{"id":"https://openalex.org/W4390748833","doi":"https://doi.org/10.1039/d3nr05971e","title":"Spherical nucleic acids: emerging amplifiers for therapeutic nanoplatforms","display_name":"Spherical nucleic acids: emerging amplifiers for therapeutic nanoplatforms","publication_year":2024,"publication_date":"2024-01-01","ids":{"openalex":"https://openalex.org/W4390748833","doi":"https://doi.org/10.1039/d3nr05971e","pmid":"https://pubmed.ncbi.nlm.nih.gov/38289178"},"language":"en","primary_location":{"id":"doi:10.1039/d3nr05971e","doi":"https://doi.org/10.1039/d3nr05971e","is_oa":true,"landing_page_url":"https://doi.org/10.1039/d3nr05971e","pdf_url":"https://pubs.rsc.org/en/content/articlepdf/2024/nr/d3nr05971e","source":{"id":"https://openalex.org/S23181512","display_name":"Nanoscale","issn_l":"2040-3364","issn":["2040-3364","2040-3372"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nanoscale","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://pubs.rsc.org/en/content/articlepdf/2024/nr/d3nr05971e","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102666241","display_name":"Zhenghao Tao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I91935597","display_name":"University of South China","ror":"https://ror.org/03mqfn238","country_code":"CN","type":"education","lineage":["https://openalex.org/I91935597"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhenghao Tao","raw_affiliation_strings":["Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, School of Pharmaceutical Science, Hengyang Medical School, University of South China, 421001, Hengyang, P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, School of Pharmaceutical Science, Hengyang Medical School, University of South China, 421001, Hengyang, P. R. China","institution_ids":["https://openalex.org/I91935597"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100454591","display_name":"Haitao Zhang","orcid":"https://orcid.org/0000-0002-6082-973X","observed_orcids":["https://orcid.org/0000-0002-6082-973X"]},"institutions":[{"id":"https://openalex.org/I91935597","display_name":"University of South China","ror":"https://ror.org/03mqfn238","country_code":"CN","type":"education","lineage":["https://openalex.org/I91935597"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Haitao Zhang","raw_affiliation_strings":["Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, School of Pharmaceutical Science, Hengyang Medical School, University of South China, 421001, Hengyang, P. R. China"],"raw_orcid":"https://orcid.org/0000-0002-6082-973X","affiliations":[{"raw_affiliation_string":"Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, School of Pharmaceutical Science, Hengyang Medical School, University of South China, 421001, Hengyang, P. R. China","institution_ids":["https://openalex.org/I91935597"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112853724","display_name":"Shang Wu","orcid":"https://orcid.org/0009-0004-4868-0065","observed_orcids":["https://orcid.org/0009-0004-4868-0065"]},"institutions":[{"id":"https://openalex.org/I91935597","display_name":"University of South China","ror":"https://ror.org/03mqfn238","country_code":"CN","type":"education","lineage":["https://openalex.org/I91935597"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shang Wu","raw_affiliation_strings":["Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, School of Pharmaceutical Science, Hengyang Medical School, University of South China, 421001, Hengyang, P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, School of Pharmaceutical Science, Hengyang Medical School, University of South China, 421001, Hengyang, P. R. China","institution_ids":["https://openalex.org/I91935597"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103017894","display_name":"Jiaheng Zhang","orcid":"https://orcid.org/0000-0002-8163-1706","observed_orcids":["https://orcid.org/0000-0002-8163-1706","https://orcid.org/0000-0002-7950-7845"]},"institutions":[{"id":"https://openalex.org/I91935597","display_name":"University of South China","ror":"https://ror.org/03mqfn238","country_code":"CN","type":"education","lineage":["https://openalex.org/I91935597"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiaheng Zhang","raw_affiliation_strings":["Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, School of Pharmaceutical Science, Hengyang Medical School, University of South China, 421001, Hengyang, P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, School of Pharmaceutical Science, Hengyang Medical School, University of South China, 421001, Hengyang, P. R. China","institution_ids":["https://openalex.org/I91935597"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100349980","display_name":"Cheng Yao","orcid":"https://orcid.org/0000-0002-7651-6682","observed_orcids":["https://orcid.org/0000-0002-7651-6682"]},"institutions":[{"id":"https://openalex.org/I91935597","display_name":"University of South China","ror":"https://ror.org/03mqfn238","country_code":"CN","type":"education","lineage":["https://openalex.org/I91935597"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yao Cheng","raw_affiliation_strings":["Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, School of Pharmaceutical Science, Hengyang Medical School, University of South China, 421001, Hengyang, P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, School of Pharmaceutical Science, Hengyang Medical School, University of South China, 421001, Hengyang, P. R. China","institution_ids":["https://openalex.org/I91935597"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102603365","display_name":"Longtianyang Lei","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I91935597","display_name":"University of South China","ror":"https://ror.org/03mqfn238","country_code":"CN","type":"education","lineage":["https://openalex.org/I91935597"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Longtianyang Lei","raw_affiliation_strings":["Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, School of Pharmaceutical Science, Hengyang Medical School, University of South China, 421001, Hengyang, P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, School of Pharmaceutical Science, Hengyang Medical School, University of South China, 421001, Hengyang, P. R. China","institution_ids":["https://openalex.org/I91935597"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100699513","display_name":"Yang Qin","orcid":"https://orcid.org/0000-0001-9022-3061","observed_orcids":["https://orcid.org/0000-0001-9022-3061"]},"institutions":[{"id":"https://openalex.org/I91935597","display_name":"University of South China","ror":"https://ror.org/03mqfn238","country_code":"CN","type":"education","lineage":["https://openalex.org/I91935597"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yang Qin","raw_affiliation_strings":["Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, School of Pharmaceutical Science, Hengyang Medical School, University of South China, 421001, Hengyang, P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, School of Pharmaceutical Science, Hengyang Medical School, University of South China, 421001, Hengyang, P. R. China","institution_ids":["https://openalex.org/I91935597"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110364933","display_name":"Hua Wei","orcid":"https://orcid.org/0000-0002-5139-9387","observed_orcids":["https://orcid.org/0000-0002-5139-9387"]},"institutions":[{"id":"https://openalex.org/I91935597","display_name":"University of South China","ror":"https://ror.org/03mqfn238","country_code":"CN","type":"education","lineage":["https://openalex.org/I91935597"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Hua Wei","raw_affiliation_strings":["Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, School of Pharmaceutical Science, Hengyang Medical School, University of South China, 421001, Hengyang, P. R. China"],"raw_orcid":"https://orcid.org/0000-0002-5139-9387","affiliations":[{"raw_affiliation_string":"Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, School of Pharmaceutical Science, Hengyang Medical School, University of South China, 421001, Hengyang, P. R. China","institution_ids":["https://openalex.org/I91935597"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103197519","display_name":"Cui\u2010Yun Yu","orcid":"https://orcid.org/0000-0001-7856-4867","observed_orcids":["https://orcid.org/0000-0001-7856-4867"]},"institutions":[{"id":"https://openalex.org/I91935597","display_name":"University of South China","ror":"https://ror.org/03mqfn238","country_code":"CN","type":"education","lineage":["https://openalex.org/I91935597"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Cui-Yun Yu","raw_affiliation_strings":["Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, School of Pharmaceutical Science, Hengyang Medical School, University of South China, 421001, Hengyang, P. R. China"],"raw_orcid":"https://orcid.org/0000-0001-7856-4867","affiliations":[{"raw_affiliation_string":"Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, School of Pharmaceutical Science, Hengyang Medical School, University of South China, 421001, Hengyang, P. R. China","institution_ids":["https://openalex.org/I91935597"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5100454591","https://openalex.org/A5103197519","https://openalex.org/A5110364933"],"corresponding_institution_ids":["https://openalex.org/I91935597"],"apc_list":null,"apc_paid":null,"fwci":0.7725,"has_fulltext":true,"cited_by_count":22,"citation_normalized_percentile":{"value":0.62390528,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":97,"max":99},"biblio":{"volume":"16","issue":"9","first_page":"4392","last_page":"4406"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.9848999977111816,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.9848999977111816,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.007899999618530273,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10207","display_name":"Advanced biosensing and bioanalysis techniques","score":0.002099999925121665,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/spherical-nucleic-acids","display_name":"spherical nucleic acids","score":1.0},{"id":"https://openalex.org/keywords/gene-therapy","display_name":"gene therapy","score":0.9269999861717224},{"id":"https://openalex.org/keywords/gene-delivery","display_name":"gene delivery","score":0.9100000262260437},{"id":"https://openalex.org/keywords/gene-amplification","display_name":"gene amplification","score":0.656000018119812},{"id":"https://openalex.org/keywords/theranostics","display_name":"theranostics","score":0.8169999718666077},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.8119999766349792},{"id":"https://openalex.org/keywords/clinical-translation","display_name":"clinical translation","score":0.9509999752044678},{"id":"https://openalex.org/keywords/nanoplatforms","display_name":"nanoplatforms","score":0.7039999961853027},{"id":"https://openalex.org/keywords/nucleic-acid-structure","display_name":"nucleic acid structure","score":0.5410000085830688}],"concepts":[{"id":"https://openalex.org/C24107716","wikidata":"https://www.wikidata.org/wiki/Q123619","display_name":"Nucleic acid","level":2,"score":0.7881884574890137},{"id":"https://openalex.org/C149364088","wikidata":"https://www.wikidata.org/wiki/Q185917","display_name":"Translation (biology)","level":4,"score":0.5431964993476868},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.5055298805236816},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3853626847267151},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.3231349587440491},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.24886634945869446},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1944175660610199},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.10578000545501709},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.04574894905090332},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D009696","descriptor_name":"Nucleic Acids","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D009696","descriptor_name":"Nucleic Acids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D015316","descriptor_name":"Genetic Therapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D018014","descriptor_name":"Gene Transfer Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1039/d3nr05971e","doi":"https://doi.org/10.1039/d3nr05971e","is_oa":true,"landing_page_url":"https://doi.org/10.1039/d3nr05971e","pdf_url":"https://pubs.rsc.org/en/content/articlepdf/2024/nr/d3nr05971e","source":{"id":"https://openalex.org/S23181512","display_name":"Nanoscale","issn_l":"2040-3364","issn":["2040-3364","2040-3372"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nanoscale","raw_type":"journal-article"},{"id":"pmid:38289178","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38289178","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nanoscale","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1039/d3nr05971e","doi":"https://doi.org/10.1039/d3nr05971e","is_oa":true,"landing_page_url":"https://doi.org/10.1039/d3nr05971e","pdf_url":"https://pubs.rsc.org/en/content/articlepdf/2024/nr/d3nr05971e","source":{"id":"https://openalex.org/S23181512","display_name":"Nanoscale","issn_l":"2040-3364","issn":["2040-3364","2040-3372"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nanoscale","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1548793821","display_name":null,"funder_award_id":"21A0284","funder_id":"https://openalex.org/F4320311213","funder_display_name":"Education Department of Hunan Province"},{"id":"https://openalex.org/G1645140326","display_name":null,"funder_award_id":"82373826","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G4086933733","display_name":null,"funder_award_id":"202113021875","funder_id":"https://openalex.org/F4320335497","funder_display_name":"Health and Family Planning Commission of Hunan Province"},{"id":"https://openalex.org/G6953751472","display_name":null,"funder_award_id":"82373826","funder_id":"https://openalex.org/F4320335577","funder_display_name":"Major Research Plan"},{"id":"https://openalex.org/G8591698987","display_name":null,"funder_award_id":"2021JJ30603","funder_id":"https://openalex.org/F4320322843","funder_display_name":"Natural Science Foundation of\u00a0Hunan Province"}],"funders":[{"id":"https://openalex.org/F4320311213","display_name":"Education Department of Hunan Province","ror":"https://ror.org/05ckg3w11"},{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320322843","display_name":"Natural Science Foundation of\u00a0Hunan Province","ror":null},{"id":"https://openalex.org/F4320335497","display_name":"Health and Family Planning Commission of Hunan Province","ror":"https://ror.org/01mv1ez88"},{"id":"https://openalex.org/F4320335577","display_name":"Major Research Plan","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4390748833.pdf","grobid_xml":"https://content.openalex.org/works/W4390748833.grobid-xml"},"referenced_works_count":129,"referenced_works":["https://openalex.org/W1964196894","https://openalex.org/W1973177425","https://openalex.org/W1981923877","https://openalex.org/W1989868163","https://openalex.org/W1993146969","https://openalex.org/W1994357966","https://openalex.org/W1996923120","https://openalex.org/W2003451349","https://openalex.org/W2005470886","https://openalex.org/W2018614342","https://openalex.org/W2048926712","https://openalex.org/W2051473632","https://openalex.org/W2052566608","https://openalex.org/W2059049433","https://openalex.org/W2083756890","https://openalex.org/W2095463022","https://openalex.org/W2097194070","https://openalex.org/W2108548328","https://openalex.org/W2116424844","https://openalex.org/W2209124408","https://openalex.org/W2231208985","https://openalex.org/W2237130707","https://openalex.org/W2328640092","https://openalex.org/W2512016627","https://openalex.org/W2526729545","https://openalex.org/W2589086684","https://openalex.org/W2605226075","https://openalex.org/W2724917816","https://openalex.org/W2733296761","https://openalex.org/W2736408126","https://openalex.org/W2740857127","https://openalex.org/W2765538791","https://openalex.org/W2769424469","https://openalex.org/W2779389688","https://openalex.org/W2792939757","https://openalex.org/W2802243500","https://openalex.org/W2809830667","https://openalex.org/W2813804716","https://openalex.org/W2885657430","https://openalex.org/W2889403130","https://openalex.org/W2890799178","https://openalex.org/W2896738880","https://openalex.org/W2897671038","https://openalex.org/W2898989437","https://openalex.org/W2900540472","https://openalex.org/W2922193292","https://openalex.org/W2926815174","https://openalex.org/W2942224185","https://openalex.org/W2943077669","https://openalex.org/W2947727383","https://openalex.org/W2955532934","https://openalex.org/W2960078955","https://openalex.org/W2968653032","https://openalex.org/W2995919385","https://openalex.org/W2995940501","https://openalex.org/W2997125990","https://openalex.org/W3000681132","https://openalex.org/W3000712822","https://openalex.org/W3033415079","https://openalex.org/W3039603402","https://openalex.org/W3040335627","https://openalex.org/W3040880602","https://openalex.org/W3043198063","https://openalex.org/W3047870834","https://openalex.org/W3049346164","https://openalex.org/W3082343104","https://openalex.org/W3098908552","https://openalex.org/W3120393067","https://openalex.org/W3121703135","https://openalex.org/W3124160933","https://openalex.org/W3126424583","https://openalex.org/W3130824274","https://openalex.org/W3133613664","https://openalex.org/W3134295746","https://openalex.org/W3134908802","https://openalex.org/W3153621695","https://openalex.org/W3157850280","https://openalex.org/W3160199253","https://openalex.org/W3164967630","https://openalex.org/W3168087411","https://openalex.org/W3174340986","https://openalex.org/W3175963482","https://openalex.org/W3184644021","https://openalex.org/W3188742396","https://openalex.org/W3199162311","https://openalex.org/W3203572663","https://openalex.org/W3203757272","https://openalex.org/W3210065931","https://openalex.org/W3215956475","https://openalex.org/W3217261109","https://openalex.org/W4200239318","https://openalex.org/W4206359630","https://openalex.org/W4206413133","https://openalex.org/W4220901162","https://openalex.org/W4220964760","https://openalex.org/W4223635874","https://openalex.org/W4229018309","https://openalex.org/W4231922148","https://openalex.org/W4281479188","https://openalex.org/W4283459934","https://openalex.org/W4283518431","https://openalex.org/W4283593580","https://openalex.org/W4293413480","https://openalex.org/W4301187651","https://openalex.org/W4302014287","https://openalex.org/W4302424974","https://openalex.org/W4308685342","https://openalex.org/W4311219792","https://openalex.org/W4311709195","https://openalex.org/W4312112368","https://openalex.org/W4312113721","https://openalex.org/W4318618140","https://openalex.org/W4319262355","https://openalex.org/W4319656487","https://openalex.org/W4378470364","https://openalex.org/W4378902504","https://openalex.org/W4379796525","https://openalex.org/W4380568974","https://openalex.org/W4382052161","https://openalex.org/W4385009219","https://openalex.org/W4385309895","https://openalex.org/W4385514509","https://openalex.org/W4385755395","https://openalex.org/W4385779507","https://openalex.org/W4385851302","https://openalex.org/W4386415175","https://openalex.org/W4386762830","https://openalex.org/W4386878236","https://openalex.org/W4388564145"],"related_works":["https://openalex.org/W4400178171","https://openalex.org/W7140288750","https://openalex.org/W2809830667","https://openalex.org/W2988018281","https://openalex.org/W4385309895","https://openalex.org/W7222913842","https://openalex.org/W3199162311","https://openalex.org/W2181227864","https://openalex.org/W4408117079","https://openalex.org/W7008379986"],"abstract_inverted_index":{"Gene":[0],"therapy":[1,69,102,115,164,205],"is":[2,25,39],"a":[3,63,184],"revolutionary":[4],"treatment":[5,165],"approach":[6],"in":[7,66,100,203],"the":[8,20,29,46,95,105,110,117,142,178,187,195,199],"21st":[9],"century,":[10],"offering":[11],"significant":[12,64],"potential":[13],"for":[14,85],"disease":[15],"prevention":[16],"and":[17,35,52,57,103,122,145,168,182,207,215],"treatment.":[18],"However,":[19],"efficacy":[21],"of":[22,32,49,98,107,113,119,148,162,180,198,201,217],"gene":[23,33,50,68,87,101,114,204,218],"delivery":[24],"often":[26],"compromised":[27],"by":[28,140,159,172,176],"inherent":[30],"challenges":[31,179],"properties":[34,147],"vector-related":[36],"defects.":[37],"It":[38],"crucial":[40],"to":[41,44,92,109,193],"explore":[42,94],"ways":[43],"enhance":[45],"curative":[47],"effect":[48,112],"drugs":[51],"achieve":[53],"safer,":[54],"more":[55,58],"widespread,":[56],"efficient":[59],"utilization,":[60],"which":[61],"represents":[62],"challenge":[65],"amplification":[67,111,188,206,216],"advancements.":[70],"Spherical":[71],"nucleic":[72,156],"acids":[73],"(SNAs),":[74],"with":[75],"their":[76,212],"unique":[77],"physicochemical":[78],"properties,":[79],"are":[80],"considered":[81],"an":[82,127,160],"innovative":[83],"solution":[84],"scalable":[86],"therapy.":[88,219],"This":[89,190],"review":[90,191],"aims":[91],"comprehensively":[93],"amplifying":[96],"contributions":[97],"SNAs":[99,108,149,181,202],"emphasize":[104],"contribution":[106],"from":[116,153],"aspects":[118],"structure,":[120],"application,":[121],"recent":[123],"clinical":[124,169,213],"translation":[125,170,214],"-":[126],"aspect":[128],"that":[129,150],"has":[130],"been":[131],"rarely":[132],"reported":[133],"or":[134],"explored":[135],"thus":[136],"far.":[137],"We":[138,174],"begin":[139],"elucidating":[141],"fundamental":[143],"characteristics":[144],"scaling-up":[146],"distinguish":[151],"them":[152],"traditional":[154],"linear":[155],"acids,":[157],"followed":[158],"analysis":[161],"combined":[163],"strategies,":[166],"theranostics,":[167],"amplified":[171],"SNAs.":[173],"conclude":[175],"discussing":[177],"provide":[183],"prospect":[185],"on":[186],"characteristics.":[189],"seeks":[192],"update":[194],"current":[196],"understanding":[197],"use":[200],"promote":[208],"further":[209],"research":[210],"into":[211]},"counts_by_year":[{"year":2026,"cited_by_count":10},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":5}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2024-01-13T00:00:00"}
