{"id":"https://openalex.org/W4390744192","doi":"https://doi.org/10.1039/d3ra05401b","title":"New pyrazolo[3,4- d ]pyrimidine derivatives as EGFR-TK inhibitors: design, green synthesis, potential anti-proliferative activity and P-glycoprotein inhibition","display_name":"New pyrazolo[3,4- d ]pyrimidine derivatives as EGFR-TK inhibitors: design, green synthesis, potential anti-proliferative activity and P-glycoprotein inhibition","publication_year":2024,"publication_date":"2024-01-01","ids":{"openalex":"https://openalex.org/W4390744192","doi":"https://doi.org/10.1039/d3ra05401b","pmid":"https://pubmed.ncbi.nlm.nih.gov/38196910","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10774712"},"language":"en","primary_location":{"id":"doi:10.1039/d3ra05401b","doi":"https://doi.org/10.1039/d3ra05401b","is_oa":true,"landing_page_url":"https://doi.org/10.1039/d3ra05401b","pdf_url":"https://pubs.rsc.org/en/content/articlepdf/2024/ra/d3ra05401b","source":{"id":"https://openalex.org/S2481244646","display_name":"RSC Advances","issn_l":"2046-2069","issn":["2046-2069"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"RSC Advances","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://pubs.rsc.org/en/content/articlepdf/2024/ra/d3ra05401b","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5053834308","display_name":"Aya Ibrahim Hassaballah","orcid":"https://orcid.org/0000-0002-8476-7705","observed_orcids":["https://orcid.org/0000-0002-8476-7705"]},"institutions":[{"id":"https://openalex.org/I107720978","display_name":"Ain Shams University","ror":"https://ror.org/00cb9w016","country_code":"EG","type":"education","lineage":["https://openalex.org/I107720978"]}],"countries":["EG"],"is_corresponding":true,"raw_author_name":"Aya I. Hassaballah","raw_affiliation_strings":["Chemistry Department, Faculty of Science, Ain Shams University, Abbassia, 11566, Cairo, Egypt"],"raw_orcid":"https://orcid.org/0000-0002-8476-7705","affiliations":[{"raw_affiliation_string":"Chemistry Department, Faculty of Science, Ain Shams University, Abbassia, 11566, Cairo, Egypt","institution_ids":["https://openalex.org/I107720978"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039860064","display_name":"Asmaa M. AboulMagd","orcid":"https://orcid.org/0000-0003-4243-9401","observed_orcids":["https://orcid.org/0000-0003-4243-9401"]},"institutions":[{"id":"https://openalex.org/I2799409690","display_name":"Nahda University","ror":"https://ror.org/05s29c959","country_code":"EG","type":"education","lineage":["https://openalex.org/I2799409690"]}],"countries":["EG"],"is_corresponding":true,"raw_author_name":"Asmaa M. AboulMagd","raw_affiliation_strings":["Pharmaceutical Chemistry Department, Faculty of Pharmacy, Nahda University (NUB), Beni-Suef, Egypt"],"raw_orcid":"https://orcid.org/0000-0003-4243-9401","affiliations":[{"raw_affiliation_string":"Pharmaceutical Chemistry Department, Faculty of Pharmacy, Nahda University (NUB), Beni-Suef, Egypt","institution_ids":["https://openalex.org/I2799409690"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034170592","display_name":"Magdy Mohamed Hemdan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I107720978","display_name":"Ain Shams University","ror":"https://ror.org/00cb9w016","country_code":"EG","type":"education","lineage":["https://openalex.org/I107720978"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Magdy M. Hemdan","raw_affiliation_strings":["Chemistry Department, Faculty of Science, Ain Shams University, Abbassia, 11566, Cairo, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemistry Department, Faculty of Science, Ain Shams University, Abbassia, 11566, Cairo, Egypt","institution_ids":["https://openalex.org/I107720978"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015091786","display_name":"Mohamed H. Hekal","orcid":"https://orcid.org/0000-0001-6059-9666","observed_orcids":["https://orcid.org/0000-0001-6059-9666"]},"institutions":[{"id":"https://openalex.org/I107720978","display_name":"Ain Shams University","ror":"https://ror.org/00cb9w016","country_code":"EG","type":"education","lineage":["https://openalex.org/I107720978"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Mohamed H. Hekal","raw_affiliation_strings":["Chemistry Department, Faculty of Science, Ain Shams University, Abbassia, 11566, Cairo, Egypt"],"raw_orcid":"https://orcid.org/0000-0001-6059-9666","affiliations":[{"raw_affiliation_string":"Chemistry Department, Faculty of Science, Ain Shams University, Abbassia, 11566, Cairo, Egypt","institution_ids":["https://openalex.org/I107720978"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004452545","display_name":"Amira A. El\u2010Sayed","orcid":"https://orcid.org/0000-0002-0840-4806","observed_orcids":["https://orcid.org/0000-0002-0840-4806"]},"institutions":[{"id":"https://openalex.org/I107720978","display_name":"Ain Shams University","ror":"https://ror.org/00cb9w016","country_code":"EG","type":"education","lineage":["https://openalex.org/I107720978"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Amira A. El-Sayed","raw_affiliation_strings":["Chemistry Department, Faculty of Science, Ain Shams University, Abbassia, 11566, Cairo, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemistry Department, Faculty of Science, Ain Shams University, Abbassia, 11566, Cairo, Egypt","institution_ids":["https://openalex.org/I107720978"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5048818175","display_name":"Paula S. Farag","orcid":"https://orcid.org/0000-0002-2290-3628","observed_orcids":["https://orcid.org/0000-0002-2290-3628"]},"institutions":[{"id":"https://openalex.org/I107720978","display_name":"Ain Shams University","ror":"https://ror.org/00cb9w016","country_code":"EG","type":"education","lineage":["https://openalex.org/I107720978"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Paula S. Farag","raw_affiliation_strings":["Chemistry Department, Faculty of Science, Ain Shams University, Abbassia, 11566, Cairo, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemistry Department, Faculty of Science, Ain Shams University, Abbassia, 11566, Cairo, Egypt","institution_ids":["https://openalex.org/I107720978"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5039860064","https://openalex.org/A5053834308"],"corresponding_institution_ids":["https://openalex.org/I107720978","https://openalex.org/I2799409690"],"apc_list":{"value":850,"currency":"GBP","value_usd":1042},"apc_paid":{"value":850,"currency":"GBP","value_usd":1042},"fwci":4.0309,"has_fulltext":true,"cited_by_count":29,"citation_normalized_percentile":{"value":0.95761114,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":100},"biblio":{"volume":"14","issue":"3","first_page":"1995","last_page":"2015"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":0.926800012588501,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":0.926800012588501,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T14099","display_name":"Synthesis and Characterization of Heterocyclic Compounds","score":0.0681999996304512,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10817","display_name":"Multicomponent Synthesis of Heterocycles","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pyrazolo-3-4-d-pyrimidines","display_name":"pyrazolo[3,4-d]pyrimidines","score":0.9829999804496765},{"id":"https://openalex.org/keywords/egfr-tyrosine-kinase-inhibitors","display_name":"EGFR tyrosine kinase inhibitors","score":0.9940000176429749},{"id":"https://openalex.org/keywords/green-synthesis","display_name":"green synthesis","score":0.9610000252723694},{"id":"https://openalex.org/keywords/antiproliferative-activity","display_name":"antiproliferative activity","score":0.9269999861717224},{"id":"https://openalex.org/keywords/p-glycoprotein-inhibition","display_name":"P-glycoprotein inhibition","score":0.9950000047683716},{"id":"https://openalex.org/keywords/mda-mb-468-breast-cancer-cells","display_name":"MDA-MB-468 breast cancer cells","score":0.8970000147819519},{"id":"https://openalex.org/keywords/s-phase-arrest","display_name":"S phase arrest","score":0.8679999709129333},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.8659999966621399},{"id":"https://openalex.org/keywords/molecular-docking","display_name":"molecular docking","score":0.8040000200271606},{"id":"https://openalex.org/keywords/anticancer-drug-design","display_name":"anticancer drug design","score":0.7699999809265137}],"concepts":[{"id":"https://openalex.org/C2779321679","wikidata":"https://www.wikidata.org/wiki/Q207722","display_name":"Pyrimidine","level":2,"score":0.7648890018463135},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6912091970443726},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.6657427549362183},{"id":"https://openalex.org/C2777752497","wikidata":"https://www.wikidata.org/wiki/Q286779","display_name":"IC50","level":3,"score":0.5625712871551514},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.5519704222679138},{"id":"https://openalex.org/C105696609","wikidata":"https://www.wikidata.org/wiki/Q1068809","display_name":"Cell cycle checkpoint","level":4,"score":0.5463311672210693},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.5280407667160034},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.499112606048584},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.48802295327186584},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.48746562004089355},{"id":"https://openalex.org/C41685203","wikidata":"https://www.wikidata.org/wiki/Q1974042","display_name":"Docking (animal)","level":2,"score":0.4519219398498535},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.44437310099601746},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.4403761923313141},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4097025394439697},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.25619104504585266},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.17797446250915527},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.07245904207229614},{"id":"https://openalex.org/C159110408","wikidata":"https://www.wikidata.org/wiki/Q121176","display_name":"Nursing","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1039/d3ra05401b","doi":"https://doi.org/10.1039/d3ra05401b","is_oa":true,"landing_page_url":"https://doi.org/10.1039/d3ra05401b","pdf_url":"https://pubs.rsc.org/en/content/articlepdf/2024/ra/d3ra05401b","source":{"id":"https://openalex.org/S2481244646","display_name":"RSC Advances","issn_l":"2046-2069","issn":["2046-2069"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"RSC Advances","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10774712","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10774712","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10774712/pdf/RA-014-D3RA05401B.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"RSC Adv","raw_type":"Text"},{"id":"pmid:38196910","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38196910","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"RSC advances","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1039/d3ra05401b","doi":"https://doi.org/10.1039/d3ra05401b","is_oa":true,"landing_page_url":"https://doi.org/10.1039/d3ra05401b","pdf_url":"https://pubs.rsc.org/en/content/articlepdf/2024/ra/d3ra05401b","source":{"id":"https://openalex.org/S2481244646","display_name":"RSC Advances","issn_l":"2046-2069","issn":["2046-2069"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"RSC Advances","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8371999859809875}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4390744192.pdf","grobid_xml":"https://content.openalex.org/works/W4390744192.grobid-xml"},"referenced_works_count":44,"referenced_works":["https://openalex.org/W1973266471","https://openalex.org/W1983790923","https://openalex.org/W2004194844","https://openalex.org/W2009867031","https://openalex.org/W2028459193","https://openalex.org/W2031871842","https://openalex.org/W2036386689","https://openalex.org/W2039559098","https://openalex.org/W2039879244","https://openalex.org/W2046847279","https://openalex.org/W2058848030","https://openalex.org/W2059034711","https://openalex.org/W2064973618","https://openalex.org/W2070822454","https://openalex.org/W2082743660","https://openalex.org/W2096670077","https://openalex.org/W2097814529","https://openalex.org/W2101630681","https://openalex.org/W2105662969","https://openalex.org/W2138951336","https://openalex.org/W2139041740","https://openalex.org/W2143278515","https://openalex.org/W2147811178","https://openalex.org/W2154583637","https://openalex.org/W2156972915","https://openalex.org/W2157704894","https://openalex.org/W2165571648","https://openalex.org/W2177215675","https://openalex.org/W2178451042","https://openalex.org/W2460300472","https://openalex.org/W2473328171","https://openalex.org/W2529453853","https://openalex.org/W2739439285","https://openalex.org/W2808351871","https://openalex.org/W2912198431","https://openalex.org/W2952959938","https://openalex.org/W3045584264","https://openalex.org/W3154042921","https://openalex.org/W3185760883","https://openalex.org/W3208414078","https://openalex.org/W3208667121","https://openalex.org/W4224088098","https://openalex.org/W4307906685","https://openalex.org/W4320498046"],"related_works":["https://openalex.org/W2316776483","https://openalex.org/W2063130697","https://openalex.org/W1966418864","https://openalex.org/W2808351871","https://openalex.org/W3198207175","https://openalex.org/W3198584721","https://openalex.org/W2337170247","https://openalex.org/W2948648471","https://openalex.org/W3152758277","https://openalex.org/W4306399260"],"abstract_inverted_index":{"=":[0],"0.267":[1],"and":[2],"0.844":[3],"\u03bcM,":[4],"respectively.":[5],"Additionally,":[6],"compound":[7],"16":[8],"was":[9,49],"found":[10],"to":[11,52],"induce":[12],"cell":[13,26,30],"cycle":[14],"arrest":[15],"at":[16],"the":[17,35,54,61],"S":[18],"phase":[19],"with":[20],"a":[21,41,45],"subsequent":[22],"increase":[23],"in":[24,28,40],"pre-G":[25],"population":[27],"MDA-MB-468":[29],"line.":[31],"It":[32],"also":[33],"increased":[34],"percentage":[36],"of":[37],"apoptotic":[38],"cells":[39],"time-dependent":[42],"manner.":[43],"Moreover,":[44],"molecular":[46],"docking":[47],"study":[48],"carried":[50],"out":[51],"explain":[53],"target":[55],"compounds'":[56],"potent":[57],"inhibitory":[58],"activity":[59],"within":[60],"EGFR":[62],"binding":[63],"site.":[64]},"counts_by_year":[{"year":2026,"cited_by_count":14},{"year":2025,"cited_by_count":11},{"year":2024,"cited_by_count":4}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2024-01-13T00:00:00"}