically Active Compounds at Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences, 142432, Chernogolovka, Russia;","institution_ids":["https://openalex.org/I1313323035","https://openalex.org/I4210162996"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078225383","display_name":"Sergey G. Klochkov","orcid":"https://orcid.org/0000-0002-0299-9183","observed_orcids":["https://orcid.org/0000-0002-0299-9183"]},"institutions":[{"id":"https://openalex.org/I1313323035","display_name":"Russian Academy of Sciences","ror":"https://ror.org/05qrfxd25","country_code":"RU","type":"government","lineage":["https://openalex.org/I1313323035"]},{"id":"https://openalex.org/I4210162996","display_name":"Institute of Physiologically Active Compounds","ror":"https://ror.org/05xw3yj26","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210145551","https://openalex.org/I4210162996"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Sergey Klochkov","raw_affiliation_strings":[". Institute of Physiologically Active Compounds at Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences, 142432, Chernogolovka, Russia;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":". Institute of Physiologically Active Compounds at Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences, 142432, Chernogolovka, Russia;","institution_ids":["https://openalex.org/I1313323035","https://openalex.org/I4210162996"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5045070576","display_name":"\u041c\u0430\u0440\u0433\u0430\u0440\u0438\u0442\u0430 \u0415. \u041d\u0435\u0433\u0430\u043d\u043e\u0432\u0430","orcid":"https://orcid.org/0000-0001-9346-5920","observed_orcids":["https://orcid.org/0000-0001-9346-5920"]},"institutions":[{"id":"https://openalex.org/I1313323035","display_name":"Russian Academy of Sciences","ror":"https://ror.org/05qrfxd25","country_code":"RU","type":"government","lineage":["https://openalex.org/I1313323035"]},{"id":"https://openalex.org/I4210162996","display_name":"Institute of Physiologically Active Compounds","ror":"https://ror.org/05xw3yj26","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210145551","https://openalex.org/I4210162996"]}],"countries":["RU"],"is_corresponding":true,"raw_author_name":"Margarita Neganova","raw_affiliation_strings":[". Institute of Physiologically Active Compounds at Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences, 142432, Chernogolovka, Russia;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":". Institute of Physiologically Active Compounds at Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences, 142432, Chernogolovka, Russia;","institution_ids":["https://openalex.org/I1313323035","https://openalex.org/I4210162996"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5045070576"],"corresponding_institution_ids":["https://openalex.org/I1313323035","https://openalex.org/I4210162996"],"apc_list":null,"apc_paid":null,"fwci":0.9634,"has_fulltext":true,"cited_by_count":7,"citation_normalized_percentile":{"value":0.69328734,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":97},"biblio":{"volume":"08","issue":"01","first_page":"1","last_page":"33"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12023","display_name":"Cholinesterase and Neurodegenerative Diseases","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12891","display_name":"Medicinal Plants and Neuroprotection","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/securinine","display_name":"securinine","score":0.925000011920929},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.8370000123977661},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9480000138282776},{"id":"https://openalex.org/keywords/5xfad-mice","display_name":"5xFAD mice","score":0.9070000052452087},{"id":"https://openalex.org/keywords/amyloid-beta-aggregation","display_name":"amyloid-beta aggregation","score":0.8309999704360962},{"id":"https://openalex.org/keywords/amyloid-beta-1-42","display_name":"amyloid-beta 42","score":0.8489999771118164},{"id":"https://openalex.org/keywords/cognitive-enhancement","display_name":"cognitive enhancement","score":0.6850000023841858},{"id":"https://openalex.org/keywords/memory-impairment","display_name":"memory impairment","score":0.7039999961853027},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.9110000133514404},{"id":"https://openalex.org/keywords/amyloid-deposits","display_name":"amyloid deposits","score":0.8379999995231628},{"id":"https://openalex.org/keywords/lewis-acid-catalysis","display_name":"Lewis acid catalysis","score":0.6819999814033508},{"id":"https://openalex.org/keywords/natural-product-derivatives","display_name":"natural product derivatives","score":0.8289999961853027}],"concepts":[{"id":"https://openalex.org/C25498285","wikidata":"https://www.wikidata.org/wiki/Q1981368","display_name":"Neuroprotection","level":2,"score":0.9242644309997559},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.6131849884986877},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5877517461776733},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.5477017164230347},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.511191189289093},{"id":"https://openalex.org/C141035611","wikidata":"https://www.wikidata.org/wiki/Q5532934","display_name":"Genetically modified mouse","level":4,"score":0.5103599429130554},{"id":"https://openalex.org/C2777633098","wikidata":"https://www.wikidata.org/wiki/Q2736051","display_name":"Amyloid (mycology)","level":2,"score":0.45684516429901123},{"id":"https://openalex.org/C2984863031","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Cognitive decline","level":4,"score":0.44907480478286743},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.43589380383491516},{"id":"https://openalex.org/C102230213","wikidata":"https://www.wikidata.org/wiki/Q430117","display_name":"Transgene","level":3,"score":0.4104553461074829},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.37359482049942017},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3538236618041992},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2976130545139313},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.24556279182434082},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2212211787700653},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.18681606650352478},{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.15336334705352783},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C179104552","wikidata":"https://www.wikidata.org/wiki/Q11165","display_name":"Inorganic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.21926/obm.neurobiol.2401207","doi":"https://doi.org/10.21926/obm.neurobiol.2401207","is_oa":true,"landing_page_url":"https://doi.org/10.21926/obm.neurobiol.2401207","pdf_url":"https://www.lidsen.com/journals/neurobiology/neurobiology-08-01-207/obm.neurobiol.2401207.pdf","source":{"id":"https://openalex.org/S4210221663","display_name":"OBM Neurobiology","issn_l":"2573-4407","issn":["2573-4407"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1","poland-20","russia-white-list-4"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"OBM Neurobiology","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.21926/obm.neurobiol.2401207","doi":"https://doi.org/10.21926/obm.neurobiol.2401207","is_oa":true,"landing_page_url":"https://doi.org/10.21926/obm.neurobiol.2401207","pdf_url":"https://www.lidsen.com/journals/neurobiology/neurobiology-08-01-207/obm.neurobiol.2401207.pdf","source":{"id":"https://openalex.org/S4210221663","display_name":"OBM Neurobiology","issn_l":"2573-4407","issn":["2573-4407"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1","poland-20","russia-white-list-4"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"OBM Neurobiology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9789000153541565,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320334801","display_name":"Russian Academy of Sciences","ror":"https://ror.org/05qrfxd25"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4390777595.pdf","grobid_xml":"https://content.openalex.org/works/W4390777595.grobid-xml"},"referenced_works_count":53,"referenced_works":["https://openalex.org/W1903912475","https://openalex.org/W1965401475","https://openalex.org/W1969215331","https://openalex.org/W1970636571","https://openalex.org/W1975691556","https://openalex.org/W1991483463","https://openalex.org/W2031168104","https://openalex.org/W2042235042","https://openalex.org/W2052765057","https://openalex.org/W2066562615","https://openalex.org/W2070624290","https://openalex.org/W2070700156","https://openalex.org/W2070998719","https://openalex.org/W2081164888","https://openalex.org/W2106383417","https://openalex.org/W2128264251","https://openalex.org/W2129153475","https://openalex.org/W2130316840","https://openalex.org/W2153698065","https://openalex.org/W2170644095","https://openalex.org/W2222589778","https://openalex.org/W2274838421","https://openalex.org/W2471760960","https://openalex.org/W2558319372","https://openalex.org/W2562525888","https://openalex.org/W2607046971","https://openalex.org/W2620525618","https://openalex.org/W2738394580","https://openalex.org/W2762990000","https://openalex.org/W2767467617","https://openalex.org/W2886382429","https://openalex.org/W2905210080","https://openalex.org/W2934233926","https://openalex.org/W2994424999","https://openalex.org/W3016614980","https://openalex.org/W3032717150","https://openalex.org/W3098335778","https://openalex.org/W3104989723","https://openalex.org/W3130500589","https://openalex.org/W3164289065","https://openalex.org/W3164582063","https://openalex.org/W3182356919","https://openalex.org/W3185726883","https://openalex.org/W3190034604","https://openalex.org/W3191232333","https://openalex.org/W3210575413","https://openalex.org/W3212222702","https://openalex.org/W4200622471","https://openalex.org/W4206046172","https://openalex.org/W4234148010","https://openalex.org/W4313502558","https://openalex.org/W4327961586","https://openalex.org/W4386378915"],"related_works":["https://openalex.org/W2811158371","https://openalex.org/W2010210547","https://openalex.org/W310702735","https://openalex.org/W2074513890","https://openalex.org/W4411332097","https://openalex.org/W2589689282","https://openalex.org/W2558319372","https://openalex.org/W2224830186","https://openalex.org/W2907929499","https://openalex.org/W61613047"],"abstract_inverted_index":{"Here,":[0],"we":[1],"report":[2],"the":[3,9,21,45,61,65,76,86,111,124,149,173,183,189,211],"results":[4,198],"of":[5,8,12,28,60,64,80,88,102,113,116,127,185,191,208,214],"an":[6,99,106,200],"investigation":[7],"neuroprotective":[10,146,212],"effects":[11,147],"securinine":[13,35],"with":[14,132],"tryptamine":[15],"conjugate-allomargaritarine":[16],"(2b),":[17],"previously":[18,50],"selected":[19],"as":[20,40,119,121,216],"leading":[22],"compound":[23,66,131],"among":[24],"a":[25,130,133,180,204,217],"wide":[26],"range":[27],"natural":[29],"derivatives.":[30],"2b":[31,97,141,159,215],"was":[32,94,176],"synthesized":[33],"from":[34],"using":[36],"various":[37],"Lewis":[38],"acids":[39],"catalysts.":[41],"In":[42,91],"addition":[43],"to":[44,74,202],"antioxidant":[46],"and":[47,165,168,188],"cytoprotective":[48],"properties":[49],"shown":[51],"for":[52,109,220],"2b,":[53],"in":[54,57,139,150,172,182,194],"this":[55,69],"work,":[56],"vitro":[58],"analysis":[59],"biological":[62,135],"activity":[63,136],"demonstrated":[67,144],"that":[68,96],"conjugate":[70],"is":[71,98],"also":[72,143,177],"able":[73],"influence":[75],"primary":[77],"pathogenetic":[78],"mechanism":[79],"Alzheimer's":[81,153,221],"disease":[82,154],"-":[83,105],"proteinopathy,":[84],"modulating":[85],"homeostasis":[87],"\u03b2-amyloid":[89,117],"peptide.":[90],"particular,":[92],"it":[93],"found":[95,138],"effective":[100],"inhibitor":[101],"\u03b2-secretase":[103],"1":[104],"enzyme":[107],"responsible":[108],"initiating":[110],"generation":[112],"pathological":[114,125],"forms":[115],"peptide,":[118],"well":[120],"directly":[122],"preventing":[123],"aggregation":[126],"A\u03b21-42.":[128],"As":[129],"promising":[134],"profile":[137],"vitro,":[140],"has":[142],"excellent":[145],"on":[148,210],"vivo":[151],"5xFAD":[152],"transgenic":[155],"mice":[156],"model.":[157],"Thus,":[158],"effectively":[160],"restored":[161],"cognitive":[162],"dysfunction:":[163],"short-term":[164],"long-term":[166],"episodic":[167],"spatial":[169],"memory,":[170],"which":[171],"post-mortem":[174],"studies":[175],"accompanied":[178],"by":[179],"decrease":[181],"number":[184],"amyloid":[186],"deposits":[187],"intensity":[190],"oxidative":[192],"stress":[193],"brain":[195],"samples.":[196],"These":[197],"provide":[199],"opportunity":[201],"draw":[203],"line":[205],"under":[206],"years":[207],"research":[209],"potential":[213],"viable":[218],"therapy":[219],"disease.":[222]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":4}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2024-01-13T00:00:00"}