{"id":"https://openalex.org/W4390744542","doi":"https://doi.org/10.1021/acs.jproteome.3c00584","title":"Proteomics Analysis of Knee Subchondral Bone Identifies Differentially Expressed Proteins Associated with Osteoarthritis","display_name":"Proteomics Analysis of Knee Subchondral Bone Identifies Differentially Expressed Proteins Associated with Osteoarthritis","publication_year":2024,"publication_date":"2024-01-11","ids":{"openalex":"https://openalex.org/W4390744542","doi":"https://doi.org/10.1021/acs.jproteome.3c00584","pmid":"https://pubmed.ncbi.nlm.nih.gov/38206579","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10846524"},"language":"en","primary_location":{"id":"doi:10.1021/acs.jproteome.3c00584","doi":"https://doi.org/10.1021/acs.jproteome.3c00584","is_oa":true,"landing_page_url":"https://doi.org/10.1021/acs.jproteome.3c00584","pdf_url":"https://pubs.acs.org/doi/pdf/10.1021/acs.jproteome.3c00584","source":{"id":"https://openalex.org/S74367812","display_name":"Journal of Proteome Research","issn_l":"1535-3893","issn":["1535-3893","1535-3907"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Proteome Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://pubs.acs.org/doi/pdf/10.1021/acs.jproteome.3c00584","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5060463153","display_name":"Qizhao Tan","orcid":"https://orcid.org/0000-0003-0922-0467","observed_orcids":["https://orcid.org/0000-0003-0922-0467"]},"institutions":[{"id":"https://openalex.org/I4210141942","display_name":"Peking University Third Hospital","ror":"https://ror.org/04wwqze12","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210141942"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qizhao Tan","raw_affiliation_strings":["Department of Orthopaedics, Peking University Third Hospital, Beijing 100191, China","Engineering Research Center of Bone and Joint Precision Medicine, Ministry of Education, Beijing 100191, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedics, Peking University Third Hospital, Beijing 100191, China","institution_ids":["https://openalex.org/I4210141942"]},{"raw_affiliation_string":"Engineering Research Center of Bone and Joint Precision Medicine, Ministry of Education, Beijing 100191, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100448874","display_name":"Feng Li","orcid":"https://orcid.org/0000-0002-1934-4650","observed_orcids":["https://orcid.org/0000-0002-1934-4650"]},"institutions":[{"id":"https://openalex.org/I4210141942","display_name":"Peking University Third Hospital","ror":"https://ror.org/04wwqze12","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210141942"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Feng Li","raw_affiliation_strings":["Department of Orthopaedics, Peking University Third Hospital, Beijing 100191, China","Engineering Research Center of Bone and Joint Precision Medicine, Ministry of Education, Beijing 100191, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedics, Peking University Third Hospital, Beijing 100191, China","institution_ids":["https://openalex.org/I4210141942"]},{"raw_affiliation_string":"Engineering Research Center of Bone and Joint Precision Medicine, Ministry of Education, Beijing 100191, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100365687","display_name":"Ke Zhang","orcid":"https://orcid.org/0000-0001-7304-5398","observed_orcids":["https://orcid.org/0000-0001-7304-5398"]},"institutions":[{"id":"https://openalex.org/I4210133846","display_name":"Peking University International Hospital","ror":"https://ror.org/03jxhcr96","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210133846"]},{"id":"https://openalex.org/I4210141942","display_name":"Peking University Third Hospital","ror":"https://ror.org/04wwqze12","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210141942"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ke Zhang","raw_affiliation_strings":["Department of Orthopaedics, Peking University International Hospital, Beijing 102206, China","Department of Orthopaedics, Peking University Third Hospital, Beijing 100191, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedics, Peking University International Hospital, Beijing 102206, China","institution_ids":["https://openalex.org/I4210133846"]},{"raw_affiliation_string":"Department of Orthopaedics, Peking University Third Hospital, Beijing 100191, China","institution_ids":["https://openalex.org/I4210141942"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101694817","display_name":"Zhongjun Liu","orcid":"https://orcid.org/0000-0002-5663-5238","observed_orcids":["https://orcid.org/0000-0002-5663-5238","https://orcid.org/0000-0003-3208-4168"]},"institutions":[{"id":"https://openalex.org/I4210141942","display_name":"Peking University Third Hospital","ror":"https://ror.org/04wwqze12","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210141942"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhongjun Liu","raw_affiliation_strings":["Department of Orthopaedics, Peking University Third Hospital, Beijing 100191, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedics, Peking University Third Hospital, Beijing 100191, China","institution_ids":["https://openalex.org/I4210141942"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020574783","display_name":"Yun Tian","orcid":"https://orcid.org/0000-0003-2310-6054","observed_orcids":["https://orcid.org/0000-0003-2310-6054"]},"institutions":[{"id":"https://openalex.org/I4210141942","display_name":"Peking University Third Hospital","ror":"https://ror.org/04wwqze12","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210141942"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yun Tian","raw_affiliation_strings":["Department of Orthopaedics, Peking University Third Hospital, Beijing 100191, China","Engineering Research Center of Bone and Joint Precision Medicine, Ministry of Education, Beijing 100191, China"],"raw_orcid":"https://orcid.org/0000-0003-2310-6054","affiliations":[{"raw_affiliation_string":"Department of Orthopaedics, Peking University Third Hospital, Beijing 100191, China","institution_ids":["https://openalex.org/I4210141942"]},{"raw_affiliation_string":"Engineering Research Center of Bone and Joint Precision Medicine, Ministry of Education, Beijing 100191, China","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5072988162","display_name":"Tengjiao Zhu","orcid":"https://orcid.org/0000-0002-2748-3773","observed_orcids":["https://orcid.org/0000-0002-2748-3773"]},"institutions":[{"id":"https://openalex.org/I4210141942","display_name":"Peking University Third Hospital","ror":"https://ror.org/04wwqze12","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210141942"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Tengjiao Zhu","raw_affiliation_strings":["Department of Orthopaedics, Peking University Third Hospital, Beijing 100191, China","Engineering Research Center of Bone and Joint Precision Medicine, Ministry of Education, Beijing 100191, China"],"raw_orcid":"https://orcid.org/0000-0002-2748-3773","affiliations":[{"raw_affiliation_string":"Department of Orthopaedics, Peking University Third Hospital, Beijing 100191, China","institution_ids":["https://openalex.org/I4210141942"]},{"raw_affiliation_string":"Engineering Research Center of Bone and Joint Precision Medicine, Ministry of Education, Beijing 100191, China","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5020574783","https://openalex.org/A5072988162"],"corresponding_institution_ids":["https://openalex.org/I4210141942"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":{"value":4500,"currency":"USD","value_usd":4500},"fwci":2.6221,"has_fulltext":true,"cited_by_count":10,"citation_normalized_percentile":{"value":0.89134057,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":98},"biblio":{"volume":"23","issue":"2","first_page":"738","last_page":"748"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12209","display_name":"Bone and Joint Diseases","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/osteoarthritis","display_name":"osteoarthritis","score":0.9649999737739563},{"id":"https://openalex.org/keywords/subchondral-bone","display_name":"subchondral bone","score":0.949999988079071},{"id":"https://openalex.org/keywords/differentially-expressed-proteins","display_name":"differentially expressed proteins","score":0.9359999895095825},{"id":"https://openalex.org/keywords/serpina5","display_name":"SERPINA5","score":0.8270000219345093},{"id":"https://openalex.org/keywords/complement-and-coagulation-cascade","display_name":"complement and coagulation cascade","score":0.8050000071525574},{"id":"https://openalex.org/keywords/bone-proteome","display_name":"bone proteome","score":0.6420000195503235},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.6039999723434448}],"concepts":[{"id":"https://openalex.org/C2776164576","wikidata":"https://www.wikidata.org/wiki/Q62736","display_name":"Osteoarthritis","level":3,"score":0.8805723786354065},{"id":"https://openalex.org/C3018615303","wikidata":"https://www.wikidata.org/wiki/Q1801229","display_name":"Subchondral bone","level":5,"score":0.8106322288513184},{"id":"https://openalex.org/C46111723","wikidata":"https://www.wikidata.org/wiki/Q471857","display_name":"Proteomics","level":3,"score":0.6323342323303223},{"id":"https://openalex.org/C104397665","wikidata":"https://www.wikidata.org/wiki/Q860947","display_name":"Proteome","level":2,"score":0.5810793042182922},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5778852701187134},{"id":"https://openalex.org/C111684460","wikidata":"https://www.wikidata.org/wiki/Q334848","display_name":"Complement system","level":3,"score":0.5480692982673645},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3925137519836426},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.35812634229660034},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.34948980808258057},{"id":"https://openalex.org/C3020332539","wikidata":"https://www.wikidata.org/wiki/Q2014564","display_name":"Articular cartilage","level":4,"score":0.24537470936775208},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.18731439113616943},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.17823845148086548},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.1001339852809906},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.07880935072898865},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.06339371204376221},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001842","descriptor_name":"Bone and Bones","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002358","descriptor_name":"Cartilage, Articular","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010003","descriptor_name":"Osteoarthritis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020370","descriptor_name":"Osteoarthritis, Knee","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D020370","descriptor_name":"Osteoarthritis, Knee","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1021/acs.jproteome.3c00584","doi":"https://doi.org/10.1021/acs.jproteome.3c00584","is_oa":true,"landing_page_url":"https://doi.org/10.1021/acs.jproteome.3c00584","pdf_url":"https://pubs.acs.org/doi/pdf/10.1021/acs.jproteome.3c00584","source":{"id":"https://openalex.org/S74367812","display_name":"Journal of Proteome Research","issn_l":"1535-3893","issn":["1535-3893","1535-3907"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Proteome Research","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10846524","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10846524","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10846524/pdf/pr3c00584.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Proteome Res","raw_type":"Text"},{"id":"pmid:38206579","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38206579","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of proteome research","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1021/acs.jproteome.3c00584","doi":"https://doi.org/10.1021/acs.jproteome.3c00584","is_oa":true,"landing_page_url":"https://doi.org/10.1021/acs.jproteome.3c00584","pdf_url":"https://pubs.acs.org/doi/pdf/10.1021/acs.jproteome.3c00584","source":{"id":"https://openalex.org/S74367812","display_name":"Journal of Proteome Research","issn_l":"1535-3893","issn":["1535-3893","1535-3907"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Proteome Research","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1577556278","display_name":null,"funder_award_id":"82002030","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G3305265913","display_name":null,"funder_award_id":"2018YFE0104200","funder_id":"https://openalex.org/F4320321540","funder_display_name":"Ministry of Science and Technology of the People's Republic of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320321540","display_name":"Ministry of Science and Technology of the People's Republic of China","ror":"https://ror.org/027s68j25"},{"id":"https://openalex.org/F4320324787","display_name":"Peking University","ror":"https://ror.org/02v51f717"},{"id":"https://openalex.org/F4320325739","display_name":"Peking University Third Hospital","ror":"https://ror.org/04wwqze12"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4390744542.pdf","grobid_xml":"https://content.openalex.org/works/W4390744542.grobid-xml"},"referenced_works_count":38,"referenced_works":["https://openalex.org/W1502673885","https://openalex.org/W1541952406","https://openalex.org/W1551907931","https://openalex.org/W1604583062","https://openalex.org/W1917694766","https://openalex.org/W1945216193","https://openalex.org/W1967057044","https://openalex.org/W1980409139","https://openalex.org/W1985293197","https://openalex.org/W1985751488","https://openalex.org/W1995158939","https://openalex.org/W2013462509","https://openalex.org/W2031932021","https://openalex.org/W2075612872","https://openalex.org/W2082152932","https://openalex.org/W2111322263","https://openalex.org/W2123188033","https://openalex.org/W2128952811","https://openalex.org/W2131948539","https://openalex.org/W2139183536","https://openalex.org/W2139464580","https://openalex.org/W2149208570","https://openalex.org/W2155037253","https://openalex.org/W2173293339","https://openalex.org/W2269139557","https://openalex.org/W2322190065","https://openalex.org/W2411211573","https://openalex.org/W2494046833","https://openalex.org/W2522694580","https://openalex.org/W2739007687","https://openalex.org/W2788614546","https://openalex.org/W2801171290","https://openalex.org/W2905120156","https://openalex.org/W3119127780","https://openalex.org/W3199380565","https://openalex.org/W4210254819","https://openalex.org/W4289844876","https://openalex.org/W4309482433"],"related_works":["https://openalex.org/W4200579052","https://openalex.org/W2072016997","https://openalex.org/W2110178671","https://openalex.org/W2774496308","https://openalex.org/W1541952406","https://openalex.org/W3085945914","https://openalex.org/W2001362493","https://openalex.org/W7162868892","https://openalex.org/W7125638510","https://openalex.org/W4410552099"],"abstract_inverted_index":{"Osteoarthritis":[0],"(OA)":[1],"is":[2,30],"a":[3,9,110,183,193],"prevalent":[4],"debilitating":[5],"whole-joint":[6],"disorder.":[7],"Currently,":[8],"growing":[10],"number":[11],"of":[12,39,98,112,118,147,159,177,188,197],"proteomic":[13,44],"studies":[14],"have":[15],"been":[16],"performed":[17,47],"to":[18,55,65,152,165],"evaluate":[19],"molecular":[20],"biomarkers":[21],"in":[22,36,74,84,115,133,142,161,185],"several":[23],"tissues":[24],"from":[25,51,77],"OA":[26,54,87,101,150],"patients;":[27],"however,":[28],"little":[29],"known":[31],"about":[32],"the":[33,75,116,119,130,134,153,157,175,186],"protein":[34,131],"profiles":[35],"subchondral":[37,49,94,145],"bone":[38,50,95,146],"OA.":[40,198],"In":[41],"this":[42],"study,":[43],"analysis":[45,107],"was":[46,102,139,168],"on":[48],"patients":[52,78,99,148],"with":[53,79,100,149],"identify":[56],"differentially":[57],"expressed":[58],"proteins":[59],"(DEPs).":[60],"Bioinformatics":[61],"tools":[62],"were":[63,72],"used":[64],"further":[66],"investigate":[67],"these":[68],"DEPs.":[69],"Thereafter,":[70],"DEPs":[71,113],"validated":[73],"samples":[76],"OA,":[80,189],"as":[81,83],"well":[82],"bilateral":[85],"ovariectomy-induced":[86],"(OVX-OA)":[88],"rats":[89,163,167],"using":[90],"immunohistochemistry.":[91],"A":[92],"comprehensive":[93],"proteome":[96],"profile":[97],"constructed.":[103],"Additionally,":[104],"biological":[105],"information":[106],"showed":[108],"that":[109,128,174],"majority":[111],"participated":[114],"dysregulation":[117,176],"complement":[120,135,180],"and":[121,136,179,190],"coagulation":[122,137,178],"cascades.":[123],"The":[124],"validation":[125],"experiments":[126],"suggested":[127],"SerpinA5,":[129],"involved":[132],"cascades,":[138],"significantly":[140],"increased":[141],"severely":[143],"damaged":[144],"compared":[151,164],"control":[154,166],"group.":[155],"Furthermore,":[156],"increase":[158],"SerpinA5":[160],"OVX-OA":[162],"also":[169],"confirmed.":[170],"Our":[171],"results":[172],"indicated":[173],"pathways":[181],"plays":[182],"role":[184],"progression":[187],"it":[191],"provides":[192],"promising":[194],"therapeutic":[195],"target":[196]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2024-01-13T00:00:00"}
