{"id":"https://openalex.org/W4390741789","doi":"https://doi.org/10.1016/j.cgh.2023.12.033","title":"Prevalence and Determinants of Liver Disease in Relatives of Italian Patients With Advanced MASLD","display_name":"Prevalence and Determinants of Liver Disease in Relatives of Italian Patients With Advanced MASLD","publication_year":2024,"publication_date":"2024-01-11","ids":{"openalex":"https://openalex.org/W4390741789","doi":"https://doi.org/10.1016/j.cgh.2023.12.033","pmid":"https://pubmed.ncbi.nlm.nih.gov/38216023"},"language":"en","primary_location":{"id":"doi:10.1016/j.cgh.2023.12.033","doi":"https://doi.org/10.1016/j.cgh.2023.12.033","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.cgh.2023.12.033","pdf_url":"http://www.cghjournal.org/article/S1542356524000466/pdf","source":{"id":"https://openalex.org/S6642600","display_name":"Clinical Gastroenterology and Hepatology","issn_l":"1542-3565","issn":["1542-3565","1542-7714"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Gastroenterology and Hepatology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"http://www.cghjournal.org/article/S1542356524000466/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5046105984","display_name":"Serena Pelusi","orcid":"https://orcid.org/0000-0003-1830-7265","observed_orcids":["https://orcid.org/0000-0003-1830-7265"]},"institutions":[{"id":"https://openalex.org/I2803066834","display_name":"Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico","ror":"https://ror.org/016zn0y21","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I189158943","https://openalex.org/I2803066834","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Serena Pelusi","raw_affiliation_strings":["Precision Medicine Lab, Biological Resource Center - Transfusion Medicine, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Precision Medicine Lab, Biological Resource Center - Transfusion Medicine, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy","institution_ids":["https://openalex.org/I2803066834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057634923","display_name":"Luisa Ronzoni","orcid":"https://orcid.org/0000-0001-7820-6533","observed_orcids":["https://orcid.org/0000-0001-7820-6533"]},"institutions":[{"id":"https://openalex.org/I2803066834","display_name":"Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico","ror":"https://ror.org/016zn0y21","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I189158943","https://openalex.org/I2803066834","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Luisa Ronzoni","raw_affiliation_strings":["Precision Medicine Lab, Biological Resource Center - Transfusion Medicine, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Precision Medicine Lab, Biological Resource Center - Transfusion Medicine, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy","institution_ids":["https://openalex.org/I2803066834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038089814","display_name":"Jessica Rondena","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2803066834","display_name":"Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico","ror":"https://ror.org/016zn0y21","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I189158943","https://openalex.org/I2803066834","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Jessica Rondena","raw_affiliation_strings":["Precision Medicine Lab, Biological Resource Center - Transfusion Medicine, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Precision Medicine Lab, Biological Resource Center - Transfusion Medicine, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy","institution_ids":["https://openalex.org/I2803066834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005284630","display_name":"Chiara Rosso","orcid":"https://orcid.org/0000-0001-6518-7089","observed_orcids":["https://orcid.org/0000-0001-6518-7089"]},"institutions":[{"id":"https://openalex.org/I55143463","display_name":"University of Turin","ror":"https://ror.org/048tbm396","country_code":"IT","type":"education","lineage":["https://openalex.org/I55143463"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Chiara Rosso","raw_affiliation_strings":["Division of Gastroenterology, Department of Medical Sciences, University of Turin, Turin, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gastroenterology, Department of Medical Sciences, University of Turin, Turin, Italy","institution_ids":["https://openalex.org/I55143463"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075129525","display_name":"Grazia Pennisi","orcid":"https://orcid.org/0000-0001-9518-4751","observed_orcids":["https://orcid.org/0000-0001-9518-4751"]},"institutions":[{"id":"https://openalex.org/I900890020","display_name":"University of Palermo","ror":"https://ror.org/044k9ta02","country_code":"IT","type":"education","lineage":["https://openalex.org/I900890020"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Grazia Pennisi","raw_affiliation_strings":["Department of Health promotion, Mother and Childcare, Internal Medicine and Medical Specialties (ProMISE), University of Palermo, Palermo, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Health promotion, Mother and Childcare, Internal Medicine and Medical Specialties (ProMISE), University of Palermo, Palermo, Italy","institution_ids":["https://openalex.org/I900890020"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048054475","display_name":"Paola Dongiovanni","orcid":"https://orcid.org/0000-0003-4343-7213","observed_orcids":["https://orcid.org/0000-0003-4343-7213"]},"institutions":[{"id":"https://openalex.org/I2803066834","display_name":"Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico","ror":"https://ror.org/016zn0y21","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I189158943","https://openalex.org/I2803066834","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Paola Dongiovanni","raw_affiliation_strings":["Medicine and Metabolic Diseases, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicine and Metabolic Diseases, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy","institution_ids":["https://openalex.org/I2803066834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042231442","display_name":"Sara Margarita","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2803066834","display_name":"Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico","ror":"https://ror.org/016zn0y21","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I189158943","https://openalex.org/I2803066834","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Sara Margarita","raw_affiliation_strings":["Precision Medicine Lab, Biological Resource Center - Transfusion Medicine, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Precision Medicine Lab, Biological Resource Center - Transfusion Medicine, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy","institution_ids":["https://openalex.org/I2803066834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084672249","display_name":"Rossana Carpani","orcid":"https://orcid.org/0009-0002-0042-0956","observed_orcids":["https://orcid.org/0009-0002-0042-0956"]},"institutions":[{"id":"https://openalex.org/I2803066834","display_name":"Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico","ror":"https://ror.org/016zn0y21","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I189158943","https://openalex.org/I2803066834","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Rossana Carpani","raw_affiliation_strings":["Precision Medicine Lab, Biological Resource Center - Transfusion Medicine, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Precision Medicine Lab, Biological Resource Center - Transfusion Medicine, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy","institution_ids":["https://openalex.org/I2803066834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087240808","display_name":"Giorgio Soardo","orcid":"https://orcid.org/0000-0003-3181-5651","observed_orcids":["https://orcid.org/0000-0003-3181-5651"]},"institutions":[{"id":"https://openalex.org/I129043915","display_name":"University of Udine","ror":"https://ror.org/05ht0mh31","country_code":"IT","type":"education","lineage":["https://openalex.org/I129043915"]},{"id":"https://openalex.org/I2801626668","display_name":"AREA Science Park","ror":"https://ror.org/01dt7qh15","country_code":"IT","type":"facility","lineage":["https://openalex.org/I2801626668"]},{"id":"https://openalex.org/I4210087406","display_name":"Fondazione Italiana Fegato","ror":"https://ror.org/00zpwa373","country_code":"IT","type":"other","lineage":["https://openalex.org/I4210087406"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giorgio Soardo","raw_affiliation_strings":["Clinica Medica-Liver Unit, Department of Medicine, University of Udine, Udine, Italy; Italian Liver Foundation, Area Science Park, Basovizza-Trieste, Italy","Clinica Medica-Liver Unit, Department of Medicine, University of Udine, Udine, Italy","Italian Liver Foundation, Area Science Park, Basovizza-Trieste, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinica Medica-Liver Unit, Department of Medicine, University of Udine, Udine, Italy; Italian Liver Foundation, Area Science Park, Basovizza-Trieste, Italy","institution_ids":["https://openalex.org/I129043915","https://openalex.org/I2801626668","https://openalex.org/I4210087406"]},{"raw_affiliation_string":"Clinica Medica-Liver Unit, Department of Medicine, University of Udine, Udine, Italy","institution_ids":["https://openalex.org/I129043915"]},{"raw_affiliation_string":"Italian Liver Foundation, Area Science Park, Basovizza-Trieste, Italy","institution_ids":["https://openalex.org/I2801626668","https://openalex.org/I4210087406"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052659695","display_name":"Daniele Prati","orcid":"https://orcid.org/0000-0002-2281-7498","observed_orcids":["https://orcid.org/0000-0002-2281-7498"]},"institutions":[{"id":"https://openalex.org/I2803066834","display_name":"Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico","ror":"https://ror.org/016zn0y21","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I189158943","https://openalex.org/I2803066834","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Daniele Prati","raw_affiliation_strings":["Precision Medicine Lab, Biological Resource Center - Transfusion Medicine, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Precision Medicine Lab, Biological Resource Center - Transfusion Medicine, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy","institution_ids":["https://openalex.org/I2803066834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073205560","display_name":"Annalisa Cespiati","orcid":"https://orcid.org/0000-0001-8116-9307","observed_orcids":["https://orcid.org/0000-0001-8116-9307"]},"institutions":[{"id":"https://openalex.org/I2803066834","display_name":"Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico","ror":"https://ror.org/016zn0y21","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I189158943","https://openalex.org/I2803066834","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Annalisa Cespiati","raw_affiliation_strings":["Medicine and Metabolic Diseases, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicine and Metabolic Diseases, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy","institution_ids":["https://openalex.org/I2803066834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069060952","display_name":"Salvatore Petta","orcid":"https://orcid.org/0000-0002-0822-9673","observed_orcids":["https://orcid.org/0000-0002-0822-9673"]},"institutions":[{"id":"https://openalex.org/I900890020","display_name":"University of Palermo","ror":"https://ror.org/044k9ta02","country_code":"IT","type":"education","lineage":["https://openalex.org/I900890020"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Salvatore Petta","raw_affiliation_strings":["Department of Health promotion, Mother and Childcare, Internal Medicine and Medical Specialties (ProMISE), University of Palermo, Palermo, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Health promotion, Mother and Childcare, Internal Medicine and Medical Specialties (ProMISE), University of Palermo, Palermo, Italy","institution_ids":["https://openalex.org/I900890020"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039389628","display_name":"Elisabetta Bugianesi","orcid":"https://orcid.org/0000-0002-0502-4381","observed_orcids":["https://orcid.org/0000-0002-0502-4381"]},"institutions":[{"id":"https://openalex.org/I55143463","display_name":"University of Turin","ror":"https://ror.org/048tbm396","country_code":"IT","type":"education","lineage":["https://openalex.org/I55143463"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Elisabetta Bugianesi","raw_affiliation_strings":["Division of Gastroenterology, Department of Medical Sciences, University of Turin, Turin, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gastroenterology, Department of Medical Sciences, University of Turin, Turin, Italy","institution_ids":["https://openalex.org/I55143463"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5050497878","display_name":"Luca V. C. Valenti","orcid":"https://orcid.org/0000-0001-8909-0345","observed_orcids":["https://orcid.org/0000-0001-8909-0345"]},"institutions":[{"id":"https://openalex.org/I189158943","display_name":"University of Milan","ror":"https://ror.org/00wjc7c48","country_code":"IT","type":"education","lineage":["https://openalex.org/I189158943"]},{"id":"https://openalex.org/I2803066834","display_name":"Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico","ror":"https://ror.org/016zn0y21","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I189158943","https://openalex.org/I2803066834","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Luca Valenti","raw_affiliation_strings":["Precision Medicine Lab, Biological Resource Center - Transfusion Medicine, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy; Department of Pathophysiology and Transplantation, Universit\u00e0 degli Studi di Milano, Milan, Italy. Electronic address: luca.valenti@unimi.it","Department of Pathophysiology and Transplantation, Universit\u00e0 degli Studi di Milano, Milan, Italy","Precision Medicine Lab, Biological Resource Center \u2013 Transfusion Medicine, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy"],"raw_orcid":"https://orcid.org/0000-0001-8909-0345","affiliations":[{"raw_affiliation_string":"Precision Medicine Lab, Biological Resource Center - Transfusion Medicine, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy; Department of Pathophysiology and Transplantation, Universit\u00e0 degli Studi di Milano, Milan, Italy. Electronic address: luca.valenti@unimi.it","institution_ids":["https://openalex.org/I189158943","https://openalex.org/I2803066834"]},{"raw_affiliation_string":"Department of Pathophysiology and Transplantation, Universit\u00e0 degli Studi di Milano, Milan, Italy","institution_ids":["https://openalex.org/I189158943"]},{"raw_affiliation_string":"Precision Medicine Lab, Biological Resource Center \u2013 Transfusion Medicine, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy","institution_ids":["https://openalex.org/I2803066834"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5050497878"],"corresponding_institution_ids":["https://openalex.org/I189158943","https://openalex.org/I2803066834"],"apc_list":{"value":4050,"currency":"USD","value_usd":4050},"apc_paid":{"value":4050,"currency":"USD","value_usd":4050},"fwci":3.2002,"has_fulltext":true,"cited_by_count":18,"citation_normalized_percentile":{"value":0.93277142,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":99},"biblio":{"volume":"22","issue":"11","first_page":"2231","last_page":"2239.e4"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10351","display_name":"Liver Disease Diagnosis and Treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10351","display_name":"Liver Disease Diagnosis and Treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11834","display_name":"Liver Diseases and Immunity","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/non-alcoholic-fatty-liver-disease","display_name":"non-alcoholic fatty liver disease","score":0.9089999794960022},{"id":"https://openalex.org/keywords/advanced-liver-fibrosis","display_name":"advanced liver fibrosis","score":0.8830000162124634},{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"hepatocellular carcinoma","score":0.7710000276565552},{"id":"https://openalex.org/keywords/family-screening","display_name":"family screening","score":0.7789999842643738},{"id":"https://openalex.org/keywords/first-degree-relatives","display_name":"first-degree relatives","score":0.8669999837875366},{"id":"https://openalex.org/keywords/genetic-risk-variants","display_name":"genetic risk variants","score":0.7879999876022339},{"id":"https://openalex.org/keywords/pnpla3","display_name":"PNPLA3","score":0.9929999709129333},{"id":"https://openalex.org/keywords/polygenic-risk-score","display_name":"polygenic risk score","score":0.9850000143051147},{"id":"https://openalex.org/keywords/diabetes-mellitus","display_name":"diabetes mellitus","score":0.5479999780654907},{"id":"https://openalex.org/keywords/body-mass-index","display_name":"body mass index","score":0.9369999766349792},{"id":"https://openalex.org/keywords/alcohol-consumption","display_name":"alcohol consumption","score":0.8510000109672546},{"id":"https://openalex.org/keywords/sex-differences","display_name":"sex differences","score":0.35600000619888306}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9585463404655457},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4783460795879364},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.46335628628730774},{"id":"https://openalex.org/C2777075537","wikidata":"https://www.wikidata.org/wiki/Q929737","display_name":"Liver disease","level":2,"score":0.42601513862609863},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.42452219128608704},{"id":"https://openalex.org/C512399662","wikidata":"https://www.wikidata.org/wiki/Q3505712","display_name":"Family medicine","level":1,"score":0.36296921968460083},{"id":"https://openalex.org/C199539241","wikidata":"https://www.wikidata.org/wiki/Q7748","display_name":"Law","level":1,"score":0.0},{"id":"https://openalex.org/C17744445","wikidata":"https://www.wikidata.org/wiki/Q36442","display_name":"Political science","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005190","descriptor_name":"Family","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005234","descriptor_name":"Fatty Liver","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005234","descriptor_name":"Fatty Liver","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007558","descriptor_name":"Italy","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D008049","descriptor_name":"Lipase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008103","descriptor_name":"Liver Cirrhosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008103","descriptor_name":"Liver Cirrhosis","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015995","descriptor_name":"Prevalence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1016/j.cgh.2023.12.033","doi":"https://doi.org/10.1016/j.cgh.2023.12.033","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.cgh.2023.12.033","pdf_url":"http://www.cghjournal.org/article/S1542356524000466/pdf","source":{"id":"https://openalex.org/S6642600","display_name":"Clinical Gastroenterology and Hepatology","issn_l":"1542-3565","issn":["1542-3565","1542-7714"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Gastroenterology and Hepatology","raw_type":"journal-article"},{"id":"pmid:38216023","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38216023","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association","raw_type":"Journal Article"},{"id":"pmh:oai:air.unimi.it:2434/1050114","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/2434/1050114","pdf_url":"https://air.unimi.it/bitstream/2434/1050114/2/Prevalence%20and%20Determinants%20of%20Liver%20Disease%20in%20Relatives%20of.pdf","source":{"id":"https://openalex.org/S4306400516","display_name":"Archivio Istituzionale della Ricerca (Universita Degli Studi Di Milano)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I189158943","host_organization_name":"University of Milan","host_organization_lineage":["https://openalex.org/I189158943"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:iris.unipa.it:10447/653995","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/10447/653995","pdf_url":"https://iris.unipa.it/bitstream/10447/653995/2/PIIS1542356524000466.pdf","source":{"id":"https://openalex.org/S4306401065","display_name":"Nova Science Publishers (Nova Science Publishers, Inc.)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:iris.unito.it:2318/2071143","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/2318/2071143","pdf_url":"https://iris.unito.it/bitstream/2318/2071143/1/Pelusi%202024_1-s2.0-S1542356524000466-main.pdf","source":{"id":"https://openalex.org/S4306400637","display_name":"Institutional Research Information System University of Turin (University of Turin)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I55143463","host_organization_name":"University of Turin","host_organization_lineage":["https://openalex.org/I55143463"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1016/j.cgh.2023.12.033","doi":"https://doi.org/10.1016/j.cgh.2023.12.033","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.cgh.2023.12.033","pdf_url":"http://www.cghjournal.org/article/S1542356524000466/pdf","source":{"id":"https://openalex.org/S6642600","display_name":"Clinical Gastroenterology and Hepatology","issn_l":"1542-3565","issn":["1542-3565","1542-7714"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Gastroenterology and Hepatology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G1033601615","display_name":null,"funder_award_id":"PE00000019","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G1125589007","display_name":null,"funder_award_id":"101016726","funder_id":"https://openalex.org/F4320325952","funder_display_name":"Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico"},{"id":"https://openalex.org/G1143825280","display_name":null,"funder_award_id":"777377","funder_id":"https://openalex.org/F4320332999","funder_display_name":"Horizon 2020 Framework Programme"},{"id":"https://openalex.org/G1345875553","display_name":null,"funder_award_id":"PNRR_2022","funder_id":"https://openalex.org/F4320321781","funder_display_name":"Ministero della Salute"},{"id":"https://openalex.org/G1424899889","display_name":null,"funder_award_id":"Gilead_IN-IT-989","funder_id":"https://openalex.org/F4320325952","funder_display_name":"Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico"},{"id":"https://openalex.org/G1535130713","display_name":null,"funder_award_id":"H2020-ICT","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G1573202140","display_name":null,"funder_award_id":"Gilead_IN-IT-989","funder_id":"https://openalex.org/F4320321781","funder_display_name":"Ministero della Salute"},{"id":"https://openalex.org/G16019395","display_name":null,"funder_award_id":"101016726","funder_id":"https://openalex.org/F4320338335","funder_display_name":"H2020 European Research Council"},{"id":"https://openalex.org/G1673562865","display_name":"Liver Investigation: Testing Marker Utility in Steatohepatitis","funder_award_id":"777377","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G2076520454","display_name":null,"funder_award_id":"2018-","funder_id":"https://openalex.org/F4320321781","funder_display_name":"Ministero della Salute"},{"id":"https://openalex.org/G214130837","display_name":"Neuronal microscopy for cell behavioural examination and manipulation","funder_award_id":"101016726","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G2220670817","display_name":null,"funder_award_id":"RF-2021\u201312374481","funder_id":"https://openalex.org/F4320321781","funder_display_name":"Ministero della Salute"},{"id":"https://openalex.org/G2220771028","display_name":null,"funder_award_id":"101016726","funder_id":"https://openalex.org/F4320321781","funder_display_name":"Ministero della Salute"},{"id":"https://openalex.org/G2332353369","display_name":null,"funder_award_id":"PR-0361","funder_id":"https://openalex.org/F4320321781","funder_display_name":"Ministero della Salute"},{"id":"https://openalex.org/G2690294921","display_name":null,"funder_award_id":"IN-IT-989-5790","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G298858806","display_name":null,"funder_award_id":"RF- 2016-02364358","funder_id":"https://openalex.org/F4320321781","funder_display_name":"Ministero della Salute"},{"id":"https://openalex.org/G303857671","display_name":null,"funder_award_id":"RF-2016-02364358","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G3335457583","display_name":null,"funder_award_id":"Gilead_IN-IT-989-5790","funder_id":"https://openalex.org/F4320308573","funder_display_name":"Gilead Sciences"},{"id":"https://openalex.org/G3512296018","display_name":"Understanding Gene ENvironment Interaction in ALcohol-related hepatocellular carcinoma","funder_award_id":"101096312","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G3562261265","display_name":null,"funder_award_id":"101096312","funder_id":"https://openalex.org/F4320332999","funder_display_name":"Horizon 2020 Framework Programme"},{"id":"https://openalex.org/G4011967545","display_name":null,"funder_award_id":"RF-2016-02364358","funder_id":"https://openalex.org/F4320325952","funder_display_name":"Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico"},{"id":"https://openalex.org/G434337789","display_name":null,"funder_award_id":"HORIZON2020","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G4828916014","display_name":null,"funder_award_id":"777377","funder_id":"https://openalex.org/F4320321781","funder_display_name":"Ministero della Salute"},{"id":"https://openalex.org/G488200810","display_name":null,"funder_award_id":"H2020-ICT-2018-20","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G4937468798","display_name":null,"funder_award_id":"H2020","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G5015164659","display_name":null,"funder_award_id":"101016726","funder_id":"https://openalex.org/F4320332999","funder_display_name":"Horizon 2020 Framework Programme"},{"id":"https://openalex.org/G5456500157","display_name":null,"funder_award_id":"H2020-ICT-2018-20/H2020-ICT-2020-2","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G5789651441","display_name":null,"funder_award_id":"777377","funder_id":"https://openalex.org/F4320338335","funder_display_name":"H2020 European Research Council"},{"id":"https://openalex.org/G5990168095","display_name":null,"funder_award_id":"RF-2021-12373889,","funder_id":"https://openalex.org/F4320321781","funder_display_name":"Ministero della Salute"},{"id":"https://openalex.org/G602845763","display_name":null,"funder_award_id":"101096312","funder_id":"https://openalex.org/F4320338335","funder_display_name":"H2020 European Research Council"},{"id":"https://openalex.org/G6416529685","display_name":null,"funder_award_id":"PE00000019 CUP B73C22001250006","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G6515864842","display_name":null,"funder_award_id":"RF-2021-12372399","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G6716910261","display_name":null,"funder_award_id":"RF\u20102021\u201012372399","funder_id":"https://openalex.org/F4320321781","funder_display_name":"Ministero della Salute"},{"id":"https://openalex.org/G686558340","display_name":null,"funder_award_id":"PNRR-MAD-2022-12375656","funder_id":"https://openalex.org/F4320321781","funder_display_name":"Ministero della Salute"},{"id":"https://openalex.org/G7623918730","display_name":null,"funder_award_id":"Gilead_IN-IT-989","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G8474960557","display_name":null,"funder_award_id":"HORIZON-MISS-2021-CANCER-02-03","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G8891374485","display_name":null,"funder_award_id":"B73C22001250006","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G8982248070","display_name":null,"funder_award_id":"777377","funder_id":"https://openalex.org/F4320325952","funder_display_name":"Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico"},{"id":"https://openalex.org/G969404240","display_name":null,"funder_award_id":"777377","funder_id":"https://openalex.org/F4320314178","funder_display_name":"European Federation of Pharmaceutical Industries and Associations"}],"funders":[{"id":"https://openalex.org/F4320307765","display_name":"Pfizer","ror":"https://ror.org/01xdqrp08"},{"id":"https://openalex.org/F4320308573","display_name":"Gilead Sciences","ror":"https://ror.org/056546b03"},{"id":"https://openalex.org/F4320314178","display_name":"European Federation of Pharmaceutical Industries and Associations","ror":"https://ror.org/00g1x4v36"},{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320321781","display_name":"Ministero della Salute","ror":"https://ror.org/00789fa95"},{"id":"https://openalex.org/F4320322436","display_name":"Novo Nordisk","ror":"https://ror.org/0435rc536"},{"id":"https://openalex.org/F4320325952","display_name":"Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico","ror":"https://ror.org/016zn0y21"},{"id":"https://openalex.org/F4320332999","display_name":"Horizon 2020 Framework Programme","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320335254","display_name":"Horizon 2020","ror":null},{"id":"https://openalex.org/F4320338335","display_name":"H2020 European Research Council","ror":"https://ror.org/0472cxd90"},{"id":"https://openalex.org/F5497039910","display_name":"Ministero dell'Istruzione e del Merito","ror":"https://ror.org/01ehyh486"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4390741789.pdf","grobid_xml":"https://content.openalex.org/works/W4390741789.grobid-xml"},"referenced_works_count":30,"referenced_works":["https://openalex.org/W1979443397","https://openalex.org/W2162530578","https://openalex.org/W2300292045","https://openalex.org/W2343343747","https://openalex.org/W2424117782","https://openalex.org/W2626867658","https://openalex.org/W2889562911","https://openalex.org/W2919587539","https://openalex.org/W3000479870","https://openalex.org/W3003361050","https://openalex.org/W3004950447","https://openalex.org/W3009973508","https://openalex.org/W3106622583","https://openalex.org/W3143409077","https://openalex.org/W3174905293","https://openalex.org/W3185695685","https://openalex.org/W3199470621","https://openalex.org/W3201561713","https://openalex.org/W4200310144","https://openalex.org/W4223546269","https://openalex.org/W4245784696","https://openalex.org/W4288050262","https://openalex.org/W4297042482","https://openalex.org/W4307717780","https://openalex.org/W4318923555","https://openalex.org/W4353042003","https://openalex.org/W4366580297","https://openalex.org/W4381893710","https://openalex.org/W4382933620","https://openalex.org/W4387420967"],"related_works":["https://openalex.org/W7214051880","https://openalex.org/W4415620362","https://openalex.org/W7204278484","https://openalex.org/W4392047088","https://openalex.org/W7160509749","https://openalex.org/W4410083914","https://openalex.org/W4414568747","https://openalex.org/W4413836881","https://openalex.org/W4394687296","https://openalex.org/W4409251161"],"abstract_inverted_index":{"BACKGROUND":[0],"&":[1],"AIMS:":[2],"Metabolic":[3],"dysfunction":[4],"associated":[5,124,138,160],"steatotic":[6],"liver":[7,44,99,250],"disease":[8,251],"(MASLD)":[9],"has":[10,232],"a":[11,47],"strong":[12],"genetic":[13,54,92,199],"component.":[14],"The":[15],"aim":[16],"of":[17,26,29,34,52,98,105,198,213,227],"this":[18,243],"study":[19],"was":[20,107,113,123,159,181,206],"to":[21,136,190,209,238,249],"examine":[22],"noninvasively":[23,78],"the":[24,40,50,177],"prevalence":[25,104],"MASLD":[27,38,72,81,106,122,193,231],"and":[28,39,73,82,94,134,149,166,188,202],"advanced":[30,37,65,83,111,157,214,230,233],"fibrosis":[31,66,84,112,158,215,259],"in":[32,115,120,183,216,224,242],"relatives":[33,77,191,226],"patients":[35,228],"with":[36,46,64,125,139,150,161,168,192,229],"risk":[41,55,96,179,200,204,246,260],"factors":[42],"for":[43,80],"involvement,":[45],"focus":[48],"on":[49],"contribution":[51],"common":[53,91],"variants.":[56],"METHODS:":[57],"We":[58,89,219],"prospectively":[59],"enrolled":[60],"98":[61],"consecutive":[62],"probands":[63,184],"and/or":[67],"hepatocellular":[68],"carcinoma":[69],"caused":[70],"by":[71],"160":[74],"nontwin":[75],"first-degree":[76],"screened":[79],"at":[85],"4":[86],"Italian":[87],"centers.":[88],"evaluated":[90],"determinants":[93],"polygenic":[95,203],"scores":[97,205],"disease.":[100],"RESULTS:":[101],"Among":[102],"relatives,":[103,121],"56.8%":[108],"overall,":[109],"whereas":[110,156],"observed":[114],"14.4%.":[116],"At":[117],"multivariable":[118],"analysis":[119],"body":[126,169],"mass":[127,170],"index":[128,171],"(odds":[129],"ratio":[130],"[OR],":[131],"1.31":[132],"[1.18-1.46])":[133],"tended":[135],"be":[137],"diabetes":[140,162],"(OR,":[141,146,153,163,172],"5.21":[142],"[0.97-28.10]),":[143],"alcohol":[144],"intake":[145],"1.32":[147],"[0.98-1.78]),":[148],"female":[151],"sex":[152],"0.54":[154],"[0.23-1.15]),":[155],"3.13":[164],"[1.16-8.45])":[165],"nearly":[167],"1.09":[173],"[1.00-1.19]).":[174],"Despite":[175],"that":[176,221],"PNPLA3":[178],"variant":[180],"enriched":[182],"(P":[185,194],"=":[186,195],".003)":[187],"overtransmitted":[189],".045),":[196],"evaluation":[197],"variants":[201,247],"not":[207,256],"useful":[208],"guide":[210],"noninvasive":[211],"screening":[212,241],"relatives.":[217],"CONCLUSIONS:":[218],"confirmed":[220],"about":[222],"1":[223],"7":[225],"fibrosis,":[234],"supporting":[235],"clinical":[236],"recommendations":[237],"perform":[239],"family":[240],"setting.":[244],"Genetic":[245],"contributed":[248],"within":[252],"families":[253],"but":[254],"did":[255],"meaningfully":[257],"improve":[258],"stratification.":[261]},"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":6}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2024-01-13T00:00:00"}