{"id":"https://openalex.org/W4390739417","doi":"https://doi.org/10.18060/27756","title":"The Potential Tripartite Connection: Alzheimer's Disease, Fracture Healing, and the Gut Microbiome","display_name":"The Potential Tripartite Connection: Alzheimer's Disease, Fracture Healing, and the Gut Microbiome","publication_year":2024,"publication_date":"2024-01-11","ids":{"openalex":"https://openalex.org/W4390739417","doi":"https://doi.org/10.18060/27756"},"language":"en","primary_location":{"id":"doi:10.18060/27756","doi":"https://doi.org/10.18060/27756","is_oa":true,"landing_page_url":"https://doi.org/10.18060/27756","pdf_url":"https://journals.iupui.edu/index.php/IMPRS/article/download/27756/25188","source":{"id":"https://openalex.org/S4210207624","display_name":"Proceedings of IMPRS","issn_l":"2641-2470","issn":["2641-2470"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310316553","host_organization_name":"Indiana University School of Medicine","host_organization_lineage":["https://openalex.org/P4310316553"],"host_organization_lineage_names":["Indiana University School of Medicine"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of IMPRS","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://journals.iupui.edu/index.php/IMPRS/article/download/27756/25188","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Reggie Parker","orcid":"https://orcid.org/0009-0002-2896-6942","observed_orcids":["https://orcid.org/0009-0002-2896-6942"]},"institutions":[{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Reggie Parker","raw_affiliation_strings":["Department of Orthopaedic Surgery, Indiana University School of Medicine"],"raw_orcid":"https://orcid.org/0009-0002-2896-6942","affiliations":[{"raw_affiliation_string":"Department of Orthopaedic Surgery, Indiana University School of Medicine","institution_ids":["https://openalex.org/I4394709130"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5093675879","display_name":"Will Varner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Will Varner","raw_affiliation_strings":["Department of Orthopaedic Surgery, Indiana University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedic Surgery, Indiana University School of Medicine","institution_ids":["https://openalex.org/I4394709130"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076729045","display_name":"Murad K. Nazzal","orcid":"https://orcid.org/0000-0002-3490-1160","observed_orcids":["https://orcid.org/0000-0002-3490-1160"]},"institutions":[{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Murad Nazzal","raw_affiliation_strings":["Department of Orthopaedic Surgery, Indiana University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedic Surgery, Indiana University School of Medicine","institution_ids":["https://openalex.org/I4394709130"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014618118","display_name":"Amy Creecy","orcid":"https://orcid.org/0000-0001-5645-0164","observed_orcids":["https://orcid.org/0000-0001-5645-0164"]},"institutions":[{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amy Creecy","raw_affiliation_strings":["Department of Orthopaedic Surgery, Indiana University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedic Surgery, Indiana University School of Medicine","institution_ids":["https://openalex.org/I4394709130"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026553102","display_name":"Sonali Jayant Karnik","orcid":"https://orcid.org/0000-0002-1905-2885","observed_orcids":["https://orcid.org/0000-0002-1905-2885"]},"institutions":[{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sonali J. Karnik","raw_affiliation_strings":["Department of Orthopaedic Surgery, Indiana University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedic Surgery, Indiana University School of Medicine","institution_ids":["https://openalex.org/I4394709130"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031785322","display_name":"Rachel J. Blosser","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rachel J. Blosser","raw_affiliation_strings":["Department of Orthopaedic Surgery, Indiana University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedic Surgery, Indiana University School of Medicine","institution_ids":["https://openalex.org/I4394709130"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112212119","display_name":"Elizabeth A. Scott","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elizabeth Scott","raw_affiliation_strings":["Department of Orthopaedic Surgery, Indiana University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedic Surgery, Indiana University School of Medicine","institution_ids":["https://openalex.org/I4394709130"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101727781","display_name":"Alexander Harris","orcid":"https://orcid.org/0009-0001-8099-5399","observed_orcids":["https://orcid.org/0009-0001-8099-5399"]},"institutions":[{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexander Harris","raw_affiliation_strings":["Department of Orthopaedic Surgery, Indiana University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedic Surgery, Indiana University School of Medicine","institution_ids":["https://openalex.org/I4394709130"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103208556","display_name":"Ashlyn J. Morris","orcid":"https://orcid.org/0000-0002-5477-1201","observed_orcids":["https://orcid.org/0000-0002-5477-1201"]},"institutions":[{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ashlyn Morris","raw_affiliation_strings":["Department of Orthopaedic Surgery, Indiana University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedic Surgery, Indiana University School of Medicine","institution_ids":["https://openalex.org/I4394709130"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111114015","display_name":"Hannah S. Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hannah Wang","raw_affiliation_strings":["Department of Orthopaedic Surgery, Indiana University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedic Surgery, Indiana University School of Medicine","institution_ids":["https://openalex.org/I4394709130"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085140344","display_name":"Tyler J. Margetts","orcid":"https://orcid.org/0000-0001-8511-352X","observed_orcids":["https://orcid.org/0000-0001-8511-352X"]},"institutions":[{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tyler Margetts","raw_affiliation_strings":["Department of Orthopaedic Surgery, Indiana University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedic Surgery, Indiana University School of Medicine","institution_ids":["https://openalex.org/I4394709130"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5093703195","display_name":"Marko V. Dragisic","orcid":"https://orcid.org/0009-0006-1900-8012","observed_orcids":["https://orcid.org/0009-0006-1900-8012"]},"institutions":[{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marko Dragisic","raw_affiliation_strings":["Department of Orthopaedic Surgery, Indiana University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedic Surgery, Indiana University School of Medicine","institution_ids":["https://openalex.org/I4394709130"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075368606","display_name":"Upasana Ganguly","orcid":"https://orcid.org/0000-0003-4042-9103","observed_orcids":["https://orcid.org/0000-0003-4042-9103"]},"institutions":[{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Upasana Ganguly","raw_affiliation_strings":["Department of Orthopaedic Surgery, Indiana University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedic Surgery, Indiana University School of Medicine","institution_ids":["https://openalex.org/I4394709130"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065178270","display_name":"Jill C. Fehrenbacher","orcid":"https://orcid.org/0000-0003-0730-9644","observed_orcids":["https://orcid.org/0000-0003-0730-9644"]},"institutions":[{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jill C. Fehrenbacher","raw_affiliation_strings":["Department of Pharmacology and Toxicology, Indiana University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Toxicology, Indiana University School of Medicine","institution_ids":["https://openalex.org/I4394709130"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068879100","display_name":"Kathryn D. Fischer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kathryn D. Fischer","raw_affiliation_strings":["Department of Pharmacology and Toxicology, Indiana University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Toxicology, Indiana University School of Medicine","institution_ids":["https://openalex.org/I4394709130"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076740896","display_name":"Alexandru Movil\u0103","orcid":"https://orcid.org/0000-0001-9827-7347","observed_orcids":["https://orcid.org/0000-0001-9827-7347","https://orcid.org/0000-0001-9612-4726"]},"institutions":[{"id":"https://openalex.org/I592451","display_name":"Indiana University","ror":"https://ror.org/01kg8sb98","country_code":"US","type":"education","lineage":["https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexandru Movila","raw_affiliation_strings":["Department of Biomedical Sciences and Comprehensive Care, Indiana University School of Dentistry"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Sciences and Comprehensive Care, Indiana University School of Dentistry","institution_ids":["https://openalex.org/I592451"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045057254","display_name":"Adrian L. Oblak","orcid":"https://orcid.org/0000-0003-1210-8791","observed_orcids":["https://orcid.org/0000-0003-1210-8791"]},"institutions":[{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Adrian L. Oblak","raw_affiliation_strings":["Department of Radiology and Imaging Sciences, Indiana University School of Medicine; The Stark Neurosciences Research Institute","Department of Radiology and Imaging Sciences, Indiana University School of Medicine","The Stark Neurosciences Research Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology and Imaging Sciences, Indiana University School of Medicine; The Stark Neurosciences Research Institute","institution_ids":["https://openalex.org/I4394709130"]},{"raw_affiliation_string":"Department of Radiology and Imaging Sciences, Indiana University School of Medicine","institution_ids":["https://openalex.org/I4394709130"]},{"raw_affiliation_string":"The Stark Neurosciences Research Institute","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059334893","display_name":"Jessica D. Hathaway\u2010Schrader","orcid":"https://orcid.org/0000-0003-2270-4378","observed_orcids":["https://orcid.org/0000-0003-2270-4378"]},"institutions":[{"id":"https://openalex.org/I153297377","display_name":"Medical University of South Carolina","ror":"https://ror.org/012jban78","country_code":"US","type":"education","lineage":["https://openalex.org/I153297377"]},{"id":"https://openalex.org/I2799886695","display_name":"Veterans Health Administration","ror":"https://ror.org/05eq41471","country_code":"US","type":"government","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695"]},{"id":"https://openalex.org/I4210132004","display_name":"Ralph H. Johnson VA Medical Center","ror":"https://ror.org/030ma0n95","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210131075","https://openalex.org/I4210132004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jessica Hathaway-Schrader","raw_affiliation_strings":["Division of Periodontics, Medical University of South Carolina; Ralph H. Johnson VA Medical Center,","Division of Periodontics, Medical University of South Carolina","Ralph H. Johnson VA Medical Center,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Periodontics, Medical University of South Carolina; Ralph H. Johnson VA Medical Center,","institution_ids":["https://openalex.org/I153297377","https://openalex.org/I4210132004"]},{"raw_affiliation_string":"Division of Periodontics, Medical University of South Carolina","institution_ids":["https://openalex.org/I153297377"]},{"raw_affiliation_string":"Ralph H. Johnson VA Medical Center,","institution_ids":["https://openalex.org/I2799886695","https://openalex.org/I4210132004"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5034416233","display_name":"Melissa A. Kacena","orcid":"https://orcid.org/0000-0001-7293-0088","observed_orcids":["https://orcid.org/0000-0001-7293-0088"]},"institutions":[{"id":"https://openalex.org/I4210110049","display_name":"Richard L. Roudebush VA Medical Center","ror":"https://ror.org/01zpmbk67","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210110049","https://openalex.org/I4210127612","https://openalex.org/I4388446366","https://openalex.org/I592451"]},{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Melissa A. Kacena","raw_affiliation_strings":["Department of Orthopaedic Surgery, Indiana University School of Medicine; Richard L. Roudebush VA Medical Center","Department of Orthopaedic Surgery, Indiana University School of Medicine","Richard L. Roudebush VA Medical Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedic Surgery, Indiana University School of Medicine; Richard L. Roudebush VA Medical Center","institution_ids":["https://openalex.org/I4210110049","https://openalex.org/I4394709130"]},{"raw_affiliation_string":"Department of Orthopaedic Surgery, Indiana University School of Medicine","institution_ids":["https://openalex.org/I4394709130"]},{"raw_affiliation_string":"Richard L. Roudebush VA Medical Center","institution_ids":["https://openalex.org/I4210110049"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.00235065,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"6","issue":"1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.002099999925121665,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.002099999925121665,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":1.0},{"id":"https://openalex.org/keywords/fracture-healing","display_name":"fracture healing","score":0.9980000257492065},{"id":"https://openalex.org/keywords/gut-microbiota","display_name":"gut microbiota","score":0.9990000128746033},{"id":"https://openalex.org/keywords/gut-dysbiosis","display_name":"gut dysbiosis","score":0.9819999933242798},{"id":"https://openalex.org/keywords/gut-brain-axis","display_name":"gut-brain axis","score":0.9829999804496765},{"id":"https://openalex.org/keywords/bone-health","display_name":"bone health","score":0.7509999871253967},{"id":"https://openalex.org/keywords/3xtg-ad-mice","display_name":"3xTg-AD mice","score":0.722000002861023},{"id":"https://openalex.org/keywords/5xfad-mice","display_name":"5xFAD mice","score":0.9950000047683716},{"id":"https://openalex.org/keywords/osteotomy","display_name":"osteotomy","score":0.9129999876022339},{"id":"https://openalex.org/keywords/pro-inflammatory-bacteria","display_name":"pro-inflammatory bacteria","score":0.7580000162124634},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.6959999799728394}],"concepts":[{"id":"https://openalex.org/C143121216","wikidata":"https://www.wikidata.org/wiki/Q1330402","display_name":"Microbiome","level":2,"score":0.6894403696060181},{"id":"https://openalex.org/C3019978661","wikidata":"https://www.wikidata.org/wiki/Q739734","display_name":"Gut microbiome","level":3,"score":0.6713756322860718},{"id":"https://openalex.org/C13355873","wikidata":"https://www.wikidata.org/wiki/Q2920850","display_name":"Connection (principal bundle)","level":2,"score":0.5918647050857544},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5682267546653748},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.4150359034538269},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4029814302921295},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3577710688114166},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3199898600578308},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.2237463891506195},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.10098123550415039},{"id":"https://openalex.org/C66938386","wikidata":"https://www.wikidata.org/wiki/Q633538","display_name":"Structural engineering","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.18060/27756","doi":"https://doi.org/10.18060/27756","is_oa":true,"landing_page_url":"https://doi.org/10.18060/27756","pdf_url":"https://journals.iupui.edu/index.php/IMPRS/article/download/27756/25188","source":{"id":"https://openalex.org/S4210207624","display_name":"Proceedings of IMPRS","issn_l":"2641-2470","issn":["2641-2470"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310316553","host_organization_name":"Indiana University School of Medicine","host_organization_lineage":["https://openalex.org/P4310316553"],"host_organization_lineage_names":["Indiana University School of Medicine"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of IMPRS","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.18060/27756","doi":"https://doi.org/10.18060/27756","is_oa":true,"landing_page_url":"https://doi.org/10.18060/27756","pdf_url":"https://journals.iupui.edu/index.php/IMPRS/article/download/27756/25188","source":{"id":"https://openalex.org/S4210207624","display_name":"Proceedings of IMPRS","issn_l":"2641-2470","issn":["2641-2470"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310316553","host_organization_name":"Indiana University School of Medicine","host_organization_lineage":["https://openalex.org/P4310316553"],"host_organization_lineage_names":["Indiana University School of Medicine"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of IMPRS","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4390739417.pdf","grobid_xml":"https://content.openalex.org/works/W4390739417.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4390739587","https://openalex.org/W4392883216","https://openalex.org/W4416715141","https://openalex.org/W4405261069","https://openalex.org/W4414678546","https://openalex.org/W4415113818","https://openalex.org/W4319215978","https://openalex.org/W4310704867","https://openalex.org/W7212272983","https://openalex.org/W4391933703"],"abstract_inverted_index":{"Alzheimer's":[0],"disease":[1],"(AD),":[2],"fracture":[3,53,80,149,173,198,220,244],"healing,":[4,150,245],"and":[5,52,99,107,124,129,145,148,157,200,217,246],"the":[6,34,42,61,67,73,76,94,162,168,212,219,237],"gut":[7,23,43,77,169,184,190,238],"microbiome":[8,78,239],"are":[9,119],"interconnected":[10],"aspects":[11],"of":[12,75,164,214],"health":[13,48],"that":[14,60,111,161,192],"have":[15,58],"gained":[16],"significant":[17],"research":[18,56],"interest.":[19],"Recent":[20],"studies":[21],"suggest":[22],"dysbiosis":[24,51],"may":[25,187],"play":[26,193],"a":[27,37,205],"role":[28,45],"in":[29,46,82,196,211,249],"AD":[30,83,95,140,165,215,247],"pathogenesis,":[31],"potentially":[32,171],"through":[33,143,178],"gut-brain":[35],"axis,":[36],"bidirectional":[38],"communication":[39],"system.":[40],"Moreover,":[41],"microbiome's":[44],"bone":[47,242],"could":[49,166,229],"link":[50],"risk.":[54],"Furthermore,":[55],"reports":[57],"revealed":[59],"brain":[62],"communicates":[63],"with":[64],"bone,":[65],"termed":[66],"bone-brain":[68],"axis.":[69],"Despite":[70],"these":[71,89,105],"insights,":[72],"effect":[74],"on":[79,104],"healing":[81,199,221],"remains":[84],"largely":[85],"unexplored.":[86],"To":[87],"uncover":[88],"connections,":[90],"our":[91],"study":[92],"uses":[93],"mouse":[96],"models,":[97],"3xTg":[98],"5xFAD.":[100],"We":[101,159,186,202],"conducted":[102],"osteotomies":[103],"mice":[106],"analyzed":[108],"fecal":[109],"samples":[110,118],"were":[112],"collected":[113],"at":[114,235],"different":[115],"timepoints.":[116],"Fecal":[117],"being":[120],"examined":[121],"via":[122],"qPCR":[123],"16s":[125],"RNA":[126],"analysis":[127],"toidentify":[128],"quantify":[130],"bacterial":[131,209],"phyla.":[132],"These":[133],"findings":[134],"will":[135],"be":[136],"linked":[137],"to":[138,240],"both":[139,197],"progression,":[141],"gauged":[142],"behavior":[144],"histological":[146],"analyses,":[147],"quantified":[151],"using":[152],"X-ray":[153],"mRUST":[154],"scoring,":[155],"microCT,":[156],"histology.":[158],"hypothesize":[160],"progression":[163,216,248],"alter":[167],"microbiome,":[170],"affecting":[172],"healing.":[174],"This":[175],"might":[176],"occur":[177],"inflammation":[179],"pathways":[180],"triggered":[181],"by":[182],"specific":[183,189],"bacteria.":[185],"identify":[188],"bacteria":[191],"critical":[194],"roles":[195],"AD.":[201],"anticipate":[203],"finding":[204],"shift":[206],"towards":[207],"pro-inflammatory":[208],"phyla":[210],"context":[213],"during":[218],"process.":[222],"If":[223],"this":[224],"hypothesis":[225],"is":[226],"validated,":[227],"it":[228],"unlock":[230],"new":[231],"therapeutic":[232],"strategies":[233],"aimed":[234],"targeting":[236],"improve":[241],"health,":[243],"patients.":[250]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2024-01-13T00:00:00"}
