{"id":"https://openalex.org/W4390744965","doi":"https://doi.org/10.3389/fimmu.2023.1341708","title":"Drug survival of IL-12/23, IL-17 and IL-23 inhibitors for moderate-to-severe plaque psoriasis: a retrospective multicenter real-world experience on 5932 treatment courses \u2013 IL PSO (Italian landscape psoriasis)","display_name":"Drug survival of IL-12/23, IL-17 and IL-23 inhibitors for moderate-to-severe plaque psoriasis: a retrospective multicenter real-world experience on 5932 treatment courses \u2013 IL PSO (Italian landscape psoriasis)","publication_year":2024,"publication_date":"2024-01-10","ids":{"openalex":"https://openalex.org/W4390744965","doi":"https://doi.org/10.3389/fimmu.2023.1341708","pmid":"https://pubmed.ncbi.nlm.nih.gov/38274801","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10808601"},"language":"en","primary_location":{"id":"doi:10.3389/fimmu.2023.1341708","doi":"https://doi.org/10.3389/fimmu.2023.1341708","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2023.1341708","pdf_url":"https://www.frontiersin.org/articles/10.3389/fimmu.2023.1341708/pdf?isPublishedV2=False","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/articles/10.3389/fimmu.2023.1341708/pdf?isPublishedV2=False","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5014834699","display_name":"Luigi Gargiulo","orcid":"https://orcid.org/0000-0002-6051-1676","observed_orcids":["https://orcid.org/0000-0002-6051-1676"]},"institutions":[{"id":"https://openalex.org/I1339471597","display_name":"Humanitas University","ror":"https://ror.org/020dggs04","country_code":"IT","type":"education","lineage":["https://openalex.org/I1339471597"]},{"id":"https://openalex.org/I4210163047","display_name":"IRCCS Humanitas Research Hospital","ror":"https://ror.org/05d538656","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126","https://openalex.org/I4210163047"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Luigi Gargiulo","raw_affiliation_strings":["Department of Biomedical Sciences, Humanitas University, Milan, Italy","Dermatology Unit, IRCCS Humanitas Research Hospital, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Sciences, Humanitas University, Milan, Italy","institution_ids":["https://openalex.org/I1339471597"]},{"raw_affiliation_string":"Dermatology Unit, IRCCS Humanitas Research Hospital, Milan, Italy","institution_ids":["https://openalex.org/I4210163047"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060737486","display_name":"Luciano Ibba","orcid":"https://orcid.org/0000-0002-7876-4866","observed_orcids":["https://orcid.org/0000-0002-7876-4866"]},"institutions":[{"id":"https://openalex.org/I1339471597","display_name":"Humanitas University","ror":"https://ror.org/020dggs04","country_code":"IT","type":"education","lineage":["https://openalex.org/I1339471597"]},{"id":"https://openalex.org/I4210163047","display_name":"IRCCS Humanitas Research Hospital","ror":"https://ror.org/05d538656","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126","https://openalex.org/I4210163047"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Luciano Ibba","raw_affiliation_strings":["Department of Biomedical Sciences, Humanitas University, Milan, Italy","Dermatology Unit, IRCCS Humanitas Research Hospital, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Sciences, Humanitas University, Milan, Italy","institution_ids":["https://openalex.org/I1339471597"]},{"raw_affiliation_string":"Dermatology Unit, IRCCS Humanitas Research Hospital, Milan, Italy","institution_ids":["https://openalex.org/I4210163047"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028135237","display_name":"Piergiorgio Malagoli","orcid":"https://orcid.org/0000-0002-6181-6922","observed_orcids":["https://orcid.org/0000-0002-6181-6922"]},"institutions":[{"id":"https://openalex.org/I4210099239","display_name":"IRCCS Policlinico San Donato","ror":"https://ror.org/01220jp31","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210099239","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Piergiorgio Malagoli","raw_affiliation_strings":["Department of Dermatology, Dermatology Unit, Azienda Ospedaliera San Donato Milanese, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, Dermatology Unit, Azienda Ospedaliera San Donato Milanese, Milan, Italy","institution_ids":["https://openalex.org/I4210099239"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054555628","display_name":"Anna Balato","orcid":"https://orcid.org/0000-0001-5485-0172","observed_orcids":["https://orcid.org/0000-0001-5485-0172"]},"institutions":[{"id":"https://openalex.org/I197809005","display_name":"University of Campania \"Luigi Vanvitelli\"","ror":"https://ror.org/02kqnpp86","country_code":"IT","type":"education","lineage":["https://openalex.org/I197809005"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Anna Balato","raw_affiliation_strings":["Dermatology Unit, University of Campania L. Vanvitelli, Naples, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dermatology Unit, University of Campania L. Vanvitelli, Naples, Italy","institution_ids":["https://openalex.org/I197809005"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063944820","display_name":"Federico Bardazzi","orcid":"https://orcid.org/0000-0001-6162-2004","observed_orcids":["https://orcid.org/0000-0001-6162-2004"]},"institutions":[{"id":"https://openalex.org/I4210097083","display_name":"IRCCS Azienda Ospedliero-Universitaria di Bologna Policlinico di Sant'Orsola","ror":"https://ror.org/00t4vnv68","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210097083"]},{"id":"https://openalex.org/I9360294","display_name":"University of Bologna","ror":"https://ror.org/01111rn36","country_code":"IT","type":"education","lineage":["https://openalex.org/I9360294"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Federico Bardazzi","raw_affiliation_strings":["Dermatology Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Policlinico S. Orsola-Malpighi, Bologna, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dermatology Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Policlinico S. Orsola-Malpighi, Bologna, Italy","institution_ids":["https://openalex.org/I4210097083","https://openalex.org/I9360294"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056135273","display_name":"Martina Burlando","orcid":"https://orcid.org/0000-0002-4381-6718","observed_orcids":["https://orcid.org/0000-0002-4381-6718"]},"institutions":[{"id":"https://openalex.org/I4210146472","display_name":"Ospedale Policlinico San Martino","ror":"https://ror.org/04d7es448","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210146472","https://openalex.org/I4210153126","https://openalex.org/I4405264730"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Martina Burlando","raw_affiliation_strings":["Section of Dermatology, Department of Health Sciences (DISSAL), IRCCS San Martino University Hospital, Genoa, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Dermatology, Department of Health Sciences (DISSAL), IRCCS San Martino University Hospital, Genoa, Italy","institution_ids":["https://openalex.org/I4210146472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110340290","display_name":"Carlo Giovanni Carrera","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2803066834","display_name":"Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico","ror":"https://ror.org/016zn0y21","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I189158943","https://openalex.org/I2803066834","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Carlo G. Carrera","raw_affiliation_strings":["Dermatology Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dermatology Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy","institution_ids":["https://openalex.org/I2803066834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022644884","display_name":"Giovanni Battista Damiani","orcid":"https://orcid.org/0000-0002-2390-6505","observed_orcids":["https://orcid.org/0000-0002-2390-6505","https://orcid.org/0000-0003-1736-9480"]},"institutions":[{"id":"https://openalex.org/I189158943","display_name":"University of Milan","ror":"https://ror.org/00wjc7c48","country_code":"IT","type":"education","lineage":["https://openalex.org/I189158943"]},{"id":"https://openalex.org/I4210133214","display_name":"IRCCS Ospedale San Raffaele","ror":"https://ror.org/039zxt351","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210133214","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giovanni Damiani","raw_affiliation_strings":["Department of Biomedical, Surgical and Dental Sciences, University of Milan, Milan, Italy","Dermatology and Cosmetology Unit, IRCCS San Raffaele Hospital, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical, Surgical and Dental Sciences, University of Milan, Milan, Italy","institution_ids":["https://openalex.org/I189158943"]},{"raw_affiliation_string":"Dermatology and Cosmetology Unit, IRCCS San Raffaele Hospital, Milan, Italy","institution_ids":["https://openalex.org/I4210133214"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035425594","display_name":"Paolo Dapavo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I55143463","display_name":"University of Turin","ror":"https://ror.org/048tbm396","country_code":"IT","type":"education","lineage":["https://openalex.org/I55143463"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Paolo Dapavo","raw_affiliation_strings":["Department of Biomedical Science and Human Oncology, Second Dermatologic Clinic, University of Turin, Turin, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Science and Human Oncology, Second Dermatologic Clinic, University of Turin, Turin, Italy","institution_ids":["https://openalex.org/I55143463"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051232333","display_name":"Valentina Dini","orcid":"https://orcid.org/0000-0002-8537-1999","observed_orcids":["https://orcid.org/0000-0002-8537-1999","https://orcid.org/0000-0002-4639-3167"]},"institutions":[{"id":"https://openalex.org/I108290504","display_name":"University of Pisa","ror":"https://ror.org/03ad39j10","country_code":"IT","type":"education","lineage":["https://openalex.org/I108290504"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Valentina Dini","raw_affiliation_strings":["Dermatology Unit, Department of Clinical and Experimental Medicine, Ospedale Santa Chiara, Pisa, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dermatology Unit, Department of Clinical and Experimental Medicine, Ospedale Santa Chiara, Pisa, Italy","institution_ids":["https://openalex.org/I108290504"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086772020","display_name":"Francesca Maria Gaiani","orcid":"https://orcid.org/0009-0003-7613-4451","observed_orcids":["https://orcid.org/0009-0003-7613-4451"]},"institutions":[{"id":"https://openalex.org/I4210099239","display_name":"IRCCS Policlinico San Donato","ror":"https://ror.org/01220jp31","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210099239","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Francesca M. Gaiani","raw_affiliation_strings":["Department of Dermatology, Dermatology Unit, Azienda Ospedaliera San Donato Milanese, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, Dermatology Unit, Azienda Ospedaliera San Donato Milanese, Milan, Italy","institution_ids":["https://openalex.org/I4210099239"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016818733","display_name":"Giampiero Girolomoni","orcid":"https://orcid.org/0000-0001-8548-0493","observed_orcids":["https://orcid.org/0000-0001-8548-0493"]},"institutions":[{"id":"https://openalex.org/I119439378","display_name":"University of Verona","ror":"https://ror.org/039bp8j42","country_code":"IT","type":"education","lineage":["https://openalex.org/I119439378"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giampiero Girolomoni","raw_affiliation_strings":["Department of Medicine, Section of Dermatology and Venereology, University of Verona, Verona, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Section of Dermatology and Venereology, University of Verona, Verona, Italy","institution_ids":["https://openalex.org/I119439378"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017034001","display_name":"Claudio Guarneri","orcid":"https://orcid.org/0000-0003-3918-8779","observed_orcids":["https://orcid.org/0000-0003-3918-8779"]},"institutions":[{"id":"https://openalex.org/I112862951","display_name":"University of Messina","ror":"https://ror.org/05ctdxz19","country_code":"IT","type":"education","lineage":["https://openalex.org/I112862951"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Claudio Guarneri","raw_affiliation_strings":["Department of Biomedical and Dental Sciences and Morphofunctional Imaging, University of Messina, Messina, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical and Dental Sciences and Morphofunctional Imaging, University of Messina, Messina, Italy","institution_ids":["https://openalex.org/I112862951"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024063313","display_name":"Claudia Lasagni","orcid":"https://orcid.org/0000-0002-0370-6602","observed_orcids":["https://orcid.org/0000-0002-0370-6602"]},"institutions":[{"id":"https://openalex.org/I122346577","display_name":"University of Modena and Reggio Emilia","ror":"https://ror.org/02d4c4y02","country_code":"IT","type":"education","lineage":["https://openalex.org/I122346577"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Claudia Lasagni","raw_affiliation_strings":["Dermatological Clinic, Department of Specialized Medicine, University of Modena, Modena, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dermatological Clinic, Department of Specialized Medicine, University of Modena, Modena, Italy","institution_ids":["https://openalex.org/I122346577"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012727285","display_name":"Francesco Loconsole","orcid":"https://orcid.org/0000-0003-2852-9451","observed_orcids":["https://orcid.org/0000-0003-2852-9451"]},"institutions":[{"id":"https://openalex.org/I5561750","display_name":"University of Bari Aldo Moro","ror":"https://ror.org/027ynra39","country_code":"IT","type":"education","lineage":["https://openalex.org/I5561750"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Francesco Loconsole","raw_affiliation_strings":["Department of Dermatology, University of Bari, Bari, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, University of Bari, Bari, Italy","institution_ids":["https://openalex.org/I5561750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005532978","display_name":"Angelo Valerio Marzano","orcid":"https://orcid.org/0000-0002-8160-4169","observed_orcids":["https://orcid.org/0000-0002-8160-4169","https://orcid.org/0000-0002-2258-8357"]},"institutions":[{"id":"https://openalex.org/I189158943","display_name":"University of Milan","ror":"https://ror.org/00wjc7c48","country_code":"IT","type":"education","lineage":["https://openalex.org/I189158943"]},{"id":"https://openalex.org/I2803066834","display_name":"Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico","ror":"https://ror.org/016zn0y21","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I189158943","https://openalex.org/I2803066834","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Angelo V. Marzano","raw_affiliation_strings":["Department of Pathophysiology and Transplantation, Universit\u00e0 degli Studi di Milano, Milan, Italy","Dermatology Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathophysiology and Transplantation, Universit\u00e0 degli Studi di Milano, Milan, Italy","institution_ids":["https://openalex.org/I189158943"]},{"raw_affiliation_string":"Dermatology Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy","institution_ids":["https://openalex.org/I2803066834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015814702","display_name":"Matteo Megna","orcid":"https://orcid.org/0000-0003-1803-2046","observed_orcids":["https://orcid.org/0000-0003-1803-2046"]},"institutions":[{"id":"https://openalex.org/I71267560","display_name":"University of Naples Federico II","ror":"https://ror.org/05290cv24","country_code":"IT","type":"education","lineage":["https://openalex.org/I71267560"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Matteo Megna","raw_affiliation_strings":["Section of Dermatology, Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Dermatology, Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy","institution_ids":["https://openalex.org/I71267560"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045865064","display_name":"Santo Raffaele Mercuri","orcid":"https://orcid.org/0000-0002-9175-4574","observed_orcids":["https://orcid.org/0000-0002-9175-4574"]},"institutions":[{"id":"https://openalex.org/I154387261","display_name":"Vita-Salute San Raffaele University","ror":"https://ror.org/01gmqr298","country_code":"IT","type":"education","lineage":["https://openalex.org/I154387261"]},{"id":"https://openalex.org/I4210133214","display_name":"IRCCS Ospedale San Raffaele","ror":"https://ror.org/039zxt351","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210133214","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Santo R. Mercuri","raw_affiliation_strings":["Dermatology Unit, Universit\u00e0 Vita-Salute San Raffaele, Milan, Italy","Dermatology and Cosmetology Unit, IRCCS San Raffaele Hospital, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dermatology Unit, Universit\u00e0 Vita-Salute San Raffaele, Milan, Italy","institution_ids":["https://openalex.org/I154387261"]},{"raw_affiliation_string":"Dermatology and Cosmetology Unit, IRCCS San Raffaele Hospital, Milan, Italy","institution_ids":["https://openalex.org/I4210133214"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026841162","display_name":"Massimo Travaglini","orcid":"https://orcid.org/0000-0001-7769-7190","observed_orcids":["https://orcid.org/0000-0001-7769-7190"]},"institutions":[{"id":"https://openalex.org/I4210103648","display_name":"Ospedale A. Perrino","ror":"https://ror.org/01ae87070","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210099368","https://openalex.org/I4210103648","https://openalex.org/I4210117053"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Massimo Travaglini","raw_affiliation_strings":["U.O.S.D. Dermatologica - Centro per la Cura della Psoriasi, Ospedale Perrino, Brindisi, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"U.O.S.D. Dermatologica - Centro per la Cura della Psoriasi, Ospedale Perrino, Brindisi, Italy","institution_ids":["https://openalex.org/I4210103648"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053176930","display_name":"Antonio Costanzo","orcid":"https://orcid.org/0000-0001-9697-2557","observed_orcids":["https://orcid.org/0000-0001-9697-2557"]},"institutions":[{"id":"https://openalex.org/I1339471597","display_name":"Humanitas University","ror":"https://ror.org/020dggs04","country_code":"IT","type":"education","lineage":["https://openalex.org/I1339471597"]},{"id":"https://openalex.org/I4210163047","display_name":"IRCCS Humanitas Research Hospital","ror":"https://ror.org/05d538656","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126","https://openalex.org/I4210163047"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Antonio Costanzo","raw_affiliation_strings":["Department of Biomedical Sciences, Humanitas University, Milan, Italy","Dermatology Unit, IRCCS Humanitas Research Hospital, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Sciences, Humanitas University, Milan, Italy","institution_ids":["https://openalex.org/I1339471597"]},{"raw_affiliation_string":"Dermatology Unit, IRCCS Humanitas Research Hospital, Milan, Italy","institution_ids":["https://openalex.org/I4210163047"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5082265951","display_name":"Alessandra Narcisi","orcid":"https://orcid.org/0000-0002-1938-8581","observed_orcids":["https://orcid.org/0000-0002-1938-8581"]},"institutions":[{"id":"https://openalex.org/I4210163047","display_name":"IRCCS Humanitas Research Hospital","ror":"https://ror.org/05d538656","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126","https://openalex.org/I4210163047"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Alessandra Narcisi","raw_affiliation_strings":["Dermatology Unit, IRCCS Humanitas Research Hospital, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dermatology Unit, IRCCS Humanitas Research Hospital, Milan, Italy","institution_ids":["https://openalex.org/I4210163047"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":19,"corresponding_author_ids":["https://openalex.org/A5060737486"],"corresponding_institution_ids":["https://openalex.org/I1339471597","https://openalex.org/I4210163047"],"apc_list":{"value":3295,"currency":"USD","value_usd":3295},"apc_paid":{"value":3295,"currency":"USD","value_usd":3295},"fwci":9.3989,"has_fulltext":true,"cited_by_count":65,"citation_normalized_percentile":{"value":0.98884691,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":100},"biblio":{"volume":"14","issue":null,"first_page":"1341708","last_page":"1341708"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10469","display_name":"Psoriasis: Treatment and Pathogenesis","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10469","display_name":"Psoriasis: Treatment and Pathogenesis","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10837","display_name":"Dermatology and Skin Diseases","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11092","display_name":"Spondyloarthritis Studies and Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/plaque-psoriasis","display_name":"plaque psoriasis","score":0.9419999718666077},{"id":"https://openalex.org/keywords/drug-survival","display_name":"drug retention","score":0.6890000104904175},{"id":"https://openalex.org/keywords/medication-persistence","display_name":"treatment persistence","score":0.9350000023841858},{"id":"https://openalex.org/keywords/il-12-23-inhibitors","display_name":"IL-12/23 inhibitors","score":0.8370000123977661},{"id":"https://openalex.org/keywords/il-17-inhibitors","display_name":"IL-17 inhibitors","score":0.9760000109672546},{"id":"https://openalex.org/keywords/il-23-inhibitors","display_name":"IL-23 inhibitors","score":0.996999979019165},{"id":"https://openalex.org/keywords/risankizumab","display_name":"risankizumab","score":0.8920000195503235},{"id":"https://openalex.org/keywords/ixekizumab","display_name":"ixekizumab","score":0.9890000224113464},{"id":"https://openalex.org/keywords/secukinumab","display_name":"secukinumab","score":0.9890000224113464},{"id":"https://openalex.org/keywords/tildrakizumab","display_name":"tildrakizumab","score":0.9539999961853027},{"id":"https://openalex.org/keywords/guselkumab","display_name":"guselkumab","score":0.9850000143051147},{"id":"https://openalex.org/keywords/brodalumab","display_name":"brodalumab","score":0.9990000128746033},{"id":"https://openalex.org/keywords/treatment-discontinuation","display_name":"treatment discontinuation","score":0.7829999923706055},{"id":"https://openalex.org/keywords/biological-therapy","display_name":"biologic therapy","score":0.4259999990463257}],"concepts":[{"id":"https://openalex.org/C2779745271","wikidata":"https://www.wikidata.org/wiki/Q13574436","display_name":"Ixekizumab","level":5,"score":0.9191943407058716},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8905889391899109},{"id":"https://openalex.org/C2779786854","wikidata":"https://www.wikidata.org/wiki/Q7444755","display_name":"Secukinumab","level":4,"score":0.7430698871612549},{"id":"https://openalex.org/C2778715236","wikidata":"https://www.wikidata.org/wiki/Q55622662","display_name":"Discontinuation","level":2,"score":0.6127487421035767},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5674659609794617},{"id":"https://openalex.org/C2780564577","wikidata":"https://www.wikidata.org/wiki/Q179945","display_name":"Psoriasis","level":2,"score":0.550220787525177},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.46759647130966187},{"id":"https://openalex.org/C500440147","wikidata":"https://www.wikidata.org/wiki/Q701216","display_name":"Pharmacotherapy","level":2,"score":0.44083690643310547},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.4197443723678589},{"id":"https://openalex.org/C2776260265","wikidata":"https://www.wikidata.org/wiki/Q511097","display_name":"Psoriatic arthritis","level":3,"score":0.32968124747276306},{"id":"https://openalex.org/C16005928","wikidata":"https://www.wikidata.org/wiki/Q171171","display_name":"Dermatology","level":1,"score":0.2744457423686981},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.26814043521881104}],"mesh":[{"descriptor_ui":"D000088902","descriptor_name":"Interleukin Inhibitors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001688","descriptor_name":"Biological Products","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007558","descriptor_name":"Italy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011565","descriptor_name":"Psoriasis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018664","descriptor_name":"Interleukin-12","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020381","descriptor_name":"Interleukin-17","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053759","descriptor_name":"Interleukin-23","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":8,"locations":[{"id":"doi:10.3389/fimmu.2023.1341708","doi":"https://doi.org/10.3389/fimmu.2023.1341708","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2023.1341708","pdf_url":"https://www.frontiersin.org/articles/10.3389/fimmu.2023.1341708/pdf?isPublishedV2=False","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10808601","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10808601","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10808601/pdf/fimmu-14-1341708.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Immunol","raw_type":"Text"},{"id":"pmid:38274801","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38274801","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in immunology","raw_type":"Multicenter Study"},{"id":"pmh:oai:air.unimi.it:2434/1115676","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/2434/1115676","pdf_url":"https://air.unimi.it/bitstream/2434/1115676/2/fimmu-14-1341708.pdf","source":{"id":"https://openalex.org/S4306400516","display_name":"Archivio Istituzionale della Ricerca (Universita Degli Studi Di Milano)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I189158943","host_organization_name":"University of Milan","host_organization_lineage":["https://openalex.org/I189158943"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:iris.unisr.it:20.500.11768/184905","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/20.500.11768/184905","pdf_url":"https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2023.1341708/pdf","source":{"id":"https://openalex.org/S7407055348","display_name":"Archivio Istituzionale della Ricerca - Universit\u00e0 Vita-Salute San Raffaele","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:arpi.unipi.it:11568/1330791","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/11568/1330791","pdf_url":null,"source":{"id":"https://openalex.org/S4377196265","display_name":"CINECA IRIS Institutial research information system (University of Pisa)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I108290504","host_organization_name":"University of Pisa","host_organization_lineage":["https://openalex.org/I108290504"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:e8adfd5931624f3f9e09c85cb9c18c40","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/e8adfd5931624f3f9e09c85cb9c18c40","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Immunology, Vol 14 (2024)","raw_type":"article"},{"id":"pmh:oai:iris.unicampania.it:11591/530348","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/11591/530348","pdf_url":null,"source":{"id":"https://openalex.org/S7407055255","display_name":"Archivio Istituzionale della Ricerca - Universit\u00e0 degli Studi della Campania \"Luigi Vanvitelli\"","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.3389/fimmu.2023.1341708","doi":"https://doi.org/10.3389/fimmu.2023.1341708","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2023.1341708","pdf_url":"https://www.frontiersin.org/articles/10.3389/fimmu.2023.1341708/pdf?isPublishedV2=False","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9940000176429749}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320321781","display_name":"Ministero della Salute","ror":"https://ror.org/00789fa95"},{"id":"https://openalex.org/F4320330887","display_name":"Humanitas Research Hospital","ror":"https://ror.org/05d538656"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4390744965.pdf","grobid_xml":"https://content.openalex.org/works/W4390744965.grobid-xml"},"referenced_works_count":17,"referenced_works":["https://openalex.org/W2083180635","https://openalex.org/W2781078917","https://openalex.org/W2887412253","https://openalex.org/W3037060742","https://openalex.org/W3128695200","https://openalex.org/W3129416935","https://openalex.org/W3143775625","https://openalex.org/W3173878348","https://openalex.org/W4206739528","https://openalex.org/W4220769473","https://openalex.org/W4284675502","https://openalex.org/W4292324125","https://openalex.org/W4378976510","https://openalex.org/W4382982498","https://openalex.org/W4383998038","https://openalex.org/W4385662437","https://openalex.org/W4386085738"],"related_works":["https://openalex.org/W4292324125","https://openalex.org/W3143775625","https://openalex.org/W4388418926","https://openalex.org/W7212120621","https://openalex.org/W7126128963","https://openalex.org/W4394873662","https://openalex.org/W4390792276","https://openalex.org/W3126106680","https://openalex.org/W4302761243","https://openalex.org/W7122760091"],"abstract_inverted_index":{"Introduction:":[0],"The":[1,127],"development":[2],"of":[3,17,23,106,121,130,157,219,237],"several":[4],"effective":[5],"biological":[6,66],"drugs":[7,94],"for":[8,64,138,196],"moderate-to-severe":[9],"plaque":[10],"psoriasis":[11],"has":[12],"dramatically":[13],"changed":[14],"the":[15,20,61,91,111,114,154,163,166],"lives":[16],"patients.":[18],"Despite":[19],"wide":[21],"use":[22],"interleukin":[24,53],"(IL)":[25],"inhibitors,":[26,198,210],"limited":[27],"data":[28],"are":[29],"available":[30],"to":[31,233],"date":[32],"regarding":[33],"long-term":[34],"treatment":[35,45,112,155,194],"persistence.":[36],"Method:":[37],"This":[38],"multicenter":[39],"retrospective":[40],"real-world":[41,202],"study":[42],"evaluated":[43],"5932":[44],"courses":[46],"across":[47],"5300":[48],"patients,":[49],"all":[50,184],"treated":[51],"with":[52,82,113,165,200],"inhibitors.":[54],"Drug":[55],"survival":[56,117,132,169,221],"was":[57,136,162],"expressed":[58],"by":[59,79,177],"using":[60],"Kaplan-Meier":[62],"estimator":[63],"each":[65],"drug":[67,116,131,168,220],"at":[68,133,170],"6,":[69],"12,":[70],"24,":[71],"36":[72],"and":[73,100,145,211,228],"48":[74],"months.":[75],"We":[76],"also":[77],"stratified":[78],"discontinuation":[80],"associated":[81],"primary":[83],"or":[84],"secondary":[85],"ineffectiveness.":[86],"Results:":[87],"In":[88],"our":[89],"study,":[90,181],"most":[92],"prescribed":[93],"were":[95,123,187,230],"secukinumab":[96],"(1412),":[97],"ixekizumab":[98,141,178,229],"(1183),":[99],"risankizumab":[101,108,161,212],"(977).":[102],"After":[103],"four":[104,134,240],"years":[105,135,172],"follow-up,":[107],"emerged":[109],"as":[110,119],"highest":[115,167],"overall,":[118],"91.6%":[120],"patients":[122,151],"still":[124],"on":[125],"treatment.":[126],"overall":[128,222],"probability":[129,218],"comparable":[137],"tildrakizumab":[139],"(83.5%),":[140],"(82.6%),":[142],"guselkumab":[143],"(82.4%)":[144],"brodalumab":[146],"(81.8%).":[147],"When":[148],"evaluating":[149],"only":[150],"who":[152],"discontinued":[153,235],"because":[156,236],"ineffectiveness,":[158],"once":[159],"again":[160],"molecule":[164],"4":[171],"(93.4%),":[173],"this":[174],"time":[175],"followed":[176],"(87%).":[179],"Our":[180,205],"in":[182,213],"which":[183],"IL":[185],"inhibitors":[186],"adequately":[188],"represented,":[189],"confirmed":[190],"a":[191,216,224],"slightly":[192],"better":[193],"persistence":[195],"IL-23":[197,209],"consistent":[199],"other":[201],"studies.":[203],"Conclusion:":[204],"experience":[206],"showed":[207],"that":[208],"particular,":[214],"had":[215],"higher":[217],"during":[223],"4-year":[225],"follow-up.":[226],"Risankizumab":[227],"less":[231],"likely":[232],"be":[234],"ineffectiveness":[238],"after":[239],"years.":[241]},"counts_by_year":[{"year":2026,"cited_by_count":24},{"year":2025,"cited_by_count":28},{"year":2024,"cited_by_count":12},{"year":2020,"cited_by_count":1}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2024-01-13T00:00:00"}