{"id":"https://openalex.org/W4390743524","doi":"https://doi.org/10.1152/japplphysiol.00444.2023","title":"Effects of aging and lifelong aerobic exercise on expression of innate immune components in skeletal muscle of women","display_name":"Effects of aging and lifelong aerobic exercise on expression of innate immune components in skeletal muscle of women","publication_year":2024,"publication_date":"2024-01-11","ids":{"openalex":"https://openalex.org/W4390743524","doi":"https://doi.org/10.1152/japplphysiol.00444.2023","pmid":"https://pubmed.ncbi.nlm.nih.gov/38205547","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11212804"},"language":"en","primary_location":{"id":"doi:10.1152/japplphysiol.00444.2023","doi":"https://doi.org/10.1152/japplphysiol.00444.2023","is_oa":false,"landing_page_url":"https://doi.org/10.1152/japplphysiol.00444.2023","pdf_url":null,"source":{"id":"https://openalex.org/S140889577","display_name":"Journal of Applied Physiology","issn_l":"0161-7567","issn":["0161-7567","1522-1601","8750-7587"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Applied Physiology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11212804","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5027558603","display_name":"Ryan K. Perkins","orcid":"https://orcid.org/0000-0002-2546-4085","observed_orcids":["https://orcid.org/0000-0002-2546-4085"]},"institutions":[{"id":"https://openalex.org/I198089087","display_name":"Ball State University","ror":"https://ror.org/00k6tx165","country_code":"US","type":"education","lineage":["https://openalex.org/I198089087"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ryan K. Perkins","raw_affiliation_strings":["Human Performance Laboratory, Ball State University, Muncie, Indiana, United States"],"raw_orcid":"https://orcid.org/0000-0002-2546-4085","affiliations":[{"raw_affiliation_string":"Human Performance Laboratory, Ball State University, Muncie, Indiana, United States","institution_ids":["https://openalex.org/I198089087"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061204715","display_name":"Kaleen M. Lavin","orcid":"https://orcid.org/0000-0003-1426-8174","observed_orcids":["https://orcid.org/0000-0003-1426-8174"]},"institutions":[{"id":"https://openalex.org/I198089087","display_name":"Ball State University","ror":"https://ror.org/00k6tx165","country_code":"US","type":"education","lineage":["https://openalex.org/I198089087"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kaleen M. Lavin","raw_affiliation_strings":["Human Performance Laboratory, Ball State University, Muncie, Indiana, United States"],"raw_orcid":"https://orcid.org/0000-0003-1426-8174","affiliations":[{"raw_affiliation_string":"Human Performance Laboratory, Ball State University, Muncie, Indiana, United States","institution_ids":["https://openalex.org/I198089087"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085217281","display_name":"Ulrika Raue","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I198089087","display_name":"Ball State University","ror":"https://ror.org/00k6tx165","country_code":"US","type":"education","lineage":["https://openalex.org/I198089087"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ulrika Raue","raw_affiliation_strings":["Human Performance Laboratory, Ball State University, Muncie, Indiana, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Human Performance Laboratory, Ball State University, Muncie, Indiana, United States","institution_ids":["https://openalex.org/I198089087"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076606826","display_name":"Bo\u017cena Jemio\u0142o","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I198089087","display_name":"Ball State University","ror":"https://ror.org/00k6tx165","country_code":"US","type":"education","lineage":["https://openalex.org/I198089087"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bozena Jemiolo","raw_affiliation_strings":["Human Performance Laboratory, Ball State University, Muncie, Indiana, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Human Performance Laboratory, Ball State University, Muncie, Indiana, United States","institution_ids":["https://openalex.org/I198089087"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017221444","display_name":"Scott W. Trappe","orcid":"https://orcid.org/0000-0002-6438-431X","observed_orcids":["https://orcid.org/0000-0002-6438-431X"]},"institutions":[{"id":"https://openalex.org/I198089087","display_name":"Ball State University","ror":"https://ror.org/00k6tx165","country_code":"US","type":"education","lineage":["https://openalex.org/I198089087"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Scott W. Trappe","raw_affiliation_strings":["Human Performance Laboratory, Ball State University, Muncie, Indiana, United States"],"raw_orcid":"https://orcid.org/0000-0002-6438-431X","affiliations":[{"raw_affiliation_string":"Human Performance Laboratory, Ball State University, Muncie, Indiana, United States","institution_ids":["https://openalex.org/I198089087"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5034038379","display_name":"Todd A. Trappe","orcid":"https://orcid.org/0000-0002-0609-5632","observed_orcids":["https://orcid.org/0000-0002-0609-5632"]},"institutions":[{"id":"https://openalex.org/I198089087","display_name":"Ball State University","ror":"https://ror.org/00k6tx165","country_code":"US","type":"education","lineage":["https://openalex.org/I198089087"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Todd A. Trappe","raw_affiliation_strings":["Human Performance Laboratory, Ball State University, Muncie, Indiana, United States"],"raw_orcid":"https://orcid.org/0000-0002-0609-5632","affiliations":[{"raw_affiliation_string":"Human Performance Laboratory, Ball State University, Muncie, Indiana, United States","institution_ids":["https://openalex.org/I198089087"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5034038379"],"corresponding_institution_ids":["https://openalex.org/I198089087"],"apc_list":null,"apc_paid":null,"fwci":1.1365,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.71706428,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"136","issue":"3","first_page":"482","last_page":"491"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11585","display_name":"Exercise and Physiological Responses","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11585","display_name":"Exercise and Physiological Responses","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.006800000090152025,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11209","display_name":"Cardiovascular and exercise physiology","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.9399999976158142},{"id":"https://openalex.org/keywords/aerobic-exercise","display_name":"aerobic exercise","score":0.949999988079071},{"id":"https://openalex.org/keywords/toll-like-receptors","display_name":"Toll-like receptors","score":0.9160000085830688},{"id":"https://openalex.org/keywords/innate-immunity","display_name":"innate immunity","score":0.9319999814033508},{"id":"https://openalex.org/keywords/skeletal-muscle","display_name":"skeletal muscle","score":0.9940000176429749},{"id":"https://openalex.org/keywords/women","display_name":"women","score":0.5659999847412109},{"id":"https://openalex.org/keywords/sexual-dimorphism","display_name":"sexual dimorphism","score":0.890999972820282},{"id":"https://openalex.org/keywords/resistance-training","display_name":"resistance training","score":0.8790000081062317},{"id":"https://openalex.org/keywords/gene-expression","display_name":"gene expression","score":0.4830000102519989}],"concepts":[{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.807335615158081},{"id":"https://openalex.org/C2779959927","wikidata":"https://www.wikidata.org/wiki/Q1048687","display_name":"Skeletal muscle","level":2,"score":0.7166123390197754},{"id":"https://openalex.org/C103038586","wikidata":"https://www.wikidata.org/wiki/Q1152037","display_name":"Aerobic exercise","level":2,"score":0.5425816178321838},{"id":"https://openalex.org/C500499127","wikidata":"https://www.wikidata.org/wiki/Q332154","display_name":"Ageing","level":2,"score":0.5316059589385986},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.519640326499939},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.42955905199050903},{"id":"https://openalex.org/C133165541","wikidata":"https://www.wikidata.org/wiki/Q472094","display_name":"Exercise physiology","level":2,"score":0.4251795709133148},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4166772663593292},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.39408618211746216},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.37552374601364136},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.35634756088256836}],"mesh":[{"descriptor_ui":"D000072000","descriptor_name":"NF-KappaB Inhibitor alpha","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007113","descriptor_name":"Immunity, Innate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015444","descriptor_name":"Exercise","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018482","descriptor_name":"Muscle, Skeletal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D033942","descriptor_name":"Adaptor Proteins, Vesicular Transport","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D048868","descriptor_name":"Adaptor Proteins, Signal Transducing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051194","descriptor_name":"Toll-Like Receptor 1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051197","descriptor_name":"Toll-Like Receptor 4","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051550","descriptor_name":"I-kappa B Kinase","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053594","descriptor_name":"Myeloid Differentiation Factor 88","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1152/japplphysiol.00444.2023","doi":"https://doi.org/10.1152/japplphysiol.00444.2023","is_oa":false,"landing_page_url":"https://doi.org/10.1152/japplphysiol.00444.2023","pdf_url":null,"source":{"id":"https://openalex.org/S140889577","display_name":"Journal of Applied Physiology","issn_l":"0161-7567","issn":["0161-7567","1522-1601","8750-7587"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Applied Physiology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11212804","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11212804","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Appl Physiol (1985)","raw_type":"Text"},{"id":"pmid:38205547","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38205547","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of applied physiology (Bethesda, Md. : 1985)","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:11212804","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11212804","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Appl Physiol (1985)","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[{"id":"https://openalex.org/G7225901711","display_name":"Skeletal Muscle Health with Aging and Life-Long Exercise","funder_award_id":"R01AG038576","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"}],"funders":[{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":57,"referenced_works":["https://openalex.org/W1839196447","https://openalex.org/W1907043835","https://openalex.org/W1970223664","https://openalex.org/W1975206576","https://openalex.org/W1987071203","https://openalex.org/W1995744610","https://openalex.org/W2005423595","https://openalex.org/W2009379137","https://openalex.org/W2026459500","https://openalex.org/W2032381721","https://openalex.org/W2041109271","https://openalex.org/W2045688706","https://openalex.org/W2071754972","https://openalex.org/W2087051284","https://openalex.org/W2091790511","https://openalex.org/W2096061116","https://openalex.org/W2097995193","https://openalex.org/W2099436724","https://openalex.org/W2107277218","https://openalex.org/W2108658335","https://openalex.org/W2109491705","https://openalex.org/W2113511704","https://openalex.org/W2114360920","https://openalex.org/W2121289998","https://openalex.org/W2127486493","https://openalex.org/W2128247037","https://openalex.org/W2129109908","https://openalex.org/W2139484084","https://openalex.org/W2139985432","https://openalex.org/W2142193433","https://openalex.org/W2148178789","https://openalex.org/W2152536923","https://openalex.org/W2161820702","https://openalex.org/W2166727175","https://openalex.org/W2187195351","https://openalex.org/W2225636283","https://openalex.org/W2518536270","https://openalex.org/W2590929482","https://openalex.org/W2756945639","https://openalex.org/W2889388742","https://openalex.org/W2970650601","https://openalex.org/W2982992594","https://openalex.org/W2989569476","https://openalex.org/W2995573937","https://openalex.org/W2996156649","https://openalex.org/W2999612022","https://openalex.org/W3006276505","https://openalex.org/W3088691838","https://openalex.org/W3093211696","https://openalex.org/W3124239923","https://openalex.org/W3128404735","https://openalex.org/W3132874044","https://openalex.org/W3164561088","https://openalex.org/W3202142733","https://openalex.org/W3215834080","https://openalex.org/W4206065608","https://openalex.org/W4213056361"],"related_works":["https://openalex.org/W3088691838","https://openalex.org/W4206065608","https://openalex.org/W2139484084","https://openalex.org/W2005423595","https://openalex.org/W2989569476","https://openalex.org/W4231737282","https://openalex.org/W195445090","https://openalex.org/W3163345693","https://openalex.org/W2099436724","https://openalex.org/W295366254"],"abstract_inverted_index":{"We":[0],"recently":[1],"reported":[2],"that":[3,40],"aging":[4,48],"increases":[5],"basal":[6,41,63],"expression":[7,33,43,67],"of":[8,34,57],"many":[9,35],"Toll-like":[10],"receptors":[11],"(TLRs)":[12],"in":[13,49],"men":[14],"and":[15,51,68],"lifelong":[16],"aerobic":[17],"exercise":[18,28,74],"does":[19],"not":[20],"prevent":[21],"this":[22],"effect.":[23],"In":[24],"addition,":[25],"a":[26,69],"resistance":[27],"(RE)":[29],"challenge":[30],"increased":[31],"the":[32,54],"TLRs.":[36],"Here":[37],"we":[38],"show":[39],"TLR":[42,66],"is":[44],"minimally":[45],"influenced":[46],"by":[47],"women":[50,60],"findings":[52],"support":[53],"sexual":[55],"dimorphism":[56],"immunity,":[58],"with":[59],"having":[61],"greater":[62],"skeletal":[64],"muscle":[65],"differential":[70],"response":[71],"to":[72],"unaccustomed":[73],"than":[75],"men.":[76]},"counts_by_year":[{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2024-01-13T00:00:00"}
